Crystal Structure of the Human mitochondrial Cysteine Desulfurase in complex with ISD11 and E. coli ACP1 protein at 2.75A. Determined by X-ray diffraction at 2.75 Å resolution. Released 26 Jul 2017.
Explore 5WGB in 3D Show helices and sheets RCSB PDB PDBe
5WGB contains 18 α-helices and 18 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 68-70 | 3 | |
| α-helix | 71-81 | 11 | |
| α-helix | 98-114 | 17 | |
| α-helix | 118-120 | 3 | |
| β-strand | 121-124 | 4 | 1 |
| α-helix | 127-141 | 15 | |
| β-strand | 148-152 | 5 | 1 |
| α-helix | 157-168 | 12 | |
| β-strand | 172-176 | 5 | 1 |
| α-helix | 177 | 1 | |
| β-strand | 178 | 1 | 2 |
| β-strand | 184 | 1 | 2 |
| α-helix | 186-192 | 7 | |
| β-strand | 197-201 | 5 | 1 |
| β-strand | 205 | 1 | 3 |
| β-strand | 211 | 1 | 4 |
| β-strand | 212 | 1 | 3 |
| α-helix | 215-225 | 11 | |
| β-strand | 228-232 | 5 | 1 |
| β-strand | 251-255 | 5 | 1 |
| β-strand | 266-270 | 5 | 1 |
| α-helix | 298-336 | 39 | |
| β-strand | 341-342 | 2 | 5 |
| α-helix | 346-348 | 3 | |
| β-strand | 349 | 1 | 4 |
| β-strand | 353-357 | 5 | 5 |
| β-strand | 405-409 | 5 | 5 |
| α-helix | 416-427 | 12 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 7-20 | 14 | |
| α-helix | 26-42 | 17 | |
| α-helix | 49-75 | 27 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 8-15 | 8 | |
| β-strand | 27 | 1 | 6 |
| α-helix | 36-50 | 15 | |
| β-strand | 64 | 1 | 6 |
| α-helix | 65-72 | 8 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Cysteine desulfurase, mitochondrial | A | protein | 426 | Homo sapiens | Q9Y697 (AlphaFold model) |
| LYR motif-containing protein 4 | B | protein | 91 | Homo sapiens | Q9HD34 (AlphaFold model) |
| Acyl carrier protein | C | protein | 77 | Escherichia coli O45:K1 (strain S88 / ExPEC) | B7MJ81 (AlphaFold model) |
>5WGB_1 Cysteine desulfurase, mitochondrial (chains A) MGSSHHHHHHSSGLVPRGSHMLEMLRPLYMDVQATTPLDPRVLDAMLPYLINYYGNPHSR THAYGWESEAAMERARQQVASLIGADPREIIFTSGATESNNIAIKGVARFYRSRKKHLIT TQTEHKCVLDSCRSLEAEGFQVTYLPVQKSGIIDLKELEAAIQPDTSLVSVMTVNNEIGV KQPIAEIGRICSSRKVYFHTDAAQAVGKIPLDVNDMKIDLMSISGHKIYGPKGVGAIYIR RRPRVRVEALQSGGGQERGMRSGTVPTPLVVGLGAACEVAQQEMEYDHKRISKLSERLIQ NIMKSLPDVVMNGDPKHHYPGCINLSFAYVEGESLLMALKDVALSSGSACTSASLEPSYV LRAIGTDEDLAHSSIRFGIGRFTTEEEVDYTVEKCIQHVKRLREMSPLWEMVQDGIDLKS IKWTQH
>5WGB_2 LYR motif-containing protein 4 (chains B) MAASSRAQVLALYRAMLRESKRFSAYNYRTYAVRRIRDAFRENKNVKDPVEIQTLVNKAK RDLGVIRRQVHIGQLYSTDKLIIENRDMPRT
>5WGB_3 Acyl carrier protein (chains C) STIEERVKKIIGEQLGVKQEEVTNNASFVEDLGADSLDTVELVMALEEEFDTEIPDEEAE KITTVQAAIDYINGHQA
| ID | Name | Formula | Copies |
|---|---|---|---|
| 8Q1 | S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}ami… | C23 H45 N2 O8 P S | 1 |
| PLP | Pyridoxal-5'-phosphate | C8 H10 N O6 P | 1 |
Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex. Boniecki, M.T., Freibert, S.A., Muhlenhoff, U. et al. Nat Commun (2017) 8:1287-1287. DOI 10.1038/s41467-017-01497-1 · PubMed
Other PDB entries of the same protein (UniProt Q9Y697 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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