6R9T: Autoinhibited human talin-1

Cryo-EM structure of autoinhibited human talin-1. Determined by electron microscopy at 6.2 Å resolution. Released 16 Oct 2019.

Method
Electron microscopy
Resolution
6.2 Å
Organism
Homo sapiens
Chains
1
Atoms
16,011
Mol. weight
270.77 kDa
Released
16 Oct 2019

Explore 6R9T in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6R9T contains 76 α-helices and 7 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 76 helices, 7 β-strands

ElementResiduesLengthSheet
α-helix211-22515
α-helix232-24716
α-helix276-28611
α-helix291-30414
β-strand311-31881
β-strand325-33281
β-strand336-34161
β-strand347-35261
β-strand358-36141
β-strand366-36941
α-helix371-3733
β-strand378-38141
α-helix385-3939
α-helix490-51122
α-helix512-5143
α-helix519-5213
α-helix526-56035
α-helix570-60132
α-helix606-62520
α-helix634-65522
α-helix662-69231
α-helix698-72225
α-helix733-75422
α-helix761-78929
α-helix802-8087
α-helix810-8145
α-helix819-84527
α-helix852-87928
α-helix884-91330
α-helix914-9185
α-helix919-93921
α-helix953-97523
α-helix980-100627
α-helix1014-104229
α-helix1049-107325
α-helix1077-10793
α-helix1084-111128
α-helix1116-114126
α-helix1145-117430
α-helix1179-120123
α-helix1209-122416
α-helix1235-125824
α-helix1264-128724
α-helix1295-132228
α-helix1329-135325
α-helix1360-137617
α-helix1389-141628
α-helix1419-144931
α-helix1464-148219
α-helix1488-151326
α-helix1519-154628
α-helix1552-157625
α-helix1579-15824
α-helix1590-162233
α-helix1627-165226
α-helix1658-168427
α-helix1695-172228
α-helix1724-175027
α-helix1755-178228
α-helix1791-182030
α-helix1827-183913
α-helix1850-187627
α-helix1879-18824
α-helix1883-189917
α-helix1903-19064
α-helix1910-193930
α-helix1945-197026
α-helix1976-200126
α-helix2016-203520
α-helix2041-206929
α-helix2075-209925
α-helix2109-213527
α-helix2141-216121
α-helix2172-219524
α-helix2198-222124
α-helix2233-225927
α-helix2263-228826
α-helix2301-232525
α-helix2341-236929
α-helix2370-23745
α-helix2383-241634
α-helix2421-244323
α-helix2453-247422

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Talin-1Aprotein2547Homo sapiensQ9Y490 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>6R9T_1 Talin-1 (chains A)
MVALSLKISIGNVVKTMQFEPSTMVYDACRIIRERIPEAPAGPPSDFGLFLSDDDPKKGI
WLEAGKALDYYMLRNGDTMEYRKKQRPLKIRMLDGTVKTIMVDDSKTVTDMLMTICARIG
ITNHDEYSLVRELMEEKKEEITGTLRKDKTLLRDEKKMEKLKQKLHTDDELNWLDHGRTL
REQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAG
FQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKGERKIFQAHKNCGQMSEIEAKVRYVK
LARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMRVDEKTKEVIQEWNLTNIKRWA
ASPKSFTLDFGDYQDGYYSVQTTEGEQIAQLIAGYIDIILKKKKSKDHFGLEGDEESTML
EDSVSPKKSTVLQQQYNRVGKVEHGSVALPAIMRSGASGPENFQVGSMPPAQQQITSGQM
HRGHMPPLTSAQQALTGTINSSMQAVQAAQATLDDFDTLPPLGQDAASKAWRKNKMDESK
HEIHSQVDAITAGTASVVNLTAGDPAETDYTAVGCAVTTISSNLTEMSRGVKLLAALLED
EGGSGRPLLQAAKGLAGAVSELLRSAQPASAEPRQNLLQAAGNVGQASGELLQQIGESDT
DPHFQDALMQLAKAVASAAAALVLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACT
KVVAPTISSPVCQEQLVEAGRLVAKAVEGCVSASQAATEDGQLLRGVGAAATAVTQALNE
LLQHVKAHATGAGPAGRYDQATDTILTVTENIFSSMGDAGEMVRQARILAQATSDLVNAI
KADAEGESDLENSRKLLSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGLRMA
TNAAAQNAIKKKLVQRLEHAAKQAAASATQTIAAAQHAASTPKASAGPQPLLVQSCKAVA
EQIPLLVQGVRGSQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASAMQL
SQCAKNLGTALAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEVKAAARDGKLKPLP
GETMEKCTQDLGNSTKAVSSAIAQLLGEVAQGNENYAGIAARDVAGGLRSLAQAARGVAA
LTSDPAVQAIVLDTASDVLDKASSLIEEAKKAAGHPGDPESQQRLAQVAKAVTQALNRCV
SCLPGQRDVDNALRAVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELVQAS
RGTPQDLARASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAK
ALSTDPAAPNLKSQLAAAARAVTDSINQLITMCTQQAPGQKECDNALRELETVRELLENP
VQPINDMSYFGCLDSVMENSKVLGEAMTGISQNAKNGNLPEFGDAISTASKALCGFTEAA
AQAAYLVGVSDPNSQAGQQGLVEPTQFARANQAIQMACQSLGEPGCTQAQVLSAATIVAK
HTSALCNSCRLASARTTNPTAKRQFVQSAKEVANSTANLVKTIKALDGAFTEENRAQCRA
ATAPLLEAVDNLSAFASNPEFSSIPAQISPEGRAAMEPIVISAKTMLESAGGLIQTARAL
AVNPRDPPSWSVLAGHSRTVSDSIKKLITSMRDKAPGQLECETAIAALNSCLRDLDQASL
AAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLANAARAEASQLGHKVSQMAQYFEP
LTLAAVGAASKTLSHPQQMALLDQTKTLAESALQLLYTAKEAGGNPKQAAHTQEALEEAV
QMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDEGPMGEPEGSFVDYQTTMVRT
AKAIAVTVQEMVTKSNTSPEELGPLANQLTSDYGRLASEAKPAAVAAENEEIGSHIKHRV
QELGHGCAALVTKAGALQCSPSDAYTKKELIECARRVSEKVSHVLAALQAGNRGTQACIT
AASAVSGIIADLDTTIMFATAGTLNREGTETFADHREGILKTAKVLVEDTKVLVQNAAGS
QEKLAQAAQSSVATITRLADVVKLGAASLGAEDPETQVVLINAVKDVAKALGDLISATKA
AAGKVGDDPAVWQLKNSAKVMVTNVTSLLKTVKAVEDEATKGTRALEATTEHIRQELAVF
CSPEPPAKTSTPEDFIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRRAIADMLRACK
EAAYHPEVAPDVRLRALHYGRECANGYLELLDHVLLTLQKPSPELKQQLTGHSKRVAGSV
TELIQAAEAMKGTEWVDPEDPTVIAENELLGAAAAIEAAAKKLEQLKPRAKPKEADESLN
FEEQILEAAKSIAAATSALVKAASAAQRELVAQGKVGAIPANALDDGQWSQGLISAARMV
AAATNNLCEAANAAVQGHASQEKLISSAKQVAASTAQLLVACKVKADQDSEAMKRLQAAG
NAVKRASDNLVKAAQKAAAFEEQENETVVVKEKMVGGIAQIIAAQEEMLRKERELEEARK
KLAQIRQQQYKFLPSELRDEHLVVLFQ

Primary citation

The Architecture of Talin1 Reveals an Autoinhibition Mechanism. Dedden, D., Schumacher, S., Kelley, C.F. et al. Cell (2019) 179:120-131.e13. DOI 10.1016/j.cell.2019.08.034 · PubMed

Other PDB entries of the same protein (UniProt Q9Y490 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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