7CIO: PDB entry 7CIO

Molecular interactions of cytoplasmic region of CTLA-4 with SH2 domains of PI3-kinase. Determined by X-ray diffraction at 1.1 Å resolution. Released 9 Dec 2020.

Method: X-ray diffraction
Resolution: 1.1 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,126
Mol. weight: 13.15 kDa
Released: 9 Dec 2020

Explore 7CIO in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7CIO contains 7 α-helices and 8 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 8 β-strands

Element	Residues	Length	Sheet
α-helix	613-615	3
α-helix	617-619	3
α-helix	621-623	3
β-strand	625	1	1
α-helix	631-638	8
α-helix	641-642	2
β-strand	645-650	6	1
β-strand	657-663	7	1
β-strand	666-672	7	1
β-strand	673-675	3	2
β-strand	678-680	3	2
β-strand	688	1	2
α-helix	691-699	9
α-helix	703-705	3
β-strand	716-717	2	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Phosphatidylinositol 3-kinase regulatory subunit alpha	A	protein	109	Homo sapiens	P27986 (AlphaFold model)
Cytotoxic T-lymphocyte protein 4	B	protein	8	Homo sapiens	P16410 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>7CIO_1 Phosphatidylinositol 3-kinase regulatory subunit alpha (chains A)
GSEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGSYAVSVVVDGEVKHLV
INKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA

Sequence of entity 2 (B), FASTA

>7CIO_2 Cytotoxic T-lymphocyte protein 4 (chains B)
GVYVKMPP

Primary citation

Molecular interactions of the CTLA-4 cytoplasmic region with the phosphoinositide 3-kinase SH2 domains. Iiyama, M., Numoto, N., Ogawa, S. et al. Mol Immunol (2021) 131:51-59. DOI 10.1016/j.molimm.2020.12.002 · PubMed

Other PDB entries of the same protein (UniProt P27986 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5GJI 0.9 Å, PI3K p85 N-terminal SH2 domain/CD28-derived peptide complex
5AUL 1.1 Å, PI3K p85 C-terminal SH2 domain/CD28-derived peptide complex
7RNS 1.14 Å, nSH2 domain of p85-alpha subunit of phosphatidylinositol 3-kinase in complex with an…
3I5R 1.7 Å, PI3K SH3 domain in complex with a peptide ligand
1H9O 1.79 Å, Phosphatidylinositol 3-kinase, P85-alpha subunit: C-terminal SH2 domain complexed with a…
2IUG 1.89 Å, Crystal structure of the PI3-kinase p85 N-terminal SH2 domain
1PBW 2.0 Å, Structure of BCR-homology (BH) domain
1PHT 2.0 Å, Phosphatidylinositol 3-kinase P85-alpha subunit SH3 domain, residues 1-85
2IUH 2.0 Å, Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with c-Kit…
4JPS 2.2 Å, Co-crystal Structures of the Lipid Kinase PI3K alpha with Pan and Isoform Selective…
7PG5 2.2 Å, Crystal Structure of PI3Kalpha
6PYR 2.21 Å, Human PI3Kdelta in complex with Compound 2-10 ((3S)-3-benzyl-3-methyl-5-[5-(2-methylpyrim…

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