Crystal Structure of ADP-bound human TRIP13. Determined by X-ray diffraction at 2.5 Å resolution. Released 25 Apr 2018.
Explore 5WC2 in 3D Show helices and sheets RCSB PDB PDBe
5WC2 contains 16 α-helices and 14 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 20-27 | 8 | 1 |
| α-helix | 35-49 | 15 | |
| β-strand | 57-58 | 2 | 1 |
| α-helix | 64-69 | 6 | |
| β-strand | 70-76 | 7 | 1 |
| β-strand | 94-101 | 8 | 1 |
| β-strand | 103 | 1 | 2 |
| β-strand | 122-127 | 6 | 3 |
| β-strand | 129 | 1 | 2 |
| α-helix | 130-132 | 3 | |
| α-helix | 135-138 | 4 | |
| α-helix | 145-161 | 17 | |
| β-strand | 174-178 | 5 | 3 |
| α-helix | 185-199 | 15 | |
| β-strand | 206-212 | 7 | 3 |
| α-helix | 229-240 | 12 | |
| β-strand | 245-251 | 7 | 3 |
| α-helix | 255-259 | 5 | |
| α-helix | 273-287 | 15 | |
| β-strand | 293-299 | 7 | 3 |
| α-helix | 308-311 | 4 | |
| β-strand | 315-318 | 4 | 3 |
| α-helix | 321-323 | 3 | |
| α-helix | 324-340 | 17 | |
| β-strand | 344 | 1 | 4 |
| α-helix | 353-358 | 6 | |
| α-helix | 368-379 | 12 | |
| α-helix | 385-399 | 15 | |
| β-strand | 405 | 1 | 4 |
| α-helix | 407-428 | 22 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Pachytene checkpoint protein 2 homolog | A | protein | 432 | Homo sapiens | Q15645 (AlphaFold model) |
>5WC2_1 Pachytene checkpoint protein 2 homolog (chains A) MDEAVGDLKQALPCVAESPTVHVEVHQRGSSTAKKEDINLSVRKLLNRHNIVFGDYTWTE FDEPFLTRNVQSVSIIDTELKVKDSQPIDLSACTVALHIFQLNEDGPSSENLEEETENII AANHWVLPAAEFHGLWDSLVYDVEVKSHLLDYVMTTLLFSDKNVNSNLITWNRVVLLHGP PGTGKTSLCKALAQKLTIRLSSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQDLI DDKDALVFVLIDAVESLTAARNACRAGTEPSDAIRVVNAVLTQIDQIKRHSNVVILTTSN ITEKIDVAFVDRADIKQYIGPPSAAAIFKIYLSCLEELMKCQIIYPRQQLLTLRELEMIG FIENNVSKLSLLLNDISRKSEGLSGRVLRKLPFLAHALYVQAPTVTIEGFLQALSLAVDK QFEERKKLAAYI
| ID | Name | Formula | Copies |
|---|---|---|---|
| ADP | Adenosine-5'-diphosphate | C10 H15 N5 O10 P2 | 1 |
Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing. Brulotte, M.L., Jeong, B.C., Li, F. et al. Nat Commun (2017) 8:1956-1956. DOI 10.1038/s41467-017-02012-2 · PubMed
Other PDB entries of the same protein (UniProt Q15645 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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