6G6W: Human PI3KDELTA

Human PI3KDELTA in complex with ligand LASW1976. Determined by X-ray diffraction at 2.72 Å resolution. Released 7 Nov 2018.

Method: X-ray diffraction
Resolution: 2.72 Å
Organisms: Homo sapiens, Bos taurus
Chains: 2
Atoms: 8,842
Mol. weight: 144.59 kDa
Ligands: EO5
Released: 7 Nov 2018

Explore 6G6W in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6G6W contains 54 α-helices and 44 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 51 helices, 44 β-strands

Element	Residues	Length	Sheet
β-strand	19-25	7	1
β-strand	31-37	7	1
β-strand	41	1	2
α-helix	42-53	12
α-helix	59-61	3
α-helix	65-67	3
β-strand	68-73	6	1
β-strand	74	1	3
β-strand	79-81	3	1
β-strand	88	1	2
α-helix	89-92	4
β-strand	94	1	3
β-strand	98-103	6	1
α-helix	108-121	14
α-helix	125-130	6
α-helix	134-156	23
α-helix	159-166	8
β-strand	171	1	4
β-strand	189-196	8	5
β-strand	202-208	7	5
α-helix	213-226	14
β-strand	239-243	5	5
β-strand	246	1	6
β-strand	249-250	2	5
α-helix	256-258	3
β-strand	259	1	4
α-helix	260-268	9
α-helix	270-272	3
β-strand	273-278	6	5
α-helix	279-287	9
α-helix	316-318	3
β-strand	322-331	10	7
β-strand	340-349	10	8
β-strand	352-353	2	8
β-strand	359	1	8
β-strand	363-364	2	8
α-helix	365	1
β-strand	370-380	11	7
α-helix	381-383	3
β-strand	389-397	9	8
β-strand	416-424	9	8
β-strand	426	1	9
β-strand	431	1	10
β-strand	432	1	9
α-helix	433	1
β-strand	435-440	6	7
α-helix	441	1
β-strand	442-443	2	8
α-helix	444-446	3
α-helix	461-462	2
β-strand	470-475	6	7
β-strand	484	1	10
α-helix	485-487	3
α-helix	488-495	8
α-helix	506-515	10
α-helix	525-533	9
α-helix	535-541	7
α-helix	543-545	3
α-helix	546-552	7
α-helix	558-569	12
α-helix	571-575	5
α-helix	576-582	7
α-helix	590-600	11
α-helix	605-618	14
α-helix	619-621	3
α-helix	628-639	12
α-helix	641-652	12
α-helix	658-673	16
α-helix	676-705	30
α-helix	708-720	13
α-helix	722-728	7
β-strand	731-732	2	11
β-strand	739	1	6
β-strand	740-741	2	11
β-strand	743-744	2	12
β-strand	750-751	2	12
β-strand	759-764	6	12
β-strand	774-780	7	12
α-helix	785-802	18
β-strand	815-819	5	12
β-strand	822-826	5	12
β-strand	831-833	3	13
α-helix	834-837	4
α-helix	854-862	9
α-helix	865-867	3
α-helix	868-888	21
β-strand	899-902	4	13
β-strand	907-909	3	13
α-helix	930-932	3
α-helix	936-942	7
α-helix	950-969	20
α-helix	971-981	11
α-helix	982-984	3
α-helix	992-1001	10
α-helix	1008-1025	18

Chain B: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	442-506	65
α-helix	520-587	68
α-helix	591-597	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	A	protein	1072	Homo sapiens	O00329 (AlphaFold model)
Phosphatidylinositol 3-kinase regulatory subunit alpha	B	protein	170	Bos taurus	P23727 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>6G6W_1 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (chains A)
MSYYHHHHHHDYDIPTTENLYFQGAMGSMPPGVDCPMEFWTKEENQSVVVDFLLPTGVYL
NFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDV
QPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAA
RRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDV
PLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTP
HLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSK
VNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCF
ALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGEL
LNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLR
EILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWP
ELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKF
LLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKL
KALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFM
DSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTP
YGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAI
EEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPF
ILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCS
KDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ

Sequence of entity 2 (B), FASTA

>6G6W_2 Phosphatidylinositol 3-kinase regulatory subunit alpha (chains B)
MYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEDYTRTSQEIQMKRTAIEAFNE
TIKIFEEQCQTQERYSKEYIEKFKREGNETEIQRIMHNYEKLKSRISEIVDSRRRLEEDL
KKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLG

Ligands and cofactors

ID	Name	Formula	Copies
EO5	~{N}-[3-[4-[[(1~{S})-1-(5-methyl-4-oxidanylidene-3-phenyl-pyrrolo[2,1-f][1,2,4]…	C28 H26 N8 O4 S	1

Primary citation

Discovery of a Novel Inhaled PI3K delta Inhibitor for the Treatment of Respiratory Diseases. Erra, M., Taltavull, J., Bernal, F.J. et al. J Med Chem (2018) 61:9551-9567. DOI 10.1021/acs.jmedchem.8b00873 · PubMed

Other PDB entries of the same protein (UniProt O00329 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6PYR 2.21 Å, Human PI3Kdelta in complex with Compound 2-10 ((3S)-3-benzyl-3-methyl-5-[5-(2-methylpyrim…
8S3R 2.28 Å, Human PI3KDELTA in complex with pyridazinone inhibitor 7
7JIS 2.42 Å, Human PI3KDELTA in complex with compound 2F
8BCY 2.43 Å, Human PI3KDELTA in complex with compound 13
9L3R 2.5 Å, Human PI3KDELTA in complex with Zandelisib
6PYU 2.54 Å, Human PI3Kdelta in complex with Compound 4-2 ((3S)-1'-(cyclopropanecarbonyl)-5-(quinoxali…
6OCO 2.58 Å, Human PI3KDELTA in complex with compound 6
5DXU 2.64 Å, p110delta/p85alpha with GDC-0326
9T07 2.75 Å, HUMAN PI3KDELTA IN COMPLEX WITH Roginolisib
6OCU 2.77 Å, Human PI3KDELTA in complex with compound 29
7LM2 2.79 Å, Human PI3KDELTA in complex with compound 3C
5VLR 2.8 Å, Crystal structure of PI3K delta in complex with a trifluoro-ethyl-pyrazol-pyrolotriazine…

Browse structure collections

About this viewer

MolViewer shows 6G6W directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.