6XU2: Human karyopherin RanBP5

Human karyopherin RanBP5 (isoform-3). Determined by X-ray diffraction at 2.83 Å resolution. Released 22 Apr 2020.

Method
X-ray diffraction
Resolution
2.83 Å
Organisms
Homo sapiens, Actinomycetia
Chains
2
Atoms
8,533
Mol. weight
126.33 kDa
Ligands
NI
Released
22 Apr 2020

Explore 6XU2 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6XU2 contains 70 α-helices and 5 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 70 helices, 5 β-strands

ElementResiduesLengthSheet
α-helix24-3512
α-helix41-5212
α-helix59-635
α-helix65-684
α-helix74-8916
α-helix101-11717
α-helix121-13919
α-helix148-15912
α-helix163-17513
α-helix183-1875
α-helix188-19912
α-helix205-22117
α-helix226-2316
α-helix232-2354
α-helix236-24611
α-helix247-2493
α-helix254-26411
α-helix266-2727
α-helix273-28513
α-helix291-30717
α-helix309-3124
α-helix316-33015
α-helix353-36816
α-helix370-38516
α-helix391-41121
α-helix415-4228
α-helix423-4275
α-helix431-44717
α-helix451-46919
α-helix474-48916
α-helix493-4964
α-helix497-4993
α-helix500-52021
α-helix525-54117
α-helix542-5487
α-helix549-56214
α-helix569-59123
α-helix595-61016
α-helix618-63316
α-helix634-6407
α-helix641-65111
α-helix654-6563
β-strand658-65921
β-strand66212
β-strand675-67841
β-strand68412
β-strand686-68941
α-helix693-71018
α-helix711-7144
α-helix715-72814
α-helix735-75218
α-helix753-7553
α-helix757-77721
α-helix781-79717
α-helix805-83228
α-helix840-87132
α-helix872-8754
α-helix876-8794
α-helix883-8897
α-helix896-91217
α-helix916-9205
α-helix921-93111
α-helix937-95216
α-helix956-9583
α-helix959-97416
α-helix984-100017
α-helix1007-101711
α-helix1018-10203
α-helix1024-103916
α-helix1048-10503
α-helix1053-10608
α-helix1074-108411
α-helix1085-10884
α-helix1090-10989
α-helix1102-111413

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Importin-5Aprotein1115Homo sapiensO00410 (AlphaFold model)
AntipainBprotein4Actinomycetia
Sequence of entity 1 (A), FASTA
>6XU2_1 Importin-5 (chains A)
MPEDQVGKLEATENTISAMAAAAAEQQQFYLLLGNLLSPDNVVRKQAEETYENIPGQSKI
TFLLQAIRNTTAAEEARQMAAVLLRRLLSSAFDEVYPALPSDVQTAIKSELLMIIQMETQ
SSMRKKVCDIAAELARNLIDEDGNNQWPEGLKFLFDSVSSQNVGLREAALHIFWNFPGIF
GNQQQHYLDVIKRMLVQCMQDQEHPSIRTLSARATAAFILANEHNVALFKHFADLLPGFL
QAVNDSCYQNDDSVLKSLVEIADTVPKYLRPHLEATLQLSLKLCGDTSLNNMQRQLALEV
IVTLSETAAAMLRKHTNIVAQTIPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGESA
LDRMACGLGGKLVLPMIKEHIMQMLQNPDWKYRHAGLMALSAIGEGCHQQMEGILNEIVN
FVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFHEKVIAALLQTMEDQGNQRVQAHA
AAALINFTEDCPKSLLIPYLDNLVKHLHSIMVLKLQELIQKGTKLVLEQVVTSIASVADT
AEEKFVPYYDLFMPSLKHIVENAVQKELRLLRGKTIECISLIGLAVGKEKFMQDASDVMQ
LLLKTQTDFNDMEDDDPQISYMISAWARMCKILGKEFQQYLPVVMGPLMKTASIKPEVAL
LDTQDMENMSDDDGWEFVNLGDQQSFGIKTAGLEEKSTACQMLVCYAKELKEGFVEYTEQ
VVKLMVPLLKFYFHDGVRVAAAESMPLLLECARVRGPEYLTQMWHFMCDALIKAIGTEPD
SDVLSEIMHSFAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDE
QVEESLQDEDDNDVYILTKVSDILHSIFSSYKEKVLPWFEQLLPLIVNLICPHRPWPDRQ
WGLCIFDDVIEHCSPASFKYAEYFLRPMLQYVCDNSPEVRQAAAYGLGVMAQYGGDNYRP
FCTEALPLLVRVIQSADSKTKENVNATENCISAVGKIMKFKPDCVNVEEVLPHWLSWLPL
HEDKEEAVQTFNYLCDLIESNHPIVLGPNNTNLPKIFSIIAEGEMHEAIKHEDPCAKRLA
NVVRQVQTSGGLWTECIAQLSPEQQAAIQELLNSA
Sequence of entity 2 (B), FASTA
>6XU2_2 Antipain (chains B)
FRVR

Ligands and cofactors

IDNameFormulaCopies
NINickel (II) ionNi1

Primary citation

X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking. Swale, C., Da Costa, B., Sedano, L. et al. J Mol Biol (2020) 432:3353-3359. DOI 10.1016/j.jmb.2020.03.021 · PubMed

Other PDB entries of the same protein (UniProt O00410 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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