6FML: CryoEM Structure INO80core Nucleosome complex

CryoEM Structure INO80core Nucleosome complex. Determined by electron microscopy at 4.34 Å resolution. Released 25 Apr 2018.

Method: Electron microscopy
Resolution: 4.34 Å
Organisms: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719), Chaetomium thermophilum var. thermophilum DSM 1495, synthetic construct
Chains: 20
Atoms: 43,460
Mol. weight: 915.38 kDa
Ligands: ADP, ATP
Released: 25 Apr 2018

Explore 6FML in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6FML contains 237 α-helices and 225 β-strands across 18 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 24 helices, 32 β-strands

Element	Residues	Length	Sheet
β-strand	16	1	1
β-strand	27	1	2
α-helix	32	1
β-strand	33	1	2
α-helix	34	1
β-strand	37	1	3
β-strand	40	1	3
α-helix	44-57	14
β-strand	66-69	4	4
α-helix	77-88	12
β-strand	94-97	4	4
α-helix	109-119	11
β-strand	121-129	9	5
β-strand	131-135	5	6
β-strand	136	1	7
β-strand	141-143	3	8
β-strand	155-158	4	8
β-strand	161-162	2	7
β-strand	169-170	2	7
β-strand	172	1	9
α-helix	175-182	8
β-strand	190-195	6	6
β-strand	201-206	6	6
β-strand	207	1	10
α-helix	208-210	3
β-strand	222	1	10
α-helix	224-226	3
β-strand	230	1	6
β-strand	233-240	8	5
α-helix	241-249	9
α-helix	258-261	4
α-helix	266-267	2
α-helix	274-289	16
β-strand	294-297	4	5
β-strand	299-302	4	4
α-helix	305-307	3
α-helix	310-320	11
α-helix	326	1
β-strand	327-331	5	4
β-strand	334	1	11
β-strand	336-338	3	12
β-strand	346-348	3	12
α-helix	355-358	4
β-strand	359-362	4	4
α-helix	363	1
α-helix	371-383	13
β-strand	387	1	13
α-helix	389-401	13
α-helix	404-407	4
α-helix	408-410	3
α-helix	412-420	9
β-strand	426	1	13
α-helix	428-437	10
β-strand	439	1	14
α-helix	441-451	11
β-strand	461	1	15

Chain B: 24 helices, 24 β-strands

Element	Residues	Length	Sheet
β-strand	27	1	16
β-strand	33	1	16
β-strand	37	1	17
β-strand	40	1	17
α-helix	44-59	16
β-strand	66-69	4	18
α-helix	77-88	12
β-strand	94-98	5	18
α-helix	99-102	4
α-helix	112-120	9
β-strand	122-141	20	19
β-strand	158-163	6	19
β-strand	168	1	20
β-strand	172-173	2	19
α-helix	178-181	4
β-strand	190-195	6	19
β-strand	201-207	7	19
α-helix	208-210	3
β-strand	221-222	2	19
α-helix	223-225	3
β-strand	230-240	11	19
α-helix	241-249	9
α-helix	257-260	4
α-helix	274-289	16
β-strand	293-296	4	19
β-strand	299-303	5	18
α-helix	305-307	3
α-helix	310-319	10
α-helix	325-326	2
β-strand	327-331	5	18
β-strand	334	1	21
β-strand	337-338	2	22
α-helix	339	1
β-strand	346-347	2	22
α-helix	348-350	3
α-helix	353-356	4
β-strand	360-362	3	18
α-helix	369-371	3
α-helix	373-383	11
β-strand	387	1	23
α-helix	389-401	13
α-helix	404-407	4
α-helix	411-419	9
β-strand	426	1	23
α-helix	428-437	10
β-strand	439	1	24
α-helix	441-446	6
α-helix	447-451	5

Chain C: 20 helices, 29 β-strands

Element	Residues	Length	Sheet
α-helix	5	1
β-strand	6	1	25
α-helix	7-8	2
β-strand	16	1	26
β-strand	27	1	27
β-strand	33	1	27
β-strand	37	1	28
β-strand	40	1	28
α-helix	44-58	15
β-strand	66-69	4	29
α-helix	77-88	12
β-strand	94	1	29
β-strand	98	1	29
α-helix	99-101	3
α-helix	109-120	12
β-strand	121-140	20	30
β-strand	143	1	31
α-helix	147-148	2
β-strand	154-155	2	31
β-strand	158-163	6	30
β-strand	168-173	6	30
α-helix	178-184	7
β-strand	190-194	5	30
β-strand	202-206	5	30
β-strand	221	1	30
β-strand	230-240	11	30
α-helix	241-249	9
α-helix	259-262	4
α-helix	274-290	17
β-strand	293-297	5	30
β-strand	299-303	5	29
α-helix	310-320	11
β-strand	327-331	5	29
β-strand	334	1	32
β-strand	336-338	3	33
β-strand	346-348	3	33
α-helix	353-356	4
β-strand	360-362	3	29
α-helix	365-368	4
α-helix	372-383	12
β-strand	387	1	34
α-helix	389-401	13
α-helix	404-407	4
α-helix	412-421	10
β-strand	426	1	34
α-helix	428-434	7
β-strand	439	1	35
α-helix	441-450	10
β-strand	461	1	36

Chain D: 15 helices, 23 β-strands

Element	Residues	Length	Sheet
β-strand	32	1	37
β-strand	39	1	37
α-helix	51-65	15
β-strand	68	1	1
β-strand	72-76	5	14
α-helix	83-94	12
β-strand	100-104	5	14
α-helix	115-124	10
β-strand	127-137	11	38
β-strand	140-149	10	31
β-strand	156-163	8	31
β-strand	168-173	6	31
α-helix	175-184	10
β-strand	190-194	5	31
β-strand	195	1	38
β-strand	201-206	6	31
β-strand	223	1	31
β-strand	233-242	10	38
α-helix	243-251	9
α-helix	269-284	16
β-strand	288-292	5	38
β-strand	294-298	5	14
α-helix	300-302	3
α-helix	305-314	10
β-strand	322-326	5	14
β-strand	329	1	15
β-strand	331-333	3	39
α-helix	334	1
β-strand	340-342	3	39
β-strand	354-357	4	14
α-helix	363-376	14
α-helix	383-396	14
α-helix	398-414	17
α-helix	422-431	10
β-strand	433	1	29
α-helix	434	1
α-helix	435-444	10
β-strand	450	1	32

Chain E: 19 helices, 27 β-strands

Element	Residues	Length	Sheet
β-strand	42-43	2	40
β-strand	46-47	2	40
α-helix	51-63	13
β-strand	72-76	5	24
α-helix	84-92	9
β-strand	100-104	5	24
α-helix	116-124	9
β-strand	127-137	11	41
β-strand	141-147	7	42
β-strand	158-163	6	42
β-strand	168-172	5	42
α-helix	175-184	10
β-strand	190-191	2	42
β-strand	194	1	43
β-strand	201	1	43
β-strand	205-206	2	42
β-strand	207	1	44
α-helix	208-213	6
β-strand	224	1	44
α-helix	226-228	3
β-strand	233-242	10	41
α-helix	243-249	7
α-helix	258-261	4
α-helix	269-284	16
β-strand	290-292	3	41
β-strand	294-298	5	24
α-helix	300-302	3
β-strand	304	1	45
α-helix	305-314	10
α-helix	321	1
β-strand	322-327	6	24
β-strand	331-333	3	46
α-helix	334	1
β-strand	335	1	45
β-strand	340-342	3	46
α-helix	347-350	4
β-strand	354-357	4	24
α-helix	360-362	3
α-helix	363-377	15
β-strand	381	1	47
α-helix	383-414	32
β-strand	420	1	47
α-helix	422-431	10
β-strand	433	1	4
α-helix	435-443	9
β-strand	450	1	11

Chain F: 23 helices, 24 β-strands

Element	Residues	Length	Sheet
β-strand	42-43	2	48
β-strand	46-47	2	48
α-helix	50-65	16
β-strand	68	1	26
β-strand	72-75	4	35
α-helix	83-92	10
β-strand	100-104	5	35
α-helix	105-107	3
α-helix	115-125	11
β-strand	127-148	22	25
β-strand	157-163	7	25
β-strand	168-173	6	25
α-helix	176-184	9
β-strand	190-195	6	25
β-strand	201-207	7	25
α-helix	208-210	3
β-strand	216	1	19
β-strand	223-224	2	25
α-helix	225-227	3
β-strand	232-242	11	25
α-helix	243-249	7
α-helix	255-257	3
α-helix	258-261	4
α-helix	269-284	16
β-strand	289-292	4	25
β-strand	294-298	5	35
α-helix	300-302	3
α-helix	305-314	10
β-strand	322-326	5	35
β-strand	329	1	36
β-strand	331-333	3	49
α-helix	334	1
β-strand	340-342	3	49
α-helix	347-350	4
β-strand	354-356	3	35
α-helix	360-362	3
α-helix	363-376	14
β-strand	381	1	50
α-helix	383-396	14
α-helix	398-401	4
α-helix	403-414	12
β-strand	420	1	50
α-helix	422-431	10
β-strand	433	1	18
α-helix	434	1
α-helix	435-444	10
β-strand	450	1	21

Chain G: 38 helices, 19 β-strands

Element	Residues	Length	Sheet
α-helix	974-988	15
β-strand	994	1	51
α-helix	1003-1016	14
β-strand	1024-1028	5	51
α-helix	1033-1043	11
β-strand	1050-1051	2	51
α-helix	1056-1064	9
β-strand	1081-1085	5	51
α-helix	1086-1091	6
α-helix	1093-1096	4
β-strand	1101-1106	6	51
α-helix	1118-1124	7
β-strand	1128-1133	6	51
α-helix	1144-1153	10
α-helix	1166-1179	14
α-helix	1187-1193	7
α-helix	1203-1207	5
β-strand	1213-1218	6	52
α-helix	1224-1240	17
α-helix	1257-1269	13
α-helix	1271-1273	3
β-strand	1283-1284	2	53
β-strand	1287	1	54
β-strand	1302	1	9
β-strand	1308	1	54
β-strand	1312-1314	3	55
α-helix	1318-1322	5
α-helix	1335-1344	10
α-helix	1353-1356	4
α-helix	1366-1369	4
α-helix	1375-1381	7
α-helix	1386-1393	8
α-helix	1403-1406	4
α-helix	1418-1420	3
α-helix	1430-1434	5
α-helix	1443-1446	4
α-helix	1448-1455	8
β-strand	1469-1470	2	53
α-helix	1472-1474	3
β-strand	1475-1477	3	55
α-helix	1481-1490	10
α-helix	1494-1501	8
α-helix	1505-1512	8
α-helix	1528-1530	3
α-helix	1542-1544	3
α-helix	1553-1568	16
β-strand	1575-1576	2	52
α-helix	1579-1591	13
β-strand	1596-1599	4	52
α-helix	1605-1617	13
β-strand	1623-1627	5	52
α-helix	1629-1631	3
β-strand	1642-1645	4	52
α-helix	1652-1662	11
α-helix	1670	1
β-strand	1671-1676	6	52
α-helix	1682-1701	20

Chain H: 3 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	385-412	28
β-strand	448-452	5	31
β-strand	457-460	4	31
α-helix	463-465	3
α-helix	471-474	4

10 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
RuvB-like helicase	A, B, C	protein	462	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	G0RYI5 (AlphaFold model)
RuvB-like helicase	D, E, F	protein	488	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	G0RYC2 (AlphaFold model)
Ino80	G	protein	1856	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
les2	H	protein	491	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719), Chaetomium thermophilum var. thermophilum DSM 1495	G0RY01 (AlphaFold model)
Ies6	I	protein	219	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	G0S590 (AlphaFold model)
Actin related protein 5	J	protein	770	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719), Chaetomium thermophilum var. thermophilum DSM 1495	G0S589
Nucleosomal DNA Strand 1	K	DNA	196	synthetic construct
Nucleosomal DNA Strand 2	L	DNA	196	synthetic construct
Histone H3.2	M, Q	protein	135	Homo sapiens	Q71DI3
Histone H4	N, R	protein	102	Homo sapiens	P62805
Histone H2A type 1	O, S	protein	129	Homo sapiens	P0C0S8
Histone H2B type 1-C/E/F/G/I	P, T	protein	125	Homo sapiens	P62807

Sequence of entity 1 (A, B, C), FASTA

>6FML_1 RuvB-like helicase (chains A, B, C)
MVQISEVRGNTRDHRTAAHTHIKGLGLNSSGIAEKQAAGFVGQCAAREACGVVVDLIKAH
KMAGRGVLLAGGPGTGKTALALAISQELGTKIPFCPITGSEIYSTEVKKTEVLMENFRRA
IGLRVRETKDVYEGEVTEMTPEEAENPLGGYGKTISTLLIGLKSARGQKKLRLDPSIYEA
IQKERVQVGDVIYIETNTGACKRVGRSDAYATEFDLEAEEYVPIPKGEVHKKKEIVQDVT
LHDLDVANARPQGGQDIISMMGQLMKPKMTEITDKLRMEINKVVQKYINQGVAELIPGVL
FIDEAHMLDIECFTYLNKALESPIAPIVVLASNRGIATIRGADDLKAAHGIPPDFLQRLL
IIPTHPYEPDEIRRIVRIRAQTEGVQLTDAAVDRVAEHGVRISLRYCLQLLAPASILARV
NGRTQVDVQDIAEAEELFLDARRSANILTSTGESGGLHGFIS

Sequence of entity 2 (D, E, F), FASTA

>6FML_2 RuvB-like helicase (chains D, E, F)
MAAPLVTSVTETKELRGLNLIAAHSHIRGLGVDADTLEPRPSSQGLVGQEKARKAAAVVL
EMIKQGKIAGRAVLIAGPPSTGKTAIAMGMAQSLGQDVPFTTLAASEIFSLEMSKTEALT
QAFRKSIGVRIKEESEIMEGEVVEIQIDRSVTGGAKQGKLTIKTTDMEAIYDMGSKMIDA
MTKERVMAGDIISIDKSSGKITKLGRSYARSRDYDAMGVDTKFLQCPEGELQKRKEVVHT
VSLHEIDVINSRTQGFLALFSGDTGEIRSEIRDQINTKVAEWKEEGKAEIVPGVLFIDEV
HMLDIECFSYINRALESDLAPIVIMASNRGVSRIRGTDYKSPHGLPLDFLDRVVIINTHP
YTPDELRQILSIRAQEEEVDLTPDALALLTKIGQEAGLRYASNLITTSQLIAAKRRAKQV
GVEDVQRSFKLFYDPARSVRFVQESEKRLIGNDGVVDFSYQGAAEAAAPTLPAAAPVDPV
GGEKMDMS

Sequence of entity 3 (G), FASTA

>6FML_3 Ino80 (chains G)
MDHFPTVLQRPPHFDEDGSAGTGRMRSNVVGNGSSNGARDDRGLRGGLRDILNPVGSASQ
TMPSASHGGTHSTPGTPGAPAPPRPHSSFSLRSPTQTGNHHASPYSAPTSSAAATSSQQP
AGACSMLNNPFVTASTPFPPPPLQAPPSLASSRTSPSGLQHPPRSPLHAPPVYYPSDVRD
RDLVRDQQTSLSFYDPTTDSKRDRDRERDRERERTGSDPESGAWSTSTQNSPPKIRDSYN
YSRSPSFNNSGNYPSATGSYPPRSPVVRPHPAPPAGSMSPSAGSRTVTSPSLRHLAMPST
HSSQSASTVLPPLARTETPAPSARATPASNTPSRASGVMSFSNILSSSEPISKPRPTSPI
SLDNNPAMVARTEPAERPDKGEKDKKQSRKIIKTRVSDIKSAESTPKMTRKSAVKPETPT
MLRIPTKRTANGSMKHKAFSADKEKTIRDIMDQFDYESIDETEFEDELLAWKERARRRRQ
EMNRRDFIHRQSRRSDFAETEALKLQIHANLGKARYSDLHYDEALQEVREQELWAEKERK
KDMQRKRRREKSMAATLEQQAAALQKASQAEDEAERLKYIREAERANKKVQQTKYILQKG
IKGPARNLPPIEPNLEGGTMATFSAENMEPGKVKGKGRGGRLKKSKEQKQAEKEQAELAQ
AAIDAGEEPPSKEETKIRIKLSKAKASAKEEAEKDKENKEPKQPKEPEKPVEEPKDPLEL
KFQSKGYNQIYDQIWRDLARKDVSKVFRLATDSYATKASNLKKTAILASKEAKRWQLRTN
KGTKDLQARAKRVMRDMMGFWKRNEREERDLRKAAERLELENARKEEADREAARQRRKLN
FLISQTELYSHFISKKIKTHEVERSTDHPDVATDEKDKIPEPTLNINVPEPTGPIAPKVT
DFNSLDFDNEDESALQAAAMANAQNAIAEAQKKAREFNKDETKLDEDGEMNFQHPELTEF
EVAQPKLLNCQLKEYQLKGLNWLVNLYEQGINGILADEMGLGKTVQSISVMAYLAERYDI
WGPFLVVAPASTLHNWQQEVSKFVPDFKVLPYWGTAADRKVLRKFWDRKHTTYKKDSPFH
VMITSYQLVVSDVAYFQKMKWQYMILDEAQAIKSSQSSRWKCLLGFHCRNRLLLTGTPIQ
NNMQELWALLHFIMPSLFDSHDEFSEWFSKDIESHAQSNTKLNEDQLKRLHMILKPFMLR
RVKKHVQKELGDKIEIDVFCELSYRQRAMYQSLRNQISIMDLIEKATVGDNEDSATLMNL
VMQFRKVCNHPDLFERADTSSPFFCGHFAETGSFLREGTNVALGYSTRSLVEYRLPRLIW
CDGGRLDKPGPGNLVAGFRSKYLNHMMNIWTPENIRSSLEGIENFTWLRFVDTSLQEAYR
ASHTDVFARAVDLASKQNRLGHMQIVYDEPEDKKWTPVHALFQICERENPKAVAEITTEG
VLRDLMNIARVKYRELGLCRLEKAARPRASAPPIEVVCDSRSAVIERENIMFHPAMRKAL
FGPTPSEIKEASFGPRPVTLYPPRALLPAPDHDKQRFTNITVPSMARFVTDSGKLAKLDE
LLRELKEGGHRVLLYFQMTRMIDLMEEYLTYRNYKYCRLDGSTKLEDRRDTVADFQTRPE
IFIFLLSTRAGGLGINLTTADTVIFYDSDWNPTIDSQAMDRAHRLGQTKQVTVYRLITRG
TIEERIRKRALQKEEVQRVVITGTGSVDFSGRRPPENRNRDIAMWLADDEQAEMIERREK
ELIESGEYDKIMQQRRKGGKRKRGAANGDTVPSLEDMYHEGEGHFDDNKGSGAATPVDAD
SLGRGGKRKKAGGSKKAKTTKQRLAIADGEIDDGEIDIDYKDDDDKGTDYKDDDDK

Sequence of entity 4 (H), FASTA

>6FML_4 les2 (chains H)
MSTRPRRHAAQRASQAITDLADRDRESDHSHGPISSRMSSFNSSSRSRLPGKGIASVSRS
EAGGASDPEHIHLTVKLPSSKLRQATSSSGIKKAGSVGSSSSSSGGGKAAVKRARGGKRS
RVLESSEEEEEENEVEVLGDEDEEEEEEEDEIEVREGEGYDEDEEDVEDEDEEMQDLGEE
DADGEDDEMDVDAEGEEDADGDVNMDAGVVGARATTVRAVPPAIKVTKPPKESPSNGKAA
TASKANDNAVPVKRPAPDSDDESLSSLESEPEEEVNVAGGEDAEGEDDDAEGEVDAEGEE
EEEEEEIEVADEDAEGEDVEQDEDEDEEEEDDDDEMISRAQTPDMSRLTARQRARLGEAS
GEYLKLSDEVQSKKHFTAEELSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKQAPRTTR
RAAQAAAAAEEAEEAAKQPKRPDPMMIRWVNNKMGSVVAVPEELLGTHAGVVFGAGPGKG
LPAGKMVEEVS

Sequence of entity 5 (I), FASTA

>6FML_5 Ies6 (chains I)
MSNPDAQSAQAAHQALVEQLDLHSIHKTFRNPNWRPNQRRNKTIKAILGESQRKEASSTS
AVATPRADDNGGGSGADTPANNDNNDGLSTSGTSTPANGNGSGAGTPASNGQPNLAQASR
SLQKLVLEKSLASAQAPDKKAANGFASSAPTATYTNIESAPSLAPMKHYCDVTGLPAPYL
DPKTRLRYHNKEIFAMIRNLPQGMGEQFLEARGAHTVLK

Sequence of entity 6 (J), FASTA

>6FML_6 Actin related protein 5 (chains J)
MAPSAVAEPPPIPQRDEPWKRLPPPTVYPVKEARFEKYIPPQLDGRERALAQPPGQVAIV
IDNGSHSVRAGWNFEDKPRLAIPPIMSKYRDRKMGKTFSFAGSDCYADTTARSHIRNAFE
AGTGIVSNWDVMEHVLDYVFVKLGMNECDGAIDMPIVMTEAVANLPYSRKSMSEIIFECY
GAPSLVYGIDSLFSFRHNQGQTGLVVSSSYSATHVIPVYNRKALLSQAIRLNWGGWHMAE
YMLKLLKLKYYTGFPGKLNSSQTEHMVRDFCYVSLDYDRELAGYLDWTGLEDRERIVQYP
YTEEVVVQKTEEELARIAERKKESGRRLQEQAAKMRLERLMKKEQELEYYKDIQRRMQGE
SKKEIKRLLDEAELKDEAALERVIRDLERSIKRARQKDLGEPEEEEVPDFSLLDVPDDQL
DEAGLRQKRQQRLLKSNWEARQRAKAEKEAEKARLAEEARLDEERRKNDLXXXXXXXXXX
XXXXXXXXXXXXXXXXXXGNRKSXXXXXXXXXXXXXXXXXNPTGSGSRKRRRGGAGADQD
DDFGADDADWGVYRSVAIGANKGDDSDDEEGXXXXXXXXXXXXXXXLRYDKTFSYDMTLD
AQRDWSKSLLHAFRYGPRPFDPSSQAETHRVHLNVERIRVPEVLFQPAAIAGVDQAGLVE
IAGDILCQRLPSLPGIQDAPDAFLRDVFLTGGNTLFQNFDERLRQGLMALLPVGAPLRVR
RAQDAILDAWRGAAGWACTEEAKAAWITREEYLEKGGEYIKEHDLGNAFA

Sequence of entity 7 (K), FASTA

>6FML_7 Nucleosomal DNA Strand 1 (chains K)
CTCGGAACACTATCCGACTGGCACCGGCAAGGTCGCTGTTCAATACATGCACAGGATGTA
TATATCTGACACGTGCCTGGAGACTAGGGAGTAATCCCCTTGGCGGTTAAAACGCGGGGG
ACAGCGCGTACGTGCGTTTAAGCGGTGCTAGAGCTTGCTACGACCAATTGAGCGGCCTCG
GCACCGGGATTCTCCA

Sequence of entity 8 (L), FASTA

>6FML_8 Nucleosomal DNA Strand 2 (chains L)
TGGAGAATCCCGGTGCCGAGGCCGCTCAATTGGTCGTAGCAAGCTCTAGCACCGCTTAAA
CGCACGTACGCGCTGTCCCCCGCGTTTTAACCGCCAAGGGGATTACTCCCTAGTCTCCAG
GCACGTGTCAGATATATACATCCTGTGCATGTATTGAACAGCGACCTTGCCGGTGCCAGT
CGGATAGTGTTCCGAG

Sequence of entity 9 (M, Q), FASTA

>6FML_9 Histone H3.2 (chains M, Q)
ARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTEL
LIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIM
PKDIQLARRIRGERA

Sequence of entity 10 (N, R), FASTA

>6FML_10 Histone H4 (chains N, R)
SGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKV
FLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG

Sequence of entity 11 (O, S), FASTA

>6FML_11 Histone H2A type 1 (chains O, S)
SGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTA
EILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKT
ESHHKAKGK

Sequence of entity 12 (P, T), FASTA

>6FML_12 Histone H2B type 1-C/E/F/G/I (chains P, T)
PEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMG
IMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTK
YTSSK

Ligands and cofactors

ID	Name	Formula	Copies
ADP	Adenosine-5'-diphosphate	C10 H15 N5 O10 P2	6
ATP	Adenosine-5'-triphosphate	C10 H16 N5 O13 P3	1

Primary citation

Structural basis for ATP-dependent chromatin remodelling by the INO80 complex. Eustermann, S., Schall, K., Kostrewa, D. et al. Nature (2018) 556:386-390. DOI 10.1038/s41586-018-0029-y · PubMed

Other PDB entries of the same protein (UniProt G0RYI5 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8OOP 2.7 Å, CryoEM Structure INO80core Hexasome complex composite model state2
8OO7 2.8 Å, CryoEM Structure INO80core Hexasome complex composite model state1
8OOR 2.87 Å, CryoEM Structure INO80core Hexasome complex Rvb core refinement state2
5FM7 2.9 Å, Double-heterohexameric rings of full-length Rvb1(ADP)Rvb2(ADP)
8OOC 2.93 Å, CryoEM Structure INO80core Hexasome complex Rvb core refinement state1
4WW4 2.94 Å, Double-heterohexameric rings of full-length Rvb1(ADP)/Rvb2(ADP)
5FM6 3.0 Å, Double-heterohexameric rings of full-length Rvb1(ADP)Rvb2(apo)
4WVY 3.64 Å, Double-heterohexameric rings of full-length Rvb1(ATP)/Rvb2(apo)
6FHS 3.75 Å, CryoEM Structure of INO80core
8AV6 4.68 Å, CryoEM structure of INO80 core nucleosome complex in closed grappler conformation

Browse structure collections

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