5XDR: Human DEAH-box RNA helicase DHX15

Crystal structure of human DEAH-box RNA helicase DHX15 in complex with ADP. Determined by X-ray diffraction at 2.0 Å resolution. Released 21 Jun 2017.

Method
X-ray diffraction
Resolution
2.0 Å
Organism
Homo sapiens
Chains
1
Atoms
5,586
Mol. weight
79.76 kDa
Ligands
ADP, MG
Released
21 Jun 2017

Explore 5XDR in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5XDR contains 38 α-helices and 30 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 38 helices, 30 β-strands

ElementResiduesLengthSheet
β-strand115-11621
β-strand121-12221
α-helix125-13410
α-helix138-1425
α-helix143-1508
β-strand155-16062
α-helix166-17914
β-strand187-19262
α-helix195-20814
β-strand21312
β-strand217-22152
β-strand224-22632
β-strand233-23752
α-helix238-2469
β-strand254-25962
α-helix262-2643
α-helix267-28216
β-strand287-29262
β-strand309-31242
β-strand319-32243
α-helix331-34515
β-strand351-35553
α-helix361-3677
α-helix381-3822
β-strand383-38863
α-helix394-3974
α-helix403-4086
β-strand415-42063
α-helix423-4264
β-strand433-43863
β-strand441-44884
β-strand453-46084
α-helix461-4622
α-helix463-4719
α-helix472-4743
β-strand479-48353
α-helix488-4914
α-helix498-5003
α-helix501-5033
α-helix508-5169
α-helix530-5323
α-helix533-54513
β-strand54915
α-helix5541
β-strand55515
α-helix5561
α-helix557-5626
α-helix569-57810
α-helix579-5813
α-helix584-59411
β-strand60016
α-helix604-6063
α-helix607-6159
β-strand61917
β-strand62217
α-helix623-63614
α-helix641-6466
β-strand64916
α-helix651-67020
α-helix684-69714
β-strand701-70447
β-strand710-71237
β-strand718-72147
β-strand733-74197
β-strand745-75287
α-helix755-7617
α-helix768-7703
α-helix775-78814

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15Aprotein690Homo sapiensO43143 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>5XDR_1 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 (chains A)
GPEFSLPQCINPFTNLPHTPRYYDILKKRLQLPVWEYKDRFTDILVRHQSFVLVGETGSG
KTTQIPQWCVEYMRSLPGPKRGVACTQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFED
CSSAKTILKYMTDGMLLREAMNDPLLERYGVIILDEAHERTLATDILMGVLKEVVRQRSD
LKVIVMSATLDAGKFQIYFDNCPLLTIPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMC
EEEEGDLLLFLTGQEEIDEACKRIKREVDDLGPEVGDIKIIPLYSTLPPQQQQRIFEPPP
PKKQNGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVTAISKAS
AQQRAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYPEILRSNLGSVVLQLKKLGIDDLVHF
DFMDPPAPETLMRALELLNYLAALNDDGDLTELGSMMAEFPLDPQLAKMVIASCDYNCSN
EVLSITAMLSVPQCFVRPTEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQNHESVQWCY
DNFINYRSLMSADNVRQQLSRIMDRFNLPRRSSDFTSRDYYINIRKALVTGYFMQVAHLE
RTGHYLTVKDNQVVQLHPSTVLDHKPEWVLYNEFVLTTKNYIRTCTDIKPEWLVKIAPQY
YDMSNFPQCEAKRQLDRIIAKLQSKEYSQY

Ligands and cofactors

IDNameFormulaCopies
ADPAdenosine-5'-diphosphateC10 H15 N5 O10 P21
MGMagnesium ionMg1

Water and common crystallization additives (SO4) are not listed.

Primary citation

The crystal structure of human DEAH-box RNA helicase 15 reveals a domain organization of the mammalian DEAH/RHA family. Murakami, K., Nakano, K., Shimizu, T. et al. Acta Crystallogr F Struct Biol Commun (2017) 73:347-355. DOI 10.1107/S2053230X17007336 · PubMed

Other PDB entries of the same protein (UniProt O43143 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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