6PQ5: AGAAAA segment 113-118 from human prion
AGAAAA segment 113-118 from human prion. Determined by X-ray diffraction at 1.5 Å resolution. Released 15 Apr 2020.
- Method
- X-ray diffraction
- Resolution
- 1.5 Å
- Organism
- Homo sapiens
- Chains
- 2
- Atoms
- 74
- Mol. weight
- 1.07 kDa
- Ligands
- MLI
- Released
- 15 Apr 2020
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RCSB PDB
PDBe
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Major prion protein | A, B | protein | 6 | Homo sapiens | P04156 (AlphaFold model) |
Sequence of entity 1 (A, B), FASTA
>6PQ5_1 Major prion protein (chains A, B)
AGAAAA
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| MLI | Malonate ion | C3 H2 O4 | 2 |
Primary citation
Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core. Glynn, C., Sawaya, M.R., Ge, P. et al. Nat Struct Mol Biol (2020) 27:417-423. DOI 10.1038/s41594-020-0403-y · PubMed
Other PDB entries of the same protein (UniProt P04156 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 2OL9 0.85 Å, Peptide corresponding to residues 170-175 of human prion
- 7RVE 0.85 Å, Segment from the S170N mutant of the human prion protein 168-176 EYNNQNNFV
- 7RVJ 1.0 Å, Segment from the human prion protein 169-175 YSNQNNF
- 7RVK 1.0 Å, Segment from Y169G mutant of the human prion protein 169-175 GSNQNNF
- 7RVL 1.0 Å, Segment from the Y169F mutant of the human prion protein 168-176 EFSNQNNFV
- 7RVC 1.0 Å, Segment from the human prion protein 168-176 EYSNQNNFV
- 3MD4 1.15 Å, Prion peptide
- 3MD5 1.4 Å, Prion peptide
- 4E1H 1.4 Å, Fragment of human prion protein
- 6PQA 1.46 Å, GAVVGG segment 119-124 from human prion
- 4KML 1.5 Å, Probing the N-terminal beta-sheet conversion in the crystal structure of the full-length…
- 4N9O 1.5 Å, Probing the N-terminal beta-sheet conversion in the crystal structure of the human prion…
Browse structure collections
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