TRPC4 in LMNG detergent. Determined by electron microscopy at 2.85 Å resolution. Released 9 Dec 2020.
Explore 7B0J in 3D Show helices and sheets RCSB PDB PDBe
7B0J contains 168 α-helices and 16 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 19 | 1 | 1 |
| α-helix | 31-42 | 12 | |
| α-helix | 45-53 | 9 | |
| β-strand | 66-67 | 2 | 2 |
| β-strand | 70-72 | 3 | 2 |
| α-helix | 73-79 | 7 | |
| α-helix | 83-91 | 9 | |
| α-helix | 99-105 | 7 | |
| α-helix | 109-115 | 7 | |
| α-helix | 145-152 | 8 | |
| α-helix | 155-164 | 10 | |
| β-strand | 167 | 1 | 3 |
| α-helix | 189-203 | 15 | |
| α-helix | 206-211 | 6 | |
| α-helix | 216-233 | 18 | |
| α-helix | 238-256 | 19 | |
| α-helix | 262-269 | 8 | |
| α-helix | 287-294 | 8 | |
| α-helix | 298-301 | 4 | |
| α-helix | 304-315 | 12 | |
| α-helix | 326-338 | 13 | |
| α-helix | 340-349 | 10 | |
| α-helix | 362-382 | 21 | |
| α-helix | 401-422 | 22 | |
| α-helix | 427-431 | 5 | |
| α-helix | 433-456 | 24 | |
| α-helix | 465-467 | 3 | |
| α-helix | 468-469 | 2 | |
| α-helix | 473-490 | 18 | |
| α-helix | 494-496 | 3 | |
| α-helix | 503-511 | 9 | |
| α-helix | 513-538 | 26 | |
| α-helix | 539-541 | 3 | |
| α-helix | 564-573 | 10 | |
| α-helix | 574-576 | 3 | |
| α-helix | 581-584 | 4 | |
| α-helix | 591-607 | 17 | |
| α-helix | 608-612 | 5 | |
| α-helix | 613-627 | 15 | |
| α-helix | 631-644 | 14 | |
| α-helix | 655-658 | 4 | |
| α-helix | 667-673 | 7 | |
| α-helix | 697-716 | 20 | |
| α-helix | 717-722 | 6 | |
| α-helix | 723-726 | 4 | |
| α-helix | 732-751 | 20 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily c member 4a | A, B, C, D | protein | 915 | Danio rerio | U3N7D8 (AlphaFold model) |
>7B0J_1 Transient receptor potential cation channel subfamily c member 4a (chains A, B, C, D) GSQLYFRRTDNSSYRDRIPLRIVRAESELSTQEKSYLSAVEKGDYASVKLALEEAEIYFK ININCIDPLGRTALLIAIENENLEIIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK PSGEKQVPPILLDKQFSDFTPDITPIILAAHTNNYEIIKMLVQKGVSVPQPHEVRCNCVE CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKAE YEELSHQCKHFAKDLLDQTRSSRELELILNFRDDMNLLQDEANNELARLKLAIKYRQKEF VAQPNCQQLLASRWYDEFPGWRRRHWAGKLITCVFIGLMFPLLSLCYLVAPKSRYGLFIR KPFIKFICHTASYLTFLFLLLLASQHIVSNNPDRQGPKPTTVEWMILPWVLGFIWTEIKQ MWDGGFQDYIHDWWNLMDFVMNSLYLATISLKIVAYVKYSGCKPRDTWEMWHPTLVAEAV FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY YENSEGMTCKGIRCERQNNAFSTLFETLQSLFWSIFGLISLYVTNVKADHKFTEFVGATM FGTYNVISLVVLLNMLIAMMNNSYQHIADHADIEWKFARTKLWMSYFEEGGTLPPPFNII PSPKSICYLITWIKVHVFKRRSKRTETFGTLGRRAAENVRLNHQYQEVLRNLVKRYVAAM IRDAKTEEGLTEENFKELKQDISSFRYEVIGMMKGNRKSTRANKSDTSASDVSHPEGSLQ YSSALKQNSKLHLYDVTTALQQQNSEEAKASLGCLANGSAVVLTEPILKDKARSDFPKDF TDFGLFPKKQNPNKIYSLAEEATESDPDILDWGKEDKPLAGKVEQDVNESKCLMEEDERV LEEQEMEHIASSHEH
| ID | Name | Formula | Copies |
|---|---|---|---|
| CA | Calcium ion | Ca | 4 |
| LPP | 2-(hexadecanoyloxy)-1-[(phosphonooxy)methyl]ethyl hexadecanoate | C35 H69 O8 P | 4 |
Structural basis of TRPC4 regulation by calmodulin and pharmacological agents. Vinayagam, D., Quentin, D., Yu-Strzelczyk, J. et al. Elife (2020) 9. DOI 10.7554/eLife.60603 · PubMed
Other PDB entries of the same protein (UniProt U3N7D8 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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