6CDF: Human CtBP1

Human CtBP1 (28-378). Determined by X-ray diffraction at 2.6 Å resolution. Released 9 May 2018.

Method: X-ray diffraction
Resolution: 2.6 Å
Organism: Homo sapiens
Chains: 1
Atoms: 2,741
Mol. weight: 41.65 kDa
Ligands: CA, NAI
Released: 9 May 2018

Explore 6CDF in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6CDF contains 20 α-helices and 17 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 20 helices, 17 β-strands

Element	Residues	Length	Sheet
α-helix	26-28	3
β-strand	29-32	4	1
α-helix	42-45	4
β-strand	50-53	4	1
α-helix	59-61	3
α-helix	64-69	6
β-strand	72-75	4	1
β-strand	81	1	2
α-helix	83-87	5
β-strand	94-97	4	1
β-strand	105	1	2
α-helix	107-112	6
β-strand	116-118	3	1
α-helix	125-141	17
α-helix	143-151	9
α-helix	159-165	7
β-strand	176-180	5	3
α-helix	184-195	12
α-helix	198	1
β-strand	199-203	5	3
α-helix	208	1
α-helix	211-214	4
β-strand	218-219	2	3
α-helix	223-229	7
β-strand	232-235	4	3
β-strand	247	1	4
α-helix	249-252	4
α-helix	256	1
β-strand	259-263	5	3
α-helix	267-269	3
β-strand	270	1	4
α-helix	272-281	10
β-strand	284-289	6	3
β-strand	310-312	3	3
α-helix	321-340	20
β-strand	350	1	1
α-helix	353-355	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
C-terminal-binding protein 1	A	protein	373	Homo sapiens	Q13363 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>6CDF_1 C-terminal-binding protein 1 (chains A)
MGSSHHHHHHSSGLVPRGSHMPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEKV
LNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVE
ETADSTLCHILNLYRRATWLHQALREGTRVQSVEQIREVASGAARIRGETLGIIGLGRVG
QAVALRAKAFGFNVLFYDPYLSDGVERALGLQRVSTLQDLLFHSDCVTLHCGLNEHNHHL
INDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFSQGPLKD
APNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIPDSLKNCVNKDHLTAATHWASMD
PAVVHPELNGAAY

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	1
NAI	1,4-dihydronicotinamide adenine dinucleotide	C21 H29 N7 O14 P2	1

Water and common crystallization additives (FMT) are not listed.

Primary citation

Assembly of human C-terminal binding protein (CtBP) into tetramers. Bellesis, A.G., Jecrois, A.M., Hayes, J.A. et al. J Biol Chem (2018) 293:9101-9112. DOI 10.1074/jbc.RA118.002514 · PubMed

Other PDB entries of the same protein (UniProt Q13363 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1MX3 1.95 Å, Crystal structure of CtBP dehydrogenase core holo form
4U6S 2.1 Å, CtBP1 in complex with substrate phenylpyruvate
9WRJ 2.2 Å, Crystal structure of CtBP1 in complex with PALI1
4U6Q 2.3 Å, CtBP1 bound to inhibitor 2-(hydroxyimino)-3-phenylpropanoic acid
7KWM 2.3 Å, CtBP1 (28-375) L182F/V185T - AMP
6V8A 2.35 Å, Human CtBP1 (28-375) in complex with AMP
4LCE 2.38 Å, CtBP1 in complex with substrate MTOB
6CDR 2.4 Å, Human CtBP1 (28-378)
6V89 2.45 Å, Human CtBP1 (28-375) in complex with AMP
8ARI 3.0 Å, Cryo-EM structure of human CtBP1/RAI2(303-362) delta(331-341) filament

Browse structure collections

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