6NVB: Kallikrein-4

Crystal structure of the inhibitor-free form of the serine protease kallikrein-4. Determined by X-ray diffraction at 1.64 Å resolution. Released 17 Jul 2019.

Method: X-ray diffraction
Resolution: 1.64 Å
Organism: Homo sapiens
Chains: 4
Atoms: 7,845
Mol. weight: 96.8 kDa
Released: 17 Jul 2019

Explore 6NVB in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6NVB contains 51 α-helices and 74 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 12 helices, 18 β-strands

Element	Residues	Length	Sheet
β-strand	17	1	1
β-strand	20-21	2	2
α-helix	22-23	2
β-strand	30-35	6	3
β-strand	38-48	10	3
β-strand	51-54	4	3
α-helix	56-58	3
β-strand	63-67	5	3
β-strand	72	1	4
α-helix	74A-76	3
β-strand	81-90	10	3
β-strand	104-108	5	3
α-helix	122	1
β-strand	123	1	2
α-helix	124	1
α-helix	128-129	2
β-strand	135-140	6	2
α-helix	150-152	3
β-strand	154	1	4
β-strand	156-162	7	2
α-helix	163-164	2
α-helix	165-171	7
β-strand	180-184	5	2
β-strand	189	1	1
β-strand	198-201	4	2
β-strand	208-215	8	2
α-helix	217	1
β-strand	225-230	6	2
α-helix	231-233	3
α-helix	235-243	9

Chain B: 12 helices, 20 β-strands

Element	Residues	Length	Sheet
β-strand	17	1	5
β-strand	20-21	2	6
α-helix	22-23	2
β-strand	30-35	6	7
β-strand	38-48	10	7
β-strand	51-54	4	7
α-helix	56-58	3
β-strand	63-67	5	7
β-strand	72	1	8
α-helix	74A-76	3
β-strand	81-90	10	7
β-strand	104-108	5	7
β-strand	115	1	9
β-strand	118	1	9
α-helix	122	1
β-strand	123	1	6
α-helix	124	1
α-helix	128-129	2
β-strand	135-140	6	6
α-helix	150-152	3
β-strand	154	1	8
β-strand	156-162	7	6
α-helix	163-164	2
α-helix	165-172	8
β-strand	180-184	5	6
β-strand	189	1	5
β-strand	198-201	4	6
β-strand	208-215	8	6
α-helix	217	1
β-strand	225-230	6	6
α-helix	231-233	3
α-helix	235-244	10

Chain C: 13 helices, 18 β-strands

Element	Residues	Length	Sheet
β-strand	17	1	10
β-strand	20-21	2	11
α-helix	22-23	2
β-strand	30-35	6	12
β-strand	38-48	10	12
β-strand	51-54	4	12
α-helix	56-58	3
β-strand	63-67	5	12
β-strand	72	1	13
α-helix	74A-76	3
β-strand	81-90	10	12
β-strand	104-108	5	12
α-helix	111-114	4
α-helix	122	1
β-strand	123	1	11
α-helix	124	1
α-helix	128-129	2
β-strand	135-140	6	11
α-helix	150-152	3
β-strand	154	1	13
β-strand	156-162	7	11
α-helix	163-164	2
α-helix	165-171	7
β-strand	180-184	5	11
β-strand	189	1	10
β-strand	198-201	4	11
β-strand	208-215	8	11
α-helix	217	1
β-strand	225-230	6	11
α-helix	231-233	3
α-helix	235-243	9

Chain D: 14 helices, 18 β-strands

Element	Residues	Length	Sheet
β-strand	17	1	14
β-strand	20-21	2	15
α-helix	22-23	2
β-strand	30-35	6	16
β-strand	38-48	10	16
β-strand	51-54	4	16
α-helix	56-58	3
β-strand	63-67	5	16
β-strand	72	1	17
α-helix	74A-76	3
β-strand	81-90	10	16
β-strand	104-108	5	16
α-helix	111-114	4
α-helix	122	1
β-strand	123	1	15
α-helix	124	1
α-helix	128-129	2
β-strand	135-140	6	15
α-helix	150-152	3
β-strand	154	1	17
β-strand	156-162	7	15
α-helix	163-164	2
α-helix	165-172	8
β-strand	180-183	4	15
β-strand	189	1	14
β-strand	198-201	4	15
β-strand	208-215	8	15
α-helix	217	1
α-helix	225	1
β-strand	226-230	5	15
α-helix	231-233	3
α-helix	235-242	8

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Kallikrein-4	A, B, C, D	protein	224	Homo sapiens	Q9Y5K2 (AlphaFold model)

Sequence of entity 1 (A, B, C, D), FASTA

>6NVB_1 Kallikrein-4 (chains A, B, C, D)
IINGEDCSPHSQPWQAALVMENELFCSGVLVHPQWVLSAAHCFQNSYTIGLGLHSLEADQ
EPGSQMVEASLSVRHPEYNRPLLANDLMLIKLDESVSESDTIRSISIASQCPTAGNSCLV
SGWGLLANGRMPTVLQCVNVSVVSEEVCSKLYDPLYHPSMFCAGGGQDQKDSCNGDSGGP
LICNGYLQGLVSFGKAPCGQVGVPGVYTNLCKFTEWIEKTVQAS

Primary citation

Crystal structure of the inhibitor-free form of the serine protease kallikrein-4. Riley, B.T., Hoke, D.E., McGowan, S. et al. Acta Crystallogr F Struct Biol Commun (2019) 75:543-546. DOI 10.1107/S2053230X19009610 · PubMed

Other PDB entries of the same protein (UniProt Q9Y5K2 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4K8Y 1.0 Å, Atomic resolution crystal structures of Kallikrein-Related Peptidase 4 complexed with…
4KEL 1.15 Å, Atomic resolution crystal structure of Kallikrein-Related Peptidase 4 complexed with a…
6O21 1.15 Å, Crystal Structure of Human KLK4 in Complex With Cleaved SFTI-FCQR(Asn14)[1,14] Inhibitor
4K1E 1.3 Å, Atomic resolution crystal structures of Kallikrein-Related Peptidase 4 complexed with a…
7JOD 1.33 Å, Crystal structure of BbKI complexed with Human Kallikrein 4
7JQK 1.33 Å, Crystal structure of the R64A mutant of Bauhinia Bauhinioides Kallikrein Inhibitor…
7JQN 1.5 Å, Crystal structure of the R64M mutant of Bauhinia Bauhinioides Kallikrein Inhibitor…
7JQO 1.6 Å, Crystal structure of the R64D mutant of Bauhinia Bauhinioides Kallikrein Inhibitor…
7JOW 1.91 Å, Crystal structure of BbKI complexed with Human Kallikrein 4
2BDG 1.95 Å, Human Kallikrein 4 complex with nickel and p-aminobenzamidine
6KBR 2.0 Å, Crystal structure of Human KLK4 and SPINK2 derived KLK4 inhibitor complex
7JOS 2.1 Å, Crystal structure of BbKI complexed with Human Kallikrein 4

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