Structure of a eukaryotic voltage-gated sodium channel at near atomic resolution. Determined by electron microscopy at 3.8 Å resolution. Released 8 Mar 2017.
Explore 5X0M in 3D Show helices and sheets RCSB PDB PDBe
5X0M contains 67 α-helices and 14 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 48-58 | 11 | |
| β-strand | 63-67 | 5 | 1 |
| β-strand | 68 | 1 | 2 |
| β-strand | 71 | 1 | 2 |
| α-helix | 95-109 | 15 | |
| β-strand | 116-119 | 4 | 1 |
| α-helix | 129-138 | 10 | |
| α-helix | 140-158 | 19 | |
| α-helix | 166-186 | 21 | |
| α-helix | 193-196 | 4 | |
| α-helix | 203-214 | 12 | |
| α-helix | 228-240 | 13 | |
| α-helix | 248-255 | 8 | |
| α-helix | 258-280 | 23 | |
| β-strand | 287-290 | 4 | 3 |
| α-helix | 306-309 | 4 | |
| β-strand | 316 | 1 | 3 |
| β-strand | 341-344 | 4 | 3 |
| α-helix | 361-373 | 13 | |
| α-helix | 377-387 | 11 | |
| α-helix | 394-397 | 4 | |
| α-helix | 398-404 | 7 | |
| α-helix | 409-434 | 26 | |
| α-helix | 503-517 | 15 | |
| α-helix | 521-536 | 16 | |
| α-helix | 545-572 | 28 | |
| α-helix | 575-578 | 4 | |
| α-helix | 582-603 | 22 | |
| α-helix | 607-619 | 13 | |
| α-helix | 620-623 | 4 | |
| α-helix | 626-634 | 9 | |
| α-helix | 640-662 | 23 | |
| α-helix | 664-666 | 3 | |
| α-helix | 667-670 | 4 | |
| α-helix | 687-699 | 13 | |
| α-helix | 703-713 | 11 | |
| α-helix | 718-723 | 6 | |
| α-helix | 726-733 | 8 | |
| α-helix | 735-743 | 9 | |
| α-helix | 834-854 | 21 | |
| α-helix | 856-874 | 19 | |
| α-helix | 885-911 | 27 | |
| α-helix | 914-917 | 4 | |
| α-helix | 921-937 | 17 | |
| α-helix | 950-952 | 3 | |
| α-helix | 955-957 | 3 | |
| α-helix | 959-962 | 4 | |
| α-helix | 969-1001 | 33 | |
| β-strand | 1011 | 1 | 4 |
| β-strand | 1012-1013 | 2 | 5 |
| β-strand | 1017-1018 | 2 | 5 |
| α-helix | 1027-1031 | 5 | |
| β-strand | 1037 | 1 | 4 |
| α-helix | 1048-1058 | 11 | |
| α-helix | 1063-1072 | 10 | |
| α-helix | 1087-1089 | 3 | |
| α-helix | 1091-1096 | 6 | |
| α-helix | 1097-1101 | 5 | |
| α-helix | 1108-1123 | 16 | |
| α-helix | 1133-1145 | 13 | |
| α-helix | 1160-1167 | 8 | |
| α-helix | 1172-1187 | 16 | |
| α-helix | 1195-1224 | 30 | |
| α-helix | 1232-1248 | 17 | |
| α-helix | 1261-1270 | 10 | |
| α-helix | 1271-1277 | 7 | |
| α-helix | 1289-1318 | 30 | |
| α-helix | 1341-1350 | 10 | |
| α-helix | 1355-1362 | 8 | |
| α-helix | 1385-1395 | 11 | |
| α-helix | 1396-1402 | 7 | |
| α-helix | 1403-1423 | 21 | |
| α-helix | 1427-1440 | 14 | |
| β-strand | 1447-1449 | 3 | 6 |
| α-helix | 1450-1458 | 9 | |
| α-helix | 1467 | 1 | |
| α-helix | 1471-1474 | 4 | |
| β-strand | 1481-1482 | 2 | 6 |
| β-strand | 1486-1488 | 3 | 6 |
| α-helix | 1489-1504 | 16 | |
| α-helix | 1509-1520 | 12 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Sodium channel protein | A | protein | 1596 | Periplaneta americana | D0E0C2 (AlphaFold model) |
>5X0M_1 Sodium channel protein (chains A) MASWSHPQFEKGGGARGGSGGGSWSHPQFEKGFDYKDDDDKGTMADNSPLIREERQRLFR PYTRAMLTAPSAQPAKENGKTEENKDNSRDKGRGANKDRDGSAHPDQALEQGSRLPARMR NIFPAELASTPLEDFDPFYKNKKTFVVVTKAGDIFRFSGEKSLWMLDPFTPIRRVAISTM VQPIFSYFIMITILIHCIFMIMPATQTTYILELVFLSIYTIEVVVKVLARGFILHPFAYL RDPWNWLDFLVTLIGYITLVVDLGHLYALRAFRVLRSWRTVTIVPGWRTIVDALSLSITS LKDLVLLLLFSLFVFAVLGLQIYMGVLTQKCVKHFPADGSWGNFTDERWFNYTSNSSHWY IPDDWIEYPLCGNSSGAGMCPPGYTCLQGYGGNPNYGYTSFDTFGWAFLSVFRLVTLDYW EDLYQLALRSAGPWHILFFIIVVFYGTFCFLNFILAVVVMSYTHMVKRADEEKAAERELK KEKKAASVANNTANGQEQTTIEMNGDEAVVIDNNDQAARQQSDPETPAPSVTQRLTDFLC VWDCCVPWQKLQGAIGAVVLSPFFELFIAVIIVLNITFMALDHHDMNIEFERILRTGNYI FTSIYIVEAVLKIIALSPKFYFKDSWNVFDFIIVVFAILELGLEGVQGLSVFRSFRLLRV FRLAKFWPTLNNFMSVMTKSYGAFVNVMYVMFLLLFIFAIIGMQLFGMNYIDNMERFPDG DLPRWNFTDFLHSFMIVFRALCGEWIESMWDCMLVGDWSCIPFFVAVFFVGNLVILNLLI ALLLNNYGSFCTSPTSDEEDSKDEDALAQIVRIFKRFKPNLNAVKLSPMKPDSEDIVESQ EIQGNNIADAEDVLAGEFPPDCCCNAFYKCFPSRPARDSSVQRMWSNIRRVCFLLAKNKY FQKFVTAVLVITSVLLALEDIYLPQRPVLVNITLYVDYVLTAFFVIEMIIMLFAVGFKKY FTSKWYWLDFIVVVAYLLNFVLMCAGIEALQTLRLLRVFRLFRPLSKVNGMQVVTSTLVE AVPHIFNVILVGIFFWLVFAIMGVQLFAGKFYKCVDENSTVLSHEITMDRNDCLHENYTW ENSPMNFDHVGNAYLSLLQVATFKGWLQIMNDAIDSREVHKQPIRETNIYMYLYFIFFIV FGSFFILKLFVCILIDIFRQQRRKAEGLSATDSRTQLIYRRAVMRTMSAKPVKRIPKPTC HPQSLMYDISVNRKFEYTMMILIILNVAVMAIDHYGQSMEFSEVLDYLNLIFIIIFFVEC VIKVSGLRHHYFKDPWNIIDFLYVVLAIAGLMLSDVIEKYFISPTLLRILRILRVGRLLR YFQSARGMRLLLLALRKALRTLFNVSFLLFVIMFVYAVFGMEFFMHIRDAGAIDDVYNFK TFGQSIILLFQLATSAGWDGVYFAIANEEDCRAPDHELGYPGNCGSRALGIAYLVSYLII TCLVVINMYAAVILDYVLEVYEDSKEGLTDDDYDMFFEVWQQFDPEATQYIRYDQLSELL EALQPPLQVQKPNKYKILSMNIPICKDDHIFYKDVLEALVKDVFSRRGSPVEAGDVQAPN VDEAEYKPVSSTLQRQREEYCVRLIQNAWRKHKQQN
| ID | Name | Formula | Copies |
|---|---|---|---|
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 1 |
Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution. Shen, H., Zhou, Q., Pan, X. et al. Science (2017) 355. DOI 10.1126/science.aal4326 · PubMed
Other PDB entries of the same protein (UniProt D0E0C2 (AlphaFold model), which also has an AlphaFold model), best resolution first:
5X0M is part of these collections:
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