7N9H: Mammalian importin a1

Structure of the mammalian importin a1 bound to the TDP-43 NLS. Determined by X-ray diffraction at 2.2 Å resolution. Released 22 Jun 2022.

Method: X-ray diffraction
Resolution: 2.2 Å
Organism: Homo sapiens
Chains: 2
Atoms: 3,554
Mol. weight: 49.13 kDa
Released: 22 Jun 2022

Explore 7N9H in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7N9H contains 31 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain C: 31 helices, 0 β-strands

Element	Residues	Length
α-helix	78-86	9
α-helix	90-104	15
α-helix	112-117	6
α-helix	121-128	8
α-helix	134-148	15
α-helix	152-160	9
α-helix	163-170	8
α-helix	176-191	16
α-helix	194-202	9
α-helix	206-211	6
α-helix	218-220	3
α-helix	223-236	14
α-helix	243-245	3
α-helix	246-260	15
α-helix	265-278	14
α-helix	283-290	8
α-helix	295-302	8
α-helix	307-321	15
α-helix	325-333	9
α-helix	336-339	4
α-helix	340-343	4
α-helix	349-363	15
α-helix	367-375	9
α-helix	379-387	9
α-helix	391-407	17
α-helix	410-418	9
α-helix	422-428	7
α-helix	434-454	21
α-helix	457-466	10
α-helix	469-476	8
α-helix	482-495	14

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Importin subunit alpha-1	C	protein	428	Homo sapiens	P52292 (AlphaFold model)
TAR DNA-binding protein 43	A	protein	24	Homo sapiens	Q13148 (AlphaFold model)

Sequence of entity 1 (C), FASTA

>7N9H_1 Importin subunit alpha-1 (chains C)
NQGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLG
KTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNI
AGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAV
EQILPTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPI
VTPALRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQ
IQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLL
SAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQRHENESVYKASL
NLIEKYFS

Sequence of entity 2 (A), FASTA

>7N9H_2 TAR DNA-binding protein 43 (chains A)
KDNKRKMDETDASSAVKVKRAVQK

Primary citation

Recognition of the TDP-43 nuclear localization signal by importin alpha 1/ beta. Doll, S.G., Meshkin, H., Bryer, A.J. et al. Cell Rep (2022) 39:111007-111007. DOI 10.1016/j.celrep.2022.111007 · PubMed

Other PDB entries of the same protein (UniProt P52292 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4WV6 1.75 Å, Heterodimer of Importin alpha 1 with nuclear localization signal of TAF8
8FZK 2.1 Å, Dimeric human importin alpha subunit
3FEY 2.2 Å, Crystal structure of the CBC-importin alpha complex.
1QGR 2.3 Å, Structure of importin beta bound to the ibb domain of importin alpha (II crystal form,…
5H43 2.3 Å, Structural and mechanistical studies of the nuclear import by Importin-alpha
1QGK 2.5 Å, Structure of importin beta bound to the ibb domain of importin alpha
4E4V 2.53 Å, The crystal structure of the dimeric human importin alpha 1 at 2.5 angstrom resolution.
3WPT 2.63 Å, Crystal structure of closed dimer of human importin-alpha1 (Rch1)
7CRU 2.8 Å, hnRNPK NLS in complex with Importin alpha 1 (KPNA2)
1EFX 3.0 Å, Structure of a complex between the human natural killer cell receptor KIR2DL2 and a…
7N8J 3.2 Å, Human importin alpha 1 in complex with Bimax2 peptide
9BFC 3.2 Å, Cryo-EM structure of importin alpha-1/beta bound to FG repeats

Browse structure collections

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