5T56: Microcin J25

[3]catenane from MccJ25 G12R/I13C/G21C lasso peptide. Determined by solution NMR. Released 12 Jul 2017.

Method: Solution NMR
Organism: Escherichia coli
Chains: 4
Atoms: 318
Mol. weight: 4.56 kDa
Released: 12 Jul 2017

Explore 5T56 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5T56 contains 0 α-helices and 5 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 0 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	2	1	1
β-strand	6-7	2	1

Chain B: 0 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	19-20	2	1

Chain C: 0 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	23-28	6	2

Chain D: 0 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	40	1	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Microcin J25	A, C	protein	12	Escherichia coli	Q9X2V7 (AlphaFold model)
Microcin J25	B, D	protein	9	Escherichia coli	Q9X2V7 (AlphaFold model)

Sequence of entity 1 (A, C), FASTA

>5T56_1 Microcin J25 (chains A, C)
GGAGHVPEYFVR

Sequence of entity 2 (B, D), FASTA

>5T56_2 Microcin J25 (chains B, D)
CGTPISFYC

Primary citation

Self-Assembly of Catenanes from Lasso Peptides. Allen, C.D., Link, A.J. J Am Chem Soc (2016) 138:14214-14217. DOI 10.1021/jacs.6b09454 · PubMed

Other PDB entries of the same protein (UniProt Q9X2V7 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4CU4 2.3 Å, FhuA from E. coli in complex with the lasso peptide microcin J25 (MccJ25)
6N60 3.68 Å, Escherichia coli RNA polymerase sigma70-holoenzyme bound to upstream fork promoter DNA…
1PP5 Structure of Antibacterial Peptide Microcin J25: a 21-Residue Lariat Protoknot
1Q71 The structure of microcin J25 is a threaded sidechain-to-backbone ring structure and not…
1S7P Solution structure of thermolysin digested microcin J25
23FQ Dipeptide removal from MccJ25 yields a new lasso peptide delta-VG
2MMT Lasso peptide-based integrin inhibitor: Microcin J25 variant with RGDF substitution of…
2MMW Lasso peptide based integrin inhibitor: microcin J25 variant with rgd substitution of…

Browse structure collections

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