7FBS: Channel

structure of a channel. Determined by electron microscopy at 3.4 Å resolution. Released 22 Sept 2021.

Method
Electron microscopy
Resolution
3.4 Å
Organisms
Rattus norvegicus, Recombinant vesicular stomatitis Indiana virus rVSV-G/GFP
Chains
1
Atoms
9,274
Mol. weight
219.02 kDa
Ligands
6OU, 4Y4, 9Z9, NAG
Released
22 Sept 2021

Explore 7FBS in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7FBS contains 66 α-helices and 12 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 66 helices, 12 β-strands

ElementResiduesLengthSheet
α-helix120-13011
α-helix132-14918
α-helix156-1583
α-helix159-18022
α-helix183-1919
α-helix194-21017
α-helix219-2224
α-helix225-2339
α-helix235-2439
α-helix246-2505
α-helix252-27322
β-strand28011
β-strand28212
β-strand28313
α-helix304-3074
β-strand31512
β-strand31714
α-helix3181
β-strand32414
α-helix325-3262
α-helix336-3372
β-strand34013
β-strand34311
α-helix359-37012
α-helix375-38511
α-helix388-3903
α-helix391-3977
α-helix398-4058
α-helix406-42823
α-helix705-71410
α-helix721-73515
α-helix744-77128
α-helix774-7796
α-helix781-79616
α-helix807-82115
α-helix824-83613
α-helix841-86828
α-helix869-8724
α-helix887-89913
α-helix903-91210
α-helix915-94329
α-helix1192-120514
α-helix1207-122418
α-helix1235-126329
α-helix1265-12695
α-helix1272-129221
α-helix1300-13045
α-helix1305-131410
α-helix1315-13184
α-helix1322-13309
α-helix1333-135725
β-strand1366-136725
β-strand138216
α-helix1385-13884
β-strand1395-139625
α-helix1407-141812
α-helix1423-14308
β-strand143816
α-helix1439-14413
α-helix1446-14483
α-helix1449-14557
α-helix1456-14627
α-helix1463-148018
α-helix1491-150212
α-helix1518-152811
α-helix1530-154819
α-helix1556-158126
α-helix1587-15904
α-helix1592-161221
α-helix1623-16275
α-helix1628-16314
α-helix1632-16365
α-helix1637-16404
α-helix1644-165411
α-helix1656-168025
α-helix1699-171012
α-helix1715-17239
α-helix1747-177630

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Sodium channel protein type 5 subunit alpha,Sodium channel protein type 5 subunit alpha,Sodium…Aprotein1838Rattus norvegicus, Recombinant vesicular stomatitis Indiana virus rVSV-G/GFPB7UCZ6, P15389 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>7FBS_1 Sodium channel protein type 5 subunit alpha,Sodium channel protein type 5 subunit alpha,Sodium channel protein type 5 subunit alpha,G protein/GFP fusion protein (chains A)
MANLLLPRGTSSFRRFTRESLAAIEKRMAEKQARGGSATSQESREGLQEEEAPRPQLDLQ
ASKKLPDLYGNPPRELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHP
VRRAAVKILVHSLFSMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILAR
GFCLHAFTFLRDPWNWLDFSVIVMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTI
VGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTELNGTNGSVEADGL
VWNSLDVYLNDPANYLLKNGTTDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFA
WAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQ
NQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSARQRALSAVSVLTSALEEL
EESHRKCPPCWNRFAQHYLIWECCPLWMSIKQKVKFVVMDPFADLTITMCIVLNTLFMAL
EHYNMTAEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMEL
GLSRMGNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVV
GMQLFGKNYSELRHRISDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSL
CLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDGEMNNLQLALARIQRGLRFVK
RTTWDFCCGILRRRPKKPAALATHSQLPSCITAPRSPPPPEVEKVPPARKETRFEEDKRP
GQGTPGDSEPVCVPIAVAESDTEDQEEDEENGKVWWRLRKTCYRIVEHSWFETFIIFMIL
LSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDF
LIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMN
VLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSECESFNVTGELYWT
KVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEDNLYMYIYFVVFIIF
GSFFTLNLFIGVIIDNFNQQKKKLGGQDQQQTEEQKKYYNAMKKLGSKKPQKPIPRPLNK
YQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKVNILAKINLLFVAIFTGECI
VKMAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRL
IRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQT
FANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGSRGNCGSPAVGILFFTTYI
IISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYLALSD
FADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQME
EKFMAANPSKISYEPITTTLEVLFQGPGSMVSKGEELFTGVVPILVELDGDVNGHKFSVS
GEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLTYGVQCFSRYPDHMKQHDFFKSAMPE
GYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNV
YIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKD
PNEKRDHMVLLEFVTAAGITLGMDELYKGSDYKDDDDK

Ligands and cofactors

IDNameFormulaCopies
6OU[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-y…C39 H76 N O8 P11
4Y41-[2-[(2R)-2-oxidanyl-3-(propylamino)propoxy]phenyl]-3-phenyl-propan-1-oneC21 H27 N O31
9Z9(3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-enC34 H56 O52
NAG2-acetamido-2-deoxy-beta-D-glucopyranoseC8 H15 N O63

Primary citation

Open-state structure and pore gating mechanism of the cardiac sodium channel. Jiang, D., Banh, R., Gamal El-Din, T.M. et al. Cell (2021) 184:5151. DOI 10.1016/j.cell.2021.08.021 · PubMed

Other PDB entries of the same protein (UniProt B7UCZ6), best resolution first:

Browse structure collections

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