6ZYM: Corepressor interacting with RBPJ 1
Human C Complex Spliceosome - High-resolution CORE. Determined by electron microscopy at 3.4 Å resolution. Released 14 Oct 2020.
- Method
- Electron microscopy
- Resolution
- 3.4 Å
- Organism
- Homo sapiens
- Chains
- 26
- Atoms
- 48,271
- Mol. weight
- 1956.93 kDa
- Ligands
- MG, IHP, GTP, ZN
- Released
- 14 Oct 2020
Explore 6ZYM in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
6ZYM contains 210 α-helices and 217 β-strands across 20 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 77 helices, 41 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 28-44 | 17 | |
| α-helix | 63-73 | 11 | |
| α-helix | 85-90 | 6 | |
| α-helix | 95-103 | 9 | |
| α-helix | 106-108 | 3 | |
| β-strand | 115-121 | 7 | 1 |
| β-strand | 127-129 | 3 | 1 |
| β-strand | 134 | 1 | 2 |
| α-helix | 137-155 | 19 | |
| α-helix | 163-165 | 3 | |
| α-helix | 174-177 | 4 | |
| β-strand | 220 | 1 | 3 |
| β-strand | 228 | 1 | 3 |
| β-strand | 229 | 1 | 4 |
| α-helix | 232-241 | 10 | |
| α-helix | 260-268 | 9 | |
| α-helix | 312-315 | 4 | |
| α-helix | 357-359 | 3 | |
| α-helix | 373-375 | 3 | |
| α-helix | 377-379 | 3 | |
| α-helix | 381-383 | 3 | |
| α-helix | 398-403 | 6 | |
| β-strand | 415 | 1 | 4 |
| β-strand | 420 | 1 | 2 |
| α-helix | 421-423 | 3 | |
| α-helix | 428-432 | 5 | |
| α-helix | 434-436 | 3 | |
| α-helix | 441-459 | 19 | |
| α-helix | 462-465 | 4 | |
| α-helix | 472-477 | 6 | |
| β-strand | 482-488 | 7 | 1 |
| α-helix | 489-504 | 16 | |
| α-helix | 507-510 | 4 | |
| β-strand | 516-518 | 3 | 5 |
| β-strand | 524-526 | 3 | 5 |
| α-helix | 532-538 | 7 | |
| α-helix | 542-565 | 24 | |
| α-helix | 571-583 | 13 | |
| α-helix | 585-588 | 4 | |
| α-helix | 599-616 | 18 | |
| α-helix | 631-660 | 30 | |
| α-helix | 669-671 | 3 | |
| α-helix | 679-696 | 18 | |
| α-helix | 711-721 | 11 | |
| α-helix | 733-763 | 31 | |
| α-helix | 769-796 | 28 | |
| α-helix | 804-819 | 16 | |
| α-helix | 822-824 | 3 | |
| β-strand | 825 | 1 | 6 |
| α-helix | 826-829 | 4 | |
| α-helix | 833-835 | 3 | |
| α-helix | 836-848 | 13 | |
| α-helix | 858-872 | 15 | |
| α-helix | 875-887 | 13 | |
| β-strand | 894-900 | 7 | 7 |
| β-strand | 905-910 | 6 | 7 |
| α-helix | 913-931 | 19 | |
| β-strand | 940-941 | 2 | 8 |
| α-helix | 948-960 | 13 | |
| β-strand | 973-980 | 8 | 8 |
| α-helix | 991-997 | 7 | |
| β-strand | 1001 | 1 | 6 |
| α-helix | 1003-1012 | 10 | |
| β-strand | 1016-1018 | 3 | 7 |
| β-strand | 1023-1025 | 3 | 7 |
| α-helix | 1037-1053 | 17 | |
| α-helix | 1056-1062 | 7 | |
| β-strand | 1085-1091 | 7 | 8 |
| β-strand | 1094-1101 | 8 | 8 |
| α-helix | 1103-1113 | 11 | |
| α-helix | 1136-1138 | 3 | |
| α-helix | 1140-1142 | 3 | |
| α-helix | 1144-1160 | 17 | |
| α-helix | 1170-1172 | 3 | |
| β-strand | 1174-1178 | 5 | 8 |
| β-strand | 1185-1189 | 5 | 9 |
| β-strand | 1192-1198 | 7 | 9 |
| β-strand | 1213-1214 | 2 | 9 |
| β-strand | 1226-1232 | 7 | 9 |
| α-helix | 1234-1249 | 16 | |
| α-helix | 1256-1271 | 16 | |
| α-helix | 1282-1301 | 20 | |
| α-helix | 1313-1317 | 5 | |
| α-helix | 1320-1322 | 3 | |
| β-strand | 1335 | 1 | 10 |
| β-strand | 1354 | 1 | 10 |
| α-helix | 1368-1371 | 4 | |
| α-helix | 1376-1397 | 22 | |
| α-helix | 1405-1407 | 3 | |
| α-helix | 1419-1421 | 3 | |
| α-helix | 1429-1432 | 4 | |
| α-helix | 1436-1442 | 7 | |
| α-helix | 1443-1445 | 3 | |
| α-helix | 1450-1451 | 2 | |
| α-helix | 1471-1478 | 8 | |
| α-helix | 1491-1493 | 3 | |
| β-strand | 1502 | 1 | 11 |
| α-helix | 1531-1537 | 7 | |
| α-helix | 1539-1542 | 4 | |
| β-strand | 1552-1553 | 2 | 12 |
| β-strand | 1562-1563 | 2 | 12 |
| α-helix | 1567-1576 | 10 | |
| α-helix | 1581-1599 | 19 | |
| β-strand | 1606-1608 | 3 | 13 |
| β-strand | 1611 | 1 | 14 |
| α-helix | 1612-1615 | 4 | |
| β-strand | 1629-1630 | 2 | 14 |
| β-strand | 1632-1633 | 2 | 13 |
| α-helix | 1639-1642 | 4 | |
| β-strand | 1643 | 1 | 15 |
| β-strand | 1661-1667 | 7 | 14 |
| α-helix | 1676-1687 | 12 | |
| β-strand | 1700-1706 | 7 | 14 |
| β-strand | 1712-1713 | 2 | 14 |
| β-strand | 1716 | 1 | 15 |
| α-helix | 1723-1735 | 13 | |
| α-helix | 1738-1751 | 14 | |
| β-strand | 1754 | 1 | 11 |
Chain B: 40 helices, 44 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 69-72 | 4 | |
| β-strand | 78 | 1 | 16 |
| α-helix | 95-97 | 3 | |
| β-strand | 103 | 1 | 17 |
| α-helix | 116-125 | 10 | |
| β-strand | 129-130 | 2 | 18 |
| β-strand | 132-136 | 5 | 19 |
| α-helix | 142-152 | 11 | |
| β-strand | 171 | 1 | 17 |
| α-helix | 174-177 | 4 | |
| β-strand | 185 | 1 | 19 |
| β-strand | 188-190 | 3 | 18 |
| β-strand | 198-200 | 3 | 18 |
| β-strand | 203-204 | 2 | 19 |
| α-helix | 209-211 | 3 | |
| α-helix | 213-219 | 7 | |
| β-strand | 224-230 | 7 | 19 |
| α-helix | 237-248 | 12 | |
| β-strand | 252-258 | 7 | 19 |
| α-helix | 271-292 | 22 | |
| β-strand | 309-311 | 3 | 20 |
| β-strand | 316-318 | 3 | 20 |
| α-helix | 320-330 | 11 | |
| α-helix | 336-339 | 4 | |
| α-helix | 340-342 | 3 | |
| β-strand | 348-349 | 2 | 21 |
| β-strand | 356-357 | 2 | 21 |
| α-helix | 370-374 | 5 | |
| α-helix | 375-386 | 12 | |
| α-helix | 392-396 | 5 | |
| α-helix | 412-423 | 12 | |
| α-helix | 428-437 | 10 | |
| α-helix | 439-440 | 2 | |
| α-helix | 445-452 | 8 | |
| β-strand | 453 | 1 | 22 |
| α-helix | 460-464 | 5 | |
| β-strand | 475-482 | 8 | 23 |
| β-strand | 491-498 | 8 | 23 |
| β-strand | 501-502 | 2 | 24 |
| β-strand | 506-509 | 4 | 23 |
| β-strand | 523-526 | 4 | 23 |
| β-strand | 530-533 | 4 | 25 |
| β-strand | 538-541 | 4 | 25 |
| β-strand | 543-544 | 2 | 24 |
| β-strand | 549-550 | 2 | 23 |
| β-strand | 565-566 | 2 | 23 |
| α-helix | 576 | 1 | |
| β-strand | 577 | 1 | 22 |
| α-helix | 578-580 | 3 | |
| β-strand | 588-594 | 7 | 26 |
| α-helix | 597-599 | 3 | |
| α-helix | 600-613 | 14 | |
| β-strand | 618-621 | 4 | 26 |
| β-strand | 627-631 | 5 | 26 |
| α-helix | 634-642 | 9 | |
| α-helix | 643-648 | 6 | |
| β-strand | 653-655 | 3 | 26 |
| β-strand | 659-660 | 2 | 26 |
| β-strand | 663-666 | 4 | 27 |
| β-strand | 685-690 | 6 | 28 |
| α-helix | 696-701 | 6 | |
| α-helix | 711-722 | 12 | |
| α-helix | 726-730 | 5 | |
| α-helix | 737-739 | 3 | |
| β-strand | 743-747 | 5 | 28 |
| α-helix | 756-761 | 6 | |
| α-helix | 768-771 | 4 | |
| β-strand | 784 | 1 | 27 |
| β-strand | 787-794 | 8 | 28 |
| α-helix | 805-821 | 17 | |
| β-strand | 825-837 | 13 | 27 |
| β-strand | 838-839 | 2 | 29 |
| α-helix | 841-843 | 3 | |
| α-helix | 844-851 | 8 | |
| β-strand | 856-859 | 4 | 27 |
| β-strand | 862 | 1 | 29 |
| α-helix | 863 | 1 | |
| β-strand | 868-869 | 2 | 29 |
| β-strand | 872-876 | 5 | 27 |
| α-helix | 878-880 | 3 | |
| α-helix | 883-887 | 5 | |
| β-strand | 896-906 | 11 | 27 |
| α-helix | 926-928 | 3 | |
| α-helix | 929-941 | 13 | |
Chain C: 13 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 88-90 | 3 | |
| β-strand | 92 | 1 | 30 |
| β-strand | 96 | 1 | 30 |
| α-helix | 99-101 | 3 | |
| α-helix | 117-119 | 3 | |
| α-helix | 121-124 | 4 | |
| α-helix | 134-136 | 3 | |
| α-helix | 137-162 | 26 | |
| β-strand | 176-180 | 5 | 31 |
| β-strand | 195-199 | 5 | 31 |
| α-helix | 201-205 | 5 | |
| α-helix | 225-228 | 4 | |
| α-helix | 233-234 | 2 | |
| α-helix | 236-238 | 3 | |
| α-helix | 239-242 | 4 | |
| α-helix | 247-250 | 4 | |
| α-helix | 283-301 | 19 | |
Chain D: 2 helices, 30 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 187-190 | 4 | |
| α-helix | 192-193 | 2 | |
| β-strand | 194-200 | 7 | 16 |
| β-strand | 207-212 | 6 | 32 |
| β-strand | 218-223 | 6 | 32 |
| β-strand | 228-232 | 5 | 32 |
| β-strand | 238-242 | 5 | 32 |
| β-strand | 249-254 | 6 | 33 |
| β-strand | 260-265 | 6 | 33 |
| β-strand | 270 | 1 | 34 |
| β-strand | 272-274 | 3 | 33 |
| β-strand | 279-280 | 2 | 33 |
| β-strand | 284 | 1 | 34 |
| β-strand | 291-296 | 6 | 35 |
| β-strand | 302-307 | 6 | 35 |
| β-strand | 312-316 | 5 | 35 |
| β-strand | 322-326 | 5 | 35 |
| β-strand | 333-338 | 6 | 36 |
| β-strand | 345-349 | 5 | 36 |
| β-strand | 354-357 | 4 | 36 |
| β-strand | 364-368 | 5 | 36 |
| β-strand | 377-380 | 4 | 37 |
| β-strand | 387-390 | 4 | 37 |
| β-strand | 395-397 | 3 | 37 |
| β-strand | 407-409 | 3 | 37 |
| β-strand | 416-421 | 6 | 38 |
| β-strand | 426-431 | 6 | 38 |
| β-strand | 435-440 | 6 | 38 |
| β-strand | 446-451 | 6 | 38 |
| β-strand | 465-470 | 6 | 16 |
| β-strand | 476-481 | 6 | 16 |
| β-strand | 486-491 | 6 | 16 |
Chain E: 2 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| α-helix | 90-92 | 3 | |
| β-strand | 114-118 | 5 | 31 |
| α-helix | 122-134 | 13 | |
Chain F: 0 helices, 34 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 61-63 | 3 | 39 |
| β-strand | 69-74 | 6 | 40 |
| β-strand | 80 | 1 | 41 |
| β-strand | 81-85 | 5 | 40 |
| β-strand | 90-92 | 3 | 40 |
| β-strand | 94 | 1 | 41 |
| β-strand | 103-105 | 3 | 40 |
| β-strand | 112-114 | 3 | 42 |
| β-strand | 117 | 1 | 43 |
| β-strand | 124 | 1 | 43 |
| β-strand | 125-128 | 4 | 42 |
| β-strand | 133-135 | 3 | 42 |
| β-strand | 145-147 | 3 | 42 |
| β-strand | 154-158 | 5 | 44 |
| β-strand | 167-171 | 5 | 44 |
| β-strand | 176-179 | 4 | 44 |
| β-strand | 198-200 | 3 | 45 |
| β-strand | 207-211 | 5 | 45 |
| β-strand | 217-221 | 5 | 45 |
| β-strand | 226 | 1 | 45 |
| β-strand | 230-231 | 2 | 45 |
| β-strand | 238-243 | 6 | 46 |
| β-strand | 250-254 | 5 | 46 |
| β-strand | 258-262 | 5 | 46 |
| β-strand | 275-278 | 4 | 46 |
| β-strand | 291-293 | 3 | 47 |
| β-strand | 300-302 | 3 | 47 |
| β-strand | 309-311 | 3 | 47 |
| β-strand | 321-323 | 3 | 47 |
| β-strand | 330-335 | 6 | 39 |
| β-strand | 337 | 1 | 48 |
| β-strand | 339 | 1 | 48 |
| β-strand | 341-346 | 6 | 39 |
| β-strand | 350-355 | 6 | 39 |
Chain L: 11 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 13-25 | 13 | |
| α-helix | 31-34 | 4 | |
| α-helix | 43-49 | 7 | |
| α-helix | 50-54 | 5 | |
| α-helix | 65-77 | 13 | |
| α-helix | 86-89 | 4 | |
| α-helix | 93-109 | 17 | |
| α-helix | 148-159 | 12 | |
| α-helix | 168-194 | 27 | |
| α-helix | 208-209 | 2 | |
| α-helix | 219-222 | 4 | |
Chain O: 16 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 191-199 | 9 | |
| α-helix | 219-237 | 19 | |
| α-helix | 243-253 | 11 | |
| α-helix | 258-271 | 14 | |
| α-helix | 277-288 | 12 | |
| α-helix | 292-305 | 14 | |
| α-helix | 310-322 | 13 | |
| α-helix | 326-336 | 11 | |
| α-helix | 337-339 | 3 | |
| α-helix | 343-356 | 14 | |
| α-helix | 360-372 | 13 | |
| α-helix | 376-386 | 11 | |
| α-helix | 387-389 | 3 | |
| α-helix | 392-405 | 14 | |
| α-helix | 416-423 | 8 | |
| α-helix | 432-438 | 7 | |
12 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| U2 snRNA | 2 | RNA | 188 | Homo sapiens | |
| U5 snRNA | 5 | RNA | 116 | Homo sapiens | |
| U6 snRNA | 6 | RNA | 79 | Homo sapiens | |
| Corepressor interacting with RBPJ 1 | 9 | protein | 450 | Homo sapiens | Q86X95 (AlphaFold model) |
| Pre-mRNA-processing-splicing factor 8 | A | protein | 1755 | Homo sapiens | Q6P2Q9 (AlphaFold model) |
| 116 kDa U5 small nuclear ribonucleoprotein component | B | protein | 952 | Homo sapiens | Q15029 (AlphaFold model) |
| SNW domain-containing protein 1 | C | protein | 536 | Homo sapiens | Q13573 (AlphaFold model) |
| Pleiotropic regulator 1 | D | protein | 514 | Homo sapiens | O43660 |
| Pre-mRNA-processing factor 17 | E | protein | 579 | Homo sapiens | O60508 |
| U5 small nuclear ribonucleoprotein 40 kDa protein | F | protein | 357 | Homo sapiens | Q96DI7 |
| Cell division cycle 5-like protein | L | protein | 802 | Homo sapiens | Q99459 |
| Crooked neck-like protein 1 | O | protein | 848 | Homo sapiens | Q9BZJ0 |
13 more molecules are not listed.
Sequence of entity 1 (2), FASTA
>6ZYM_1 U2 snRNA (chains 2)
AUCGCUUCUCGGCCUUUUGGCUAAGAUCAAGUGUAGUAUCUGUUCUUAUCAGUUUAAUAU
CUGAUACGUCCUCUAUCCGAGGACAAUAUAUUAAAUGGAUUUUUGGAGCAGGGAGAUGGA
AUAGGAGCUUGCUCCGUCCACUCCACGCAUCGACCUGGUAUUGCAGUACCUCCAGGAACG
GUGCACCC
Sequence of entity 2 (5), FASTA
>6ZYM_2 U5 snRNA (chains 5)
AUACUCUGGUUUCUCUUCAGAUCGCAUAAAUCUUUCGCCUUUUACUAAAGAUUUCCGUGG
AGAGGAACAACUCUGAGUCUUAACCCAAUUUUUUGAGCCUUGCCUUGGCAAGGCUA
Sequence of entity 3 (6), FASTA
>6ZYM_3 U6 snRNA (chains 6)
GUGCUCGCUUCGGCAGCACAUAUACUAAAAUUGGAACGAUACAGAGAAGAUUAGCAUGGC
CCCUGCGCAAGGAUGACAC
Sequence of entity 4 (9), FASTA
>6ZYM_4 Corepressor interacting with RBPJ 1 (chains 9)
MGKSFANFMCKKDFHPASKSNIKKVWMAEQKISYDKKKQEELMQQYLKEQESYDNRLLMG
DERVKNGLNFMYEAPPGAKKENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFG
IQVRNVRCIKCHKWGHVNTDRECPLFGLSGINASSVPTDGSGPSMHPSELIAEMRNSGFA
LKRNVLGRNLTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDR
KKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCS
GHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSR
THKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRND
SRSHGTDLYRGEKMYREHPGGTHTKVTQRE
Sequence of entity 5 (A), FASTA
>6ZYM_5 Pre-mRNA-processing-splicing factor 8 (chains A)
MAGVFPYRGPGNPVPGPLAPLPDYMSEEKLQEKARKWQQLQAKRYAEKRKFGFVDAQKED
MPPEHVRKIIRDHGDMTNRKFRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVPVLY
HITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYAD
NILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYR
LANQLLTDLVDDNYFYLFDLKAFFTSKALNMAIPGGPKFEPLVRDINLQDEDWNEFNDIN
KIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKTEDPDLPAFYFDPLINPIS
HRHSVKSQEPLPDDDEEFELPEFVEPFLKDTPLYTDNTANGIALLWAPRPFNLRSGRTRR
ALDIPLVKNWYREHCPAGQPVKVRVSYQKLLKYYVLNALKHRPPKAQKKRYLFRSFKATK
FFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRF
GNAFHLCREVLRLTKLVVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMR
QIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAAGWRVWLFFMRGITPLLERWLGNLLARQF
EGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARTILQHLSEAWRCW
KANIPWKVPGLPTPIENMILRYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLT
RLYLKAEQERQHNYLKDGPYITAEEAVAVYTTTVHWLESRRFSPIPFPPLSYKHDTKLLI
LALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMD
LYSHLVPVYDVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPADTEPPPLLVYKWCQGIN
NLQDVWETSEGECNVMLESRFEKMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYK
DMNHTNSYGIIRGLQFASFIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATE
AAHPIRLFCRYIDRIHIFFRFTADEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARM
RLMKHDVNLGRAVFWDIKNRLPRSVTTVQWENSFVSVYSKDNPNLLFNMCGFECRILPKC
RTSYEEFTHKDGVWNLQNEVTKERTAQCFLRVDDESMQRFHNRVRQILMASGSTTFTKIV
NKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPK
ELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHEEDQLIPNLYRYIQPWESEFI
DSQRVWAEYALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRT
DFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEG
LFWEKASGFEESMKWKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGI
FMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQKETIHPRKSY
KMNSSCADILLFASYKWNVSRPSLLADSKDVMDSTTTQKYWIDIQLRWGDYDSHDIERYA
RAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGSKPLIQQAMAKIMKANPAL
YVLRERIRKGLQLYS
Sequence of entity 6 (B), FASTA
>6ZYM_6 116 kDa U5 small nuclear ribonucleoprotein component (chains B)
MDTDLYDEFGNYIGPELDSDEDDDELGRETKDLDEMDDDDDDDDVGDHDDDHPGMEVVLH
EDKKYYPTAEEVYGPEVETIVQEEDTQPLTEPIIKPVKTKKFTLMEQTLPVTVYEMDFLA
DLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERGVG
IKSTPVTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGVMLNTE
RLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLRHIVDEVNGLISMYSTDENLIL
SPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWGDIYFNPKTRKFTKKA
PTSSSQRSFVEFILEPLYKILAQVVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVC
KKFFGEFTGFVDMCVQHIPSPKVGAKPKIEHTYTGGVDSDLGEAMSDCDPDGPLMCHTTK
MYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWISVARYHIE
VNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQIFRPLKFNTTSVIKIAVEPVNPSEL
PKMLDGLRKVNKSYPSLTTKVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVV
TFCETVVETSSLKCFAETPNKKNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQT
KYDWDLLAARSIWAFGPDATGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTREGPLC
DELIRNVKFKILDAVVAQEPLHRGGGQIIPTARRVVYSAFLMATPRLMEPYYFVEVQAPA
DCVSAVYTVLARRRGHVTQDAPIPGSPLYTIKAFIPAIDSFGFETDLRTHTQGQAFSLSV
FHHWQIVPGDPLDKSIVIRPLEPQPAPHLAREFMIKTRRRKGLSEDVSISKF
Sequence of entity 7 (C), FASTA
>6ZYM_7 SNW domain-containing protein 1 (chains C)
MALTSFLPAPTQLSQDQLEAEEKARSQRSRQTSLVSSRREPPPYGYRKGWIPRLLEDFGD
GGAFPEIHVAQYPLDMGRKKKMSNALAIQVDSEGKIKYDAIARQGQSKDKVIYSKYTDLV
PKEVMNADDPDLQRPDEEAIKEITEKTRVALEKSVSQKVAAAMPVRAADKLAPAQYIRYT
PSQQGVAFNSGAKQRVIRMVEMQKDPMEPPRFKINKKIPRGPPSPPAPVMHSPSRKMTVK
EQQEWKIPPCISNWKNAKGYTIPLDKRLAADGRGLQTVHINENFAKLAEALYIADRKARE
AVEMRAQVERKMAQKEKEKHEEKLREMAQKARERRAGIKTHVEKEDGEARERDEIRHDRR
KERQHDRNLSRAAPDKRSKLQRNENRDISEVIALGVPNPRTSNEVQYDQRLFNQSKGMDS
GFAGGEDEIYNVYDQAWRGGKDMAQSIYRPSKNLDKDMYGDDLEARIKTNRFVPDKEFSG
SDRRQRGREGPVQFEEDPFGLDKFLEEAKQHGGSKRPSDSSRPKEHEHEGKKRRKE
Sequence of entity 8 (D), FASTA
>6ZYM_8 Pleiotropic regulator 1 (chains D)
MVEEVQKHSVHTLVFRSLKRTHDMFVADNGKPVPLDEESHKRKMAIKLRNEYGPVLHMPT
SKENLKEKGPQNATDSYVHKQYPANQGQEVEYFVAGTHPYPPGPGVALTADTKIQRMPSE
SAAQSLAVALPLQTKADANRTAPSGSEYRHPGASDRPQPTAMNSIVMETGNTKNSALMAK
KAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKL
SLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTI
DVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLV
AGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLT
VNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTA
EADKTIKVYREDDTATEETHPVSWKPEIIKRKRF
Sequence of entity 9 (E), FASTA
>6ZYM_9 Pre-mRNA-processing factor 17 (chains E)
MSAAIAALAASYGSGSGSESDSDSESSRCPLPAADSLMHLTKSPSSKPSLAVAVDSAPEV
AVKEDLETGVHLDPAVKEVQYNPTYETMFAPEFGPENPFRTQQMAAPRNMLSGYAEPAHI
NDFMFEQQRRTFATYGYALDPSLDNHQVSAKYIGSVEEAEKNQGLTVFETGQKKTEKRKK
FKENDASNIDGFLGPWAKYVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEKPGEEKTI
LHVKEMYDYQGRSYLHIPQDVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLS
GHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD
TETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGA
VNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQS
MDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTT
KLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD
Sequence of entity 10 (F), FASTA
>6ZYM_10 U5 small nuclear ribonucleoprotein 40 kDa protein (chains F)
MIEQQKRKGPELPLVPVKRQRHELLLGAGSGPGAGQQQATPGALLQAGPPRCSSLQAPIM
LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTD
GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD
IRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTG
LSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKI
AAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ
Sequence of entity 11 (L), FASTA
>6ZYM_11 Cell division cycle 5-like protein (chains L)
MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKK
TEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDKAAQRDNEEETTDDP
RKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEAR
RLAALQKRRELRAAGIEIQKKRKRKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFR
KLRQQDLDGELRSEKEGRDRKKDKQHLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAP
QISDAELQEVVKVGQASEIARQTAEESGITNSASSTLLSEYNVTNNSVALRTPRTPASQD
RILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPFRTPSNGA
EGLTPRSGTTPKPVINSTPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGL
LGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQAIRDAERVKEMKRMHKA
VQKDLPRPSEVNETILRPLNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKG
KTVGFGTNNSEHITYLEHNPYEKFSKEELKKAQDVLVQEMEVVKQGMSHGELSSEAYNQV
WEECYSQVLYLPGQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKIL
LGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKHEDSAIPRRLECLKEDVQRQQER
EKELQHRYADLLLEKETLKSKF
Sequence of entity 12 (O), FASTA
>6ZYM_12 Crooked neck-like protein 1 (chains O)
MTATVENLTFQKDTLGNAVDKNTSRLELRSYSLAGRHGSTEPLVLAWSSQFRRLTWGCAL
DALHRSPCVAASQHGVTHLIRSSRTPHSTRCRKEDAQPGHHGNGAASVTAQARGQRSVLQ
VPLPVPRSCLFSESFVVSVSSQSRFLASVPGTGVQRSTAADMAASTAAGKQRIPKVAKVK
NKAPAEVQITAEQLLREAKERELELLPPPPQQKITDEEELNDYKLRKRKTFEDNIRKNRT
VISNWIKYAQWEESLKEIQRARSIYERALDVDYRNITLWLKYAEMEMKNRQVNHARNIWD
RAITTLPRVNQFWYKYTYMEEMLGNVAGARQVFERWMEWQPEEQAWHSYINFELRYKEVD
RARTIYERFVLVHPDVKNWIKYARFEEKHAYFAHARKVYERAVEFFGDEHMDEHLYVAFA
KFEENQKEFERVRVIYKYALDRISKQDAQELFKNYTIFEKKFGDRRGIEDIIVSKRRFQY
EEEVKANPHNYDAWFDYLRLVESDAEAEAVREVYERAIANVPPIQEKRHWKRYIYLWINY
ALYEELEAKDPERTRQVYQASLELIPHKKFTFAKMWILYAQFEIRQKNLSLARRALGTSI
GKCPKNKLFKVYIELELQLREFDRCRKLYEKFLEFGPENCTSWIKFAELETILGDIDRAR
AIYELAISQPRLDMPEVLWKSYIDFEIEQEETERTRNLYRRLLQRTQHVKVWISFAQFEL
SSGKEGSLTKCRQIYEEANKTMRNCEEKEERLMLLESWRSFEEEFGTASDKERVDKLMPE
KVKKRRKVQTDDGSDAGWEEYFDYIFPEDAANQPNLKLLAMAKLWKKQQQEKEDAEHHPD
EDVDESES
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| MG | Magnesium ion | Mg | 5 |
| IHP | Inositol hexakisphosphate | C6 H18 O24 P6 | 1 |
| GTP | Guanosine-5'-triphosphate | C10 H16 N5 O14 P3 | 1 |
| ZN | Zinc ion | Zn | 7 |
Primary citation
Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome. Bertram, K., El Ayoubi, L., Dybkov, O. et al. Mol Cell (2020) 80:127-139.e6. DOI 10.1016/j.molcel.2020.09.012 · PubMed
Other PDB entries of the same protein (UniProt Q86X95 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 8I0W 3.4 Å, The cryo-EM structure of human C complex
Browse structure collections
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