6EHP: Human LAMTOR complex

The crystal structure of the human LAMTOR complex. Determined by X-ray diffraction at 2.3 Å resolution. Released 4 Oct 2017.

Method: X-ray diffraction
Resolution: 2.3 Å
Organism: Homo sapiens
Chains: 5
Atoms: 3,816
Mol. weight: 63.72 kDa
Released: 4 Oct 2017

Explore 6EHP in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6EHP contains 21 α-helices and 20 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	2-10	9
α-helix	13-15	3
β-strand	19-26	8	1
β-strand	31-36	6	1
α-helix	47-50	4
α-helix	52-60	9
β-strand	68-75	8	1
β-strand	78-85	8	1
β-strand	88-95	8	1
α-helix	100-109	10
α-helix	111-116	6
α-helix	117-120	4

Chain B: 3 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	7-12	6
β-strand	19-26	8	1
β-strand	31-36	6	1
α-helix	42-59	18
β-strand	69-76	8	1
β-strand	79-86	8	1
β-strand	89-95	7	1
α-helix	101-121	21

Chain C: 4 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	3-13	11
β-strand	18-24	7	2
β-strand	30-35	6	2
α-helix	39-41	3
α-helix	42-53	12
α-helix	62-63	2
β-strand	64-69	6	2
β-strand	72-79	8	2
β-strand	82-89	8	2

Chain D: 2 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	4-10	7
β-strand	15-22	8	2
β-strand	25-31	7	2
α-helix	37-51	15
β-strand	65-69	5	2
β-strand	73-80	8	2
β-strand	83-90	8	2

Chain E: 5 helices, 0 β-strands

Element	Residues	Length
α-helix	83-93	11
α-helix	100-104	5
α-helix	115-120	6
α-helix	122-125	4
α-helix	126-143	18

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Ragulator complex protein LAMTOR3	A	protein	127	Homo sapiens	Q9UHA4 (AlphaFold model)
Ragulator complex protein LAMTOR2	B	protein	126	Homo sapiens	Q9Y2Q5 (AlphaFold model)
Ragulator complex protein LAMTOR5	C	protein	91	Homo sapiens	O43504 (AlphaFold model)
Ragulator complex protein LAMTOR4	D	protein	99	Homo sapiens	Q0VGL1 (AlphaFold model)
Ragulator complex protein LAMTOR1	E	protein	145	Homo sapiens	Q6IAA8

Sequence of entity 1 (A), FASTA

>6EHP_1 Ragulator complex protein LAMTOR3 (chains A)
GAHMADDLKRFLYKKLPSVEGLHAIVVSDRDGVPVIKVANDNAPEHALRPGFLSTFALAT
DQGSKLGLSKNKSIICYYNTYQVVQFNRLPLVVSFIASSSANTGLIVSLEKELAPLFEEL
RQVVEVS

Sequence of entity 2 (B), FASTA

>6EHP_2 Ragulator complex protein LAMTOR2 (chains B)
MGLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRN
GNQAFNEDNLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEPL
TQVAAS

Sequence of entity 3 (C), FASTA

>6EHP_3 Ragulator complex protein LAMTOR5 (chains C)
MEATLEQHLEDTMKNPSIVGVLCTDSQGLNLGCRGTLSDEHAGVISVLAQQAAKLTSDPT
DIPVVCLESDNGNIMIQKHDGITVAVHKMAS

Sequence of entity 4 (D), FASTA

>6EHP_4 Ragulator complex protein LAMTOR4 (chains D)
MTSALTQGLERIPDQLGYLVLSEGAVLASSGDLENDEQAASAISELVSTACGFRLHRGMN
VPFKRLSVVFGEHTLLVTVSGQRVFVVKRQNRGREPIDV

Sequence of entity 5 (E), FASTA

>6EHP_5 Ragulator complex protein LAMTOR1 (chains E)
SLMTLLLDPSSPPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGM
EQHEYMDRARQYSTRLAVLSSSLTHWKKLPPLPSLTSQPHQVLASEPIPFSDLQQVSRIA
AYAYSALSQIRVDAKEELVVQFGIP

Primary citation

Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling. de Araujo, M.E.G., Naschberger, A., Furnrohr, B.G. et al. Science (2017) 358:377-381. DOI 10.1126/science.aao1583 · PubMed

Other PDB entries of the same protein (UniProt Q9UHA4 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6B9X 1.42 Å, Crystal structure of Ragulator
3CPT 1.9 Å, MP1-p14 Scaffolding complex
1SKO 2.0 Å, MP1-p14 Complex
2ZL1 2.0 Å, MP1-p14 Scaffolding complex
5X6V 2.02 Å, Crystal structure of human heteroheptameric complex
5X6U 2.4 Å, Crystal structure of human heteropentameric complex
5Y39 2.65 Å, Crystal structure of Ragulator complex (p18 76-145)
6EHR 2.9 Å, The crystal structure of the human LAMTOR-RagA CTD-RagC CTD complex
5Y3A 2.9 Å, Crystal structure of Ragulator complex (p18 49-161)
7UX2 2.9 Å, cryo-EM structure of the Raptor-TFEB-Rag-Ragulator complex
5YK3 3.01 Å, human Ragulator complex
6U62 3.18 Å, Raptor-Rag-Ragulator complex

Browse structure collections

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