Crystal structure of drosophila melanogaster CENP-C cumin domain. Determined by X-ray diffraction at 1.82 Å resolution. Released 1 Apr 2020.
Explore 6XWU in 3D Show helices and sheets RCSB PDB PDBe
6XWU contains 4 α-helices and 10 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 1275-1287 | 13 | |
| α-helix | 1292-1296 | 5 | |
| α-helix | 1299-1302 | 4 | |
| α-helix | 1309-1311 | 3 | |
| β-strand | 1315-1317 | 3 | 1 |
| β-strand | 1320-1324 | 5 | 1 |
| β-strand | 1333-1338 | 6 | 1 |
| β-strand | 1343-1348 | 6 | 2 |
| β-strand | 1354-1360 | 7 | 1 |
| β-strand | 1362-1368 | 7 | 2 |
| β-strand | 1376-1381 | 6 | 2 |
| β-strand | 1385-1388 | 4 | 1 |
| β-strand | 1393-1398 | 6 | 2 |
| β-strand | 1404-1410 | 7 | 1 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| RE68959p | A | protein | 1411 | Drosophila melanogaster | Q9VHP9 (AlphaFold model) |
>6XWU_1 RE68959p (chains A) MSKPQNNDTLELDDILSQPVKDKERFAAFMMRKLAENKPAQNDNLFGNFKLDFDLDFEVP LIKKSQAKPKSKLPEVQPLGELVSKNSAATEKVNEPPVDQAPNENVPPRRSPTLSPNNRR SMRRSGNVPGSDKLRRHAIRRRSRSCGRQLLPEFEETVNLTRSISSPVNFLPEISSTPCT EKQKEEVAKNTTRVETDKPAEKPMELSQEPEPENPLQTKVTSPARNPILAAEIEQICKER QSSFHKNVLQLDYSGRAPYSRPPTPSSPSVAGLRRTYTMEKGPAPGQLLLSPSHRYDTPS KMPVVKAKRFNQELMVPDTPERQSHDPAWQSEPQPEFVVPETQPQDLGELVQTLSRSAIS PIVVINTSNSNRSVRRDAVAMKSVPTSPVTALSSPPIAPSPRRSAAASPQKSIAQLPRVE ENMDAIMTDDESDEHPSTVPLNLAPSGGNTTRQRRLRSSNRARATIESQESSMRLLNLHK SVNAKKSKPRKTAIPLNKAPSAPINGEQFARELTRMSNYEILDLRKRNSLNEIYPLNGHR NHRSEKLILEEEIQRELLRRNLMDEAEGLPKQQSSDDSNEDYIPVPPKTQSLRTKSNDRS QGRGRPRSTRRDLPMTTELVNYLGLSQTLETRRKSSKDGKRCLYTKGSSDHEDNDSLSPV KLPRLSKSIQIVPPPPVSLRYSQSLQNLPCSGKFDFDNVVMAAPPDFHDSVNSDAIEIAP PPPEYVVNTRGRSTSGRKSNKNDLVLPPPGYEGGQEEEHDERPSQPRCTAKELQQSTQNG RRAMENELVPPPIEYVEEENRNNEQSRRSTKNGNLVDRNTHNAVEYCEPPEPPEYDDSDH GQASILRRSGKKLQHSKQSVQKSNKEQIIAPSYENNEDYDSDEEPIYNEEYGKEESQNKN VTRRKSDKDEMASHTLECIEGPDPNWNSSCNKQNRNHQNASKSKENDKLANRSSKSQKLS NPRQNAVGTEKSVALSNRGEECTEKSSDVMESLRVNTPTPPIDQNSDDVPSRNPSPSRTL LSDDVPSTSRAALEFLQRSQNMSKSRPPDESSADVVFKKPLAPAPRAKSKKGKSEVDKLK LAKMPVEAEELNTTGIRRSKRGQVPLQMSWCHTMDPSKFNFMSGFIEPRSKNSKTKKGNL SKAKKASATKPKPTVEKNLPDNRGPLCSSTPRISEKLPGAIPHSESLGLSTLTWEETEVQ AEAEKVPKKRGRPKKAVGGVQTDTEAEPEPEPEPMISSVAPLTSDQEEPDVPDEQAPYTE AALGPVVFSTPLRDEQEEASTKLMQWLRGVGDAPPSASMSDENASVSSANELIFYQVDGI DYAFYNTKEKAMLGYMRFKPYQKRSMKQAKVHPLKLLVQFGEFNVETLAVGEEKEVHSVL RVGDMIEIDRGTRYSIQNAIDKVSVLMCIRS
Structural basis for centromere maintenance by Drosophila CENP-A chaperone CAL1. Medina-Pritchard, B., Lazou, V., Zou, J. et al. EMBO J (2020) 39:e103234-e103234. DOI 10.15252/embj.2019103234 · PubMed
Other PDB entries of the same protein (UniProt Q9VHP9 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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