6TRJ: LEDGF/p75 IBD dimer

LEDGF/p75 IBD dimer. Determined by X-ray diffraction at 1.3 Å resolution. Released 9 Sept 2020.

Method: X-ray diffraction
Resolution: 1.3 Å
Organism: Homo sapiens
Chains: 1
Atoms: 818
Mol. weight: 10.52 kDa
Released: 9 Sept 2020

Explore 6TRJ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6TRJ contains 6 α-helices and 2 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 6 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	8-23	16
β-strand	24-25	2	1
β-strand	28-29	2	1
α-helix	31-43	13
α-helix	48-51	4
α-helix	52-54	3
α-helix	55-64	10
α-helix	71-89	19

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
PC4 and SFRS1-interacting protein	A	protein	91	Homo sapiens	O75475 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>6TRJ_1 PC4 and SFRS1-interacting protein (chains A)
SNAASETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITT
LKKIRRFKVSQVIMEKSTMLYNKFKNMFLVG

Primary citation

Fine-tuning of the LEDGF/p75 interaction network by dimerization. Lux, V., Brouns, T., Cermakova, K. et al. Structure.

Other PDB entries of the same protein (UniProt O75475 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9S81 1.63 Å, Crystal structure of the LEDGF PWWP domain
5N88 1.7 Å, Crystal structure of antibody bound to viral protein
2B4J 2.02 Å, Structural basis for the recognition between HIV-1 integrase and LEDGF/p75
5OYM 2.05 Å, HIV Integrase Binding Domain of Lens Epithelium-Derived Growth Factor
4FU6 2.1 Å, Crystal structure of the PSIP1 PWWP domain
9S83 2.1 Å, Crystal structure of de novo designed binder JUBO4 and the LEDGF PWWP domain
3HPH 2.64 Å, Closed tetramer of Visna virus integrase (residues 1-219) in complex with LEDGF IBD
8PEO 2.69 Å, H3K36me2 nucleosome-LEDGF/p75 PWWP domain complex
9S28 2.8 Å, MVV STC intasome in complex with LEDGF
9S29 2.8 Å, MVV CSC intasome in complex with LEDGF
3U88 3.0 Å, Crystal structure of human menin in complex with MLL1 and LEDGF
7OUF 3.0 Å, Structure of the STLV intasome:B56 complex bound to the strand-transfer inhibitor XZ450

Browse structure collections

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