7F4U: TELO2-TTI1-TTI2 complex

Cryo-EM structure of TELO2-TTI1-TTI2 complex. Determined by electron microscopy at 4.2 Å resolution. Released 22 Jun 2022.

Method
Electron microscopy
Resolution
4.2 Å
Organism
Homo sapiens
Chains
3
Atoms
8,079
Mol. weight
263.92 kDa
Released
22 Jun 2022

Explore 7F4U in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7F4U contains 77 α-helices and 0 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 28 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix8-2013
α-helix25-3713
α-helix49-524
α-helix53-586
α-helix59-646
α-helix65-695
α-helix74-774
α-helix83-9210
α-helix97-10913
α-helix117-12913
α-helix137-1393
α-helix146-16621
α-helix170-1756
α-helix184-20219
α-helix209-22416
α-helix231-24212
α-helix246-25712
α-helix266-2738
α-helix278-2858
α-helix294-30512
α-helix314-32512
α-helix332-34817
α-helix351-3533
α-helix354-36916
α-helix379-39416
α-helix400-41516
α-helix422-4298
α-helix443-4486
Chain B: 43 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix167-18418
α-helix194-1985
α-helix199-2079
α-helix214-2218
α-helix235-26026
α-helix266-27914
α-helix289-30012
α-helix302-3043
α-helix310-32415
α-helix332-3409
α-helix349-35810
α-helix369-38416
α-helix386-3894
α-helix397-41014
α-helix416-4194
α-helix422-43514
α-helix484-49411
α-helix502-51413
α-helix519-53416
α-helix550-56718
α-helix617-64024
α-helix644-6463
α-helix649-65911
α-helix664-6685
α-helix669-68214
α-helix688-6925
α-helix696-70712
α-helix716-7227
α-helix728-7303
α-helix731-74717
α-helix752-76817
α-helix769-7735
α-helix858-87215
α-helix879-89113
α-helix899-91416
α-helix925-93410
α-helix940-95314
α-helix978-99013
α-helix996-10027
α-helix1023-10275
α-helix1047-10504
α-helix1060-10667
α-helix1067-10693
Chain C: 6 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix42-476
α-helix68-758
α-helix96-11015
α-helix122-1309
α-helix144-16219
α-helix178-18710

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Telomere length regulation protein TEL2 homologAprotein837Homo sapiensQ9Y4R8 (AlphaFold model)
TELO2-interacting protein 1 homologBprotein1095Homo sapiensO43156 (AlphaFold model)
TELO2-interacting protein 2Cprotein508Homo sapiens
Sequence of entity 1 (A), FASTA
>7F4U_1 Telomere length regulation protein TEL2 homolog (chains A)
MEPAPSEVRLAVREAIHALSSSEDGGHIFCTLESLKRYLGEMEPPALPREKEEFASAHFS
PVLRCLASRLSPAWLELLPHGRLEELWASFFLEGPADQAFLVLMETIEGAAGPSFRLMKM
ARLLARFLREGRLAVLMEAQCRQQTQPGFILLRETLLGKVVALPDHLGNRLQQENLAEFF
PQNYFRLLGEEVVRVLQAVVDSLQGGLDSSVSFVSQVLGKACVHGRQQEILGVLVPRLAA
LTQGSYLHQRVCWRLVEQVPDRAMEAVLTGLVEAALGPEVLSRLLGNLVVKNKKAQFVMT
QKLLFLQSRLTTPMLQSLLGHLAMDSQRRPLLLQVLKELLETWGSSSAIRHTPLPQQRHV
SKAVLICLAQLGEPELRDSRDELLASMMAGVKCRLDSSLPPVRRLGMIVAEVVSARIHPE
GPPLKFQYEEDELSLELLALASPQPAGDGASEAGTSLVPATAEPPAETPAEIVDGGVPQA
QLAGSDSDLDSDDEFVPYDMSGDRELKSSKAPAYVRDCVEALTTSEDIERWEAALRALEG
LVYRSPTATREVSVELAKVLLHLEEKTCVVGFAGLRQRALVAVTVTDPAPVADYLTSQFY
ALNYSLRQRMDILDVLTLAAQELSRPGCLGRTPQPGSPSPNTPCLPEAAVSQPGSAVASD
WRVVVEERIRSKTQRLSKGGPRQGPAGSPSRFNSVAGHFFFPLLQRFDRPLVTFDLLGED
QLVLGRLAHTLGALMCLAVNTTVAVAMGKALLEFVWALRFHIDAYVRQGLLSAVSSVLLS
LPAARLLEDLMDELLEARSWLADVAEKDPDEDCRTLALRALLLLQRLKNRLLPPASP
Sequence of entity 2 (B), FASTA
>7F4U_2 TELO2-interacting protein 1 homolog (chains B)
MHHHHHMAVFDTPEEAFGVLRPVCVQLTKTQTVENVEHLQTRLQAVSDSALQELQQYILF
PLRFTLKTPGPKRERLIQSVVECLTFVLSSTCVKEQELLQELFSELSACLYSPSSQKPAA
VSEELKLAVIQGLSTLMHSAYGDIILTFYEPSILPRLGFAVSLLLGLAEQEXXXXXXXXX
XXXXXXXXXXXDCQDHPRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGDFKQGHSIVVS
SLKIFYKTVSFIMADEQLKRISKVQAKPAVEHRVAELMVYREADWVKKTGDKLTILIKKI
IECVSVHPHWKVRLELVELVEDLLLKCSQSLVECAGPLLKALVGLVNDESPEIQAQCNKV
LRHFADQKVVVGNKALADILSESLHSLATSLPRLMNSQDDQGKFSTLSLLLGYLKLLGPK
INFVLNSVAHLQRLSKALIQVLELDVADIKIVEERRWNSDDLNASPKTSATQPWNRIQRR
YFRFFTDERIFMLLRQVCQLLGYYGNLYLLVDHFMELYHQSVVYRKQAAMILNELVTGAA
GLEVEDLHEKHIKTNPEELREIVTSILEEYTSQENWYLVTCLETEEMGEELMMEHPGLQA
ITSGEHTCQVTSFLAFSKPSPTICSMNSNIWQICIQLEGIGQFAYALGKDFCLLLMSALY
PVLEKAGDQTLLISQVATSTMMDVCRACGYDSLQHLINQNSDYLVNGISLNLRHLALHPH
TPKVLEVMLRNSDANLLPLVADVVQDVLATLDQFYDKRAASFVSVLHALMAALAQWFPDT
GNLGHLQEQSLGEEGSHLNQRPAALEKSTTTAEDIEQFLLNYLKEKDVADGNVSDFDNEE
EEQSVPPKVDENDTRPDVEPPLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXRLTRDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXLVTQAPISARAGPVYSHXXXXXXXXXXXXXXXXXXXXXXXXXXXLNKVADACLIY
LSVKQPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGQQ
NPYTTNVLQLLKELQ
Sequence of entity 3 (C), FASTA
>7F4U_3 TELO2-interacting protein 2 (chains C)
MELDSALEAPSQEDSNLSEELSHSAFGQAFSKILHCLARPXXXXXXXXDAVLKDLGDLIE
ATEFXXXXXXXXXXXXXXXXXXXXVAKALEKYAAXXXXXXXXXXXXXXXXXXXXQVGLLF
XXXXXXXXXXXXXLVGPAWQTGLXXXXXXXXXXXXXXXXXXXXXTPRSREVAREXXXXXX
XXXXXXXXXXFLHGENEDEKGRLSVILGLLKPDLYKESWKNNPAIKHVFSWTLQQVTRPW
LSQHLERVLPASLVISDDYQTENKILGVHCLHHIVLNVPAADLLQYNRAQVLYHAISNHL
YTPEHHLIQAVLLCLLDLFPILEKTLHWKGDGARPTTHCDEVLRLILTHMEPEHRLLLRR
TYARNLPAFVNRLGILTVRHLKRLERVIIGYLEVYDGPEEEARLKILETLKLLMQHTWPR
VSCRLVVLLKALLKLICDVARDPNLTPESVKSALLQEATDCLILLDRCSQGRVKGLLAKI
PQSCEDRKVVNYIRKVQQVSEGAPYNGT

Primary citation

Structure of the Human TELO2-TTI1-TTI2 Complex. Kim, Y., Park, J., Joo, S.Y. et al. J Mol Biol (2022) 434:167370-167370. DOI 10.1016/j.jmb.2021.167370 · PubMed

Other PDB entries of the same protein (UniProt Q9Y4R8 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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