6MC9: Human Nav1.4 C-Terminal (1599-1754) domain

Crystal Structure of Human Nav1.4 C-Terminal (1599-1754) domain in complex with calcium-bound calmodulin. Determined by X-ray diffraction at 3.3 Å resolution. Released 10 Apr 2019.

Method: X-ray diffraction
Resolution: 3.3 Å
Organisms: Homo sapiens, Rattus norvegicus
Chains: 2
Atoms: 2,330
Mol. weight: 36.22 kDa
Ligands: CA
Released: 10 Apr 2019

Explore 6MC9 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6MC9 contains 14 α-helices and 8 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 6 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	1614-1627	14
β-strand	1634-1636	3	1
α-helix	1637-1645	9
α-helix	1658-1664	7
β-strand	1667-1669	3	1
β-strand	1673-1675	3	1
α-helix	1676-1687	12
α-helix	1692-1708	17
β-strand	1719-1720	2	1
α-helix	1721-1759	39

Chain B: 8 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	12-19	8
β-strand	27	1	2
α-helix	29-39	11
α-helix	45-54	10
β-strand	63	1	2
α-helix	65-76	12
α-helix	82-92	11
β-strand	99-101	3	3
α-helix	102-110	9
α-helix	118-128	11
β-strand	135-137	3	3
α-helix	138-145	8

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Sodium channel protein type 4 subunit alpha	A	protein	168	Homo sapiens	P35499 (AlphaFold model)
Calmodulin-1	B	protein	149	Rattus norvegicus	P0DP29 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>6MC9_1 Sodium channel protein type 4 subunit alpha (chains A)
GPLGSENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRI
AKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSKV
SYEPITTTLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYLTRAAAS

Sequence of entity 2 (B), FASTA

>6MC9_2 Calmodulin-1 (chains B)
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	4

Primary citation

Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif. Yoder, J.B., Ben-Johny, M., Farinelli, F. et al. Nat Commun (2019) 10:1514-1514. DOI 10.1038/s41467-019-09570-7 · PubMed

Other PDB entries of the same protein (UniProt P35499 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6MBA 1.8 Å, Crystal Structure of Human Nav1.4 CTerminal Domain in Complex with apo Calmodulin
6AGF 3.2 Å, Structure of the human voltage-gated sodium channel Nav1.4 in complex with beta1

Browse structure collections

About this viewer

MolViewer shows 6MC9 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.