6EJ8: Human Xylosyltransferase 1

Human Xylosyltransferase 1 in complex with peptide QEEEGSGGGQGG. Determined by X-ray diffraction at 2.09 Å resolution. Released 2 May 2018.

Method
X-ray diffraction
Resolution
2.09 Å
Organism
Homo sapiens
Chains
2
Atoms
5,890
Mol. weight
88.06 kDa
Ligands
PO4, NAG
Released
2 May 2018

Explore 6EJ8 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6EJ8 contains 37 α-helices and 37 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 37 helices, 36 β-strands

ElementResiduesLengthSheet
α-helix262-2709
α-helix274-28815
β-strand29611
α-helix315-3195
β-strand328-33472
α-helix339-34911
β-strand355-36062
α-helix365-37713
β-strand381-38332
α-helix396-41015
β-strand418-42252
β-strand426-42833
α-helix432-44110
β-strand446-44832
β-strand45014
α-helix455-4628
β-strand466-47055
β-strand475-48065
α-helix482-4843
β-strand48511
β-strand49214
β-strand497-49932
α-helix500-5089
α-helix512-5209
α-helix521-5233
α-helix527-5293
α-helix531-5388
α-helix542-5443
β-strand545-54732
β-strand551-55333
α-helix557-5604
β-strand56915
β-strand57316
α-helix576-5794
α-helix581-5888
β-strand596-59833
α-helix607-61711
α-helix619-6213
β-strand629-63687
α-helix637-6393
α-helix641-6433
α-helix646-66621
β-strand677-691157
β-strand694-706137
β-strand711-721117
α-helix722-7232
β-strand726-72728
β-strand737-74379
β-strand746-747210
β-strand752-753210
β-strand767-77269
β-strand778-78588
β-strand791-79998
β-strand805-80849
α-helix816-8183
β-strand819-82798
β-strand830-839108
α-helix840-8423
β-strand844-845211
β-strand848-849211
α-helix850-8512
α-helix852-8587
α-helix873-8753
α-helix876-8794
α-helix882-8843
α-helix885-89511
α-helix899-91315
β-strand914-92187
α-helix930-9312
β-strand93217
α-helix933-9353
α-helix945-9473
α-helix951-9533
Chain B: 0 helices, 1 β-strand
ElementResiduesLengthSheet
β-strand21616

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Xylosyltransferase 1Aprotein755Homo sapiensQ86Y38 (AlphaFold model)
Protein AMBPBprotein12Homo sapiensP02760 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>6EJ8_1 Xylosyltransferase 1 (chains A)
RALAAPLVHHHHHHALDENLYFQGALADVSRPPHARKTGGSSPETKYDQPPKCDISGKEA
ISALSRAKSKHCRQEIGETYCRHKLGLLMPEKVTRFCPLEGKANKNVQWDEDSVEYMPAN
PVRIAFVLVVHGRASRQLQRMFKAIYHKDHFYYIHVDKRSNYLHRQVLQVSRQYSNVRVT
PWRMATIWGGASLLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRD
MNFLKSHGRDNARFIRKQGLDRLFLECDAHMWRLGDRRIPEGIAVDGGSDWFLLNRRFVE
YVTFSTDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQ
YKHIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKFEAVVNQEIIGQLDYYLYGNYPAGT
PGLRSYWENVYDEPDGIHSLSDVTLTLYHSFARLGLRRAETSLHTDGENSCRYYPMGHPA
SVHLYFLADRFQGFLIKHHATNLAVSKLETLETWVMPKKVFKIASPPSDFGRLQFSEVGT
DWDAKERLFRNFGGLLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIESTAE
FTHYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNRQPIKPEEALKLHNGPLR
NAYMEQSFQSLNPVLSLPINPAQVEQARRNAASTGTALEGWLDSLVGGMWTAMDICATGP
TACPVMQTCSQTAWSSFSPDPKSELGAVKPDGRLR
Sequence of entity 2 (B), FASTA
>6EJ8_2 Protein AMBP (chains B)
QEEEGSGGGQGG

Ligands and cofactors

IDNameFormulaCopies
PO4Phosphate ionO4 P2
NAG2-acetamido-2-deoxy-beta-D-glucopyranoseC8 H15 N O61

Water and common crystallization additives (NA) are not listed.

Primary citation

Structural Basis for the Initiation of Glycosaminoglycan Biosynthesis by Human Xylosyltransferase 1. Briggs, D.C., Hohenester, E. Structure (2018) 26:801-809.e3. DOI 10.1016/j.str.2018.03.014 · PubMed

Other PDB entries of the same protein (UniProt Q86Y38 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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