Kinesin binding protein complexed with Kif15 motor domain. Determined by electron microscopy at 6.9 Å resolution. Released 30 Dec 2020.
Explore 6ZPH in 3D Show helices and sheets RCSB PDB PDBe
6ZPH contains 30 α-helices and 17 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 6-22 | 17 | |
| α-helix | 35-49 | 15 | |
| α-helix | 88-108 | 21 | |
| α-helix | 112-126 | 15 | |
| α-helix | 137-152 | 16 | |
| α-helix | 155-172 | 18 | |
| α-helix | 201-220 | 20 | |
| α-helix | 224-238 | 15 | |
| α-helix | 250-262 | 13 | |
| α-helix | 268-281 | 14 | |
| α-helix | 306-329 | 24 | |
| α-helix | 393-412 | 20 | |
| α-helix | 417-431 | 15 | |
| α-helix | 438-461 | 24 | |
| α-helix | 464-493 | 30 | |
| α-helix | 500-523 | 24 | |
| α-helix | 541-556 | 16 | |
| α-helix | 564-582 | 19 | |
| α-helix | 590-606 | 17 | |
| α-helix | 608-611 | 4 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 28-33 | 6 | 1 |
| β-strand | 51-53 | 3 | 2 |
| β-strand | 58-61 | 4 | 2 |
| β-strand | 68-71 | 4 | 2 |
| β-strand | 74-75 | 2 | 1 |
| α-helix | 82-85 | 4 | |
| α-helix | 86-91 | 6 | |
| α-helix | 92-98 | 7 | |
| β-strand | 104-105 | 2 | 1 |
| α-helix | 115 | 1 | |
| α-helix | 116-120 | 5 | |
| α-helix | 135-150 | 16 | |
| β-strand | 161-170 | 10 | 1 |
| β-strand | 173-175 | 3 | 1 |
| β-strand | 183 | 1 | 1 |
| β-strand | 187-189 | 3 | 3 |
| β-strand | 195-197 | 3 | 3 |
| β-strand | 203 | 1 | 1 |
| α-helix | 208-227 | 20 | |
| β-strand | 237-245 | 9 | 1 |
| β-strand | 247 | 1 | 4 |
| β-strand | 256 | 1 | 4 |
| β-strand | 259-265 | 7 | 1 |
| α-helix | 289-303 | 15 | |
| α-helix | 319-325 | 7 | |
| β-strand | 335-340 | 6 | 1 |
| α-helix | 347-361 | 15 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| KIF-binding protein | A | protein | 621 | Homo sapiens | Q96EK5 (AlphaFold model) |
| Kinesin-like protein KIF15 | B | protein | 383 | Homo sapiens | Q9NS87 (AlphaFold model) |
>6ZPH_1 KIF-binding protein (chains A) MANVPWAEVCEKFQAALALSRVELHKNPEKEPYKSKYSARALLEEVKALLGPAPEDEDER PEAEDGPGAGDHALGLPAEVVEPEGPVAQRAVRLAVIEFHLGVNHIDTEELSAGEEHLVK CLRLLRRYRLSHDCISLCIQAQNNLGILWSEREEIETAQAYLESSEALYNQYMKEVGSPP LDPTERFLPEEEKLTEQERSKRFEKVYTHNLYYLAQVYQHLEMFEKAAHYCHSTLKRQLE HNAYHPIEWAINAATLSQFYINKLCFMEARHCLSAANVIFGQTGKISATEDTPEAEGEVP ELYHQRKGEIARCWIKYCLTLMQNAQLSMQDNIGELDLDKQSELRALRKKELDEEESIRK KAVQFGTGELCDAISAVEEKVSYLRPLDFEEARELFLLGQHYVFEAKEFFQIDGYVTDHI EVVQDHSALFKVLAFFETDMERRCKMHKRRIAMLEPLTVDLNPQYYLLVNRQIQFEIAHA YYDMMDLKVAIADRLRDPDSHIVKKINNLNKSALKYYQLFLDSLRDPNKVFPEHIGEDVL RPAMLAKFRVARLYGKIITADPKKELENLATSLEHYKFIVDYCEKHPEAAQEIEVELELS KEMVSLLPTKMERFRTKMALT
>6ZPH_2 Kinesin-like protein KIF15 (chains B) MAPGSKTELRSVTNGQSNQPSNEGDAIKVFVRIRPPAERSGSADGEQNLSLSVLSSTSLR LHSNPEPKTFTFDHVADVDTTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMM GPSESDNFSHNLRGVIPRSFEYLFSLIDREKEKAGAGKSFLSKCSFIEIYNEQIYDLLDS ASAGLYLREHIKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVF TITIESMEKCNEIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSTLGQVIT ALVDVGNGKQRHVSYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRSFGETLSTLNFAQRA KLIKNKAVVNEDTQCLEHHHHHH
The mechanism of kinesin inhibition by kinesin-binding protein. Atherton, J., Hummel, J.J., Olieric, N. et al. Elife (2020) 9. DOI 10.7554/eLife.61481 · PubMed
Other PDB entries of the same protein (UniProt Q96EK5 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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