6SC2: Dynein-2 complex; IFT-train bound model
Structure of the dynein-2 complex; IFT-train bound model. Determined by electron microscopy at 3.9 Å resolution. Released 4 Sept 2019.
- Method
- Electron microscopy
- Resolution
- 3.9 Å
- Organism
- Homo sapiens
- Chains
- 14
- Atoms
- 50,276
- Mol. weight
- 1363.28 kDa
- Ligands
- ATP, ADP, MG
- Released
- 4 Sept 2019
Explore 6SC2 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
6SC2 contains 430 α-helices and 275 β-strands across 14 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 184 helices, 82 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 12-21 | 10 | |
| α-helix | 26-28 | 3 | |
| α-helix | 36-44 | 9 | |
| β-strand | 50-56 | 7 | 1 |
| β-strand | 59-63 | 5 | 1 |
| β-strand | 74-80 | 7 | 1 |
| β-strand | 95-101 | 7 | 1 |
| α-helix | 106-111 | 6 | |
| α-helix | 112-116 | 5 | |
| α-helix | 117-122 | 6 | |
| α-helix | 131-149 | 19 | |
| α-helix | 192-209 | 18 | |
| α-helix | 212-214 | 3 | |
| α-helix | 217-234 | 18 | |
| α-helix | 245-268 | 24 | |
| α-helix | 277-308 | 32 | |
| α-helix | 323-346 | 24 | |
| α-helix | 348-350 | 3 | |
| α-helix | 352-366 | 15 | |
| α-helix | 379-408 | 30 | |
| α-helix | 414-423 | 10 | |
| α-helix | 425-428 | 4 | |
| α-helix | 431-436 | 6 | |
| α-helix | 438-460 | 23 | |
| α-helix | 482-506 | 25 | |
| α-helix | 511-545 | 35 | |
| α-helix | 546-550 | 5 | |
| α-helix | 555-557 | 3 | |
| β-strand | 558-560 | 3 | 2 |
| β-strand | 570-572 | 3 | 2 |
| α-helix | 576-591 | 16 | |
| α-helix | 598-631 | 34 | |
| α-helix | 637-655 | 19 | |
| α-helix | 657-660 | 4 | |
| α-helix | 663-666 | 4 | |
| α-helix | 669-706 | 38 | |
| α-helix | 715-733 | 19 | |
| α-helix | 739-767 | 29 | |
| α-helix | 773-774 | 2 | |
| β-strand | 775-782 | 8 | 3 |
| β-strand | 785-789 | 5 | 3 |
| α-helix | 792-807 | 16 | |
| α-helix | 823-831 | 9 | |
| α-helix | 835-860 | 26 | |
| α-helix | 868-875 | 8 | |
| α-helix | 879-896 | 18 | |
| β-strand | 902-904 | 3 | 3 |
| β-strand | 908-911 | 4 | 3 |
| α-helix | 913-956 | 44 | |
| α-helix | 964-966 | 3 | |
| α-helix | 970-983 | 14 | |
| α-helix | 986-1000 | 15 | |
| α-helix | 1006-1060 | 55 | |
| α-helix | 1075-1103 | 29 | |
| α-helix | 1119-1145 | 27 | |
| α-helix | 1151-1154 | 4 | |
| α-helix | 1157-1170 | 14 | |
| α-helix | 1178-1192 | 15 | |
| α-helix | 1194-1199 | 6 | |
| α-helix | 1207-1217 | 11 | |
| α-helix | 1220-1223 | 4 | |
| α-helix | 1225-1227 | 3 | |
| α-helix | 1230-1233 | 4 | |
| α-helix | 1237-1242 | 6 | |
| α-helix | 1244-1270 | 27 | |
| α-helix | 1271-1273 | 3 | |
| β-strand | 1275 | 1 | 4 |
| β-strand | 1279-1281 | 3 | 5 |
| β-strand | 1289-1291 | 3 | 5 |
| α-helix | 1295-1312 | 18 | |
| α-helix | 1316-1320 | 5 | |
| α-helix | 1322-1358 | 37 | |
| α-helix | 1362-1384 | 23 | |
| β-strand | 1387 | 1 | 4 |
| α-helix | 1388-1390 | 3 | |
| α-helix | 1397-1425 | 29 | |
| α-helix | 1427-1430 | 4 | |
| α-helix | 1434-1442 | 9 | |
| α-helix | 1447-1453 | 7 | |
| β-strand | 1464 | 1 | 6 |
| β-strand | 1472-1476 | 5 | 6 |
| β-strand | 1484-1491 | 8 | 6 |
| α-helix | 1497-1522 | 26 | |
| α-helix | 1536-1557 | 22 | |
| α-helix | 1561-1582 | 22 | |
| α-helix | 1594-1616 | 23 | |
| α-helix | 1624-1627 | 4 | |
| β-strand | 1631-1634 | 4 | 7 |
| β-strand | 1640-1643 | 4 | 7 |
| β-strand | 1648 | 1 | 7 |
| α-helix | 1667-1680 | 14 | |
| β-strand | 1686-1688 | 3 | 8 |
| α-helix | 1695-1706 | 12 | |
| β-strand | 1710-1712 | 3 | 9 |
| α-helix | 1721-1734 | 14 | |
| β-strand | 1737-1741 | 5 | 9 |
| α-helix | 1748-1766 | 19 | |
| β-strand | 1771 | 1 | 10 |
| α-helix | 1779 | 1 | |
| β-strand | 1780 | 1 | 10 |
| α-helix | 1781-1782 | 2 | |
| β-strand | 1787-1790 | 4 | 9 |
| α-helix | 1802-1805 | 4 | |
| α-helix | 1806-1809 | 4 | |
| β-strand | 1814-1816 | 3 | 8 |
| α-helix | 1823-1832 | 10 | |
| α-helix | 1838-1855 | 18 | |
| α-helix | 1866-1885 | 20 | |
| α-helix | 1892-1906 | 15 | |
| α-helix | 1912-1925 | 14 | |
| α-helix | 1938-1949 | 12 | |
| α-helix | 1956-1971 | 16 | |
| β-strand | 1974-1977 | 4 | 11 |
| α-helix | 1987-1997 | 11 | |
| β-strand | 2004-2008 | 5 | 11 |
| α-helix | 2015-2018 | 4 | |
| β-strand | 2021-2023 | 3 | 12 |
| β-strand | 2028-2030 | 3 | 12 |
| α-helix | 2033-2043 | 11 | |
| β-strand | 2050-2054 | 5 | 11 |
| α-helix | 2060-2063 | 4 | |
| α-helix | 2064-2066 | 3 | |
| β-strand | 2075-2077 | 3 | 13 |
| β-strand | 2083-2085 | 3 | 13 |
| β-strand | 2091-2095 | 5 | 11 |
| α-helix | 2104-2107 | 4 | |
| β-strand | 2111-2113 | 3 | 11 |
| α-helix | 2123-2131 | 9 | |
| α-helix | 2138-2159 | 22 | |
| α-helix | 2168-2176 | 9 | |
| α-helix | 2185-2196 | 12 | |
| α-helix | 2202-2214 | 13 | |
| β-strand | 2244 | 1 | 14 |
| β-strand | 2264 | 1 | 14 |
| α-helix | 2266-2275 | 10 | |
| β-strand | 2287-2291 | 5 | 15 |
| α-helix | 2297-2306 | 10 | |
| β-strand | 2311-2316 | 6 | 16 |
| α-helix | 2324-2332 | 9 | |
| β-strand | 2335-2338 | 4 | 17 |
| β-strand | 2345-2348 | 4 | 17 |
| β-strand | 2353-2358 | 6 | 16 |
| α-helix | 2373-2384 | 12 | |
| β-strand | 2386-2389 | 4 | 17 |
| β-strand | 2393-2397 | 5 | 17 |
| β-strand | 2400-2402 | 3 | 16 |
| β-strand | 2404-2407 | 4 | 15 |
| α-helix | 2415-2418 | 4 | |
| α-helix | 2419-2424 | 6 | |
| β-strand | 2426-2429 | 4 | 15 |
| α-helix | 2435-2450 | 16 | |
| α-helix | 2464-2483 | 20 | |
| α-helix | 2496-2503 | 8 | |
| α-helix | 2505-2507 | 3 | |
| β-strand | 2509 | 1 | 18 |
| α-helix | 2520-2535 | 16 | |
| α-helix | 2536-2538 | 3 | |
| α-helix | 2542-2559 | 18 | |
| β-strand | 2574 | 1 | 19 |
| α-helix | 2592-2593 | 2 | |
| β-strand | 2599 | 1 | 18 |
| β-strand | 2600 | 1 | 19 |
| α-helix | 2604-2620 | 17 | |
| α-helix | 2623-2625 | 3 | |
| α-helix | 2631-2644 | 14 | |
| β-strand | 2651-2655 | 5 | 20 |
| α-helix | 2662-2671 | 10 | |
| β-strand | 2675-2677 | 3 | 20 |
| α-helix | 2688-2703 | 16 | |
| β-strand | 2708-2713 | 6 | 20 |
| α-helix | 2714-2716 | 3 | |
| α-helix | 2722-2731 | 10 | |
| α-helix | 2745-2748 | 4 | |
| α-helix | 2749-2751 | 3 | |
| α-helix | 2752-2758 | 7 | |
| α-helix | 2764-2774 | 11 | |
| β-strand | 2776-2783 | 8 | 20 |
| α-helix | 2787-2789 | 3 | |
| α-helix | 2791-2794 | 4 | |
| α-helix | 2797-2800 | 4 | |
| β-strand | 2804-2807 | 4 | 20 |
| α-helix | 2813-2822 | 10 | |
| α-helix | 2848-2862 | 15 | |
| α-helix | 2863-2865 | 3 | |
| α-helix | 2869-2911 | 43 | |
| α-helix | 2914-2924 | 11 | |
| α-helix | 3169-3186 | 18 | |
| α-helix | 3189-3196 | 8 | |
| α-helix | 3200-3213 | 14 | |
| α-helix | 3219-3233 | 15 | |
| α-helix | 3241-3244 | 4 | |
| α-helix | 3247-3254 | 8 | |
| α-helix | 3262-3270 | 9 | |
| β-strand | 3277-3281 | 5 | 21 |
| α-helix | 3286-3294 | 9 | |
| β-strand | 3300-3303 | 4 | 21 |
| α-helix | 3310-3319 | 10 | |
| β-strand | 3323-3329 | 7 | 21 |
| α-helix | 3337-3340 | 4 | |
| β-strand | 3345-3347 | 3 | 22 |
| β-strand | 3350-3355 | 6 | 22 |
| β-strand | 3358-3361 | 4 | 22 |
| β-strand | 3367-3372 | 6 | 21 |
| β-strand | 3387-3391 | 5 | 21 |
| α-helix | 3396-3411 | 16 | |
| α-helix | 3413-3436 | 24 | |
| α-helix | 3437-3439 | 3 | |
| α-helix | 3440-3445 | 6 | |
| α-helix | 3456-3489 | 34 | |
| α-helix | 3493-3507 | 15 | |
| α-helix | 3521-3532 | 12 | |
| α-helix | 3541-3560 | 20 | |
| α-helix | 3568-3579 | 12 | |
| α-helix | 3589-3592 | 4 | |
| α-helix | 3620-3632 | 13 | |
| α-helix | 3634-3640 | 7 | |
| α-helix | 3647-3651 | 5 | |
| α-helix | 3663-3665 | 3 | |
| α-helix | 3671-3681 | 11 | |
| α-helix | 3686-3698 | 13 | |
| β-strand | 3723-3726 | 4 | 23 |
| α-helix | 3734-3744 | 11 | |
| β-strand | 3752-3754 | 3 | 23 |
| α-helix | 3760-3773 | 14 | |
| β-strand | 3777-3780 | 4 | 23 |
| α-helix | 3789-3798 | 10 | |
| β-strand | 3807-3811 | 5 | 23 |
| α-helix | 3819-3823 | 5 | |
| β-strand | 3826-3829 | 4 | 23 |
| α-helix | 3836-3846 | 11 | |
| α-helix | 3849-3852 | 4 | |
| α-helix | 3858-3876 | 19 | |
| α-helix | 3877-3879 | 3 | |
| α-helix | 3893-3907 | 15 | |
| α-helix | 3915-3921 | 7 | |
| α-helix | 3922-3927 | 6 | |
| α-helix | 3928-3930 | 3 | |
| α-helix | 3934-3946 | 13 | |
| α-helix | 3977-3986 | 10 | |
| α-helix | 3993-3995 | 3 | |
| α-helix | 4001-4020 | 20 | |
| α-helix | 4033-4036 | 4 | |
| α-helix | 4041-4050 | 10 | |
| α-helix | 4062-4064 | 3 | |
| α-helix | 4073-4099 | 27 | |
| α-helix | 4110-4119 | 10 | |
| α-helix | 4122-4124 | 3 | |
| α-helix | 4125-4130 | 6 | |
| α-helix | 4137-4158 | 22 | |
| β-strand | 4168-4169 | 2 | 24 |
| α-helix | 4170-4172 | 3 | |
| α-helix | 4176-4191 | 16 | |
| α-helix | 4195-4197 | 3 | |
| β-strand | 4198-4203 | 6 | 24 |
| β-strand | 4215-4218 | 4 | 24 |
| β-strand | 4221-4223 | 3 | 25 |
| β-strand | 4226-4228 | 3 | 26 |
| β-strand | 4231-4233 | 3 | 26 |
| β-strand | 4243-4244 | 2 | 25 |
| β-strand | 4248-4254 | 7 | 24 |
| α-helix | 4263-4265 | 3 | |
| β-strand | 4266-4270 | 5 | 27 |
| β-strand | 4272 | 1 | 25 |
| β-strand | 4283-4287 | 5 | 27 |
| α-helix | 4293-4297 | 5 | |
| β-strand | 4301-4303 | 3 | 25 |
Chain B: 188 helices, 82 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 12-21 | 10 | |
| α-helix | 26-28 | 3 | |
| α-helix | 36-44 | 9 | |
| β-strand | 50-56 | 7 | 1 |
| β-strand | 59-63 | 5 | 1 |
| β-strand | 74-80 | 7 | 1 |
| β-strand | 95-101 | 7 | 1 |
| α-helix | 106-110 | 5 | |
| α-helix | 111-116 | 6 | |
| α-helix | 117-122 | 6 | |
| α-helix | 131-149 | 19 | |
| α-helix | 192-210 | 19 | |
| α-helix | 217-234 | 18 | |
| α-helix | 245-268 | 24 | |
| α-helix | 277-308 | 32 | |
| α-helix | 323-346 | 24 | |
| α-helix | 352-366 | 15 | |
| α-helix | 375-377 | 3 | |
| α-helix | 378-408 | 31 | |
| α-helix | 414-423 | 10 | |
| α-helix | 425-428 | 4 | |
| α-helix | 431-436 | 6 | |
| α-helix | 438-460 | 23 | |
| α-helix | 468-471 | 4 | |
| α-helix | 475-478 | 4 | |
| α-helix | 482-507 | 26 | |
| α-helix | 511-545 | 35 | |
| α-helix | 546-550 | 5 | |
| α-helix | 557-559 | 3 | |
| β-strand | 560 | 1 | 28 |
| β-strand | 570 | 1 | 28 |
| α-helix | 575-591 | 17 | |
| α-helix | 598-630 | 33 | |
| α-helix | 631-633 | 3 | |
| α-helix | 637-654 | 18 | |
| α-helix | 657-660 | 4 | |
| α-helix | 663-666 | 4 | |
| α-helix | 669-706 | 38 | |
| α-helix | 711-733 | 23 | |
| α-helix | 739-767 | 29 | |
| α-helix | 769-771 | 3 | |
| α-helix | 773-774 | 2 | |
| β-strand | 775-782 | 8 | 29 |
| β-strand | 785-789 | 5 | 29 |
| α-helix | 792-807 | 16 | |
| α-helix | 823-831 | 9 | |
| α-helix | 835-860 | 26 | |
| α-helix | 869-875 | 7 | |
| α-helix | 879-896 | 18 | |
| β-strand | 902-904 | 3 | 29 |
| β-strand | 908-911 | 4 | 29 |
| α-helix | 913-959 | 47 | |
| α-helix | 964-966 | 3 | |
| α-helix | 969-1001 | 33 | |
| α-helix | 1004-1059 | 56 | |
| α-helix | 1075-1103 | 29 | |
| α-helix | 1119-1145 | 27 | |
| β-strand | 1148 | 1 | 30 |
| α-helix | 1149-1152 | 4 | |
| α-helix | 1158-1170 | 13 | |
| α-helix | 1178-1192 | 15 | |
| α-helix | 1194-1199 | 6 | |
| α-helix | 1207-1216 | 10 | |
| α-helix | 1220-1223 | 4 | |
| α-helix | 1225-1227 | 3 | |
| β-strand | 1229 | 1 | 30 |
| α-helix | 1230-1234 | 5 | |
| α-helix | 1239-1242 | 4 | |
| α-helix | 1244-1252 | 9 | |
| α-helix | 1253-1255 | 3 | |
| α-helix | 1257-1270 | 14 | |
| α-helix | 1275-1277 | 3 | |
| β-strand | 1279-1281 | 3 | 31 |
| β-strand | 1289-1291 | 3 | 31 |
| α-helix | 1295-1312 | 18 | |
| α-helix | 1316-1320 | 5 | |
| α-helix | 1322-1358 | 37 | |
| α-helix | 1362-1384 | 23 | |
| α-helix | 1388-1390 | 3 | |
| α-helix | 1397-1425 | 29 | |
| α-helix | 1427-1430 | 4 | |
| α-helix | 1434-1442 | 9 | |
| α-helix | 1447-1453 | 7 | |
| β-strand | 1464 | 1 | 32 |
| β-strand | 1472-1476 | 5 | 32 |
| β-strand | 1484-1491 | 8 | 32 |
| α-helix | 1497-1522 | 26 | |
| α-helix | 1536-1557 | 22 | |
| α-helix | 1561-1582 | 22 | |
| α-helix | 1594-1616 | 23 | |
| α-helix | 1624-1627 | 4 | |
| β-strand | 1631-1634 | 4 | 33 |
| β-strand | 1640-1643 | 4 | 33 |
| β-strand | 1648 | 1 | 33 |
| α-helix | 1667-1680 | 14 | |
| β-strand | 1686-1688 | 3 | 34 |
| α-helix | 1695-1706 | 12 | |
| β-strand | 1710-1712 | 3 | 35 |
| α-helix | 1721-1734 | 14 | |
| β-strand | 1737-1741 | 5 | 35 |
| α-helix | 1748-1766 | 19 | |
| β-strand | 1771 | 1 | 36 |
| α-helix | 1779 | 1 | |
| β-strand | 1780 | 1 | 36 |
| α-helix | 1781-1782 | 2 | |
| β-strand | 1787-1790 | 4 | 35 |
| α-helix | 1802-1805 | 4 | |
| α-helix | 1806-1809 | 4 | |
| β-strand | 1814-1816 | 3 | 34 |
| α-helix | 1823-1832 | 10 | |
| α-helix | 1838-1855 | 18 | |
| α-helix | 1866-1885 | 20 | |
| α-helix | 1892-1906 | 15 | |
| α-helix | 1912-1925 | 14 | |
| α-helix | 1938-1949 | 12 | |
| α-helix | 1956-1971 | 16 | |
| β-strand | 1974-1977 | 4 | 37 |
| α-helix | 1987-1997 | 11 | |
| β-strand | 2004-2008 | 5 | 37 |
| α-helix | 2015-2018 | 4 | |
| β-strand | 2021-2023 | 3 | 38 |
| β-strand | 2028-2030 | 3 | 38 |
| α-helix | 2033-2043 | 11 | |
| β-strand | 2050-2054 | 5 | 37 |
| α-helix | 2060-2063 | 4 | |
| α-helix | 2064-2066 | 3 | |
| β-strand | 2075-2077 | 3 | 39 |
| β-strand | 2083-2085 | 3 | 39 |
| β-strand | 2091-2095 | 5 | 37 |
| α-helix | 2104-2107 | 4 | |
| β-strand | 2111-2113 | 3 | 37 |
| α-helix | 2123-2131 | 9 | |
| α-helix | 2138-2159 | 22 | |
| α-helix | 2168-2176 | 9 | |
| α-helix | 2185-2196 | 12 | |
| α-helix | 2202-2214 | 13 | |
| β-strand | 2244 | 1 | 40 |
| β-strand | 2264 | 1 | 40 |
| α-helix | 2266-2275 | 10 | |
| β-strand | 2287-2291 | 5 | 41 |
| α-helix | 2297-2306 | 10 | |
| β-strand | 2311-2316 | 6 | 42 |
| α-helix | 2324-2332 | 9 | |
| β-strand | 2335-2338 | 4 | 43 |
| β-strand | 2345-2348 | 4 | 43 |
| β-strand | 2353-2358 | 6 | 42 |
| α-helix | 2373-2384 | 12 | |
| β-strand | 2386-2389 | 4 | 43 |
| β-strand | 2393-2397 | 5 | 43 |
| β-strand | 2400-2402 | 3 | 42 |
| β-strand | 2404-2407 | 4 | 41 |
| α-helix | 2415-2418 | 4 | |
| α-helix | 2419-2424 | 6 | |
| β-strand | 2426-2429 | 4 | 41 |
| α-helix | 2435-2450 | 16 | |
| α-helix | 2464-2483 | 20 | |
| α-helix | 2496-2503 | 8 | |
| α-helix | 2505-2507 | 3 | |
| β-strand | 2509 | 1 | 44 |
| α-helix | 2520-2535 | 16 | |
| α-helix | 2536-2538 | 3 | |
| α-helix | 2542-2559 | 18 | |
| β-strand | 2574 | 1 | 45 |
| α-helix | 2592-2593 | 2 | |
| β-strand | 2599 | 1 | 44 |
| β-strand | 2600 | 1 | 45 |
| α-helix | 2604-2620 | 17 | |
| α-helix | 2623-2625 | 3 | |
| α-helix | 2631-2644 | 14 | |
| β-strand | 2651-2655 | 5 | 46 |
| α-helix | 2662-2671 | 10 | |
| β-strand | 2675-2677 | 3 | 46 |
| α-helix | 2688-2703 | 16 | |
| β-strand | 2708-2713 | 6 | 46 |
| α-helix | 2714-2716 | 3 | |
| α-helix | 2722-2731 | 10 | |
| α-helix | 2745-2748 | 4 | |
| α-helix | 2749-2751 | 3 | |
| α-helix | 2752-2758 | 7 | |
| α-helix | 2764-2774 | 11 | |
| β-strand | 2776-2783 | 8 | 46 |
| α-helix | 2787-2789 | 3 | |
| α-helix | 2791-2794 | 4 | |
| α-helix | 2797-2800 | 4 | |
| β-strand | 2804-2807 | 4 | 46 |
| α-helix | 2813-2822 | 10 | |
| α-helix | 2848-2862 | 15 | |
| α-helix | 2863-2865 | 3 | |
| α-helix | 2869-2911 | 43 | |
| α-helix | 2914-2924 | 11 | |
| α-helix | 3169-3186 | 18 | |
| α-helix | 3189-3196 | 8 | |
| α-helix | 3200-3213 | 14 | |
| α-helix | 3219-3233 | 15 | |
| α-helix | 3241-3244 | 4 | |
| α-helix | 3247-3254 | 8 | |
| α-helix | 3262-3270 | 9 | |
| β-strand | 3277-3281 | 5 | 47 |
| α-helix | 3286-3294 | 9 | |
| β-strand | 3300-3303 | 4 | 47 |
| α-helix | 3310-3319 | 10 | |
| β-strand | 3323-3329 | 7 | 47 |
| α-helix | 3337-3340 | 4 | |
| β-strand | 3345-3347 | 3 | 48 |
| β-strand | 3350-3355 | 6 | 48 |
| β-strand | 3358-3361 | 4 | 48 |
| β-strand | 3367-3372 | 6 | 47 |
| β-strand | 3387-3391 | 5 | 47 |
| α-helix | 3396-3411 | 16 | |
| α-helix | 3413-3436 | 24 | |
| α-helix | 3437-3439 | 3 | |
| α-helix | 3440-3445 | 6 | |
| α-helix | 3456-3489 | 34 | |
| α-helix | 3493-3507 | 15 | |
| α-helix | 3521-3532 | 12 | |
| α-helix | 3541-3560 | 20 | |
| α-helix | 3568-3579 | 12 | |
| α-helix | 3589-3592 | 4 | |
| α-helix | 3620-3632 | 13 | |
| α-helix | 3634-3640 | 7 | |
| α-helix | 3647-3651 | 5 | |
| α-helix | 3663-3665 | 3 | |
| α-helix | 3671-3681 | 11 | |
| α-helix | 3686-3698 | 13 | |
| β-strand | 3723-3726 | 4 | 49 |
| α-helix | 3734-3744 | 11 | |
| β-strand | 3752-3754 | 3 | 49 |
| α-helix | 3760-3773 | 14 | |
| β-strand | 3777-3780 | 4 | 49 |
| α-helix | 3789-3798 | 10 | |
| β-strand | 3807-3811 | 5 | 49 |
| α-helix | 3819-3823 | 5 | |
| β-strand | 3826-3829 | 4 | 49 |
| α-helix | 3836-3846 | 11 | |
| α-helix | 3849-3852 | 4 | |
| α-helix | 3858-3876 | 19 | |
| α-helix | 3877-3879 | 3 | |
| α-helix | 3893-3907 | 15 | |
| α-helix | 3915-3921 | 7 | |
| α-helix | 3922-3927 | 6 | |
| α-helix | 3928-3930 | 3 | |
| α-helix | 3934-3946 | 13 | |
| α-helix | 3977-3986 | 10 | |
| α-helix | 3993-3995 | 3 | |
| α-helix | 4001-4020 | 20 | |
| α-helix | 4033-4036 | 4 | |
| α-helix | 4041-4050 | 10 | |
| α-helix | 4062-4064 | 3 | |
| α-helix | 4073-4099 | 27 | |
| α-helix | 4110-4119 | 10 | |
| α-helix | 4122-4124 | 3 | |
| α-helix | 4125-4130 | 6 | |
| α-helix | 4137-4158 | 22 | |
| β-strand | 4168-4169 | 2 | 50 |
| α-helix | 4170-4172 | 3 | |
| α-helix | 4176-4191 | 16 | |
| α-helix | 4195-4197 | 3 | |
| β-strand | 4198-4203 | 6 | 50 |
| β-strand | 4215-4218 | 4 | 50 |
| β-strand | 4221-4223 | 3 | 51 |
| β-strand | 4226-4228 | 3 | 52 |
| β-strand | 4231-4233 | 3 | 52 |
| β-strand | 4243-4244 | 2 | 51 |
| β-strand | 4248-4254 | 7 | 50 |
| α-helix | 4263-4265 | 3 | |
| β-strand | 4266-4270 | 5 | 53 |
| β-strand | 4272 | 1 | 51 |
| β-strand | 4283-4287 | 5 | 53 |
| α-helix | 4293-4297 | 5 | |
| β-strand | 4301-4303 | 3 | 51 |
Chain C: 7 helices, 32 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 528-534 | 7 | 54 |
| β-strand | 540-545 | 6 | 55 |
| β-strand | 551-557 | 7 | 56 |
| α-helix | 580-583 | 4 | |
| α-helix | 586-606 | 21 | |
| β-strand | 630-631 | 2 | 57 |
| β-strand | 643-649 | 7 | 58 |
| β-strand | 656-662 | 7 | 58 |
| β-strand | 676-682 | 7 | 58 |
| α-helix | 686 | 1 | |
| β-strand | 691-695 | 5 | 58 |
| β-strand | 699-704 | 6 | 59 |
| β-strand | 711-716 | 6 | 59 |
| β-strand | 721-725 | 5 | 59 |
| β-strand | 735 | 1 | 60 |
| β-strand | 744 | 1 | 60 |
| β-strand | 765-771 | 7 | 61 |
| α-helix | 784-786 | 3 | |
| α-helix | 790-792 | 3 | |
| β-strand | 798-803 | 6 | 61 |
| β-strand | 808-811 | 4 | 61 |
| β-strand | 838-840 | 3 | 61 |
| β-strand | 865-868 | 4 | 62 |
| β-strand | 875-879 | 5 | 62 |
| β-strand | 885-889 | 5 | 62 |
| β-strand | 899-900 | 2 | 62 |
| β-strand | 914-917 | 4 | 63 |
| β-strand | 924-928 | 5 | 63 |
| β-strand | 933-938 | 6 | 63 |
| β-strand | 948-949 | 2 | 63 |
| β-strand | 957-962 | 6 | 64 |
| β-strand | 969-974 | 6 | 64 |
| β-strand | 978-983 | 6 | 64 |
| β-strand | 993-996 | 4 | 64 |
| β-strand | 1002-1010 | 9 | 57 |
| β-strand | 1018-1025 | 8 | 57 |
| β-strand | 1030-1033 | 4 | 57 |
| α-helix | 1036-1038 | 3 | |
| α-helix | 1043-1054 | 12 | |
Chain D: 8 helices, 31 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 60-66 | 7 | 54 |
| β-strand | 72-78 | 7 | 55 |
| β-strand | 82-88 | 7 | 56 |
| α-helix | 105-127 | 23 | |
| α-helix | 141-143 | 3 | |
| β-strand | 151-153 | 3 | 65 |
| α-helix | 158-160 | 3 | |
| β-strand | 163-169 | 7 | 66 |
| β-strand | 176-182 | 7 | 66 |
| β-strand | 195-199 | 5 | 66 |
| β-strand | 212-214 | 3 | 66 |
| β-strand | 220-225 | 6 | 67 |
| β-strand | 232-237 | 6 | 67 |
| β-strand | 242-246 | 5 | 67 |
| α-helix | 247-249 | 3 | |
| β-strand | 255-257 | 3 | 67 |
| β-strand | 272-276 | 5 | 68 |
| β-strand | 284-289 | 6 | 68 |
| β-strand | 295-298 | 4 | 68 |
| α-helix | 301-303 | 3 | |
| β-strand | 308 | 1 | 68 |
| β-strand | 337-342 | 6 | 69 |
| β-strand | 350-354 | 5 | 69 |
| β-strand | 360-362 | 3 | 69 |
| β-strand | 384-387 | 4 | 69 |
| α-helix | 394 | 1 | |
| β-strand | 395-399 | 5 | 70 |
| β-strand | 408-412 | 5 | 70 |
| β-strand | 417-420 | 4 | 70 |
| β-strand | 429-431 | 3 | 70 |
| β-strand | 438-442 | 5 | 71 |
| β-strand | 450-455 | 6 | 71 |
| β-strand | 460-464 | 5 | 71 |
| β-strand | 475-476 | 2 | 71 |
| α-helix | 482-485 | 4 | |
| β-strand | 487-490 | 4 | 65 |
| β-strand | 498-501 | 4 | 65 |
| β-strand | 507-510 | 4 | 65 |
| α-helix | 523-533 | 11 | |
Chain E: 13 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-16 | 12 | |
| β-strand | 33-38 | 6 | 72 |
| α-helix | 44-51 | 8 | |
| α-helix | 56-59 | 4 | |
| β-strand | 67-71 | 5 | 72 |
| β-strand | 80-88 | 9 | 72 |
| α-helix | 93-97 | 5 | |
| α-helix | 103-105 | 3 | |
| β-strand | 109-116 | 8 | 72 |
| α-helix | 120-144 | 25 | |
| α-helix | 151-160 | 10 | |
| β-strand | 181-186 | 6 | 72 |
| α-helix | 188-193 | 6 | |
| α-helix | 196-213 | 18 | |
| β-strand | 216-218 | 3 | 72 |
| α-helix | 226-234 | 9 | |
| β-strand | 256-257 | 2 | 72 |
| α-helix | 264-267 | 4 | |
| α-helix | 286-296 | 11 | |
| α-helix | 320-338 | 19 | |
Chain F: 14 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-16 | 12 | |
| α-helix | 29-31 | 3 | |
| β-strand | 33-38 | 6 | 73 |
| α-helix | 44-51 | 8 | |
| α-helix | 56-59 | 4 | |
| β-strand | 65-71 | 7 | 73 |
| β-strand | 80-88 | 9 | 73 |
| α-helix | 93-97 | 5 | |
| α-helix | 103-108 | 6 | |
| β-strand | 109-116 | 8 | 73 |
| α-helix | 120-144 | 25 | |
| α-helix | 151-160 | 10 | |
| β-strand | 181-186 | 6 | 73 |
| α-helix | 188-193 | 6 | |
| α-helix | 196-213 | 18 | |
| β-strand | 216-218 | 3 | 73 |
| α-helix | 226-234 | 9 | |
| β-strand | 256-257 | 2 | 73 |
| α-helix | 264-267 | 4 | |
| α-helix | 286-296 | 11 | |
| α-helix | 320-338 | 19 | |
Chain G: 2 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 605-613 | 9 | |
| β-strand | 618-624 | 7 | 74 |
| β-strand | 630-633 | 4 | 74 |
| α-helix | 637-661 | 25 | |
| β-strand | 667-674 | 8 | 74 |
| β-strand | 678-681 | 4 | 74 |
| β-strand | 689-693 | 5 | 74 |
Chain H: 2 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 512-520 | 9 | |
| β-strand | 525-533 | 9 | 74 |
| β-strand | 536-540 | 5 | 74 |
| α-helix | 544-568 | 25 | |
| β-strand | 574-581 | 8 | 74 |
| β-strand | 585-589 | 5 | 74 |
| β-strand | 596-600 | 5 | 74 |
2 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| O6-alkylguanine-DNA alkyltransferase mutant,DYNC2H1 variant protein,O6-alkylguanine-DNA… | A | protein | 4513 | Homo sapiens | B0I1S0, E5BBQ0 (AlphaFold model) |
| O6-alkylguanine-DNA alkyltransferase mutant,DYNC2H1 variant protein,O6-alkylguanine-DNA… | B | protein | 4513 | Homo sapiens | B0I1S0, E5BBQ0 (AlphaFold model) |
| WD repeat-containing protein 60 | C | protein | 1066 | Homo sapiens | Q8WVS4 (AlphaFold model) |
| WD repeat-containing protein 34 | D | protein | 564 | Homo sapiens | Q96EX3 (AlphaFold model) |
| Cytoplasmic dynein 2 light intermediate chain 1 | E, F | protein | 351 | Homo sapiens | Q8TCX1 |
| Dynein light chain roadblock-type 1 | G, H | protein | 96 | Homo sapiens | Q9NP97 |
| Dynein light chain 1, cytoplasmic | I, J, K, L, M, N | protein | 89 | Homo sapiens | P63167 |
Sequence of entity 1 (A), FASTA
>6SC2_1 O6-alkylguanine-DNA alkyltransferase mutant,DYNC2H1 variant protein,O6-alkylguanine-DNA alkyltransferase mutant,Cytoplasmic dynein 2 heavy chain 1,DYNC2H1 variant protein,DYNC2H1 variant protein,DYNC2H1 variant protein (chains A)
GDKDCEMKRTTLDSPLGKLELSGCEQGLHRIIFLGKGTSAADAVEVPAPAAVLGGPEPLM
QATAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKLLKVVKFGEVISYSHLAAL
AGNPAATAAVKTALSGNPVPILIPCHRVVQGDLDVGGYEGGLAVKEWLLAHEGHRLGKPG
LGGSLEVLFQGPDYDIPTTLEVLFQGPANGTADVRKLFIFTTTQNYFGLMSELWDQPLLC
NCLEINNFLDDGNQMLLRVQRSDAGISFSNTIEFGDTKDKVLVFFKLRPEVITDENLHDN
ILVSSMLESPISSLYQAVRQVFAPMLLKDQEWSRNFDPKLQNLLSELEAGLGIVLRRSDT
NLTKLKFKEDDTRGILTPSDEFQFWIEQAHRGNKQISKERANYFKELFETIAREFYNLDS
LSLLEVVDLVETTQDVVDDVWRQTEHDHYPESRMLHLLDIIGGSFGRFVQKKLGTLNLWE
DPYYLVKESLKAGISICEQWVIVCNHLTGQVWQRYVPHPWKNEKYFPETLDKLGKRLEEV
LAIRTIHEKFLYFLPASEEKIICLTRVFEPFTGLNPVQYNPYTEPLWKAAVSQYEKIIAP
AEQKIAGKLKNYISEIQDSPQQLLQAFLKYKELVKRPTISKELMLERETLLARLVDSIKD
FRLDFENRCRGIPGDASGPLSGKNLSEVVNSIVWVRQLELKVDDTIKIAEALLSDLPGFR
CFHQSAKDLLDQLKLYEQEQFDDWSRDIQSGLSDSRSGLCIEASSRIMELDSNDGLLKVH
YSDRLVILLREVRQLSALGFVIPAKIQQVANIAQKFCKQAIILKQVAHFYNSIDQQMIQS
QRPMMLQSALAFEQIIKNSKAGSGGKSQITWDNPKELEGYIQKLQNAAERLATENRKLRK
WHTTFCEKVVVLMNIDLLRQQQRWKDGLQELRTGLATVEAQGFQASDMHAWKQHWNHQLY
KALEHQYQMGLEALNENLPEINIDLTYKQGRLQFRPPFEEIRAKYYREMKRFIGIPNQFK
GVGEAGDESIFSIMIDRNASGFLTIFSKAEDLFRRLSAVLHQHKEWIVIGQVDMEALVEK
HLFTVHDWEKNFKALKIKGKEVERLPSAVKVDCLNINCNPVKTVIDDLIQKLFDLLVLSL
KKSIQAHLHEIDTFVTEAMEVLTIMPQSVEEIGDANLQYSKLQERKPEILPLFQEAEDKN
RLLRTVAGGGLETISNLKAKWDKFELXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXKPGDDVIETGQHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXHHFRLEEPNF
SLAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTLIDYEDSQSRTMKLIKD
WKDIVNQVGDNRCLLQSLKDSPYYKGFEDKVSIWERKLAELDEYLQNLNHIQRKWVYLEP
IFGRGALPKEQTRFNRVDEDFRSIMTDIKKDNRVTTLTTHAGIRNSLLTILDQLQRCQRS
LNEFLEEKRSAFPRFYFIGDDDLLEILGQSTNPSVIQSHLKKLFAGINSVCFDEKSKHIT
AMKSLEGEVVPFKNKVPLSNNVETWLNDLALEMKKTLEQLLKECVTTGRSSQGAVDPSLF
PSQILCLAEQIKFTEDVENAIKDHSLHQIETQLVNKLEQYTNIDTSSEDPGNTESGILEL
KLKALILDIIHNIDVVKQLNQIQVHTTEDWAWKKQLRFYMKSDHTCCVQMVDSEFQYTYE
YQGNASKLVYTPLTDKCYLTLTQAMKMGLGGNPYGPAGTGKTESVKALGGLLGRQVLVFN
CDEGIDVKSMGRIFVGLVKCGAWGCFDEFNRLEESVLSAVSMQIQTIQDALKNHRTVCEL
LGKEVEVNSNSGIFITMNPAGKGYGGRQKLPDNLKQLFRPVAMSHPDNELIAEVILYSEG
FKDAKVLSRKLVAIFNLSRELLTPQQHYDWGLRALKTVLRGSGNLLRQLNKSGTTQNANE
SHIVVQALRLNTMSKFTFTDCTRFDALIKDVFPGIELKEVEYDELSAALKQVFEEANYEI
IPNQIKKALELYEQLCQRMGVVIVGPSGAGKSTLWRMLRAALCKTGKVVKQYTMNPKAMP
RYQLLGHIDMDTREWSDGVLTNSARQVVREPQDVSSWIICDGDIDPEWIESLNSVLDDNR
LLTMPSGERIQFGPNVNFVFETHDLSCASPATISRMGMIFLSDEETDLNSLIKSWLRNQP
AEYRNNLENWIGDYFEKALQWVLKQNDYVVETSLVGTVMNGLSHLHGCRDHDEFIINLIR
GLGGNLNMKSRLEFTKEVFHWARESPPDFHKPMDTYYDSTRGRLATYVLKKPEDLTADDF
SNGLTLPVIQTPDMQRGLDYFKPWLSSDTKQPFILVGPEGCGKGMLLRYAFSQLRSTQIA
TVHCSAQTTSRHLLQKLSQTCMVISTNTGRVYRPKDCERLVLYLKDINLPKLDKWGTSTL
VAFLQQVLTYQGFYDENLEWVGLENIQIVASMSAGGRLGRHKLTTRFTSIVRLCSIDYPE
REQLQTIYGAYLEPVLHKNLKNHSIWGSSSKIYLLAGSMVQVYEQVRAKFTVDDYSHYFF
TPCILTQWVLGLFRYDLEGGSSNHPLDYVLEIVAYEARRLFRDKIVGAKELHLFDIILTS
VFQGDWGSDILDNMSDSFYVTWGARHNSGARAAPGQPLPPHGKPLGKLNSTDLKDVIKKG
LIHYGRDNQNLDILLFHEVLEYMSRIDRVLSFPGGSLLLAGRSGVGRRTITSLVSHMHGA
VLFSPKISRGYELKQFKNDLKHVLQLAGIEAQQVVLLLEDYQFVHPTFLEMINSLLSSGE
VPGLYTLEELEPLLLPLKDQASQDGFFGPVFNYFTYRIQQNLHIVLIMDSANSNFMINCE
SNPALHKKCQVLWMEGWSNSSMKKIPEMLFSETGGGEKYNDKKRKEEKKKNSVDPDFLKS
FLLIHESCKAYGATPSQYMTFLHVYSAISSSKKKELLKRQSHLQAGVSKLNEAKALVDEL
NRKAGEQSVLLKTKQDEADAALQMITVSMQDASEQKTELERLKHRIAEEVVKIEERKNKI
DDELKEVQPLVNEAKLAVGNIKPESLSEIRSLRMPPDVIRDILEGVLRLMGIFDTSWVSM
KSFLAKRGVREDIATFDARNISKEIRESVEELLFKNKGSFDPKNAKRASTAAAPLAAWVK
ANIQYSHVLERIHPLETEQAGLESNLKKTEDRKRKLEELLNSVGQKVSELKEKFQSRTSE
AAKLEAEVSKAQETIKAAEVLINQLDREHKRWNAQVVEITEELATLPKRAQLAAAFITYL
SAAPESLRKTCLEEWTKSAGLEKFDLRRFLCTESEQLIWKSEGLPSDDLSIENALVILQS
RVCPFLIDPSSQATEWLKTHLKDSRLEVINQQDSNFITALELAVRFGKTLIIQEMDGVEP
VLYPLLRRDLVAQGPRYVVQIGDKIIDYNEEFRLFLSTRNPNPFIPPDAASIVTEVNFTT
TRSGLRGQLLALTIQHEKPDLEEQKTKLLQQEEDKKIQLAKLEESLLETLATSQGNILEN
KDLIESLNQTKASSALIQESLKESYKLQISLDQERDAYLPLAESASKMYFIISDLSKINN
MYRFSLAAFLRLFQRALQNKQDSENTEQRIQSLISSLQHMVYEYICRCLFKADQLMFALH
FVRGMHPELFQENEWDTFTGVVVGDMLRKADSQQKIRDQLPSWIDQERSWAVATLKIALP
SLYQTLCFEDAALWRTYYNNSMCEQEFPSILAKKVSLFQQILVVQVLRPDRLQSAMALFA
CKTLGLKEVSPLPLNLKRLYKETLEIEPILIIISPGADPSQELQELANAERSGECYHQVA
MGQGQADLAIQMLKECARNGDWLCLKNLHLVVSWLPVLEKELNTLQPKDTFRLWLTAEVH
PNFTPILLQSSLKITYESPPGLKKNLMRTYESWTPEQISKKDNTHRAHALFSLAWFHAAC
QERRNYIPQGWTKFYEFSLSDLRAGYNIIDRLFDGAKDVQWEFVHGLLENAIYGGRIDNY
FDLRVLQSYLKQFFNSSVIDVFNQRNKKSIFPYSVSLPQSCSILDYRAVIEKIPEDDKPS
FFGLPANIARSSQRMISSQVISQLRILGRSITAGSKFDREIWSNELSPVLNLWKKLNQNS
NLIHQKVPPPNDRQGSPILSFIILEQFNAIRLVQSVHQSLAALSKVIRGTTLLSSEVQKL
ASALLNQKCPLAWQSKWEGPEDPLQYLRGLVARALAIQNWVDKAEKQALLSETLDLSELF
HPDTFLNALRQETARAVGRSVDSLKFVASWKGRLQEAKLQIKISGLLLEGCSFDGNQLSE
NQLDSPSVSSVLPCFMGWIPQDACGPYSPDECISLPVYTSAERDRVVTNIDVPCGGNQDQ
WIQCGAALFLKNQ
Sequence of entity 2 (B), FASTA
>6SC2_2 O6-alkylguanine-DNA alkyltransferase mutant,DYNC2H1 variant protein,O6-alkylguanine-DNA alkyltransferase mutant,Cytoplasmic dynein 2 heavy chain 1,DYNC2H1 variant protein,DYNC2H1 variant protein,DYNC2H1 variant protein (chains B)
GDKDCEMKRTTLDSPLGKLELSGCEQGLHRIIFLGKGTSAADAVEVPAPAAVLGGPEPLM
QATAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKLLKVVKFGEVISYSHLAAL
AGNPAATAAVKTALSGNPVPILIPCHRVVQGDLDVGGYEGGLAVKEWLLAHEGHRLGKPG
LGGSLEVLFQGPDYDIPTTLEVLFQGPANGTADVRKLFIFTTTQNYFGLMSELWDQPLLC
NCLEINNFLDDGNQMLLRVQRSDAGISFSNTIEFGDTKDKVLVFFKLRPEVITDENLHDN
ILVSSMLESPISSLYQAVRQVFAPMLLKDQEWSRNFDPKLQNLLSELEAGLGIVLRRSDT
NLTKLKFKEDDTRGILTPSDEFQFWIEQAHRGNKQISKERANYFKELFETIAREFYNLDS
LSLLEVVDLVETTQDVVDDVWRQTEHDHYPESRMLHLLDIIGGSFGRFVQKKLGTLNLWE
DPYYLVKESLKAGISICEQWVIVCNHLTGQVWQRYVPHPWKNEKYFPETLDKLGKRLEEV
LAIRTIHEKFLYFLPASEEKIICLTRVFEPFTGLNPVQYNPYTEPLWKAAVSQYEKIIAP
AEQKIAGKLKNYISEIQDSPQQLLQAFLKYKELVKRPTISKELMLERETLLARLVDSIKD
FRLDFENRCRGIPGDASGPLSGKNLSEVVNSIVWVRQLELKVDDTIKIAEALLSDLPGFR
CFHQSAKDLLDQLKLYEQEQFDDWSRDIQSGLSDSRSGLCIEASSRIMELDSNDGLLKVH
YSDRLVILLREVRQLSALGFVIPAKIQQVANIAQKFCKQAIILKQVAHFYNSIDQQMIQS
QRPMMLQSALAFEQIIKNSKAGSGGKSQITWDNPKELEGYIQKLQNAAERLATENRKLRK
WHTTFCEKVVVLMNIDLLRQQQRWKDGLQELRTGLATVEAQGFQASDMHAWKQHWNHQLY
KALEHQYQMGLEALNENLPEINIDLTYKQGRLQFRPPFEEIRAKYYREMKRFIGIPNQFK
GVGEAGDESIFSIMIDRNASGFLTIFSKAEDLFRRLSAVLHQHKEWIVIGQVDMEALVEK
HLFTVHDWEKNFKALKIKGKEVERLPSAVKVDCLNINCNPVKTVIDDLIQKXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXLKPGDDVIETGQHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXHHFRLEEPNF
SLAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTLIDYEDSQSRTMKLIKD
WKDIVNQVGDNRCLLQSLKDSPYYKGFEDKVSIWERKLAELDEYLQNLNHIQRKWVYLEP
IFGRGALPKEQTRFNRVDEDFRSIMTDIKKDNRVTTLTTHAGIRNSLLTILDQLQRCQRS
LNEFLEEKRSAFPRFYFIGDDDLLEILGQSTNPSVIQSHLKKLFAGINSVCFDEKSKHIT
AMKSLEGEVVPFKNKVPLSNNVETWLNDLALEMKKTLEQLLKECVTTGRSSQGAVDPSLF
PSQILCLAEQIKFTEDVENAIKDHSLHQIETQLVNKLEQYTNIDTSSEDPGNTESGILEL
KLKALILDIIHNIDVVKQLNQIQVHTTEDWAWKKQLRFYMKSDHTCCVQMVDSEFQYTYE
YQGNASKLVYTPLTDKCYLTLTQAMKMGLGGNPYGPAGTGKTESVKALGGLLGRQVLVFN
CDEGIDVKSMGRIFVGLVKCGAWGCFDEFNRLEESVLSAVSMQIQTIQDALKNHRTVCEL
LGKEVEVNSNSGIFITMNPAGKGYGGRQKLPDNLKQLFRPVAMSHPDNELIAEVILYSEG
FKDAKVLSRKLVAIFNLSRELLTPQQHYDWGLRALKTVLRGSGNLLRQLNKSGTTQNANE
SHIVVQALRLNTMSKFTFTDCTRFDALIKDVFPGIELKEVEYDELSAALKQVFEEANYEI
IPNQIKKALELYEQLCQRMGVVIVGPSGAGKSTLWRMLRAALCKTGKVVKQYTMNPKAMP
RYQLLGHIDMDTREWSDGVLTNSARQVVREPQDVSSWIICDGDIDPEWIESLNSVLDDNR
LLTMPSGERIQFGPNVNFVFETHDLSCASPATISRMGMIFLSDEETDLNSLIKSWLRNQP
AEYRNNLENWIGDYFEKALQWVLKQNDYVVETSLVGTVMNGLSHLHGCRDHDEFIINLIR
GLGGNLNMKSRLEFTKEVFHWARESPPDFHKPMDTYYDSTRGRLATYVLKKPEDLTADDF
SNGLTLPVIQTPDMQRGLDYFKPWLSSDTKQPFILVGPEGCGKGMLLRYAFSQLRSTQIA
TVHCSAQTTSRHLLQKLSQTCMVISTNTGRVYRPKDCERLVLYLKDINLPKLDKWGTSTL
VAFLQQVLTYQGFYDENLEWVGLENIQIVASMSAGGRLGRHKLTTRFTSIVRLCSIDYPE
REQLQTIYGAYLEPVLHKNLKNHSIWGSSSKIYLLAGSMVQVYEQVRAKFTVDDYSHYFF
TPCILTQWVLGLFRYDLEGGSSNHPLDYVLEIVAYEARRLFRDKIVGAKELHLFDIILTS
VFQGDWGSDILDNMSDSFYVTWGARHNSGARAAPGQPLPPHGKPLGKLNSTDLKDVIKKG
LIHYGRDNQNLDILLFHEVLEYMSRIDRVLSFPGGSLLLAGRSGVGRRTITSLVSHMHGA
VLFSPKISRGYELKQFKNDLKHVLQLAGIEAQQVVLLLEDYQFVHPTFLEMINSLLSSGE
VPGLYTLEELEPLLLPLKDQASQDGFFGPVFNYFTYRIQQNLHIVLIMDSANSNFMINCE
SNPALHKKCQVLWMEGWSNSSMKKIPEMLFSETGGGEKYNDKKRKEEKKKNSVDPDFLKS
FLLIHESCKAYGATPSQYMTFLHVYSAISSSKKKELLKRQSHLQAGVSKLNEAKALVDEL
NRKAGEQSVLLKTKQDEADAALQMITVSMQDASEQKTELERLKHRIAEEVVKIEERKNKI
DDELKEVQPLVNEAKLAVGNIKPESLSEIRSLRMPPDVIRDILEGVLRLMGIFDTSWVSM
KSFLAKRGVREDIATFDARNISKEIRESVEELLFKNKGSFDPKNAKRASTAAAPLAAWVK
ANIQYSHVLERIHPLETEQAGLESNLKKTEDRKRKLEELLNSVGQKVSELKEKFQSRTSE
AAKLEAEVSKAQETIKAAEVLINQLDREHKRWNAQVVEITEELATLPKRAQLAAAFITYL
SAAPESLRKTCLEEWTKSAGLEKFDLRRFLCTESEQLIWKSEGLPSDDLSIENALVILQS
RVCPFLIDPSSQATEWLKTHLKDSRLEVINQQDSNFITALELAVRFGKTLIIQEMDGVEP
VLYPLLRRDLVAQGPRYVVQIGDKIIDYNEEFRLFLSTRNPNPFIPPDAASIVTEVNFTT
TRSGLRGQLLALTIQHEKPDLEEQKTKLLQQEEDKKIQLAKLEESLLETLATSQGNILEN
KDLIESLNQTKASSALIQESLKESYKLQISLDQERDAYLPLAESASKMYFIISDLSKINN
MYRFSLAAFLRLFQRALQNKQDSENTEQRIQSLISSLQHMVYEYICRCLFKADQLMFALH
FVRGMHPELFQENEWDTFTGVVVGDMLRKADSQQKIRDQLPSWIDQERSWAVATLKIALP
SLYQTLCFEDAALWRTYYNNSMCEQEFPSILAKKVSLFQQILVVQVLRPDRLQSAMALFA
CKTLGLKEVSPLPLNLKRLYKETLEIEPILIIISPGADPSQELQELANAERSGECYHQVA
MGQGQADLAIQMLKECARNGDWLCLKNLHLVVSWLPVLEKELNTLQPKDTFRLWLTAEVH
PNFTPILLQSSLKITYESPPGLKKNLMRTYESWTPEQISKKDNTHRAHALFSLAWFHAAC
QERRNYIPQGWTKFYEFSLSDLRAGYNIIDRLFDGAKDVQWEFVHGLLENAIYGGRIDNY
FDLRVLQSYLKQFFNSSVIDVFNQRNKKSIFPYSVSLPQSCSILDYRAVIEKIPEDDKPS
FFGLPANIARSSQRMISSQVISQLRILGRSITAGSKFDREIWSNELSPVLNLWKKLNQNS
NLIHQKVPPPNDRQGSPILSFIILEQFNAIRLVQSVHQSLAALSKVIRGTTLLSSEVQKL
ASALLNQKCPLAWQSKWEGPEDPLQYLRGLVARALAIQNWVDKAEKQALLSETLDLSELF
HPDTFLNALRQETARAVGRSVDSLKFVASWKGRLQEAKLQIKISGLLLEGCSFDGNQLSE
NQLDSPSVSSVLPCFMGWIPQDACGPYSPDECISLPVYTSAERDRVVTNIDVPCGGNQDQ
WIQCGAALFLKNQ
Sequence of entity 3 (C), FASTA
>6SC2_3 WD repeat-containing protein 60 (chains C)
MEPGKRRTKDDTWKADDLRKHLWAIQSGGSKEERKHREKKLRKESEMDLPEHKEPRCRDP
DQDARSRDRVAEVHTAKESPRGERDRDRQRERRRDAKDREKEKLKEKHREAEKSHSRGKD
REKEKDRRARKEELRQTVAHHNLLGQETRDRQLLERAERKGRSVSKVRSEEKDEDSERGD
EDRERRYRERKLQYGDSKDNPLKYWLYKEEGERRHRKPREPDRDKKHREKSSTREKREKY
SKEKSNSFSDKGEERHKEKRHKEGFHFDDERHQSNVDRKEKSAKDEPRKREFQNGEHRNR
GASSKRDGTSSQHAENLVRNHGKDKDSRRKHGHEEGSSVWWKLDQRPGGEETVEIEKEET
DLENARADAYTASCEDDFEDYEDDFEVCDGDDDESSNEPESREKLEELPLAQKKEIQEIQ
RAINAENERIGELSLKLFQKRGRTEFEKEPRTDTNSSPSRASVCGIFVDFASASHRQKSR
TQALKQKMRSTKLLRLIDLDFSFTFSLLDLPPVNEYDMYIRNFGKKNTKQAYVQCNEDNV
ERDIQTEEIETREVWTQHPGESTVVSGGSEQRDTSDAVVMPKIDTPRLCSFLRAACQVMA
VLLEEDRLAAEPSWNLRAQDRALYFSDSSSQLNTSLPFLQNRKVSSLHTSRVQRQMVVSV
HDLPEKSFVPLLDSKYVLCVWDIWQPSGPQKVLICESQVTCCCLSPLKAFLLFAGTAHGS
VVVWDLREDSRLHYSVTLSDGFWTFRTATFSTDGILTSVNHRSPLQAVEPISTSVHKKQS
FVLSPFSTQEEMSGLSFHIASLDESGVLNVWVVVELPKADIAGSISDLGLMPGGRVKLVH
SALIQLGDSLSHKGNEFWGTTQTLNVKFLPSDPNHFIIGTDMGLISHGTRQDLRVAPKLF
KPQQHGIRPVKVNVIDFSPFGEPIFLAGCSDGSIRLHQLSSAFPLLQWDSSTDSHAVTGL
QWSPTRPAVFLVQDDTSNIYIWDLLQSDLGPVAKQQVSPNRLVAMAAVGEPEKAGGSFLA
LVLARASGSIDIQHLKRRWAAPEVDECNRLRLLLQEALWPEGKLHK
Sequence of entity 4 (D), FASTA
>6SC2_4 WD repeat-containing protein 34 (chains D)
MATRAQPGPLSQAGSAGVAALATVGVASGPGPGRPGPLQDETLGVASVPSQWRAVQGIRW
ETKSCQTASIATASASAQARNHVDAQVQTEAPVPVSVQPPSQYDIPRLAAFLRRVEAMVI
RELNKNWQSHAFDGFEVNWTEQQQMVSCLYTLGYPPAQAQGLHVTSISWNSTGSVVACAY
GRLDHGDWSTLKSFVCAWNLDRRDLRPQQPSAVVEVPSAVLCLAFHPTQPSHVAGGLYSG
EVLVWDLSRLEDPLLWRTGLTDDTHTDPVSQVVWLPEPGHSHRFQVLSVATDGKVLLWQG
IGVGQLQLTEGFALVMQQLPRSTKLKKHPRGETEVGATAVAFSSFDPRLFILGTEGGFPL
KCSLAAGEAALTRMPSSVPLRAPAQFTFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLY
SMLQAPPLTSLQLSLKYLFAVRWSPVRPLVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQ
DESPVYCLEFNSQQTQLLAAGDAQGTVKVWQLSTEFTEQGPREAEDLDCLAAEVAAWSHP
QFEKGSAGSAAGSGAGWSHPQFEK
Sequence of entity 5 (E, F), FASTA
>6SC2_5 Cytoplasmic dynein 2 light intermediate chain 1 (chains E, F)
MPSETLWEIAKAEVEKRGINGSEGDGAEIAEKFVFFIGSKNGGKTTIILRCLDRDEPPKP
TLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSLVLVLDLSKP
NDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVP
LVIIGSKYDVFQDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLAFG
IDKSKSICVDQNKPLFITAGLDSFGQIGSPPVPENDIGKLHAHSPMELWKKVYEKLFPPK
SINTLKDIKDPARDPQYAENEVDEMRIQKDLELEQYKRSSSKSWKQIELDS
Sequence of entity 6 (G, H), FASTA
>6SC2_6 Dynein light chain roadblock-type 1 (chains G, H)
MAEVEETLKRLQSQKGVQGIIVVNTEGIPIKSTMDNPTTTQYASLMHSFILKARSTVRDI
DPQNDLTFLRIRSKKNEIMVAPDKDYFLIVIQNPTE
Sequence of entity 7 (I, J, K, L, M, N), FASTA
>6SC2_7 Dynein light chain 1, cytoplasmic (chains I, J, K, L, M, N)
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGR
NFGSYVTHETKHFIYFYLGQVAILLFKSG
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ATP | Adenosine-5'-triphosphate | C10 H16 N5 O13 P3 | 2 |
| ADP | Adenosine-5'-diphosphate | C10 H15 N5 O10 P2 | 6 |
| MG | Magnesium ion | Mg | 2 |
Primary citation
Structure of the dynein-2 complex and its assembly with intraflagellar transport trains. Toropova, K., Zalyte, R., Mukhopadhyay, A.G. et al. Nat Struct Mol Biol (2019) 26:823-829. DOI 10.1038/s41594-019-0286-y · PubMed
Other PDB entries of the same protein (UniProt B0I1S0), best resolution first:
- 6RLA 3.9 Å, Structure of the dynein-2 complex; motor domains
Browse structure collections
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