Cryo-EM structure of hDisp1NNN-3C-Cleavage. Determined by electron microscopy at 3.68 Å resolution. Released 8 Dec 2021.
Explore 7E2H in 3D Show helices and sheets RCSB PDB PDBe
7E2H contains 44 α-helices and 12 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 184-187 | 4 | |
| α-helix | 189-209 | 21 | |
| α-helix | 212-214 | 3 | |
| α-helix | 232-242 | 11 | |
| α-helix | 256-262 | 7 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 300-306 | 7 | 1 |
| α-helix | 316-329 | 14 | |
| α-helix | 354-359 | 6 | |
| α-helix | 361-363 | 3 | |
| α-helix | 374-385 | 12 | |
| α-helix | 386-388 | 3 | |
| α-helix | 423-426 | 4 | |
| α-helix | 427-431 | 5 | |
| β-strand | 432 | 1 | 1 |
| α-helix | 442 | 1 | |
| β-strand | 451-459 | 9 | 1 |
| α-helix | 460 | 1 | |
| α-helix | 464-471 | 8 | |
| β-strand | 483-487 | 5 | 1 |
| α-helix | 496-502 | 7 | |
| α-helix | 505-521 | 17 | |
| α-helix | 525-544 | 20 | |
| α-helix | 545-549 | 5 | |
| α-helix | 559-567 | 9 | |
| α-helix | 570-587 | 18 | |
| α-helix | 593-620 | 28 | |
| α-helix | 621-624 | 4 | |
| α-helix | 629-658 | 30 | |
| α-helix | 689-704 | 16 | |
| α-helix | 705-709 | 5 | |
| α-helix | 710-717 | 8 | |
| α-helix | 720-737 | 18 | |
| β-strand | 755 | 1 | 2 |
| α-helix | 760-766 | 7 | |
| α-helix | 768-770 | 3 | |
| α-helix | 773-779 | 7 | |
| β-strand | 784 | 1 | 3 |
| β-strand | 787-790 | 4 | 4 |
| α-helix | 821-834 | 14 | |
| α-helix | 852-859 | 8 | |
| α-helix | 884-900 | 17 | |
| α-helix | 912 | 1 | |
| β-strand | 913-914 | 2 | 5 |
| β-strand | 920-922 | 3 | 5 |
| β-strand | 924-927 | 4 | 4 |
| β-strand | 932 | 1 | 3 |
| α-helix | 933 | 1 | |
| α-helix | 938-951 | 14 | |
| α-helix | 973-1003 | 31 | |
| α-helix | 1006-1030 | 25 | |
| α-helix | 1038-1060 | 23 | |
| α-helix | 1072-1094 | 23 | |
| β-strand | 1102 | 1 | 2 |
| α-helix | 1103-1121 | 19 | |
| α-helix | 1122-1126 | 5 | |
| α-helix | 1127-1128 | 2 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Protein dispatched homolog 1 | D | protein | 270 | Homo sapiens | Q96F81 (AlphaFold model) |
| Protein dispatched homolog 1 | E | protein | 1248 | Homo sapiens | Q96F81 (AlphaFold model) |
>7E2H_1 Protein dispatched homolog 1 (chains D) MAMSNGNNDFVVLSNSSIATSAANPSPLTPCDGDHAAQQLTPKEATRTKVSPNGCLQLNG TVKSSFLPLDNQRMPQMLPQCCHPCPYHHPLTSHSSHQECHPEAGPAAPSALASCCMQPH SEYSASLCPNHSPVYQTTCCLQPSPSFCLHHPWPDHFQHQPVQQHIANIRPSRPFKLPKS YAALIADWPVVVLGMCTMFIVVCALVGVLVPELPDFSDPLLGFEPRGTAIGQRLVTWNNM VKNTGYKATLANYPFKYADEQASSLEVLFQ
>7E2H_2 Protein dispatched homolog 1 (chains E) GPGSEVDWNFHKDSFFCDVPSDRYSRVVFTSSGGETLWNLPAIKSMCNVDNSRIRSHPQF GDLCQRTTAASCCPSWTLGNYIAILNNRSSCQKIVERDVSHTLKLLRTCAKHYQNGTLGP DCWDMAARRKDQLKCTNVPRKCTKYNAVYQILHYLVDKDFMTPKTADYATPALKYSMLFS PTEKGESMMNIYLDNFENWNSSDGVTTITGIEFGIKHSLFQDYLLMDTVYPAIAIVIVLL VMCVYTKSMFITLMTMFAIISSLIVSYFLYRVVFHFEFFPFMNLTALIILVGIGANNAFV LCDVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVY AGTAILVNYVLMVTWLPAVVVLHERYLLNIFTCFKKPQQQIYDNKSCWTVACQKCHKVLF AISEASRIFFEKVLPCIVIKFRYLWLFWFLALTVGGAYIVCINPKMKLPSLELSEFQVFR SSHPFERYDAEYKKLFMFERVHHGEELHMPITVIWGVSPEDNGNPLNPKSKGKLTLDSSF NIASPASQAWILHFCQKLRNQTFFYQTDEQDFTSCFIETFKQWMENQDCDEPALYPCCSH WSFPYKQEIFELCIKRAIMELERSTGYHLDSKTPGPRFDINDTIRAVVLEFQSTYLFTLA YEKMHQFYKEVDSWISSELSSAPEGLSNGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAF SVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVNFAVHY GVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIM CISWAFATFFFQCMCRCLGPQGTCGQIPLPKKLQCSAFSHALSTSPSDKGQSKTHTINAY HLDPRGPKSELEHEFYELEPLASHSCTAPEKTTYEETHICSEFFNSQAKNLGMPVHAAYN SELSKSTESDAGSALLQPPLEQHTVCHFFSLNQRCSCPDAYKHLNYGPHSCQQMGDCLCH QCSPTTSSFVQIQNGVAPLKATHQAVEGFVHPITHIHHCPCLQGRVKPAGMQNSLPRNFF LHPVQHIQAQEKIGKTNVHSLQRSIEEHLPKMAEPSSFVCRSTGSLLKTCCDPENKQREL CKNRDVSNLESSGGTENKAGGKVELSLSQTDASVNSEHFNQNEPKVLFNHLMGEAGCRSC PNNSQSCGRIVRVKCNSVDCQMPNMEANVPAVLTHSELSGESLLIKTL
| ID | Name | Formula | Copies |
|---|---|---|---|
| Y01 | Cholesterol hemisuccinate | C31 H50 O4 | 8 |
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 4 |
Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release. Li, W., Wang, L., Wierbowski, B.M. et al. Nat Commun (2021) 12:6966-6966. DOI 10.1038/s41467-021-27257-w · PubMed
Other PDB entries of the same protein (UniProt Q96F81 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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