Cryo-EM structure of a human-cockroach hybrid Nav channel. Determined by electron microscopy at 3.4 Å resolution. Released 20 Feb 2019.
Explore 6NT3 in 3D Show helices and sheets RCSB PDB PDBe
6NT3 contains 69 α-helices and 13 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 53-56 | 4 | |
| α-helix | 99-107 | 9 | |
| α-helix | 130-137 | 8 | |
| α-helix | 142-157 | 16 | |
| α-helix | 165-185 | 21 | |
| α-helix | 192-194 | 3 | |
| α-helix | 196-198 | 3 | |
| α-helix | 200-216 | 17 | |
| α-helix | 231-239 | 9 | |
| α-helix | 245-279 | 35 | |
| β-strand | 287-290 | 4 | 1 |
| β-strand | 296 | 1 | 2 |
| β-strand | 299 | 1 | 2 |
| α-helix | 305-309 | 5 | |
| α-helix | 313-315 | 3 | |
| β-strand | 316 | 1 | 1 |
| α-helix | 325-327 | 3 | |
| β-strand | 341-344 | 4 | 1 |
| α-helix | 361-372 | 12 | |
| α-helix | 377-387 | 11 | |
| α-helix | 390-392 | 3 | |
| α-helix | 393-403 | 11 | |
| α-helix | 410-431 | 22 | |
| α-helix | 504-514 | 11 | |
| α-helix | 519-535 | 17 | |
| α-helix | 545-570 | 26 | |
| α-helix | 585-602 | 18 | |
| α-helix | 612-619 | 8 | |
| α-helix | 625-635 | 11 | |
| α-helix | 639-662 | 24 | |
| α-helix | 666-669 | 4 | |
| α-helix | 687-698 | 12 | |
| α-helix | 703-712 | 10 | |
| α-helix | 718-726 | 9 | |
| α-helix | 729-733 | 5 | |
| α-helix | 734-737 | 4 | |
| α-helix | 839-853 | 15 | |
| α-helix | 856-871 | 16 | |
| α-helix | 884-912 | 29 | |
| α-helix | 915-918 | 4 | |
| α-helix | 921-937 | 17 | |
| α-helix | 944-947 | 4 | |
| α-helix | 948-951 | 4 | |
| α-helix | 953-958 | 6 | |
| α-helix | 959-962 | 4 | |
| α-helix | 969-1004 | 36 | |
| β-strand | 1009-1011 | 3 | 3 |
| β-strand | 1012 | 1 | 4 |
| β-strand | 1018 | 1 | 4 |
| β-strand | 1026 | 1 | 5 |
| α-helix | 1027-1032 | 6 | |
| β-strand | 1037-1039 | 3 | 3 |
| α-helix | 1048-1057 | 10 | |
| α-helix | 1064-1072 | 9 | |
| β-strand | 1078 | 1 | 5 |
| α-helix | 1079-1081 | 3 | |
| α-helix | 1086-1088 | 3 | |
| α-helix | 1089-1099 | 11 | |
| α-helix | 1104-1106 | 3 | |
| α-helix | 1108-1110 | 3 | |
| α-helix | 1112-1122 | 11 | |
| α-helix | 1133-1141 | 9 | |
| α-helix | 1158-1161 | 4 | |
| α-helix | 1164-1167 | 4 | |
| α-helix | 1177-1186 | 10 | |
| α-helix | 1196-1223 | 28 | |
| α-helix | 1232-1250 | 19 | |
| α-helix | 1261-1267 | 7 | |
| α-helix | 1268-1279 | 12 | |
| α-helix | 1284-1293 | 10 | |
| α-helix | 1297-1320 | 24 | |
| α-helix | 1339-1349 | 11 | |
| α-helix | 1355-1362 | 8 | |
| α-helix | 1385-1391 | 7 | |
| α-helix | 1403-1422 | 20 | |
| α-helix | 1429-1435 | 7 | |
| β-strand | 1448 | 1 | 6 |
| α-helix | 1453-1456 | 4 | |
| α-helix | 1462-1464 | 3 | |
| α-helix | 1471-1476 | 6 | |
| β-strand | 1487 | 1 | 6 |
| α-helix | 1489-1504 | 16 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Sodium channel protein type 9 subunit alpha, Sodium channel protein PaFPC1, chimeric construct | A | protein | 1559 | Periplaneta americana, Homo sapiens | D0E0C2 (AlphaFold model), Q15858 (AlphaFold model) |
>6NT3_1 Sodium channel protein type 9 subunit alpha, Sodium channel protein PaFPC1, chimeric construct (chains A) WSHPQFEKGGGSGGGSGGSAWSHPQFEKGGSGGDYKDDDDKGGSGGDYKDDDDKMADNSP LIREERQRLFRPYTRAMLTAPSAQPAKENGKTEENKDNSRDKGRGANKDRDGSAHPDQAL EQGSRLPARMRNIFPAELASTPLEDFDPFYKNKKTFVVVTKAGDIFRFSGEKSLWMLDPF TPIRRVAISTMVQPIFSYFIMITILIHCIFMIMPATQTTYILELVFLSIYTIEVVVKVLA RGFILHPFAYLRDPWNWLDFLVTLIGYITLVVDLGHLYALRAFRVLRSWRTVTIVPGWRT IVDALSLSITSLKDLVLLLLFSLSVFALIGLQLFMGNLKHKCVKHFPADGSWGNFTDERW FNYTSNSSHWYIPDDWIEYPLCGNSSGAGMCPPGYTCLQGYGGNPNYGYTSFDTFGWAFL SVFRLVTLDYWEDLYQLALRSAGPWHILFFIIVVFYGTFCFLNFILAVVVMSYTHMVKRA DEEKAAERELKKEKKAASVANNTANGQEQTTIEMNGDEAVVIDNNDQAARQQSDPETPAP SVTQRLTDFLCVWDCCVPWQKLQGAIGAVVLSPFFELFIAVIIVLNITFMALDHHDMNIE FERILRTGNYIFTSIYIVEAVLKIIALSPKFYFKDSWNVFDFIIVVFAILELGLEGVQGL SVFRSFRLLRVFRLAKFWPTLNNFMSVMTKSYGAFVNVMYVMFLLLFIFAIIGMQLFGMN YIDNMERFPDGDLPRWNFTDFLHSFMIVFRALCGEWIESMWDCMLVGDWSCIPFFVAVFF VGNLVILNLLIALLLNNYGSFCTSPTSDEEDSKDEDALAQIVRIFKRFKPNLNAVKLSPM KPDSEDIVESQEIQGNNIADAEDVLAGEFPPDCCCNAFYKCFPSRPARDSSVQRMWSNIR RVCFLLAKNKYFQKFVTAVLVITSVLLALEDIYLPQRPVLVNITLYVDYVLTAFFVIEMI IMLFAVGFKKYFTSKWYWLDFIVVVAYLLNFVLMCAGIEALQTLRLLRVFRLFRPLSKVN GMQVVTSTLVEAVPHIFNVILVGIFFWLVFAIMGVQLFAGKFYKCVDENSTVLSHEITMD RNDCLHENYTWENSPMNFDHVGNAYLSLLQVATFKGWLQIMNDAIDSREVHKQPIRETNI YMYLYFIFFIVFGSFFILKLFVCILIDIFRQQRRKAEGLSATDSRTQLIYRRAVMRTMSA KPVKRIPKPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWIN VVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRV IRLARIGRILRLVKGAKGIRLLLLALRKALRTLFNVSFLLFVIMFVYAVFGMEFFMHIRD AGAIDDVYNFKTFGQSIILLFQLATSAGWDGVYFAIANEEDCRAPDHELGYPGNCGSRAL GIAYLVSYLIITCLVVINMYAAVILDYVLEVYEDSKEGLTDDDYDMFFEVWQQFDPEATQ YIRYDQLSELLEALQPPLQVQKPNKYKILSMNIPICKDDHIFYKDVLEALVKDVFSRRG
| ID | Name | Formula | Copies |
|---|---|---|---|
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 4 |
| Y01 | Cholesterol hemisuccinate | C31 H50 O4 | 1 |
| 76F | (7E,21R,24S)-27-amino-24-hydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosph… | C41 H76 N O8 P | 4 |
| LHG | 1,2-dipalmitoyl-phosphatidyl-glycerole | C38 H75 O10 P | 1 |
| AJP | Digitonin | C56 H92 O29 | 1 |
Cryo-EM structures of a human-cockroach hybrid Nav channel in the presence and absence of the alpha-scorpion toxin AaH2. Clairfeuille, T., Rohou, A., Payandeh, J. Science (2019).
Other PDB entries of the same protein (UniProt D0E0C2 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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