Structure of human Patched1 in complex with native Sonic Hedgehog. Determined by electron microscopy at 3.8 Å resolution. Released 17 Apr 2019.
Explore 6OEV in 3D Show helices and sheets RCSB PDB PDBe
6OEV contains 56 α-helices and 23 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 78-95 | 18 | |
| α-helix | 97-99 | 3 | |
| α-helix | 101-114 | 14 | |
| α-helix | 115-117 | 3 | |
| α-helix | 125-128 | 4 | |
| α-helix | 135-146 | 12 | |
| β-strand | 153-154 | 2 | 1 |
| β-strand | 158-162 | 5 | 2 |
| α-helix | 172-186 | 15 | |
| β-strand | 203 | 1 | 1 |
| α-helix | 215-222 | 8 | |
| α-helix | 232-234 | 3 | |
| α-helix | 239-241 | 3 | |
| α-helix | 253-254 | 2 | |
| α-helix | 261-270 | 10 | |
| α-helix | 276-282 | 7 | |
| α-helix | 339-342 | 4 | |
| β-strand | 343-344 | 2 | 2 |
| β-strand | 359-362 | 4 | 2 |
| β-strand | 366-367 | 2 | 1 |
| α-helix | 368 | 1 | |
| α-helix | 369-375 | 7 | |
| α-helix | 380-382 | 3 | |
| α-helix | 389-409 | 21 | |
| β-strand | 417-421 | 5 | 2 |
| α-helix | 425-435 | 11 | |
| α-helix | 439-456 | 18 | |
| α-helix | 463-466 | 4 | |
| α-helix | 470-490 | 21 | |
| α-helix | 503-524 | 22 | |
| α-helix | 536-563 | 28 | |
| α-helix | 568-601 | 34 | |
| α-helix | 733-740 | 8 | |
| α-helix | 741-744 | 4 | |
| α-helix | 747-769 | 23 | |
| β-strand | 773 | 1 | 3 |
| α-helix | 786-796 | 11 | |
| β-strand | 800-807 | 8 | 4 |
| α-helix | 812-814 | 3 | |
| α-helix | 817-824 | 8 | |
| β-strand | 832 | 1 | 4 |
| α-helix | 833-834 | 2 | |
| β-strand | 835 | 1 | 5 |
| β-strand | 839 | 1 | 5 |
| α-helix | 840-842 | 3 | |
| α-helix | 844-865 | 22 | |
| α-helix | 878-886 | 9 | |
| α-helix | 916-918 | 3 | |
| α-helix | 919-929 | 11 | |
| α-helix | 931-937 | 7 | |
| α-helix | 944-947 | 4 | |
| α-helix | 965-969 | 5 | |
| β-strand | 972-979 | 8 | 4 |
| α-helix | 986-1004 | 19 | |
| β-strand | 1008-1011 | 4 | 4 |
| α-helix | 1013-1017 | 5 | |
| α-helix | 1019-1021 | 3 | |
| α-helix | 1024-1047 | 24 | |
| α-helix | 1050-1074 | 25 | |
| β-strand | 1078 | 1 | 3 |
| α-helix | 1080-1101 | 22 | |
| α-helix | 1102-1105 | 4 | |
| α-helix | 1113-1121 | 9 | |
| α-helix | 1123-1138 | 16 | |
| α-helix | 1146-1148 | 3 | |
| α-helix | 1149-1154 | 6 | |
| α-helix | 1155-1174 | 20 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 47 | 1 | 6 |
| α-helix | 72-75 | 4 | |
| β-strand | 77-78 | 2 | 7 |
| β-strand | 85-86 | 2 | 6 |
| α-helix | 94-96 | 3 | |
| β-strand | 97-98 | 2 | 7 |
| α-helix | 100-116 | 17 | |
| β-strand | 122-124 | 3 | 6 |
| β-strand | 146-150 | 5 | 6 |
| α-helix | 158-168 | 11 | |
| β-strand | 172-174 | 3 | 6 |
| β-strand | 181-184 | 4 | 6 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Protein patched homolog 1 | A | protein | 1447 | Homo sapiens | Q13635 (AlphaFold model) |
| Sonic hedgehog protein | C | protein | 175 | Homo sapiens | Q15465 (AlphaFold model) |
>6OEV_1 Protein patched homolog 1 (chains A) MASAGNAAEPQDRGGGGSGCIGAPGRPAGGGRRRRTGGLRRAAAPDRDYLHRPSYCDAAF ALEQISKGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAAN LETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLD SALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAK LQSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPA DPDCPATAPNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHAL QTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVL SFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALS VAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGEC LKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDL YRREDRRLDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQS TVQLRTEYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSL HCLEPPCTKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDI VPRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQL PKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDIS QLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETR LRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQ YIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSA VPVVILIASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLML AGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPSPEP PPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVIVEATE NPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRR DAFEISTEGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVA VHPPPVPGPGRNPRGGLCPGYPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEER PRGSSSN
>6OEV_2 Sonic hedgehog protein (chains C) XCGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKISRNSERFKELTPNYNP DIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYE GRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGG
Structures of human Patched and its complex with native palmitoylated sonic hedgehog. Qi, X., Schmiege, P., Coutavas, E. et al. Nature (2018) 560:128-132. DOI 10.1038/s41586-018-0308-7 · PubMed
Other PDB entries of the same protein (UniProt Q13635 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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