Structure of the Tir-CesT effector-chaperone complex. Determined by X-ray diffraction at 2.74 Å resolution. Released 11 Jul 2018.
Explore 5WEZ in 3D Show helices and sheets RCSB PDB PDBe
5WEZ contains 3 α-helices and 7 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 4-16 | 13 | |
| β-strand | 28-33 | 6 | 1 |
| β-strand | 37-42 | 6 | 1 |
| β-strand | 48-57 | 10 | 1 |
| α-helix | 66-79 | 14 | |
| β-strand | 83-86 | 4 | 1 |
| β-strand | 92-100 | 9 | 1 |
| α-helix | 106-126 | 21 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 36-37 | 2 | 1 |
| β-strand | 48-50 | 3 | 1 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Tir chaperone | A | protein | 139 | Escherichia coli O127:H6 (strain E2348/69 / EPEC) | P21244 (AlphaFold model) |
| Translocated intimin receptor Tir | B | protein | 63 | Escherichia coli O127:H6 (strain E2348/69 / EPEC) | B7UM99 (AlphaFold model) |
>5WEZ_1 Tir chaperone (chains A) MASSRSELLLDRFAEKIGVGSISFNENRLCSFAIDEIYYISLSDANDEYMMIYGVCGKFP TDNPNFALEILNANLWFAENGGPYLCYESGAQSLLLALRFPLDDATPEKLENEIEVVVKS MENLYLVLHNQGITLENEH
>5WEZ_2 Translocated intimin receptor Tir (chains B) MGSSHHHHHHSQDPGGTGHLISSTGALGSRSLFSPLRNSMADSVDSRDIPGLPTNPSRLA AAT
Molecular basis for CesT recognition of type III secretion effectors in enteropathogenic Escherichia coli. Little, D.J., Coombes, B.K. PLoS Pathog (2018) 14:e1007224-e1007224. DOI 10.1371/journal.ppat.1007224 · PubMed
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