7RVK: Major prion protein
Segment from Y169G mutant of the human prion protein 169-175 GSNQNNF. Determined by electron crystallography at 1.0 Å resolution. Released 24 Aug 2022.
- Method
- Electron crystallography
- Resolution
- 1.0 Å
- Organism
- Homo sapiens
- Chains
- 1
- Atoms
- 66
- Mol. weight
- 0.9 kDa
- Ligands
- ZN
- Released
- 24 Aug 2022
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RCSB PDB
PDBe
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Major prion protein | A | protein | 7 | Homo sapiens | P04156 (AlphaFold model) |
Sequence of entity 1 (A), FASTA
>7RVK_1 Major prion protein (chains A)
GSNQNNF
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 1 |
Water and common crystallization additives (ACT) are not listed.
Primary citation
Structural and Biophysical Consequences of Sequence Variation in the B2a2 Loop of Mammalian Prions. Glynn, C., Hernandez, E., Gallagher-Jones, M. et al. To be published.
Other PDB entries of the same protein (UniProt P04156 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 2OL9 0.85 Å, Peptide corresponding to residues 170-175 of human prion
- 7RVE 0.85 Å, Segment from the S170N mutant of the human prion protein 168-176 EYNNQNNFV
- 7RVJ 1.0 Å, Segment from the human prion protein 169-175 YSNQNNF
- 7RVL 1.0 Å, Segment from the Y169F mutant of the human prion protein 168-176 EFSNQNNFV
- 7RVC 1.0 Å, Segment from the human prion protein 168-176 EYSNQNNFV
- 3MD4 1.15 Å, Prion peptide
- 3MD5 1.4 Å, Prion peptide
- 4E1H 1.4 Å, Fragment of human prion protein
- 6PQA 1.46 Å, GAVVGG segment 119-124 from human prion
- 4KML 1.5 Å, Probing the N-terminal beta-sheet conversion in the crystal structure of the full-length…
- 4N9O 1.5 Å, Probing the N-terminal beta-sheet conversion in the crystal structure of the human prion…
- 6PQ5 1.5 Å, AGAAAA segment 113-118 from human prion
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