6TAY: PDB entry 6TAY

Mouse RNF213 mutant R4753K modeling the Moyamoya-disease-related Human variant R4810K. Determined by electron microscopy at 3.2 Å resolution. Released 1 Jul 2020.

Method
Electron microscopy
Resolution
3.2 Å
Organism
Mus musculus
Chains
1
Atoms
35,241
Mol. weight
528.31 kDa
Ligands
ZN, MG, ATP
Released
1 Jul 2020

Explore 6TAY in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6TAY contains 239 α-helices and 92 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 239 helices, 92 β-strands

ElementResiduesLengthSheet
α-helix478-49013
α-helix497-51014
α-helix518-53821
α-helix592-60110
α-helix602-6043
α-helix609-6135
α-helix614-6196
α-helix629-6346
α-helix637-6393
α-helix644-65512
α-helix664-6663
α-helix670-6723
β-strand68311
β-strand68711
α-helix689-6935
α-helix700-7034
α-helix712-7198
α-helix721-7255
α-helix730-7378
α-helix740-7423
α-helix743-7497
α-helix751-7566
α-helix761-7699
α-helix781-80020
α-helix811-82717
α-helix836-85015
α-helix853-8542
α-helix864-88825
β-strand894-89522
β-strand902-90322
α-helix908-9169
α-helix928-93811
α-helix943-9486
α-helix963-98119
α-helix995-100814
α-helix1021-103010
α-helix1033-104210
α-helix1048-10503
α-helix1053-106917
β-strand107913
α-helix1080-10878
α-helix1090-110213
α-helix1114-114027
β-strand1149-115134
α-helix1155-11595
β-strand116613
α-helix1167-11704
α-helix1191-120313
α-helix1207-121812
β-strand1231-123334
α-helix1234-12374
α-helix1238-12425
α-helix1243-125816
α-helix1263-12697
α-helix1270-12723
α-helix1278-128811
α-helix1299-132931
α-helix1339-13435
α-helix1362-13676
α-helix1378-13869
α-helix1388-139710
α-helix1401-14033
α-helix1404-141411
α-helix1419-143416
α-helix1448-146215
α-helix1468-14769
α-helix1479-14835
α-helix1496-150611
β-strand1508-151145
β-strand1526-153165
β-strand1540-154345
α-helix1545-155612
α-helix1559-15602
α-helix1564-159330
β-strand1602-160655
β-strand1612-161655
β-strand1625-162735
α-helix1631-165929
α-helix1662-16643
α-helix1668-167811
α-helix1685-16906
α-helix1691-16933
α-helix1700-17089
α-helix1713-173119
α-helix1736-174914
α-helix1761-177111
α-helix1782-17843
β-strand1792-179656
α-helix1802-18098
α-helix1817-18182
β-strand1824-182636
α-helix1833-184311
β-strand1853-185756
α-helix1864-187916
β-strand1887-189266
α-helix1894-18963
α-helix1900-19056
α-helix1906-19083
β-strand190916
α-helix1918-192912
α-helix1939-19413
β-strand1948-195367
α-helix1960-197415
β-strand1982-198767
α-helix1994-200512
β-strand2015-202067
α-helix2028-20325
α-helix2033-20375
β-strand2040-204238
β-strand2048-205038
β-strand2056-206277
α-helix2085-20873
β-strand2090-209237
α-helix2096-21005
α-helix2117-21204
α-helix2127-213610
α-helix2155-216511
α-helix2173-219119
α-helix2195-22028
α-helix2208-222316
β-strand2266-226949
β-strand2276-227949
β-strand2282-2285410
β-strand2290-2294510
β-strand2301110
β-strand2307-2308210
α-helix2309-23179
α-helix2331-234111
α-helix2358-237316
β-strand2377-2380411
α-helix2387-239913
β-strand2407-2411511
α-helix2418-243922
β-strand2444-2448511
α-helix2456-24638
β-strand2467-2468212
β-strand2471-2472212
α-helix2473-24742
β-strand2480-2485611
β-strand2490113
α-helix2493-24997
β-strand2516114
β-strand2521114
β-strand2525113
α-helix2531-25333
α-helix2537-25393
β-strand2540-2542311
α-helix2549-256214
α-helix2570-258819
α-helix2599-261416
α-helix2619-263012
α-helix2643-26508
α-helix2651-26555
α-helix2661-26688
α-helix2674-26763
α-helix2679-269517
α-helix2698-26992
α-helix2707-272115
β-strand2726-2729415
α-helix2738-27469
β-strand2763-2768615
α-helix2776-279015
β-strand2799-2804615
α-helix2818-28203
α-helix2821-28266
β-strand2841-2846615
α-helix2852-28554
β-strand2859-2862415
α-helix2868-287912
α-helix2883-28897
α-helix2890-28923
α-helix2893-290614
α-helix2914-293118
α-helix2937-294711
α-helix2956-29638
α-helix2975-29839
β-strand3002-3006516
α-helix3011-30144
α-helix3015-30195
β-strand3026-3028316
α-helix3038-305518
β-strand3059-3061316
α-helix3064-30674
α-helix3072-30754
β-strand3080-3082317
β-strand3085-3092817
β-strand3095-3101717
β-strand3107-3112616
α-helix3113-31186
α-helix3122-31254
β-strand3130-3132316
α-helix3141-315818
β-strand3160118
α-helix3173-31764
β-strand3177119
β-strand3179120
α-helix3186-319611
α-helix3204-321815
β-strand3221119
α-helix3223-32286
α-helix3229-32313
β-strand3232118
α-helix3235-324713
α-helix3255-32639
β-strand3272-3279821
α-helix3282-32843
α-helix3287-32959
α-helix33031
β-strand3304-3307421
α-helix3308-33103
α-helix3314-332512
β-strand3332-3339821
α-helix3350-336415
β-strand3371-3378821
α-helix3384-33874
β-strand3389120
β-strand3396-3400521
β-strand3410122
α-helix3414-34196
α-helix3423-34264
β-strand3475122
α-helix3477-348913
β-strand3492-3493223
α-helix3502-351110
α-helix3519-354022
α-helix3544-35474
α-helix3549-35546
α-helix3557-35637
α-helix3566-358924
α-helix3595-35995
α-helix3605-361511
β-strand3639-3640223
α-helix3658-367518
α-helix3681-369010
α-helix3693-36986
α-helix3703-372119
α-helix3728-374417
α-helix3762-37709
α-helix3772-378413
α-helix3788-379912
α-helix3808-382215
α-helix3829-383810
α-helix3840-38467
α-helix3857-387923
α-helix3880-38845
α-helix3885-38895
α-helix3895-390915
α-helix3918-394023
α-helix3953-39542
β-strand3957-3959324
β-strand3965-3967324
α-helix3968-39747
α-helix4001-402222
α-helix4023-40275
α-helix4036-40449
β-strand4047125
β-strand4064125
β-strand4075125
β-strand4080126
α-helix4083-40886
α-helix4093-40953
α-helix4097-410610
α-helix4107-41115
α-helix4118-413720
α-helix4143-415412
α-helix4172-419524
α-helix4204-421815
α-helix4223-423513
α-helix4238-42425
α-helix4252-42543
α-helix4280-429213
α-helix4298-43047
α-helix4310-432112
α-helix4322-43265
α-helix4327-43304
α-helix4343-435210
α-helix4354-43563
α-helix4362-43698
α-helix4385-440218
α-helix4409-44157
β-strand4425127
β-strand4502127
β-strand4503128
α-helix4523-454321
α-helix4545-45517
β-strand4552128
α-helix4560-457718
α-helix4582-459514
α-helix4614-463219
α-helix4635-464713
α-helix4656-46594
α-helix4692-470110
α-helix4704-47074
α-helix4709-47168
α-helix4718-47214
α-helix4724-47263
α-helix4727-474014
β-strand4751129
α-helix4752-47565
α-helix4762-478221
α-helix4785-47884
β-strand4808129
α-helix4809-48124
α-helix4821-484121
α-helix4842-48465
β-strand4854130
α-helix4855-48573
α-helix4868-48725
α-helix4873-48775
β-strand4880-4883431
β-strand4884126
β-strand4891-4894431
α-helix4896-490611
β-strand4915130
α-helix4930-494011
α-helix4945-49473
α-helix4948-495710
α-helix4961-497919
α-helix5004-50096
α-helix5010-50123
α-helix5019-503517
β-strand5049132
α-helix5054-506512
α-helix5069-508315
β-strand5098133
α-helix5099-510810
α-helix5114-51163
α-helix5118-51214
β-strand5127133
β-strand5130132
α-helix5131-514818

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
RNF213,E3 ubiquitin-protein ligase RNF213,E3 ubiquitin-protein ligase RNF213Aprotein4638Mus musculusE9Q555
Sequence of entity 1 (A), FASTA
>6TAY_1 RNF213,E3 ubiquitin-protein ligase RNF213,E3 ubiquitin-protein ligase RNF213 (chains A)
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXKLTLGLSILFMVEAAEFTVPKKDLDSLCYLLIPSAGSPEALHSDLSPVLRIRQ
RWRIYLTNLCLRCIDERCDRWLGILPLLHTCMQKSPPKKNSKSQPEDTWAGLEGISFSEF
RDKAPTRSQPLQFMQSKMALLRVDEYLFRSWLSVVPLESLSSYLENSIDYLSDVPVRVLD
CLQGISYRLPGLRKISNQNMKKDVENVFKMLMHLVDIYQHRIFGENLLQIYLTECLTLHE
TVCNITANHQFFEIPALSAELICKLLELSPPGHTDEGLPEKSYEDLVTSTLQEALATTRN
WLRSLFKSRMLSISSAYVRLTYSEEMAVWRRLVEIGFPEKHGWKGSLLGDMEGRLKQEPP
RLQISFFCSSQCRDGGLHDSVSRSFEKCVIEAVSSACQSQTSVLEGLSCQDLQKFGTLLS
AVITKSWPVHNGEPVFDVDEIFKYLLKWPDVRQLFELCGTNEKIIDNITEEGRQLMATAE
SVFQKVAGELENGTIVVGQLELILEHQSQFLDIWNLNRRRLPSQEKACDVRSLLKRRRDD
LLFLKQEKRYVESLLRQLGRVKHLVQVDFGNIEIIHSQDLSNKKLNEAVIKLPNSSSYKR
ETHYCLSPDIREMASKLDSLKDSHIFQDFWQETAESLNTLDKDPRELKVSLPEVLEYLYN
PCYDNFYTLYENLKSGKITFAEVDAIFKDFVDKYDELKNDLKFMCTMNPQDQKGWISERV
GQIKEYHTLHQAVSSAKVILQVRRALGVTGDFSVLNPLLNFADSFEDFGNEKLDQISPQF
IKAKQLLQDISEPRQRCLEELARQTELVAWLHKALEDINELKVFVDLASISAGENDIDVD
RVACFHDAVQGYASLLYKMDERTNFSDFMNHLQELWRALDNDQHLPDKLKDSARNLEWLK
TVKESHGSVELSSLSLATAINSRGVYVIEAPKDGQKISPDTVLRLLLPDGHGYPEALRTY
STEELKELLNKLMLMSGKKDHNSNTEVEKFSEVFSNMQRLVHVFIKLHCAGNMLFRTWTA
KVYCCPDGGIFMNFGLELLSQLTEKGDVIQLLGALCRQMEDFLDNWKTVVAQKRAEHFYL
NFYTAEQLVYLSSELRKPRPSEAALMMLSFIKGKCTVQDLVQATSACESKADRYCLREVM
KKLPQQLLSEPSLMGKLQVIMMQSLVYMSAFLPHCLDLDALGRCLAHLATMGGTPVERPL
PKGLQAGQPNLILCGHSEVLPAALAIYMQAPRQPLPTFDEVLLCTPATTIEEVELLLRRC
LTSGSQGHKVYSLLFADQLSYEVGCQAEEFFQSLCTRAHREDYQLVILCDAAREHCYIPS
TFSQYKVPLVPQAPLPNIQAYLQSHYQVPKRLLSAATVFRDGLCVGIVTSERAGVGKSLY
VNTLHTKLKAKLRDETVPLKIIRLTEPHLDENQVLSALLPFLKEKYQKMPVIFHIDISTS
VQTGIPIFLFKLLILQYLMDINGKIWRRSPGHLYLVEIPQGLSVQPKRSSKLNARAPLFK
FLDLFPKVTCRPPKEVIDMELTPERSHTDPAMDPVEFCSEAFQRPYQYLKRFHQQQNLDT
FQYEKGSVEGSPEECLQHFLIYCGLINPSWSELRNFAWFLNCQLKDCEASIFCKSAFTGD
TLRGFKNFVVTFMILMARDFATPTLHTSDQSPGRQSVTIGEVVEEDLAPFSLRKRWESEP
HPYVFFNGDHMTMTFIGFHLETNNNGYVDAINPSNGKVIKKDVMTKELFDGLRLQRVPFN
IDFDNLPRYEKLERLCLALGIEWPIDPDETYELTTDNMLKILAIEMRFRCGIPVIIMGET
GCGKTRLIKFLSDLKRGSVEAETMKLVKVHGGTTPSMIYSKVKEAERTAFSNKAQHKLDT
ILFFDEANTTEAVSCIKEILCDRTVDGEHLHEDSGLHIIAACNPYRKHSQEMILRLESAG
LGYRVSAEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLNDSAEKLYIQQIVQRLV
DSVSVNPSETCVIADVLSASQMFMRKRENECGFVSLRDVERCVKVFRWFHDHSDMLLKEL
DKFLHESSDSTHTFERDPVLWSLVMAIGVCYHASLEEKASYRTAIARCFPKPYNSSRAIL
DEVTHVQDLFLRGAPIRTNIARNLALKENVFMMVICIELKIPLFLVGKPGSSKSLAKIIV
ADAMQGQAAFSELFRCLKQVHLVSFQCSPHSTPQGIISTFKQCARFQQGKDLGQYVSVVV
LDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPYKKVGFVGISNWALDPAKMNRGIFVSR
GSPNEKELIESAEGICSSDRLVQDKIRGYFAPFAKAYETVCQKQDKEFFGLRDYYSLIKM
VFAKAKASKRGLSPQDITHAVLRNFSGKDNIQALSIFTASLPEARYKEEVSTVELIKQNI
YPGPQASSRGLDGAESRYLLVLTRNYVALQILQQTFFEGQQPEIIFGSSFPQDQEYTQIC
RNINRVKICMETGKMVVLLNLQNLYESLYDALNQYYVYLGGQKYVDLGLGTHRVKCRVHT
AFRLIVIEEKDVVYKQFPVPLINRLEKHYLDMNTVLQPWQKSIVQELQQWAHEFADVKAD
QFIARHKYSPADVFIGYHSDACASVVLQAVERQGCRDLTEELYRKVSEEARSILLDCATP
DAVVRLSGSSLGSFTAKQLSQEYYYAQQHNSFVDFLQAHLRMTHHECRAVFTEITTFSRL
LTGNDCDVLASELRGLASKPVVLSLQQYDTEYSFLKDVRSWLTNPGKRKVLVIQADFDDG
TRSAQLVASAKYTAINEINKTQGTKDFVFVYFVTKLSRMGSGTSYVGFHGGLWRSVHIDD
LRRSTIMASDVTKLQNVTISQLFKPEDKPEQEEMEIETSQSKELAEEQMEVEDSEEMKKA
SDPRSCDCSQFLDTTRLVQSCVQGAVGMLRDQNESCARNMRRVTILLDLLNEDNTRNASF
LRESKMRLHVLLNKQEENQVRSLKEWVTREAANQDALQEAGTFRHTLWKRVQDVVTPILA
SMIAHIDRDGNLELLAQPDSPAWVQDLWMFIYSDIKFLNISLVLNNTRSNSEMSFILVQS
HMNLLKDAYNAVPFSWRIRDYLEELWVQAQYITDTEGLSKKFVEIFQKTPLGVFLAQFPV
AQQQKLLQSYLKDFLLLTMKVSSREELMFLQMALWSCLRELQEASGTPDETYKFPLSLPW
VHLAFQHFRTRLQNFSRILTIHPQVLSSLSQAAEKHSLAGCEMTLDAFAAMACAEMLKGD
LLKPSPKAWLQLVKNLSTPLELVCSEGYLCDSGSMTRSVIQEVRALWNRIFSIALFVEHV
LLGTESHIPELSPLVTTYVSLLDKCLEEDSNLKTCRPFVAVMTTLCDCKDKASKKFSRFG
IQPCFICHGDAQDPVCLPCDHVYCLRCIQTWLIPGQMMCPYCLTDLPDKFSPTVSQDHRK
AIEKHAQFRHMCNSFFVDLVSTMCFKDNTPPEKSVIDTLLSLLFVQKELLRDASQKHREH
TKSLSPFDDVVDQTPVIRSVLLKLLLKYSFHEVKDYIQNYLTQLEKKAFLTEDKTELYLL
FISCLEDSVHQKTSAGCRNLEQVLREEGHFLRTYSPGLQGQEPVRIASVEYLQEVARVRL
CLDLAADFLSELQEGSELAEDKRRFLKHVEEFCTRVNNDWHRVYLVRKLSSQRGMEFVQS
FSKQGHPCQWVFPRKVIAQQKDHVSLMDRYLVHGNEYKAVRDATAKAVLECKTLDIGNAL
MACRSPKPQQTAYLLLALYTEVAALYRSPNGSLHPEAKQLEAVNKFIKESKILSDPNIRC
FARSLVDNTLPLLKIRSANSILKGTVTEMAVHVATILLCGHNQILKPLRNLAFYPVNMAN
AFLPTMPEDLLVHARTWRGLENVTWYTCPRGHPCSVGECGRPMQESTCLDCGLPVGGLNH
TPHEGFSAIRNNEDRTQTGHVLGSPQSSGVAEVSDRGQSPVVFILTRLLTHLAMLVGATH
NPQALTVIIKPWVQDPQGFLQQHIQRDLEQLTKMLGRSADETIHVVHLILSSLLRVQSHG
VLNFNAELSTKGCRNNWEKHFETLLLRELKHLDKNLPAINALISQDERISSNPVTKIIYG
DPATFLPHLPQKSIIHCSKIWSCRRKITVEYLQHIVEQKNGKETVPVLWHFLQKEAELRL
VKFLPEILALQRDLVKQFQNVSRVEYSSIKGFIHSHSSDGLRKLLHDRITIFLSTWNALR
RSLETNGEIKLPKDYCCSDLDLDAEFEVILPRRQGLGLCGTALVSYLISLHNNMVYTVQK
FSNEDNSYSVDISEVADLHVISYEVERDLNPLILSNCQYQVQQGGETSQEFDLEKIQRQI
SSRFLQGKPRLTLKGIPTLVYRRDWNYEHLFMDIKNKMAQSSLPNLAISTISGQLQSYSD
ACEALSIIEITLGFLSTAGGDPGMDLNVYIEEVLRMCDQTAQVLKAFSRCQLRHIIALWQ
FLSAHKSEQRLRLNKELFREIDVQYKEELSTQHQRLLGTFLNEAGLDAFLLELHEMIVLK
LKGPRAANSFNPNWSLKDTLVSYMETKDSDILSEVESQFPEEILMSSCISVWKIAATRKW
DRQSRGGGHHHHHHHHHH

Ligands and cofactors

IDNameFormulaCopies
ZNZinc ionZn2
MGMagnesium ionMg1
ATPAdenosine-5'-triphosphateC10 H16 N5 O13 P31

Primary citation

Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism. Ahel, J., Lehner, A., Vogel, A. et al. Elife (2020) 9. DOI 10.7554/eLife.56185 · PubMed

Other PDB entries of the same protein (UniProt E9Q555), best resolution first:

Browse structure collections

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