6RLA: Dynein-2 complex; motor domains

Structure of the dynein-2 complex; motor domains. Determined by electron microscopy at 3.9 Å resolution. Released 28 Aug 2019.

Method
Electron microscopy
Resolution
3.9 Å
Organism
Homo sapiens
Chains
2
Atoms
43,034
Mol. weight
1034.07 kDa
Ligands
ADP, ATP, MG
Released
28 Aug 2019

Explore 6RLA in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6RLA contains 258 α-helices and 144 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and B: 129 helices, 72 β-strands

ElementResiduesLengthSheet
α-helix1257-127317
β-strand127511
β-strand1278-128142
β-strand1289-129242
α-helix1295-131218
α-helix1316-13205
α-helix1322-135837
α-helix1362-138423
β-strand138711
α-helix1388-13903
α-helix1397-142529
α-helix1427-14304
α-helix1434-14429
α-helix1447-14537
β-strand146413
β-strand1472-147653
β-strand1484-149183
α-helix1497-152226
α-helix1536-155722
α-helix1561-158222
α-helix1594-161623
α-helix1624-16274
β-strand1631-163444
β-strand1640-164344
β-strand164814
α-helix1667-168014
β-strand1686-168835
α-helix1695-170612
β-strand1710-171236
α-helix1721-173414
β-strand1737-174156
α-helix1748-176619
β-strand177117
α-helix17791
β-strand178017
α-helix1781-17822
β-strand1787-179046
α-helix1802-18054
α-helix1806-18094
β-strand1814-181635
α-helix1823-183210
α-helix1838-185518
α-helix1866-188520
α-helix1892-190615
α-helix1912-192514
α-helix1938-194912
α-helix1956-197116
β-strand1974-197748
α-helix1987-199711
β-strand2004-200858
α-helix2015-20184
β-strand2021-202339
β-strand2028-203039
α-helix2033-204311
β-strand2050-205458
α-helix2060-20634
α-helix2064-20663
β-strand2075-2077310
β-strand2083-2085310
β-strand2091-209558
α-helix2104-21074
β-strand2111-211338
α-helix2123-21319
α-helix2138-215922
α-helix2168-21769
α-helix2185-219612
α-helix2202-221413
β-strand2244111
β-strand2264111
α-helix2266-227510
β-strand2287-2291512
α-helix2297-230610
β-strand2311-2316613
α-helix2324-23329
β-strand2335-2338414
β-strand2345-2348414
β-strand2353-2358613
α-helix2373-238412
β-strand2386-2389414
β-strand2393-2397514
β-strand2400-2402313
β-strand2404-2407412
α-helix2415-24184
α-helix2419-24246
β-strand2426-2429412
α-helix2435-245016
α-helix2464-248320
α-helix2496-25038
α-helix2505-25073
β-strand2509115
α-helix2520-253516
α-helix2536-25383
α-helix2542-255918
β-strand2574116
α-helix2592-25932
β-strand2599115
β-strand2600116
α-helix2604-262017
α-helix2623-26253
α-helix2631-264414
β-strand2651-2655517
α-helix2662-267110
β-strand2675-2677317
α-helix2688-270316
β-strand2708-2713617
α-helix2714-27163
α-helix2722-273110
α-helix2745-27484
α-helix2749-27513
α-helix2752-27587
α-helix2764-277411
β-strand2776-2783817
α-helix2787-27893
α-helix2791-27944
α-helix2797-28004
β-strand2804-2807417
α-helix2813-282210
α-helix2848-286215
α-helix2863-28653
α-helix2869-291143
α-helix2914-292411
α-helix3169-318618
α-helix3189-31968
α-helix3200-321314
α-helix3219-323315
α-helix3241-32444
α-helix3247-32548
α-helix3262-32709
β-strand3277-3281518
α-helix3286-32949
β-strand3300-3303418
α-helix3310-331910
β-strand3323-3329718
α-helix3337-33404
β-strand3345-3347319
β-strand3350-3355619
β-strand3358-3361419
β-strand3367-3372618
β-strand3387-3391518
α-helix3396-341116
α-helix3413-343624
α-helix3437-34393
α-helix3440-34456
α-helix3456-348934
α-helix3493-350715
α-helix3521-353212
α-helix3541-356020
α-helix3568-357912
α-helix3589-35924
α-helix3620-363213
α-helix3634-36407
α-helix3647-36515
α-helix3663-36653
α-helix3671-368111
α-helix3686-369813
β-strand3723-3726420
α-helix3734-374411
β-strand3752-3754320
α-helix3760-377314
β-strand3777-3780420
α-helix3789-379810
β-strand3807-3811520
α-helix3819-38235
β-strand3826-3829420
α-helix3836-384611
α-helix3849-38524
α-helix3858-387619
α-helix3877-38793
α-helix3893-390715
α-helix3915-39217
α-helix3922-39276
α-helix3928-39303
α-helix3934-394613
α-helix3977-398610
α-helix3993-39953
α-helix4001-402020
α-helix4033-40364
α-helix4041-405010
α-helix4062-40643
α-helix4073-409927
α-helix4110-411910
α-helix4122-41243
α-helix4125-41306
α-helix4137-415822
β-strand4168-4169221
α-helix4170-41723
α-helix4176-419116
α-helix4195-41973
β-strand4198-4203621
β-strand4215-4218421
β-strand4221-4223322
β-strand4226-4228323
β-strand4231-4233323
β-strand4243-4244222
β-strand4248-4254721
α-helix4263-42653
β-strand4266-4270524
β-strand4272122
β-strand4283-4287524
α-helix4293-42975
β-strand4301-4303322

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
O6-alkylguanine-DNA alkyltransferase mutant,DYNC2H1 variant proteinA, Bprotein4513Homo sapiensB0I1S0, E5BBQ0 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>6RLA_1 O6-alkylguanine-DNA alkyltransferase mutant,DYNC2H1 variant protein (chains A, B)
GDKDCEMKRTTLDSPLGKLELSGCEQGLHRIIFLGKGTSAADAVEVPAPAAVLGGPEPLM
QATAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKLLKVVKFGEVISYSHLAAL
AGNPAATAAVKTALSGNPVPILIPCHRVVQGDLDVGGYEGGLAVKEWLLAHEGHRLGKPG
LGGSLEVLFQGPDYDIPTTLEVLFQGPANGTADVRKLFIFTTTQNYFGLMSELWDQPLLC
NCLEINNFLDDGNQMLLRVQRSDAGISFSNTIEFGDTKDKVLVFFKLRPEVITDENLHDN
ILVSSMLESPISSLYQAVRQVFAPMLLKDQEWSRNFDPKLQNLLSELEAGLGIVLRRSDT
NLTKLKFKEDDTRGILTPSDEFQFWIEQAHRGNKQISKERANYFKELFETIAREFYNLDS
LSLLEVVDLVETTQDVVDDVWRQTEHDHYPESRMLHLLDIIGGSFGRFVQKKLGTLNLWE
DPYYLVKESLKAGISICEQWVIVCNHLTGQVWQRYVPHPWKNEKYFPETLDKLGKRLEEV
LAIRTIHEKFLYFLPASEEKIICLTRVFEPFTGLNPVQYNPYTEPLWKAAVSQYEKIIAP
AEQKIAGKLKNYISEIQDSPQQLLQAFLKYKELVKRPTISKELMLERETLLARLVDSIKD
FRLDFENRCRGIPGDASGPLSGKNLSEVVNSIVWVRQLELKVDDTIKIAEALLSDLPGFR
CFHQSAKDLLDQLKLYEQEQFDDWSRDIQSGLSDSRSGLCIEASSRIMELDSNDGLLKVH
YSDRLVILLREVRQLSALGFVIPAKIQQVANIAQKFCKQAIILKQVAHFYNSIDQQMIQS
QRPMMLQSALAFEQIIKNSKAGSGGKSQITWDNPKELEGYIQKLQNAAERLATENRKLRK
WHTTFCEKVVVLMNIDLLRQQQRWKDGLQELRTGLATVEAQGFQASDMHAWKQHWNHQLY
KALEHQYQMGLEALNENLPEINIDLTYKQGRLQFRPPFEEIRAKYYREMKRFIGIPNQFK
GVGEAGDESIFSIMIDRNASGFLTIFSKAEDLFRRLSAVLHQHKEWIVIGQVDMEALVEK
HLFTVHDWEKNFKALKIKGKEVERLPSAVKVDCLNINCNPVKTVIDDLIQKLFDLLVLSL
KKSIQAHLHEIDTFVTEAMEVLTIMPQSVEEIGDANLQYSKLQERKPEILPLFQEAEDKN
RLLRTVAGGGLETISNLKAKWDKFELMMESHQLMIKDQIEVMKGNVKSRLQIYYQELEKF
KARWDQLKPGDDVIETGQHNTLDKSAKLIKEKKIEFDDLEVTRKKLVDDCHHFRLEEPNF
SLASSISKDIESCAQIWAFYEEFQQGFQEMANEDWITFRTKTYLFEEFLMNWHDRLRKVE
EHSVMTVKLQSEVDKYKIVIPILKYVRGEHLSPDHWLDLFRLLGLPRGTSLEKLLFGDLL
RVADTIVAKAADLKDLNSRAQGEVTIREALRELDLWGVGAVFTLIDYEDSQSRTMKLIKD
WKDIVNQVGDNRCLLQSLKDSPYYKGFEDKVSIWERKLAELDEYLQNLNHIQRKWVYLEP
IFGRGALPKEQTRFNRVDEDFRSIMTDIKKDNRVTTLTTHAGIRNSLLTILDQLQRCQRS
LNEFLEEKRSAFPRFYFIGDDDLLEILGQSTNPSVIQSHLKKLFAGINSVCFDEKSKHIT
AMKSLEGEVVPFKNKVPLSNNVETWLNDLALEMKKTLEQLLKECVTTGRSSQGAVDPSLF
PSQILCLAEQIKFTEDVENAIKDHSLHQIETQLVNKLEQYTNIDTSSEDPGNTESGILEL
KLKALILDIIHNIDVVKQLNQIQVHTTEDWAWKKQLRFYMKSDHTCCVQMVDSEFQYTYE
YQGNASKLVYTPLTDKCYLTLTQAMKMGLGGNPYGPAGTGKTESVKALGGLLGRQVLVFN
CDEGIDVKSMGRIFVGLVKCGAWGCFDEFNRLEESVLSAVSMQIQTIQDALKNHRTVCEL
LGKEVEVNSNSGIFITMNPAGKGYGGRQKLPDNLKQLFRPVAMSHPDNELIAEVILYSEG
FKDAKVLSRKLVAIFNLSRELLTPQQHYDWGLRALKTVLRGSGNLLRQLNKSGTTQNANE
SHIVVQALRLNTMSKFTFTDCTRFDALIKDVFPGIELKEVEYDELSAALKQVFEEANYEI
IPNQIKKALELYEQLCQRMGVVIVGPSGAGKSTLWRMLRAALCKTGKVVKQYTMNPKAMP
RYQLLGHIDMDTREWSDGVLTNSARQVVREPQDVSSWIICDGDIDPEWIESLNSVLDDNR
LLTMPSGERIQFGPNVNFVFETHDLSCASPATISRMGMIFLSDEETDLNSLIKSWLRNQP
AEYRNNLENWIGDYFEKALQWVLKQNDYVVETSLVGTVMNGLSHLHGCRDHDEFIINLIR
GLGGNLNMKSRLEFTKEVFHWARESPPDFHKPMDTYYDSTRGRLATYVLKKPEDLTADDF
SNGLTLPVIQTPDMQRGLDYFKPWLSSDTKQPFILVGPEGCGKGMLLRYAFSQLRSTQIA
TVHCSAQTTSRHLLQKLSQTCMVISTNTGRVYRPKDCERLVLYLKDINLPKLDKWGTSTL
VAFLQQVLTYQGFYDENLEWVGLENIQIVASMSAGGRLGRHKLTTRFTSIVRLCSIDYPE
REQLQTIYGAYLEPVLHKNLKNHSIWGSSSKIYLLAGSMVQVYEQVRAKFTVDDYSHYFF
TPCILTQWVLGLFRYDLEGGSSNHPLDYVLEIVAYEARRLFRDKIVGAKELHLFDIILTS
VFQGDWGSDILDNMSDSFYVTWGARHNSGARAAPGQPLPPHGKPLGKLNSTDLKDVIKKG
LIHYGRDNQNLDILLFHEVLEYMSRIDRVLSFPGGSLLLAGRSGVGRRTITSLVSHMHGA
VLFSPKISRGYELKQFKNDLKHVLQLAGIEAQQVVLLLEDYQFVHPTFLEMINSLLSSGE
VPGLYTLEELEPLLLPLKDQASQDGFFGPVFNYFTYRIQQNLHIVLIMDSANSNFMINCE
SNPALHKKCQVLWMEGWSNSSMKKIPEMLFSETGGGEKYNDKKRKEEKKKNSVDPDFLKS
FLLIHESCKAYGATPSQYMTFLHVYSAISSSKKKELLKRQSHLQAGVSKLNEAKALVDEL
NRKAGEQSVLLKTKQDEADAALQMITVSMQDASEQKTELERLKHRIAEEVVKIEERKNKI
DDELKEVQPLVNEAKLAVGNIKPESLSEIRSLRMPPDVIRDILEGVLRLMGIFDTSWVSM
KSFLAKRGVREDIATFDARNISKEIRESVEELLFKNKGSFDPKNAKRASTAAAPLAAWVK
ANIQYSHVLERIHPLETEQAGLESNLKKTEDRKRKLEELLNSVGQKVSELKEKFQSRTSE
AAKLEAEVSKAQETIKAAEVLINQLDREHKRWNAQVVEITEELATLPKRAQLAAAFITYL
SAAPESLRKTCLEEWTKSAGLEKFDLRRFLCTESEQLIWKSEGLPSDDLSIENALVILQS
RVCPFLIDPSSQATEWLKTHLKDSRLEVINQQDSNFITALELAVRFGKTLIIQEMDGVEP
VLYPLLRRDLVAQGPRYVVQIGDKIIDYNEEFRLFLSTRNPNPFIPPDAASIVTEVNFTT
TRSGLRGQLLALTIQHEKPDLEEQKTKLLQQEEDKKIQLAKLEESLLETLATSQGNILEN
KDLIESLNQTKASSALIQESLKESYKLQISLDQERDAYLPLAESASKMYFIISDLSKINN
MYRFSLAAFLRLFQRALQNKQDSENTEQRIQSLISSLQHMVYEYICRCLFKADQLMFALH
FVRGMHPELFQENEWDTFTGVVVGDMLRKADSQQKIRDQLPSWIDQERSWAVATLKIALP
SLYQTLCFEDAALWRTYYNNSMCEQEFPSILAKKVSLFQQILVVQVLRPDRLQSAMALFA
CKTLGLKEVSPLPLNLKRLYKETLEIEPILIIISPGADPSQELQELANAERSGECYHQVA
MGQGQADLAIQMLKECARNGDWLCLKNLHLVVSWLPVLEKELNTLQPKDTFRLWLTAEVH
PNFTPILLQSSLKITYESPPGLKKNLMRTYESWTPEQISKKDNTHRAHALFSLAWFHAAC
QERRNYIPQGWTKFYEFSLSDLRAGYNIIDRLFDGAKDVQWEFVHGLLENAIYGGRIDNY
FDLRVLQSYLKQFFNSSVIDVFNQRNKKSIFPYSVSLPQSCSILDYRAVIEKIPEDDKPS
FFGLPANIARSSQRMISSQVISQLRILGRSITAGSKFDREIWSNELSPVLNLWKKLNQNS
NLIHQKVPPPNDRQGSPILSFIILEQFNAIRLVQSVHQSLAALSKVIRGTTLLSSEVQKL
ASALLNQKCPLAWQSKWEGPEDPLQYLRGLVARALAIQNWVDKAEKQALLSETLDLSELF
HPDTFLNALRQETARAVGRSVDSLKFVASWKGRLQEAKLQIKISGLLLEGCSFDGNQLSE
NQLDSPSVSSVLPCFMGWIPQDACGPYSPDECISLPVYTSAERDRVVTNIDVPCGGNQDQ
WIQCGAALFLKNQ

Ligands and cofactors

IDNameFormulaCopies
ADPAdenosine-5'-diphosphateC10 H15 N5 O10 P26
ATPAdenosine-5'-triphosphateC10 H16 N5 O13 P32
MGMagnesium ionMg2

Primary citation

Structure of the dynein-2 complex and its assembly with intraflagellar transport trains. Toropova, K., Zalyte, R., Mukhopadhyay, A.G. et al. Nat Struct Mol Biol (2019) 26:823-829. DOI 10.1038/s41594-019-0286-y · PubMed

Other PDB entries of the same protein (UniProt B0I1S0), best resolution first:

Browse structure collections

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