6H3E: Receptor-bound Ghrelin conformation

Receptor-bound Ghrelin conformation. Determined by solution NMR. Released 24 Jul 2019.

Method

Solution NMR

Organism

Homo sapiens

Chains

1

Atoms

158

Mol. weight

2.26 kDa

Ligands

FKZ

Released

24 Jul 2019

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Molecules and chains

>6H3E_1 Appetite-regulating hormone (chains A)
GSDFLSPEHQRVQQRKESX

Ligands and cofactors

Primary citation

Structure and dynamics of G protein-coupled receptor-bound ghrelin reveal the critical role of the octanoyl chain. Ferre, G., Louet, M., Saurel, O. et al. Proc Natl Acad Sci U S A (2019) 116:17525-17530. DOI 10.1073/pnas.1905105116 · PubMed

Related structures

Other PDB entries of the same protein (UniProt Q9UBU3 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 7NA7 2.7 Å, Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist
• 7W2Z 2.8 Å, Cryo-EM structure of the ghrelin-bound human ghrelin receptor-Go complex
• 7F9Y 2.9 Å, ghrelin-bound ghrelin receptor in complex with Gq
• 8ZZO Structural Model of Ghrelin Bound to its G Protein-Coupled Receptor

Browse structure collections

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