TRPC4 in complex with inhibitor GFB-8438. Determined by electron microscopy at 3.6 Å resolution. Released 9 Dec 2020.
Explore 7B0S in 3D Show helices and sheets RCSB PDB PDBe
7B0S contains 148 α-helices and 8 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 31-42 | 12 | |
| α-helix | 46-58 | 13 | |
| α-helix | 73-80 | 8 | |
| α-helix | 83-91 | 9 | |
| α-helix | 99-105 | 7 | |
| α-helix | 110-116 | 7 | |
| α-helix | 145-151 | 7 | |
| α-helix | 155-164 | 10 | |
| α-helix | 171-173 | 3 | |
| α-helix | 189-203 | 15 | |
| α-helix | 206-211 | 6 | |
| α-helix | 216-233 | 18 | |
| α-helix | 239-257 | 19 | |
| α-helix | 262-269 | 8 | |
| α-helix | 287-294 | 8 | |
| α-helix | 298-301 | 4 | |
| α-helix | 306-315 | 10 | |
| α-helix | 330-338 | 9 | |
| α-helix | 340-349 | 10 | |
| α-helix | 356-358 | 3 | |
| α-helix | 362-382 | 21 | |
| α-helix | 397-399 | 3 | |
| α-helix | 403-424 | 22 | |
| α-helix | 433-456 | 24 | |
| α-helix | 465-467 | 3 | |
| α-helix | 473-491 | 19 | |
| α-helix | 492-498 | 7 | |
| α-helix | 503-511 | 9 | |
| α-helix | 514-517 | 4 | |
| α-helix | 519-538 | 20 | |
| β-strand | 551 | 1 | 1 |
| β-strand | 558 | 1 | 1 |
| α-helix | 564-573 | 10 | |
| α-helix | 591-606 | 16 | |
| α-helix | 607-611 | 5 | |
| α-helix | 614-625 | 12 | |
| α-helix | 631-644 | 14 | |
| α-helix | 702-720 | 19 | |
| α-helix | 732-752 | 21 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily c member 4a | A, B, C, D | protein | 915 | Danio rerio | U3N7D8 (AlphaFold model) |
>7B0S_1 Transient receptor potential cation channel subfamily c member 4a (chains A, B, C, D) MSQLYFRRTDNSSYRDRIPLRIVRAESELSTQEKSYLSAVEKGDYASVKLALEEAEIYFK ININCIDPLGRTALLIAIENENLEIIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK PSGEKQVPPILLDKQFSDFTPDITPIILAAHTNNYEIIKMLVQKGVSVPQPHEVRCNCVE CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKAE YEELSHQCKHFAKDLLDQTRSSRELELILNFRDDMNLLQDEANNELARLKLAIKYRQKEF VAQPNCQQLLASRWYDEFPGWRRRHWAGKLITCVFIGLMFPLLSLCYLVAPKSRYGLFIR KPFIKFICHTASYLTFLFLLLLASQHIVSNNPDRQGPKPTTVEWMILPWVLGFIWTEIKQ MWDGGFQDYIHDWWNLMDFVMNSLYLATISLKIVAYVKYSGCKPRDTWEMWHPTLVAEAV FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY YENSEGMTCKGIRCERQNNAFSTLFETLQSLFWSIFGLISLYVTNVKADHKFTEFVGATM FGTYNVISLVVLLNMLIAMMNNSYQHIADHADIEWKFARTKLWMSYFEEGGTLPPPFNII PSPKSICYLITWIKVHVFKRRSKRTETFGTLGRRAAENVRLNHQYQEVLRNLVKRYVAAM IRDAKTEEGLTEENFKELKQDISSFRYEVIGMMKGNRKSTRANKSDTSASDVSHPEGSLQ YSSALKQNSKLHLYDVTTALQQQNSEEAKASLGCLANGSAVVLTEPILKDKARSDFPKDF TDFGLFPKKQNPNKIYSLAEEATESDPDILDWGKEDKPLAGKVEQDVNESKCLMEEDERV LEEQEMEHIASSHEH
| ID | Name | Formula | Copies |
|---|---|---|---|
| 44E | (2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate | C15 H29 O8 P | 4 |
| CA | Calcium ion | Ca | 4 |
| S9Q | 5-chloranyl-4-[3-oxidanylidene-4-[[2-(trifluoromethyl)phenyl]methyl]piperazin-1… | C16 H14 Cl F3 N4 O2 | 4 |
Structural basis of TRPC4 regulation by calmodulin and pharmacological agents. Vinayagam, D., Quentin, D., Yu-Strzelczyk, J. et al. Elife (2020) 9. DOI 10.7554/eLife.60603 · PubMed
Other PDB entries of the same protein (UniProt U3N7D8 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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