6CFH: TAR DNA-binding protein 43
SWGMMGMLASQ segment from the low complexity domain of TDP-43. Determined by electron crystallography at 1.5 Å resolution. Released 23 May 2018.
- Method
- Electron crystallography
- Resolution
- 1.5 Å
- Organism
- Homo sapiens
- Chains
- 2
- Atoms
- 161
- Mol. weight
- 2.4 kDa
- Released
- 23 May 2018
Explore 6CFH in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
6CFH contains 0 α-helices and 2 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chains A and B: 0 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| β-strand | 334-342 | 9 | 1 |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| TAR DNA-binding protein 43 | A, B | protein | 11 | Homo sapiens | Q13148 (AlphaFold model) |
Sequence of entity 1 (A, B), FASTA
>6CFH_1 TAR DNA-binding protein 43 (chains A, B)
SWGMMGMLASQ
Primary citation
Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Guenther, E.L., Cao, Q., Trinh, H. et al. Nat Struct Mol Biol (2018) 25:463-471. DOI 10.1038/s41594-018-0064-2 · PubMed
Other PDB entries of the same protein (UniProt Q13148 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 6CF4 0.75 Å, Segment NFGTFS, with familial mutation A315T and phosphorylated threonine, from the low…
- 5WHP 1.0 Å, Crystal structure of the segment, NFGTFS, from the A315T familial variant of the low…
- 5WKB 1.0 Å, MicroED structure of the segment, NFGEFS, from the A315E familial variant of the low…
- 5WIA 1.0 Å, Crystal structure of the segment, GNNSYS, from the low complexity domain of TDP-43,…
- 5WHN 1.1 Å, Crystal structure of the segment, NFGAFS, from the low complexity domain of TDP-43,…
- 5WIQ 1.25 Å, Crystal structure of the segment, GFNGGFG, from the low complexity domain of TDP-43,…
- 5W50 1.4 Å, Crystal structure of the segment, LIIKGI, from the RRM2 of TDP-43, residues 248-253
- 5W52 1.4 Å, MicroED structure of the segment, DLIIKGISVHI, from the RRM2 of TDP-43, residues 247-257
- 5WKD 1.8 Å, Crystal structure of the segment, GNNQGSN, from the low complexity domain of TDP-43,…
- 5MDI 2.1 Å, Crystal structure of TDP-43 N-terminal domain at 2.1 A resolution
- 7N9H 2.2 Å, Structure of the mammalian importin a1 bound to the TDP-43 NLS
- 8CG3 2.39 Å, Structure of TDP-43 amyloid filament from type A FTLD-TDP (variant 1)
Browse structure collections
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