7LRG: Actin, alpha cardiac muscle 1

Filamentous actin decorated with human cardiac myosin binding protein C C2 domain. Determined by electron microscopy at 6.1 Å resolution. Released 11 Aug 2021.

Method
Electron microscopy
Resolution
6.1 Å
Organisms
Sus scrofa, Homo sapiens
Chains
12
Atoms
21,828
Mol. weight
315.39 kDa
Released
11 Aug 2021

Explore 7LRG in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7LRG contains 138 α-helices and 186 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A, B, C, D, E and F: 22 helices, 21 β-strands

ElementResiduesLengthSheet
β-strand8-921
β-strand17-1932
β-strand20-2121
β-strand29-3132
β-strand35-3843
β-strand53-5423
α-helix55-595
α-helix62-643
β-strand65-6843
β-strand7114
β-strand7614
α-helix79-8810
α-helix89-946
α-helix98-1003
β-strand103-10751
α-helix113-1219
α-helix122-1276
β-strand131-13661
α-helix137-1437
β-strand152-15545
β-strand160-16345
β-strand165-16626
β-strand169-17026
β-strand177-17825
α-helix182-19312
α-helix203-2053
α-helix206-21510
α-helix224-2307
β-strand238-24037
β-strand248-25037
α-helix258-2614
α-helix264-2663
α-helix277-2837
α-helix290-2956
β-strand297-30045
α-helix303-3053
α-helix309-32012
β-strand329-33025
α-helix338-3469
α-helix351-3555
β-strand357-35821
α-helix359-3657
α-helix366-3694
Chains G, H, I, J, K and L: 1 helix, 10 β-strands
ElementResiduesLengthSheet
β-strand365-367343
β-strand372-376544
β-strand379-382445
β-strand386-387243
α-helix392-3943
β-strand395-398444
β-strand401-402244
β-strand411-415545
β-strand418-426945
β-strand433-438644
β-strand441-4501044

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Actin, alpha cardiac muscle 1A, B, C, D, E, Fprotein377Sus scrofaB6VNT8 (AlphaFold model)
Myosin-binding protein C, cardiac-typeG, H, I, J, K, Lprotein94Homo sapiensQ14896 (AlphaFold model)
Sequence of entity 1 (A, B, C, D, E, F), FASTA
>7LRG_1 Actin, alpha cardiac muscle 1 (chains A, B, C, D, E, F)
MCDDEETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEA
QSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREK
MTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRL
DLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEK
SYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV
LSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWIS
KQEYDEAGPSIVHRKCF
Sequence of entity 2 (G, H, I, J, K, L), FASTA
>7LRG_2 Myosin-binding protein C, cardiac-type (chains G, H, I, J, K, L)
DEKKSTAFQKKLEPAYQVSKGHKIRLTVELADHDAEVKWLKNGQEIQMSGSKYIFESIGA
KRTLTISQCSLADDAAYQCVVGGEKCSTELFVKE

Primary citation

Interaction of the C2 Ig-like Domain of Cardiac Myosin Binding Protein-C with F-actin. Risi, C.M., Patra, M., Belknap, B. et al. J Mol Biol (2021) 433:167178-167178. DOI 10.1016/j.jmb.2021.167178 · PubMed

Other PDB entries of the same protein (UniProt B6VNT8 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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