Crystal structure of drosophila melanogaster CENP-C bound to CAL1. Determined by X-ray diffraction at 2.27 Å resolution. Released 1 Apr 2020.
Explore 6XWV in 3D Show helices and sheets RCSB PDB PDBe
6XWV contains 14 α-helices and 45 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 1275-1287 | 13 | |
| β-strand | 1306-1307 | 2 | 1 |
| α-helix | 1309-1311 | 3 | |
| β-strand | 1314-1317 | 4 | 2 |
| β-strand | 1320-1324 | 5 | 2 |
| β-strand | 1333-1338 | 6 | 2 |
| β-strand | 1343-1348 | 6 | 3 |
| β-strand | 1354-1360 | 7 | 2 |
| β-strand | 1362-1368 | 7 | 3 |
| α-helix | 1374-1375 | 2 | |
| β-strand | 1376-1381 | 6 | 3 |
| β-strand | 1385-1388 | 4 | 2 |
| β-strand | 1393-1398 | 6 | 3 |
| β-strand | 1404-1409 | 6 | 2 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 1275-1287 | 13 | |
| β-strand | 1306-1307 | 2 | 2 |
| α-helix | 1309-1311 | 3 | |
| β-strand | 1314-1317 | 4 | 1 |
| β-strand | 1320-1324 | 5 | 1 |
| β-strand | 1333-1338 | 6 | 1 |
| β-strand | 1343-1348 | 6 | 4 |
| β-strand | 1354-1360 | 7 | 1 |
| β-strand | 1363-1368 | 6 | 4 |
| α-helix | 1375 | 1 | |
| β-strand | 1376-1380 | 5 | 4 |
| β-strand | 1385-1388 | 4 | 1 |
| β-strand | 1393-1398 | 6 | 4 |
| β-strand | 1404-1410 | 7 | 1 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 1275-1287 | 13 | |
| β-strand | 1306-1307 | 2 | 5 |
| α-helix | 1309-1311 | 3 | |
| β-strand | 1315-1317 | 3 | 6 |
| β-strand | 1320-1324 | 5 | 6 |
| β-strand | 1333-1338 | 6 | 6 |
| β-strand | 1343-1348 | 6 | 7 |
| β-strand | 1354-1360 | 7 | 6 |
| β-strand | 1363-1368 | 6 | 7 |
| α-helix | 1375 | 1 | |
| β-strand | 1376-1380 | 5 | 7 |
| β-strand | 1385-1388 | 4 | 6 |
| β-strand | 1393-1398 | 6 | 7 |
| β-strand | 1404-1410 | 7 | 6 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 1275-1287 | 13 | |
| β-strand | 1307 | 1 | 6 |
| α-helix | 1309-1311 | 3 | |
| β-strand | 1314-1317 | 4 | 5 |
| β-strand | 1320-1324 | 5 | 5 |
| β-strand | 1333-1338 | 6 | 5 |
| β-strand | 1343-1348 | 6 | 8 |
| β-strand | 1354-1360 | 7 | 5 |
| β-strand | 1363-1368 | 6 | 8 |
| α-helix | 1375 | 1 | |
| β-strand | 1376-1380 | 5 | 8 |
| β-strand | 1385-1388 | 4 | 5 |
| β-strand | 1393-1398 | 6 | 8 |
| β-strand | 1404-1409 | 6 | 5 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 891 | 1 | 2 |
| α-helix | 893-908 | 16 | |
| α-helix | 909-911 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Calmodulin | A, B, C, D | protein | 1411 | Drosophila melanogaster | Q9VHP9 (AlphaFold model) |
| Ryanodine Receptor 2 | E | protein | 979 | Drosophila melanogaster | Q9VEN2 (AlphaFold model) |
>6XWV_1 Calmodulin (chains A, B, C, D) MSKPQNNDTLELDDILSQPVKDKERFAAFMMRKLAENKPAQNDNLFGNFKLDFDLDFEVP LIKKSQAKPKSKLPEVQPLGELVSKNSAATEKVNEPPVDQAPNENVPPRRSPTLSPNNRR SMRRSGNVPGSDKLRRHAIRRRSRSCGRQLLPEFEETVNLTRSISSPVNFLPEISSTPCT EKQKEEVAKNTTRVETDKPAEKPMELSQEPEPENPLQTKVTSPARNPILAAEIEQICKER QSSFHKNVLQLDYSGRAPYSRPPTPSSPSVAGLRRTYTMEKGPAPGQLLLSPSHRYDTPS KMPVVKAKRFNQELMVPDTPERQSHDPAWQSEPQPEFVVPETQPQDLGELVQTLSRSAIS PIVVINTSNSNRSVRRDAVAMKSVPTSPVTALSSPPIAPSPRRSAAASPQKSIAQLPRVE ENMDAIMTDDESDEHPSTVPLNLAPSGGNTTRQRRLRSSNRARATIESQESSMRLLNLHK SVNAKKSKPRKTAIPLNKAPSAPINGEQFARELTRMSNYEILDLRKRNSLNEIYPLNGHR NHRSEKLILEEEIQRELLRRNLMDEAEGLPKQQSSDDSNEDYIPVPPKTQSLRTKSNDRS QGRGRPRSTRRDLPMTTELVNYLGLSQTLETRRKSSKDGKRCLYTKGSSDHEDNDSLSPV KLPRLSKSIQIVPPPPVSLRYSQSLQNLPCSGKFDFDNVVMAAPPDFHDSVNSDAIEIAP PPPEYVVNTRGRSTSGRKSNKNDLVLPPPGYEGGQEEEHDERPSQPRCTAKELQQSTQNG RRAMENELVPPPIEYVEEENRNNEQSRRSTKNGNLVDRNTHNAVEYCEPPEPPEYDDSDH GQASILRRSGKKLQHSKQSVQKSNKEQIIAPSYENNEDYDSDEEPIYNEEYGKEESQNKN VTRRKSDKDEMASHTLECIEGPDPNWNSSCNKQNRNHQNASKSKENDKLANRSSKSQKLS NPRQNAVGTEKSVALSNRGEECTEKSSDVMESLRVNTPTPPIDQNSDDVPSRNPSPSRTL LSDDVPSTSRAALEFLQRSQNMSKSRPPDESSADVVFKKPLAPAPRAKSKKGKSEVDKLK LAKMPVEAEELNTTGIRRSKRGQVPLQMSWCHTMDPSKFNFMSGFIEPRSKNSKTKKGNL SKAKKASATKPKPTVEKNLPDNRGPLCSSTPRISEKLPGAIPHSESLGLSTLTWEETEVQ AEAEKVPKKRGRPKKAVGGVQTDTEAEPEPEPEPMISSVAPLTSDQEEPDVPDEQAPYTE AALGPVVFSTPLRDEQEEASTKLMQWLRGVGDAPPSASMSDENASVSSANELIFYQVDGI DYAFYNTKEKAMLGYMRFKPYQKRSMKQAKVHPLKLLVQFGEFNVETLAVGEEKEVHSVL RVGDMIEIDRGTRYSIQNAIDKVSVLMCIRS
>6XWV_2 Ryanodine Receptor 2 (chains E) MANAVVDEETLEAMVYERSKAWSSKMADFASLEDGMEIDVAEFDNLFHGEDEDPDLDDVA KEAVEDNVPDEAKLEMGHINATSVTELTLILCANEDNEAKAEIEEILNQTVPVVEEHKRK WREAGLDRILDTFDEKQIEHHVGRWMRRHNSVYLEASPPKYLPPHHNSISDESDESMHSI DTARYIQQSRRRNAHMTNKNMTTIKMYRKHSHKRDELRAKYAYGDEQEHRHHMQAVLLRR RERERQLAYLASTPMQCVYSSGHHMRRKNLRKRRINSWMFDSASSSEEDTSFGGCDCHSC RRHYALSRSVYQSCPYGRGQREYHHRQMASRTMHTMRRQHTFDMEMDLRPRLPENECSCC NSDRLCSNVIHIANSSTEEWVVENRSNHLTQETQEKTRKQKHQPMDARKVSHQPVCSKGH EQKPLSSKATSVSKLVLSKEKYMQMFDSESSDEDNALAKKGLLCCSDKKKGMTFPTPNAA GKITHPTSSAKKAIRKEARPNGLAQIQEEGPTATNSPIESTYLPVAHMKSVSIDGSSGTS ATFESPAKKAPKRGIRETSPLNGNELQQLISTIPIADEKASSLMEKVDNCIGRESFDDRN KDFMHMENSSTKTAVEKSTKQKRVSGKKSEIPKSIITNNEILEKNSTETLSEKQVAAKAK KQSVRKTGATGKPSTSRLKKSEKTKTTSSVTSTSKLEQVREEESDVSSEVLAKPKPQCST TASILKQGGDGASNSEDDLQIALAMSKATYKEEQQKRKKTKREPSNKQPQSPAEKSMTVF NNQSVACNSTALANDTACYRVLPKRRGVKRAAAVSTTEEKTATNSSSSPTSSLEEMGSPT GGDPDCTVVTSTTGCEPPASERQEIPATIKITKRGILLHSPSAPEGASFTLTEQGLGKII GERWARKYLKYHIGSRSFDSRHSVYYQPTPQLAAALSAPQDAQNIGNISGSSASDDDIFE QINRYGTVYSILENNSGDK
Structural basis for centromere maintenance by Drosophila CENP-A chaperone CAL1. Medina-Pritchard, B., Lazou, V., Zou, J. et al. EMBO J (2020) 39:e103234-e103234. DOI 10.15252/embj.2019103234 · PubMed
Other PDB entries of the same protein (UniProt Q9VHP9 (AlphaFold model), which also has an AlphaFold model), best resolution first:
MolViewer shows 6XWV directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.