Crystal structure of Slx1-Slx4. Determined by X-ray diffraction at 1.45 Å resolution. Released 16 Jun 2021.
Explore 7CQ3 in 3D Show helices and sheets RCSB PDB PDBe
7CQ3 contains 22 α-helices and 13 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 15-21 | 7 | 1 |
| β-strand | 28-33 | 6 | 1 |
| α-helix | 36-44 | 9 | |
| α-helix | 53-56 | 4 | |
| α-helix | 61 | 1 | |
| β-strand | 63-70 | 8 | 1 |
| α-helix | 75-86 | 12 | |
| α-helix | 88-90 | 3 | |
| α-helix | 96-98 | 3 | |
| α-helix | 110-122 | 13 | |
| α-helix | 124-127 | 4 | |
| β-strand | 132-137 | 6 | 1 |
| α-helix | 138-146 | 9 | |
| β-strand | 159-167 | 9 | 1 |
| α-helix | 168-170 | 3 | |
| α-helix | 175-211 | 37 | |
| β-strand | 216-217 | 2 | 2 |
| β-strand | 224-225 | 2 | 2 |
| α-helix | 232-234 | 3 | |
| β-strand | 238-240 | 3 | 3 |
| β-strand | 249-251 | 3 | 3 |
| α-helix | 252-267 | 16 | |
| β-strand | 276-278 | 3 | 4 |
| β-strand | 285-287 | 3 | 4 |
| α-helix | 288-302 | 15 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 676-678 | 3 | |
| α-helix | 681-692 | 12 | |
| α-helix | 696-703 | 8 | |
| β-strand | 708-709 | 2 | 5 |
| α-helix | 710-720 | 11 | |
| α-helix | 722-726 | 5 | |
| α-helix | 729-739 | 11 | |
| α-helix | 741-742 | 2 | |
| β-strand | 743-744 | 2 | 5 |
| α-helix | 745-746 | 2 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Structure-specific endonuclease subunit SLX1 | A | protein | 304 | Saccharomyces cerevisiae (strain YJM789) | P38324 (AlphaFold model) |
| SLX4 isoform 1 | B | protein | 86 | Saccharomyces cerevisiae | Q12098 (AlphaFold model) |
>7CQ3_1 Structure-specific endonuclease subunit SLX1 (chains A) MSQKIQQHQFPDFYCCYLLQSINKRQSFYVGSTPNPVRRLRQHNGKLAVGGAYRTKRDGS RPWEMIMIVRGFPSKIAALQFEHAWQHGYQTHYIAEKDRVVKHKAGGRTLHHKVALMKLL LKHEFFQRMNLIVEVFNIKAWEVWKQDKFFIERDRFPINIQINENALEEPKEKTVDVLMD HSDENLKVVEAVYTKVIENERNIFETFEKKLTTGVVRCEICEKEIDYTSEEQNLKPFVAL CNNKDCGCVNHLKCLHRYFLDDEQLIVGRRNLIPRGGKCPKCDMFCDWTTLVKFSTRMKL AHGK
>7CQ3_2 SLX4 isoform 1 (chains B) MGSSHHHHHHSQGVANFSKIEIFDHLTELIEAFPDFLERIYTFEPIPLNELIEKLFSAEP FVSQIDEMTIREWADVQGICLRNDKK
| ID | Name | Formula | Copies |
|---|---|---|---|
| ZN | Zinc ion | Zn | 2 |
Water and common crystallization additives (SO4) are not listed.
Structure specific DNA recognition by the SLX1-SLX4 endonuclease complex. Xu, X., Wang, M., Sun, J. et al. Nucleic Acids Res (2021) 49:7740-7752. DOI 10.1093/nar/gkab542 · PubMed
Other PDB entries of the same protein (UniProt P38324 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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