6W8O: Apo membrane protein

Name: PDB 6W8O: Structure of an Apo membrane protein
Published: 2021-08-04
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: membrane protein

Structure of an Apo membrane protein. Determined by electron microscopy at 3.4 Å resolution. Released 4 Aug 2021.

Method: Electron microscopy
Resolution: 3.4 Å
Organism: Homo sapiens
Chains: 2
Atoms: 6,332
Mol. weight: 111.33 kDa
Released: 4 Aug 2021

Explore 6W8O in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6W8O contains 55 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 27 helices, 0 β-strands

Element	Residues	Length
α-helix	35-48	14
α-helix	49-52	4
α-helix	53-56	4
α-helix	67-100	34
α-helix	107-121	15
α-helix	123-131	9
α-helix	137-163	27
α-helix	165-168	4
α-helix	172-175	4
α-helix	181-203	23
α-helix	213-219	7
α-helix	220-224	5
α-helix	225-227	3
α-helix	254-257	4
α-helix	258-283	26
α-helix	288-291	4
α-helix	299-303	5
α-helix	304-306	3
α-helix	307-331	25
α-helix	339-362	24
α-helix	372-374	3
α-helix	375-394	20
α-helix	407-409	3
α-helix	416-435	20
α-helix	436-438	3
α-helix	442-444	3
α-helix	445-468	24

Chain B: 28 helices, 0 β-strands

Element	Residues	Length
α-helix	35-49	15
α-helix	50-52	3
α-helix	53-56	4
α-helix	67-100	34
α-helix	107-121	15
α-helix	123-131	9
α-helix	137-163	27
α-helix	165-168	4
α-helix	172-175	4
α-helix	181-204	24
α-helix	213-219	7
α-helix	220-224	5
α-helix	225-227	3
α-helix	254-257	4
α-helix	258-283	26
α-helix	288-291	4
α-helix	299-303	5
α-helix	304-306	3
α-helix	307-331	25
α-helix	339-362	24
α-helix	374-394	21
α-helix	395-397	3
α-helix	407-409	3
α-helix	416-434	19
α-helix	435-438	4
α-helix	445-457	13
α-helix	459-462	4
α-helix	464-468	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Endosomal/lysosomal potassium channel TMEM175	A, B	protein	504	Homo sapiens	Q9BSA9 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>6W8O_1 Endosomal/lysosomal potassium channel TMEM175 (chains A, B)
MSQPRTPEQALDTPGDCPPGRRDEDAGEGIQCSQRMLSFSDALLSIIATVMILPVTHTEI
SPEQQFDRSVQRLLATRIAVYLMTFLIVTVAWAAHTRLFQVVGKTDDTLALLNLACMMTI
TFLPYTFSLMVTFPDVPLGIFLFCVCVIAIGVVQALIVGYAFHFPHLLSPQIQRSAHRAL
YRRHVLGIVLQGPALCFAAAIFSLFFVPLSYLLMVTVILLPYVSKVTGWCRDRLLGHREP
SAHPVEVFSFDLHEPLSKERVEAFSDGVYAIVATLLILDICEDNVPDPKDVKERFSGSLV
AALSATGPRFLAYFGSFATVGLLWFAHHSLFLHVRKATRAMGLLNTLSLAFVGGLPLAYQ
QTSAFARQPRDELERVRVSCTIIFLASIFQLAMWTTALLHQAETLQPSVWFGGREHVLMF
AKLALYPCASLLAFASTCLLSRFSVGIFHLMQIAVPCAFLLLRLLVGLALATLRVLRGLA
RPEHPPPAPTGQDDPQSQLLPAPC

Primary citation

Structure of an Apo membrane protein. Shen, C., Fu, T.M., Wang, L.F. et al. To be published.

Other PDB entries of the same protein (UniProt Q9BSA9 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7UNL 2.45 Å, Human TMEM175 in an open state
7UNM 2.61 Å, Human TMEM175 in an closed state
6WC9 2.64 Å, Human open state TMEM175 in KCl
8DHM 2.73 Å, Human TMEM175 in complex with 4-aminopyridine
9VSQ 2.74 Å, The TUG-891-bound structure of TMEM175
9VSR 2.92 Å, The DCY1040 and TUG-891-bound structure of TMEM175
6WCA 3.03 Å, Human closed state TMEM175 in KCl
6WCB 3.17 Å, Human open state TMEM175 in CsCl
6W8N 3.2 Å, Structure of a trans-membrane protein
6WCC 3.24 Å, Human closed state TMEM175 in CsCl
8FYF 3.4 Å, Human TMEM175-LAMP1 transmembrane domain only complex
9VSP 3.4 Å, The DCY1020-bound structure of TMEM175

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