7LBP: Human Survivin

Crystal structure of human Survivin bound to histone H3T3phK4ac peptide. Determined by X-ray diffraction at 2.6 Å resolution. Released 12 Jan 2022.

Method: X-ray diffraction
Resolution: 2.6 Å
Organism: Homo sapiens
Chains: 4
Atoms: 2,237
Mol. weight: 36.64 kDa
Ligands: ZN
Released: 12 Jan 2022

Explore 7LBP in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7LBP contains 14 α-helices and 10 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	11-13	3
α-helix	15-20	6
α-helix	35-40	6
β-strand	43-45	3	1
β-strand	55-57	3	1
β-strand	63-65	3	1
α-helix	73-80	8
α-helix	85-88	4
α-helix	93-95	3
β-strand	97	1	2
α-helix	98-139	42

Chains B and D: 0 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	2-3	2	1

Chain C: 7 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	8-13	6
α-helix	15-20	6
α-helix	35-40	6
β-strand	43-45	3	3
β-strand	55-57	3	3
β-strand	63-65	3	3
α-helix	73-80	8
α-helix	85-88	4
α-helix	93-95	3
β-strand	97	1	2
α-helix	98-141	44

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Baculoviral IAP repeat-containing protein 5	A, C	protein	146	Homo sapiens	O15392 (AlphaFold model)
histone H3T3phK4ac peptide	B, D	protein	12	Homo sapiens	P68431 (AlphaFold model)

Sequence of entity 1 (A, C), FASTA

>7LBP_1 Baculoviral IAP repeat-containing protein 5 (chains A, C)
GSHEMGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQ
CFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKE
TNNKKKEFEETAKKVRRAIEQLAAMD

Sequence of entity 2 (B, D), FASTA

>7LBP_2 histone H3T3phK4ac peptide (chains B, D)
ARTKQTARKSTG

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	2

Primary citation

Tip60 acetylation of histone H3K4 temporally controls chromosome passenger complex localization. Niedzialkowska, E., Liu, L., Kuscu, C. et al. Mol Biol Cell (2022) 33:br15-br15. DOI 10.1091/mbc.E21-06-0283 · PubMed

Other PDB entries of the same protein (UniProt O15392 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2QFA 1.4 Å, Crystal structure of a Survivin-Borealin-INCENP core complex
9TPI 1.8 Å, Survivin 1-122 in complex with a molecular tweezer-Histone-H3-peptide conjugate
6YIF 1.81 Å, Structure of Chromosomal Passenger Complex (CPC) bound to phosphorylated Histone 3…
9TPH 2.0 Å, Survivin 1-127 in complex with a molecular tweezer-Histone-H3-peptide conjugate
3UEC 2.18 Å, Crystal structure of human Survivin bound to histone H3 phosphorylated on threonine-3.
2RAW 2.4 Å, Crystal structure of the Borealin-Survivin complex
3UIG 2.4 Å, crystal structure of human Survivin in complex with T3 phosphorylated H3(1-15) peptide
3UIH 2.4 Å, crystal structure of human Survivin in complex with Smac/DIABLO(1-15) peptide
8RUP 2.42 Å, Chromosome Passenger Complex (CPC) localization module in complex with H3.T3p-nucleosome
3UEF 2.45 Å, Crystal structure of human Survivin bound to histone H3 (C2 space group).
7LBO 2.5 Å, Crystal structure of human Survivin bound to histone H3 T3phK4me1 peptide
6YIH 2.55 Å, Structure of Chromosomal Passenger Complex (CPC) bound to phosphorylated Histone 3…

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