7EGD: Transcription initiation factor TFIID subunit 1
SCP promoter-bound TFIID-TFIIA in initial TBP-loading state. Determined by electron microscopy at 6.75 Å resolution. Released 12 May 2021.
- Method
- Electron microscopy
- Resolution
- 6.75 Å
- Organism
- Homo sapiens
- Chains
- 24
- Atoms
- 46,820
- Mol. weight
- 1379.49 kDa
- Released
- 12 May 2021
Explore 7EGD in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7EGD contains 254 α-helices and 188 β-strands across 22 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 34 helices, 17 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 347-353 | 7 | |
| α-helix | 399-402 | 4 | |
| α-helix | 410-413 | 4 | |
| α-helix | 469-471 | 3 | |
| α-helix | 473-477 | 5 | |
| α-helix | 480-483 | 4 | |
| α-helix | 497-500 | 4 | |
| α-helix | 570-573 | 4 | |
| α-helix | 593-596 | 4 | |
| α-helix | 609-613 | 5 | |
| α-helix | 621-623 | 3 | |
| β-strand | 634-638 | 5 | 1 |
| α-helix | 641-656 | 16 | |
| α-helix | 668-671 | 4 | |
| β-strand | 679-683 | 5 | 1 |
| α-helix | 692-693 | 2 | |
| β-strand | 697-704 | 8 | 1 |
| α-helix | 705-707 | 3 | |
| α-helix | 714-716 | 3 | |
| β-strand | 721-723 | 3 | 1 |
| α-helix | 734-735 | 2 | |
| β-strand | 739-744 | 6 | 1 |
| β-strand | 748-756 | 9 | 1 |
| α-helix | 757-758 | 2 | |
| β-strand | 761-766 | 6 | 1 |
| β-strand | 771-775 | 5 | 1 |
| β-strand | 778-782 | 5 | 1 |
| β-strand | 786-787 | 2 | 1 |
| α-helix | 790-793 | 4 | |
| α-helix | 797-816 | 20 | |
| β-strand | 824-825 | 2 | 2 |
| α-helix | 827-833 | 7 | |
| α-helix | 839-847 | 9 | |
| β-strand | 850-853 | 4 | 2 |
| β-strand | 861-864 | 4 | 2 |
| α-helix | 865 | 1 | |
| α-helix | 873-879 | 7 | |
| α-helix | 882-900 | 19 | |
| α-helix | 925-928 | 4 | |
| α-helix | 931-943 | 13 | |
| β-strand | 947-948 | 2 | 3 |
| β-strand | 967-968 | 2 | 3 |
| α-helix | 993-996 | 4 | |
| α-helix | 1001-1010 | 10 | |
| α-helix | 1014-1019 | 6 | |
| α-helix | 1022-1034 | 13 | |
| α-helix | 1056-1078 | 23 | |
| β-strand | 1165-1170 | 6 | 4 |
| β-strand | 1180-1185 | 6 | 4 |
| α-helix | 1188-1203 | 16 | |
| α-helix | 1217-1241 | 25 | |
Chain B: 44 helices, 39 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 26-39 | 14 | 5 |
| β-strand | 44-55 | 12 | 5 |
| β-strand | 63-65 | 3 | 6 |
| β-strand | 66 | 1 | 7 |
| β-strand | 71-77 | 7 | 5 |
| β-strand | 80-81 | 2 | 5 |
| β-strand | 83-86 | 4 | 6 |
| α-helix | 103-116 | 14 | |
| β-strand | 126-129 | 4 | 6 |
| α-helix | 130-131 | 2 | |
| α-helix | 132-134 | 3 | |
| α-helix | 135-138 | 4 | |
| β-strand | 144-152 | 9 | 5 |
| β-strand | 159-162 | 4 | 8 |
| α-helix | 170-173 | 4 | |
| β-strand | 176-179 | 4 | 8 |
| α-helix | 186-188 | 3 | |
| β-strand | 192 | 1 | 7 |
| β-strand | 200-209 | 10 | 5 |
| β-strand | 213-216 | 4 | 8 |
| β-strand | 219-225 | 7 | 5 |
| α-helix | 226 | 1 | |
| β-strand | 231-242 | 12 | 5 |
| α-helix | 244-246 | 3 | |
| β-strand | 249-252 | 4 | 8 |
| α-helix | 254 | 1 | |
| β-strand | 255-258 | 4 | 9 |
| β-strand | 265-269 | 5 | 9 |
| α-helix | 274-280 | 7 | |
| α-helix | 284-294 | 11 | |
| α-helix | 298-299 | 2 | |
| β-strand | 304-309 | 6 | 9 |
| β-strand | 316-319 | 4 | 9 |
| β-strand | 322-326 | 5 | 9 |
| α-helix | 327-329 | 3 | |
| α-helix | 339-352 | 14 | |
| α-helix | 353-358 | 6 | |
| β-strand | 360-361 | 2 | 10 |
| α-helix | 367-408 | 42 | |
| α-helix | 438-440 | 3 | |
| α-helix | 443-463 | 21 | |
| α-helix | 466-483 | 18 | |
| α-helix | 493-495 | 3 | |
| β-strand | 497-498 | 2 | 10 |
| α-helix | 500-511 | 12 | |
| α-helix | 516-522 | 7 | |
| β-strand | 528 | 1 | 11 |
| β-strand | 529-538 | 10 | 12 |
| β-strand | 543-550 | 8 | 12 |
| β-strand | 557 | 1 | 11 |
| β-strand | 563-570 | 8 | 13 |
| β-strand | 573-580 | 8 | 13 |
| β-strand | 587-591 | 5 | 12 |
| α-helix | 596-599 | 4 | |
| α-helix | 603 | 1 | |
| β-strand | 604-605 | 2 | 14 |
| β-strand | 611-612 | 2 | 14 |
| β-strand | 625-630 | 6 | 13 |
| β-strand | 638-643 | 6 | 12 |
| α-helix | 646-655 | 10 | |
| α-helix | 659-668 | 10 | |
| α-helix | 669-671 | 3 | |
| α-helix | 675-685 | 11 | |
| β-strand | 688 | 1 | 15 |
| β-strand | 690 | 1 | 15 |
| α-helix | 692-708 | 17 | |
| α-helix | 717 | 1 | |
| α-helix | 720-727 | 8 | |
| β-strand | 728 | 1 | 16 |
| β-strand | 736 | 1 | 16 |
| α-helix | 737-739 | 3 | |
| α-helix | 746-757 | 12 | |
| α-helix | 769-780 | 12 | |
| α-helix | 792-804 | 13 | |
| α-helix | 807-809 | 3 | |
| α-helix | 824-842 | 19 | |
| α-helix | 849-863 | 15 | |
| α-helix | 872-877 | 6 | |
| α-helix | 884-900 | 17 | |
| α-helix | 904-915 | 12 | |
| α-helix | 920-932 | 13 | |
| α-helix | 947-958 | 12 | |
| α-helix | 967-979 | 13 | |
Chain c: 5 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 2-15 | 14 | |
| α-helix | 17-20 | 4 | |
| β-strand | 25-27 | 3 | 39 |
| α-helix | 28-55 | 28 | |
| α-helix | 63-73 | 11 | |
| α-helix | 77-86 | 10 | |
| β-strand | 101 | 1 | 40 |
Chain d: 8 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 850-854 | 5 | |
| α-helix | 855-857 | 3 | |
| β-strand | 865 | 1 | 41 |
| α-helix | 875-884 | 10 | |
| β-strand | 893-894 | 2 | 42 |
| α-helix | 899-921 | 23 | |
| α-helix | 923-925 | 3 | |
| β-strand | 934-936 | 3 | 43 |
| α-helix | 940-967 | 28 | |
| β-strand | 1056 | 1 | 44 |
| α-helix | 1060-1068 | 9 | |
| α-helix | 1077-1082 | 6 | |
Chain D: 8 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 843-856 | 14 | |
| α-helix | 875-885 | 11 | |
| α-helix | 886-888 | 3 | |
| α-helix | 899-921 | 23 | |
| β-strand | 934-936 | 3 | 17 |
| α-helix | 940-970 | 31 | |
| α-helix | 978-1011 | 34 | |
| β-strand | 1056-1058 | 3 | 18 |
| α-helix | 1060-1065 | 6 | |
| α-helix | 1077-1082 | 6 | |
Chain e: 17 helices, 33 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 214-227 | 14 | |
| α-helix | 230-254 | 25 | |
| α-helix | 257-267 | 11 | |
| α-helix | 277-284 | 8 | |
| α-helix | 288-291 | 4 | |
| β-strand | 307 | 1 | 45 |
| β-strand | 310 | 1 | 46 |
| α-helix | 311-321 | 11 | |
| α-helix | 330-333 | 4 | |
| β-strand | 339 | 1 | 45 |
| β-strand | 342 | 1 | 46 |
| α-helix | 376-377 | 2 | |
| α-helix | 421-423 | 3 | |
| α-helix | 429-432 | 4 | |
| α-helix | 434-448 | 15 | |
| α-helix | 458-460 | 3 | |
| β-strand | 461-466 | 6 | 47 |
| β-strand | 473-478 | 6 | 48 |
| β-strand | 484-489 | 6 | 48 |
| β-strand | 493-498 | 6 | 48 |
| α-helix | 503-504 | 2 | |
| β-strand | 506-507 | 2 | 49 |
| α-helix | 508 | 1 | |
| α-helix | 510-515 | 6 | |
| α-helix | 517 | 1 | |
| α-helix | 523-526 | 4 | |
| β-strand | 528-529 | 2 | 49 |
| β-strand | 536-540 | 5 | 48 |
| β-strand | 546-550 | 5 | 50 |
| β-strand | 558-562 | 5 | 50 |
| β-strand | 567-570 | 4 | 50 |
| β-strand | 577-581 | 5 | 50 |
| β-strand | 588-593 | 6 | 51 |
| β-strand | 600-604 | 5 | 51 |
| β-strand | 609-612 | 4 | 51 |
| β-strand | 621-622 | 2 | 51 |
| β-strand | 632-635 | 4 | 52 |
| β-strand | 641-645 | 5 | 52 |
| β-strand | 651-655 | 5 | 52 |
| β-strand | 661-665 | 5 | 52 |
| β-strand | 672-677 | 6 | 53 |
| β-strand | 683-688 | 6 | 53 |
| β-strand | 692-697 | 6 | 53 |
| β-strand | 703-707 | 5 | 53 |
| β-strand | 716-719 | 4 | 54 |
| β-strand | 725-729 | 5 | 54 |
| β-strand | 734-739 | 6 | 54 |
| β-strand | 771-774 | 4 | 54 |
| β-strand | 782-785 | 4 | 47 |
| β-strand | 791-794 | 4 | 47 |
Chain E: 28 helices, 33 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 211-213 | 3 | |
| α-helix | 214-226 | 13 | |
| α-helix | 230-236 | 7 | |
| α-helix | 237-239 | 3 | |
| α-helix | 240-253 | 14 | |
| α-helix | 257-267 | 11 | |
| α-helix | 268-270 | 3 | |
| α-helix | 273-275 | 3 | |
| α-helix | 276-284 | 9 | |
| α-helix | 288-291 | 4 | |
| α-helix | 297-302 | 6 | |
| β-strand | 305 | 1 | 19 |
| β-strand | 308-310 | 3 | 20 |
| α-helix | 311-318 | 8 | |
| α-helix | 324-326 | 3 | |
| α-helix | 329-336 | 8 | |
| β-strand | 337 | 1 | 19 |
| β-strand | 340-342 | 3 | 20 |
| α-helix | 345-348 | 4 | |
| α-helix | 349-355 | 7 | |
| α-helix | 376-377 | 2 | |
| α-helix | 421-423 | 3 | |
| α-helix | 429-431 | 3 | |
| α-helix | 434-448 | 15 | |
| α-helix | 450-452 | 3 | |
| α-helix | 458-460 | 3 | |
| β-strand | 461-466 | 6 | 21 |
| α-helix | 472 | 1 | |
| β-strand | 473-478 | 6 | 22 |
| β-strand | 484-489 | 6 | 22 |
| β-strand | 493-498 | 6 | 22 |
| β-strand | 504-507 | 4 | 23 |
| α-helix | 508-509 | 2 | |
| α-helix | 510-515 | 6 | |
| α-helix | 524-527 | 4 | |
| β-strand | 528-534 | 7 | 23 |
| β-strand | 536-540 | 5 | 22 |
| β-strand | 546-550 | 5 | 24 |
| β-strand | 558-562 | 5 | 24 |
| β-strand | 566-570 | 5 | 24 |
| β-strand | 577-582 | 6 | 24 |
| β-strand | 588-593 | 6 | 25 |
| β-strand | 600-604 | 5 | 25 |
| β-strand | 609-612 | 4 | 25 |
| β-strand | 621-623 | 3 | 25 |
| β-strand | 634-635 | 2 | 26 |
| β-strand | 641-645 | 5 | 26 |
| β-strand | 650-655 | 6 | 26 |
| β-strand | 661-666 | 6 | 26 |
| β-strand | 672-677 | 6 | 27 |
| β-strand | 683-688 | 6 | 27 |
| β-strand | 693-697 | 5 | 27 |
| β-strand | 703-707 | 5 | 27 |
| β-strand | 714-719 | 6 | 28 |
| β-strand | 725-730 | 6 | 28 |
| β-strand | 734-739 | 6 | 28 |
| α-helix | 742-744 | 3 | |
| α-helix | 765-768 | 4 | |
| β-strand | 769-774 | 6 | 28 |
| β-strand | 782-785 | 4 | 21 |
| β-strand | 791-796 | 6 | 21 |
Chain f: 23 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 17-26 | 10 | |
| α-helix | 33-60 | 28 | |
| α-helix | 68-75 | 8 | |
| α-helix | 80-82 | 3 | |
| β-strand | 95-97 | 3 | 55 |
| β-strand | 104-106 | 3 | 55 |
| β-strand | 111-113 | 3 | 39 |
| α-helix | 115-118 | 4 | |
| α-helix | 120-126 | 7 | |
| β-strand | 127 | 1 | 40 |
| β-strand | 131-137 | 7 | 47 |
| α-helix | 142-143 | 2 | |
| α-helix | 215-217 | 3 | |
| α-helix | 218-230 | 13 | |
| α-helix | 236-247 | 12 | |
| α-helix | 256-268 | 13 | |
| α-helix | 276-290 | 15 | |
| α-helix | 301-313 | 13 | |
| α-helix | 326-340 | 15 | |
| α-helix | 351-363 | 13 | |
| α-helix | 370-383 | 14 | |
| α-helix | 385-387 | 3 | |
| α-helix | 388-392 | 5 | |
| α-helix | 393-397 | 5 | |
| α-helix | 398-403 | 6 | |
| α-helix | 416-437 | 22 | |
| α-helix | 446-449 | 4 | |
| α-helix | 455-472 | 18 | |
14 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Transcription initiation factor TFIID subunit 1 | A | protein | 1872 | Homo sapiens | P21675 (AlphaFold model) |
| Transcription initiation factor TFIID subunit 2 | B | protein | 1199 | Homo sapiens | Q6P1X5 (AlphaFold model) |
| Transcription initiation factor TFIID subunit 4 | D, d | protein | 1085 | Homo sapiens | O00268 (AlphaFold model) |
| Transcription initiation factor TFIID subunit 5 | E, e | protein | 800 | Homo sapiens | Q15542 (AlphaFold model) |
| Transcription initiation factor TFIID subunit 6 | F, f | protein | 677 | Homo sapiens | P49848 |
| Transcription initiation factor TFIID subunit 7 | G | protein | 349 | Homo sapiens | Q15545 |
| Transcription initiation factor TFIID subunit 8 | H | protein | 310 | Homo sapiens | Q7Z7C8 |
| Transcription initiation factor TFIID subunit 9 | I, i | protein | 264 | Homo sapiens | Q16594 |
| Transcription initiation factor TFIID subunit 10 | J, j | protein | 218 | Homo sapiens | Q12962 |
| Transcription initiation factor TFIID subunit 12 | L, l | protein | 161 | Homo sapiens | Q16514 |
| Transcription initiation factor IIA subunit 2 | O | protein | 109 | Homo sapiens | P52657 |
| TATA-box-binding protein | P | protein | 339 | Homo sapiens | P20226 |
6 more molecules are not listed.
Sequence of entity 1 (A), FASTA
>7EGD_1 Transcription initiation factor TFIID subunit 1 (chains A)
MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD
ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE
SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGEKV
DFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLR
FLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVECSVESEVSQKSLWNYDYAPPP
PPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVAEWRYGPARLWYDMLGVPEDGS
GFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLADENFLMVTQLHWEDDIIWDGED
VKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLDDDKPWYSIFPIDNEDLVYGRW
EDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEEATSNSPSKESKKESSLKKSRI
LLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQGLRGTFGGNIIQHSIPAVELRQ
PFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGG
EMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYG
ETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIF
VVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSES
SIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKD
AGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCG
EGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKL
SRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSST
EVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSREREEQERKELQRMLLAAGSAA
SGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTT
KDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDL
KLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQEEELEKTVIHNDNEELIKVEG
TKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRRTD
PMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRLYP
SREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLD
DDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKH
KYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICT
AKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMSRDASVFQDESNMSVLDIPSAT
PEKQVTQEGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSA
IQLSESGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISY
GSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPSVLSQVHLSEDEEDSEDFH
SIAGDSDLDSDE
Sequence of entity 2 (B), FASTA
>7EGD_2 Transcription initiation factor TFIID subunit 2 (chains B)
MPLTGVEPARMNRKKGDKGFESPRPYKLTHQVVCINNINFQRKSVVGFVELTIFPTVANL
NRIKLNSKQCRIYRVRINDLEAAFIYNDPTLEVCHSESKQRNLNYFSNAYAAAVSAVDPD
AGNGELCIKVPSELWKHVDELKVLKIHINFSLDQPKGGLHFVVPSVEGSMAERGAHVFSC
GYQNSTRFWFPCVDSYSELCTWKLEFTVDAAMVAVSNGDLVETVYTHDMRKKTFHYMLTI
PTAASNISLAIGPFEILVDPYMHEVTHFCLPQLLPLLKHTTSYLHEVFEFYEEILTCRYP
YSCFKTVFIDEAYVEVAAYASMSIFSTNLLHSAMIIDETPLTRRCLAQSLAQQFFGCFIS
RMSWSDEWVLKGISGYIYGLWMKKTFGVNEYRHWIKEELDKIVAYELKTGGVLLHPIFGG
GKEKDNPASHLHFSIKHPHTLSWEYYSMFQCKAHLVMRLIENRISMEFMLQVFNKLLSLA
STASSQKFQSHMWSQMLVSTSGFLKSISNVSGKDIQPLIKQWVDQSGVVKFYGSFAFNRK
RNVLELEIKQDYTSPGTQKYVGPLKVTVQELDGSFNHTLQIEENSLKHDIPCHSKSRRNK
KKKIPLMNGEEVDMDLSAMDADSPLLWIRIDPDMSVLRKVEFEQADFMWQYQLRYERDVV
AQQESILALEKFPTPASRLALTDILEQEQCFYRVRMSACFCLAKIANSMVSTWTGPPAMK
SLFTRMFCCKSCPNIVKTNNFMSFQSYFLQKTMPVAMALLRDVHNLCPKEVLTFILDLIK
YNDNRKNKFSDNYYRAEMIDALANSVTPAVSVNNEVRTLDNLNPDVRLILEEITRFLNME
KLLPSYRHTITVSCLRAIRVLQKNGHVPSDPALFKSYAEYGHFVDIRIAALEAVVDYTKV
DRSYEELQWLLNMIQNDPVPYVRHKILNMLTKNPPFTKNMESPLCNEALVDQLWKLMNSG
TSHDWRLRCGAVDLYFTLFGLSRPSCLPLPELGLVLNLKEKKAVLNPTIIPESVAGNQEA
ANNPSSHPQLVGFQNPFSSSQDEEEIDMDTVHDSQAFISHHLNMLERPSTPGLSKYRPAS
SRSALIPQHSAGCDSTPTTKPQWSLELARKGTGKEQAPLEMSMHPAASAPLSVFTKESTA
SKHSDHHHHHHHEHKKKKKKHKHKHKHKHKHDSKEKDKEPFTFSSPASGRSIRSPSLSD
Sequence of entity 3 (D, d), FASTA
>7EGD_3 Transcription initiation factor TFIID subunit 4 (chains D, d)
MAAGSDLLDEVFFNSEVDEKVVSDLVGSLESQLAASAAHHHHLAPRTPEVRAAAAGALGN
HVVSGSPAGAAGAGPAAPAEGAPGAAPEPPPAGRARPGGGGPQRPGPPSPRRPLVPAGPA
PPAAKLRPPPEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPGPGP
GPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQT
PPFVGAAAPPAPAAPSPPAAPAPAAPAAAPPPPPPAPATLARPPGHPAGPPTAAPAVPPP
AAAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAPGVKAESPKRVVQAAPPAAQT
LAASGPASTAASMVIGPTMQGALPSPAAVPPPAPGTPTGLPKGAAGAVTQSLSRTPTATT
SGIRATLTPTVLAPRLPQPPQNPTNIQNFQLPPGMVLVRSENGQLLMIPQQALAQMQAQA
HAQPQTTMAPRPATPTSAPPVQISTVQAPGTPIIARQVTPTTIIKQVSQAQTTVQPSATL
QRSPGVQPQLVLGGAAQTASLGTATAVQTGTPQRTVPGATTTSSAATETMENVKKCKNFL
STLIKLASSGKQSTETAANVKELVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRS
LPALRQLTPDSAAFIQQSQQQPPPPTSQATTALTAVVLSSSVQRTAGKTAATVTSALQPP
VLSLTQPTQVGVGKQGQPTPLVIQQPPKPGALIRPPQVTLTQTPMVALRQPHNRIMLTTP
QQIQLNPLQPVPVVKPAVLPGTKALSAVSAQAAAAQKNKLKEPGGGSFRDDDDINDVASM
AGVNLSEESARILATNSELVGTLTRSCKDETFLLQAPLQRRILEIGKKHGITELHPDVVS
YVSHATQQRLQNLVEKISETAQQKNFSYKDDDRYEQASDVRAQLKFFEQLDQIEKQRKDE
QEREILMRAAKSRSRQEDPEQLRLKQKAKEMQQQELAQMRQRDANLTALAAIGPRKKRKV
DCPGPGSGAEGSGPGSVVPGSSGVGTPRQFTRQRITRVNLRDLIFCLENERETSHSLLLY
KAFLK
Sequence of entity 4 (E, e), FASTA
>7EGD_4 Transcription initiation factor TFIID subunit 5 (chains E, e)
MAALAEEQTEVAVKLEPEGPPTLLPPQAGDGAGEGSGGTTNNGPNGGGGNVAASSSTGGD
GGTPKPTVAVSAAAPAGAAPVPAAAPDAGAPHDRQTLLAVLQFLRQSKLREAEEALRREA
GLLEEAVAGSGAPGEVDSAGAEVTSALLSRVTASAPGPAAPDPPGTGASGATVVSGSASG
PAAPGKVGSVAVEDQPDVSAVLSAYNQQGDPTMYEEYYSGLKHFIECSLDCHRAELSQLF
YPLFVHMYLELVYNQHENEAKSFFEKFHGDQECYYQDDLRVLSSLTKKEHMKGNETMLDF
RTSKFVLRISRDSYQLLKRHLQEKQNNQIWNIVQEHLYIDIFDGMPRSKQQIDAMVGSLA
GEAKREANKSKVFFGLLKEPEIEVPLDDEDEEGENEEGKPKKKKPKKDSIGSKSKKQDPN
APPQNRIPLPELKDSDKLDKIMNMKETTKRVRLGPDCLPSICFYTFLNAYQGLTAVDVTD
DSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILY
GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYF
VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN
CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS
RDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPV
VHLHFTRRNLVLAAGAYSPQ
Sequence of entity 5 (F, f), FASTA
>7EGD_5 Transcription initiation factor TFIID subunit 6 (chains F, f)
MAEEKKLKLSNTVLPSESMKVVAESMGIAQIQEETCQLLTDEVSYRIKEIAQDALKFMHM
GKRQKLTTSDIDYALKLKNVEPLYGFHAQEFIPFRFASGGGRELYFYEEKEVDLSDIINT
PLPRVPLDVCLKAHWLSIEGCQPAIPENPPPAPKEQQKAEATEPLKSAKPGQEEDGPLKG
KGQGATTADGKGKEKKAPPLLEGAPLRLKPRSIHELSVEQQLYYKEITEACVGSCEAKRA
EALQSIATDPGLYQMLPRFSTFISEGVRVNVVQNNLALLIYLMRMVKALMDNPTLYLEKY
VHELIPAVMTCIVSRQLCLRPDVDNHWALRDFAARLVAQICKHFSTTTNNIQSRITKTFT
KSWVDEKTPWTTRYGSIAGLAELGHDVIKTLILPRLQQEGERIRSVLDGPVLSNIDRIGA
DHVQSLLLKHCAPVLAKLRPPPDNQDAYRAEFGSLGPLLCSQVVKARAQAALQAQQVNRT
TLTITQPRPTLTLSQAPQPGPRTPGLLKVPGSIALPVQTLVSARAAAPPQPSPPPTKFIV
MSSSSSAPSTQQVLSLSTSAPGSGSTTTSPVTTTVPSVQPIVKLVSTATTAPPSTAPSGP
GSVQKYIVVSLPPTGEGKGGPTSHPSPVPPPASSPSPLSGSALCGGKQEAGDSPPPAPGT
PKANGSQPNSGSPQPAP
Sequence of entity 6 (G), FASTA
>7EGD_6 Transcription initiation factor TFIID subunit 7 (chains G)
MSKSKDDAPHELESQFILRLPPEYASTVRRAVQSGHVNLKDRLTIELHPDGRHGIVRVDR
VPLASKLVDLPCVMESLKTIDKKTFYKTADICQMLVSTVDGDLYPPVEEPVASTDPKASK
KKDKDKEKKFIWNHGITLPLKNVRKRRFRKTAKKKYIESPDVEKEVKRLLSTDAEAVSTR
WEIIAEDETKEAENQGLDISSPGMSGHRQGHDSLEHDELREIFNDLSSSSEDEDETQHQD
EEDINIIDTEEDLERQLQDKLNESDEQHQENEGTNQLVMGIQKQIDNMKGKLQETQDRAK
RQEDLIMKVENLALKNRFQAVLDELKQKEDREKEQLSSLQEELESLLEK
Sequence of entity 7 (H), FASTA
>7EGD_7 Transcription initiation factor TFIID subunit 8 (chains H)
MADAAATAGAGGSGTRSGSKQSTNPADNYHLARRRTLQVVVSSLLTEAGFESAEKASVET
LTEMLQSYISEIGRSAKSYCEHTARTQPTLSDIVVTLVEMGFNVDTLPAYAKRSQRMVIT
APPVTNQPVTPKALTAGQNRPHPPHIPSHFPEFPDPHTYIKTPTYREPVSDYQVLREKAA
SQRRDVERALTRFMAKTGETQSLFKDDVSTFPLIAARPFTIPYLTALLPSELEMQQMEET
DSSEQDEQTDTENLALHISMEDSGAEKENTSVLQQNPSLSGSRNGEENIIDNPYLRPVKK
PKIRRKKSLS
Sequence of entity 8 (I, i), FASTA
>7EGD_8 Transcription initiation factor TFIID subunit 9 (chains I, i)
MESGKTASPKSMPKDAQMMAQILKDMGITEYEPRVINQMLEFAFRYVTTILDDAKIYSSH
AKKATVDADDVRLAIQCRADQSFTSPPPRDFLLDIARQRNQTPLPLIKPYSGPRLPPDRY
CLTAPNYRLKSLQKKASTSAGRITVPRLSVGSVTSRPSTPTLGTPTPQTMSVSTKVGTPM
SLTGQRFTVQMPTSQSPAVKASIPATSAVQNVLINPSLIGSKNILITTNMMSSQNTANES
SNALKRKREDDDDDDDDDDDYDNL
Sequence of entity 9 (J, j), FASTA
>7EGD_9 Transcription initiation factor TFIID subunit 10 (chains J, j)
MSCSGSGADPEAAPASAASAPGPAPPVSAPAALPSSTAAENKASPAGTAGGPGAGAAAGG
TGPLAARAGEPAERRGAAPVSAGGAAPPEGAISNGVYVLPSAANGDVKPVVSSTPLVDFL
MQLEDYTPTIPDAVTGYYLNRAGFEASDPRIIRLISLAAQKFISDIANDALQHCKMKGTA
SGSSRSKSKDRKYTLTMEDLTPALSEYGINVKKPHYFT
Sequence of entity 10 (L, l), FASTA
>7EGD_10 Transcription initiation factor TFIID subunit 12 (chains L, l)
MNQFGPSALINLSNFSSIKPEPASTPPQGSMANSTAVVKIPGTPGAGGRLSPENNQVLTK
KKLQDLVREVDPNEQLDEDVEEMLLQIADDFIESVVTAACQLARHRKSSTLEVKDVQLHL
ERQWNMWIPGFGSEEIRPYKKACTTEAHKQRMALIRKTTKK
Sequence of entity 11 (O), FASTA
>7EGD_11 Transcription initiation factor IIA subunit 2 (chains O)
MAYQLYRNTTLGNSLQESLDELIQSQQITPQLALQVLLQFDKAINAALAQRVRNRVNFRG
SLNTYRFCDNVWTFVLNDVEFREVTELIKVDKVKIVACDGKNTGSNTTE
Sequence of entity 12 (P), FASTA
>7EGD_12 TATA-box-binding protein (chains P)
MDQNNSLPPYAQGLASPQGAMTPGIPIFSPMMPYGTGLTPQPIQNTNSLSILEEQQRQQQ
QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQAVAAAAVQQSTSQQATQGTSGQAPQ
LFHSQTLTTAPLPGTTPLYPSPMTPMTPITPATPASESSGIVPQLQNIVSTVNLGCKLDL
KTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARV
VQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRI
VLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKGFRKTT
Primary citation
Structural insights into preinitiation complex assembly on core promoters. Chen, X., Qi, Y., Wu, Z. et al. Science (2021) 372. DOI 10.1126/science.aba8490 · PubMed
Other PDB entries of the same protein (UniProt P21675 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 5I29 1.21 Å, TAF1(2) bound to a pyrrolopyridone compound
- 7LB1 1.35 Å, Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to ZS1-585
- 4YYM 1.5 Å, Crystal structure of TAF1 BD2 Bromodomain bound to a butyryllysine peptide
- 5I1Q 1.5 Å, Second bromodomain of TAF1 bound to a pyrrolopyridone compound
- 7K27 1.5 Å, Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to ATR…
- 7JJG 1.6 Å, Crystal structure of the second bromodomain (BD2) of human TAF1 bound to ATR kinase…
- 7K03 1.6 Å, Crystal structure of the tandem bromodomain (BD1 and BD2) of human TAF1 bound to ATR…
- 7T36 1.65 Å, Crystal structure of the tandem bromodomain (BD1 and BD2) of human TAF1 bound to ZS1-322
- 7JSP 1.7 Å, Crystal structure of the second bromodomain (BD2) of human TAF1 bound to ATR kinase…
- 7K3O 1.7 Å, Crystal structure of the unliganded second bromodomain (BD2) of human TAF1
- 7K42 1.7 Å, Crystal structure of the second bromodomain (BD2) of human TAF1 bound to dioxane
- 7LB2 1.7 Å, Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to ZS1-589
Browse structure collections
About this viewer
MolViewer shows 7EGD directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.