Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with SHU9119. Determined by X-ray diffraction at 2.75 Å resolution. Released 29 Apr 2020.
Explore 6W25 in 3D Show helices and sheets RCSB PDB PDBe
6W25 contains 23 α-helices and 10 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 48-71 | 24 | |
| α-helix | 73-75 | 3 | |
| α-helix | 78-109 | 32 | |
| α-helix | 116-152 | 37 | |
| α-helix | 154-160 | 7 | |
| α-helix | 163-186 | 24 | |
| α-helix | 191-212 | 22 | |
| α-helix | 213-217 | 5 | |
| α-helix | 219-222 | 4 | |
| β-strand | 1002 | 1 | 1 |
| α-helix | 1009-1011 | 3 | |
| α-helix | 1016-1026 | 11 | |
| β-strand | 1033-1038 | 6 | 2 |
| β-strand | 1041 | 1 | 3 |
| α-helix | 1048-1059 | 12 | |
| α-helix | 1062-1066 | 5 | |
| β-strand | 1067-1072 | 6 | 2 |
| β-strand | 1075 | 1 | 3 |
| α-helix | 1077-1090 | 14 | |
| β-strand | 1093-1096 | 4 | 2 |
| α-helix | 1102-1109 | 8 | |
| β-strand | 1114-1117 | 4 | 2 |
| α-helix | 1126-1133 | 8 | |
| β-strand | 1137-1141 | 5 | 2 |
| α-helix | 1144-1149 | 6 | |
| β-strand | 1156-1158 | 3 | 2 |
| α-helix | 1163-1176 | 14 | |
| α-helix | 1182-1194 | 13 | |
| β-strand | 1196 | 1 | 1 |
| α-helix | 239-270 | 32 | |
| α-helix | 275-281 | 7 | |
| α-helix | 284-305 | 22 | |
| α-helix | 307-2007 | 22 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Melanocortin receptor 4,GlgA glycogen synthase,Melanocortin receptor 4 | A | protein | 535 | Homo sapiens, Pyrococcus abyssi | P32245 (AlphaFold model), Q9V2J8 (AlphaFold model) |
| SHU9119 | B | protein | 9 | synthetic construct |
>6W25_1 Melanocortin receptor 4,GlgA glycogen synthase,Melanocortin receptor 4 (chains A) MKTIIALSYIFCLVFADYKDDDDAGRAWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSP VVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSLGFETIVITLLN STDTDAQSFTVNIDNVIDSVICASLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGI IISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHGIDCSF WNESYLTGSRDERKKSLLSKFGMDEGVTFMFIGRFDRGQKGVDVLLKAIEILSSKKEFQE MRFIIIGKGDPELEGWARSLEEKHGNVKVITEMLSREFVRELYGSVDFVIIPSYFEPFGL VALEAMCLGAIPIASAVGGLRDIITNETGILVKAGDPGELANAILKALELSRSDLSKFRE NCKKRAMSFSRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFN LYLILIMCNSIINPLIYALRSQELRKTFKEIICCYEFLEVLFQGPHHHHHHHHHH
>6W25_2 SHU9119 (chains B) XLDHXRWKX
Determination of the melanocortin-4 receptor structure identifies Ca2+as a cofactor for ligand binding. Yu, J., Gimenez, L.E., Hernandez, C.C. et al. Science (2020) 368:428-433. DOI 10.1126/science.aaz8995 · PubMed
Other PDB entries of the same protein (UniProt P32245 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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