7MQ9: Human SSU processome, state pre-A1*
Cryo-EM structure of the human SSU processome, state pre-A1*. Determined by electron microscopy at 3.87 Å resolution. Released 22 Sept 2021.
- Method
- Electron microscopy
- Resolution
- 3.87 Å
- Organism
- Homo sapiens
- Chains
- 74
- Atoms
- 223,184
- Mol. weight
- 5736.63 kDa
- Ligands
- GTP, SAH, ATP, ZN
- Released
- 22 Sept 2021
Explore 7MQ9 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7MQ9 contains 1,199 α-helices and 1,089 β-strands across 70 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain L3: 6 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 6-8 | 3 | |
| β-strand | 12-15 | 4 | 27 |
| β-strand | 18-21 | 4 | 27 |
| β-strand | 25 | 1 | 28 |
| α-helix | 26-30 | 5 | |
| α-helix | 38-47 | 10 | |
| β-strand | 55 | 1 | 28 |
| α-helix | 56-58 | 3 | |
| α-helix | 61-72 | 12 | |
| α-helix | 95-115 | 21 | |
Chain L4: 9 helices, 23 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 9-10 | 2 | 32 |
| α-helix | 16-18 | 3 | |
| β-strand | 27-28 | 2 | 32 |
| α-helix | 30-32 | 3 | |
| β-strand | 42-43 | 2 | 33 |
| α-helix | 44-45 | 2 | |
| α-helix | 46-51 | 6 | |
| α-helix | 58-65 | 8 | |
| β-strand | 70-72 | 3 | 34 |
| β-strand | 75-76 | 2 | 34 |
| α-helix | 82 | 1 | |
| β-strand | 83-84 | 2 | 33 |
| β-strand | 89-92 | 4 | 34 |
| β-strand | 97-100 | 4 | 34 |
| β-strand | 102-103 | 2 | 35 |
| β-strand | 109-110 | 2 | 35 |
| β-strand | 113 | 1 | 34 |
| α-helix | 118-120 | 3 | |
| β-strand | 121-125 | 5 | 36 |
| β-strand | 126-131 | 6 | 37 |
| α-helix | 133-135 | 3 | |
| β-strand | 137-141 | 5 | 37 |
| β-strand | 146-148 | 3 | 37 |
| β-strand | 159-163 | 5 | 36 |
| β-strand | 168-173 | 6 | 36 |
| β-strand | 180-183 | 4 | 38 |
| β-strand | 192-199 | 8 | 38 |
| β-strand | 207-211 | 5 | 38 |
| β-strand | 217-221 | 5 | 38 |
| α-helix | 222-224 | 3 | |
| β-strand | 225-230 | 6 | 38 |
| β-strand | 233-234 | 2 | 38 |
Chain L5: 8 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 19 | 1 | 43 |
| β-strand | 23 | 1 | 43 |
| α-helix | 36-38 | 3 | |
| α-helix | 62-65 | 4 | |
| α-helix | 68-78 | 11 | |
| α-helix | 86-104 | 19 | |
| α-helix | 108-119 | 12 | |
| β-strand | 123-129 | 7 | 44 |
| β-strand | 134-141 | 8 | 44 |
| α-helix | 143-162 | 20 | |
| α-helix | 169-182 | 14 | |
| α-helix | 188-202 | 15 | |
Chain L6: 8 helices, 13 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 2-7 | 6 | 47 |
| β-strand | 12-17 | 6 | 47 |
| α-helix | 21-24 | 4 | |
| α-helix | 25-27 | 3 | |
| β-strand | 35-37 | 3 | 47 |
| α-helix | 39-41 | 3 | |
| β-strand | 49-56 | 8 | 47 |
| β-strand | 62 | 1 | 47 |
| β-strand | 63 | 1 | 48 |
| β-strand | 72-77 | 6 | 48 |
| β-strand | 93-98 | 6 | 48 |
| β-strand | 108-115 | 8 | 47 |
| β-strand | 137 | 1 | 49 |
| α-helix | 138-145 | 8 | |
| α-helix | 153-156 | 4 | |
| α-helix | 157-159 | 3 | |
| β-strand | 160-162 | 3 | 50 |
| β-strand | 170-172 | 3 | 50 |
| α-helix | 174-176 | 3 | |
| β-strand | 177 | 1 | 49 |
| α-helix | 182-234 | 53 | |
Chain L7: 9 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 9 | 1 | 52 |
| α-helix | 15-17 | 3 | |
| α-helix | 18-32 | 15 | |
| α-helix | 37-40 | 4 | |
| β-strand | 45 | 1 | 52 |
| β-strand | 47-53 | 7 | 53 |
| β-strand | 57-64 | 8 | 53 |
| α-helix | 69-74 | 6 | |
| α-helix | 76-86 | 11 | |
| β-strand | 91-96 | 6 | 53 |
| α-helix | 122-133 | 12 | |
| β-strand | 139-146 | 8 | 54 |
| β-strand | 152-158 | 7 | 54 |
| α-helix | 163-166 | 4 | |
| α-helix | 167-169 | 3 | |
| α-helix | 170-180 | 11 | |
| β-strand | 185-188 | 4 | 54 |
Chain L8: 9 helices, 12 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 3-4 | 2 | 58 |
| α-helix | 11-12 | 2 | |
| α-helix | 26-28 | 3 | |
| β-strand | 29-30 | 2 | 58 |
| β-strand | 36 | 1 | 59 |
| β-strand | 37-38 | 2 | 60 |
| β-strand | 42-47 | 6 | 60 |
| α-helix | 49-51 | 3 | |
| β-strand | 53-60 | 8 | 60 |
| β-strand | 62-67 | 6 | 61 |
| β-strand | 72-83 | 12 | 61 |
| α-helix | 89-93 | 5 | |
| β-strand | 96 | 1 | 59 |
| β-strand | 101-105 | 5 | 61 |
| α-helix | 107-116 | 10 | |
| α-helix | 152-154 | 3 | |
| α-helix | 160-168 | 9 | |
| β-strand | 170-175 | 6 | 61 |
| α-helix | 179-182 | 4 | |
| β-strand | 187-189 | 3 | 61 |
| α-helix | 192-205 | 14 | |
Chain L9: 11 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 22-35 | 14 | |
| α-helix | 41-61 | 21 | |
| α-helix | 68-83 | 16 | |
| α-helix | 94-98 | 5 | |
| α-helix | 102-106 | 5 | |
| β-strand | 109 | 1 | 75 |
| α-helix | 110-116 | 7 | |
| α-helix | 123-131 | 9 | |
| β-strand | 135-137 | 3 | 76 |
| β-strand | 140-141 | 2 | 76 |
| α-helix | 147 | 1 | |
| β-strand | 148 | 1 | 75 |
| α-helix | 149-150 | 2 | |
| α-helix | 152-156 | 5 | |
| β-strand | 157-159 | 3 | 76 |
| α-helix | 172-180 | 9 | |
Chain LA: 6 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 12-27 | 16 | |
| β-strand | 32-33 | 2 | 89 |
| α-helix | 35-44 | 10 | |
| β-strand | 49-53 | 5 | 89 |
| α-helix | 61-72 | 12 | |
| β-strand | 75-79 | 5 | 89 |
| α-helix | 83-89 | 7 | |
| β-strand | 93 | 1 | 90 |
| α-helix | 100 | 1 | |
| β-strand | 101 | 1 | 90 |
| β-strand | 108-111 | 4 | 89 |
| α-helix | 121-129 | 9 | |
62 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| 5'ETS rRNA | L0 | RNA | 3617 | Homo sapiens | |
| 18S rRNA | L1 | RNA | 1872 | Homo sapiens | |
| U3 snoRNA | L2 | RNA | 217 | Homo sapiens | |
| 40S ribosomal protein S18 | L3 | protein | 116 | Homo sapiens | P62269 (AlphaFold model) |
| 40S ribosomal protein S4 X isoform | L4 | protein | 263 | Homo sapiens | P62701 (AlphaFold model) |
| 40S ribosomal protein S5 | L5 | protein | 204 | Homo sapiens | P46782 (AlphaFold model) |
| 40S ribosomal protein S6 | L6 | protein | 249 | Homo sapiens | P62753 (AlphaFold model) |
| 40S ribosomal protein S7 | L7 | protein | 194 | Homo sapiens | P62081 |
| 40S ribosomal protein S8 | L8 | protein | 208 | Homo sapiens | P62241 |
| 40S ribosomal protein S9 | L9 | protein | 194 | Homo sapiens | P46781 |
| 40S ribosomal protein S12 | LA | protein | 132 | Homo sapiens | P25398 |
| 40S ribosomal protein S16 | LC | protein | 146 | Homo sapiens | P62249 |
57 more molecules are not listed.
Sequence of entity 1 (L0), FASTA
>7MQ9_1 5'ETS rRNA (chains L0)
GCUGACACGCUGUCCUCUGGCGACCUGUCGCUGGAGAGGUUGGGCCUCCGGAUGCGCGCG
GGGCUCUGGCCUACCGGUGACCCGGCUAGCCGGCCGCGCUCCUGCUUGAGCCGCCUGCCG
GGGCCCGCGGGCCUGCUGUUCUCUCGCGCGUCCGAGCGUCCCGACUCCCGGUGCCGGCCC
GGGUCCGGGUCUCUGACCCACCCGGGGGCGGCGGGGAAGGCGGCGAGGGCCACCGUGCCC
CCGUGCGCUCUCCGCUGCGGGCGCCCGGGGCGGCCGCGACAACCCCACCCCGCUGGCUCC
GUGCCGUGCGUGUCAGGCGUUCUCGUCUCCGCGGGGUUGUCCGCCGCCCCUUCCCCGGAG
UGGGGGGUUGGCCGGAGCCGAUCGGCUCGCUGGCCGGCCGGCCGGCCUCCGCUCCCGGGG
GGCUCUUCGUGAUCGAUGUGGUGACGUCGUGCUCUCCCGGGCCGGGUCCGAGCCGCGACG
GGCGAGGGGCGGACGUUCGUGGCGAACGGGACCGUCCUUCUCGCUCCGCCCCGCGGGGGU
CCCCUCGUCUCUCCUCUCCCCGCCCGCCGGCGGUGCGUGUGGGAAGGCGUGGGGUGCGGA
CCCCGGCCCGACCUCGCCGUCCCGCCCGCCGCCUUCUGCGUCGCGGGUGCGGGCCGGCGG
GGUCCUCUGACGCGGCAGACAGCCCUCGCUGUCGCCUCCAGUGGUUGUCGACUUGCGGGC
GGCCCCCCUCCGCGGCGGUGGGGGUGCCGUCCCGCCGGCCCGUCGUGCUGCCGUCUCGGG
GGGUUUGCGCGAGCGUCGGCUCCGCCUGGGCCCUUGCGGUGCUCCUGGAGCGCUCCGGGU
UGUCCCUCAGGUGCCCGAGGCCGAACGGUGGUGUGUCGUUCCCGCCCCCGGCGCCCCCUC
CUCCGGUCGCCGCCGCGGUGUCCGCGCGUGGGUCCUGAGGGAGCUCGUCGGUGUGGGGUU
CGAGGCGGUUUGAGUGAGACGAGACGAGACGCGCCCCUCCCACGCGGGGAAGGGCGCCCG
CCUGCUCUCGGUGAGCGCACGUCCCGUGCUCCCCUCUGGCGGGUGCGCGCGGGCCGUGUG
AGCGAUCGCGGUGGGUUCGGGCCGGUGUGACGCGUGCGCCGGCCGGCCGCCGAGGGGCUG
CCGUUCUGCCUCCGACCGGUCGUGUGUGGGUUGACUUCGGAGGCGCUCUGCCUCGGAAGG
AAGGAGGUGGGUGGACGGGGGGGCCUGGUGGGGUUGCGCGCACGCGCGCACCGGCCGGGC
CCCCGCCCUGAACGCGAACGCUCGAGGUGGCCGCGCGCAGGUGUUUCCUCGUACCGCAGG
GCCCCCUCCCUUCCCCAGGCGUCCCUCGGCGCCUCUGCGGGCCCGAGGAGGAGCGGCUGG
CGGGUGGGGGGAGUGUGACCCACCCUCGGUGAGAAAAGCCUUCUCUAGCGAUCUGAGAGG
CGUGCCUUGGGGGUACCGGAUCCCCCGGGCCGCCGCCUCUGUCUCUGCCUCCGUUAUGGU
AGCGCUGCCGUAGCGACCCGCUCGCAGAGGACCCUCCUCCGCUUCCCCCUCGACGGGGUU
GGGGGGGAGAAGCGAGGGUUCCGCCGGCCACCGCGGUGGUGGCCGAGUGCGGCUCGUCGC
CUACUGUGGCCCGCGCCUCCCCCUUCCGAGUCGGGGGAGGAUCCCGCCGGGCCGGGCCCG
GCGUUCCCAGCGGGUUGGGACGCGGCGGCCGGCGGGCGGUGGGUGUGCGCGCCCGGCGCU
CUGUCCGGCGCGUGACCCCCUCCGCCGCGAGUCGGCUCUCCGCCCGCUCCCGUGCCGAGU
CGUGACCGGUGCCGACGACCGCGUUUGCGUGGCACGGGGUCGGGCCCGCCUGGCCCUGGG
AAAGCGUCCCACGGUGGGGGCGCGCCGGUCUCCCGGAGCGGGACCGGGUCGGAGGAUGGA
CGAGAAUCACGAGCGACGGUGGUGGUGGCGUGUCGGGUUCGUGGCUGCGGUCGCUCCGGG
GCCCCCGGUGGCGGGGCCCCGGGGCUCGCGAGGCGGUUCUCGGUGGGGGCCGAGGGCCGU
CCGGCGUCCCAGGCGGGGCGCCGCGGGACCGCCCUCGUGUCUGUGGCGGUGGGAUCCCGC
GGCCGUGUUUUCCUGGUGGCCCGGCCGUGCCUGAGGUUUCUCCCCGAGCCGCCGCCUCUG
CGGGCUCCCGGGUGCCCUUGCCCUCGCGGUCCCCGGCCCUCGCCCGUCUGUGCCCUCUUC
CCCGCCCGCCGCCCGCCGAUCCUCUUCUUCCCCCGAGCGGCUCACCGGCUUCACGUCCGU
UGGUGGCCCCGCCUGGGACCGAACCCGGCACCGCCUCGUGGGGCGCCGCCGCCGGCCACU
GAUCGGCCCGGCGUCCGCGUCCCCCGGCGCGCGCCUUGGGGACCGGGUCGGUGGCGCCCC
GCGUGGGGCCCGGUGGGCUUCCAGGAGGGUUCCGGGGGUCGGCCUGCGGCGCGUGCGGGG
GAGGAGACGGUUCCGGGGGACCGGCCGCGACUGCGGCGGCGGUGGUGGGGGGAGCCGCGG
GGAUCGCCGAGGGCCGGUCGGCCGCCCCGGGUGCCGCGCGGUGCCGCCGGCGGCGGUGAG
GCCCCGCGCGUGUGUCCCGGCCGCGGUCGGCCGCGCUCGAGGGGUCCCCGUGGCGUCCCC
UUCCCCGCCGGCCGCCUUUCUCGCGCCUUCCCCGUCGCCCCGGCCUCGCCCGUGGUCUCU
CGUCUUCUCCCGGCCCGCUCUUCCGAACCGGGUCGGCGCGUCCCCCGGGUGCGCCUCGCU
UCCCGGGCCUGCCGCGGCCCUUCCCCGAGGCGUCCGUCCCGGGCGUCGGCGUCGGGGAGA
GCCCGUCCUCCCCGCGUGGCGUCGCCCCGUUCGGCGCGCGCGUGCGCCCGAGCGCGGCCC
GGUGGUCCCUCCCGGACAGGCGUUCGUGCGACGUGUGGCGUGGGUCGACCUCCGCCUUGC
CGGUCGCUCGCCCUCUCCCCGGGUCGGGGGGUGGGGCCCGGGCCGGGGCCUCGGCCCCGG
UCGCGGUCCCCCGUCCCGGGCGGGGGCGGGCGCGCCGGCCGGCCUCGGUCGCCCUCCCUU
GGCCGUCGUGUGGCGUGUGCCACCCCUGCGCCCGCGCCCGCCGGCGGGGCUCGGAGCCGG
GCUUCGGCCGGGCCCCGGGCCCUCGACCGGACCGGUGCGCGGGCGCUGCGGCCGCACGGC
GCGACUGUCCCCGGGCCGGGCACCGCGGUCCGCCUCUCGCUCGCCGCCCGGACGUCGGGG
CCGCCCCGCGGGGCGGGCGGAGCGCCGUCCCCGCCUCGCCGCCGCCCGCGGGCGCCGGCC
GCGCGCGCGCGCGCGUGGCCGCCGGUCCCUCCCGGCCGCCGGGCGCGGGUCGGGCCGUCC
GCCUCCUCGCGGGCGGGCGCGACGAAGAAGCGUCGCGGGUCUGUGGCGCGGGGCCCCCGG
UGGUCGUGUCGCGUGGGGGGCGGGUGGUUGGGGCGUCCGGUUCGCCGCGCCCCGCCCCGG
CCCCACCGGUCCCGGCCGCCGCCCCCGCGCCCGCUCGCUCCCUCCCGUCCGCCCGUCCGC
GGCCCGUCCGUCCGUCCGUCCGUCGUCCUCCUCGCUUGCGGGGCGCCGGGCCCGUCCUCG
ACGCGCUCUACCUUACC
Sequence of entity 2 (L1), FASTA
>7MQ9_2 18S rRNA (chains L1)
UACCUGGUUGAUCCUGCCAGUAGCAUAUGCUUGUCUCAAAGAUUAAGCCAUGCAUGUCUA
AGUACGCACGGCCGGUACAGUGAAACUGCGAAUGGCUCAUUAAAUCAGUUAUGGUUCCUU
UGGUCGCUCGCUCCUCUCCUACUUGGAUAACUGUGGUAAUUCUAGAGCUAAUACAUGCCG
ACGGGCGCUGACCCCCUUCGCGGGGGGGAUGCGUGCAUUUAUCAGAUCAAAACCAACCCG
GUCAGCCCCUCUCCGGCCCCGGCCGGGGGGCGGGCGCCGGCGGCUUUGGUGACUCUAGAU
AACCUCGGGCCGAUCGCACGCCCCCCGUGGCGGCGACGACCCAUUCGAACGUCUGCCCUA
UCAACUUUCGAUGGUAGUCGCCGUGCCUACCAUGGUGACCACGGGUGACGGGGAAUCAGG
GUUCGAUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCCAAGGAAGGCAGCAGGCG
CGCAAAUUACCCACUCCCGACCCGGGGAGGUAGUGACGAAAAAUAACAAUACAGGACUCU
UUCGAGGCCCUGUAAUUGGAAUGAGUCCACUUUAAAUCCUUUAACGAGGAUCCAUUGGAG
GGCAAGUCUGGUGCCAGCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAAGUUGC
UGCAGUUAAAAAGCUCGUAGUUGGAUCUUGGGAGCGGGCGGGCGGUCCGCCGCGAGGCGA
GCCACCGCCCGUCCCCGCCCCUUGCCUCUCGGCGCCCCCUCGAUGCUCUUAGCUGAGUGU
CCCGCGGGGCCCGAAGCGUUUACUUUGAAAAAAUUAGAGUGUUCAAAGCAGGCCCGAGCC
GCCUGGAUACCGCAGCUAGGAAUAAUGGAAUAGGACCGCGGUUCUAUUUUGUUGGUUUUC
GGAACUGAGGCCAUGAUUAAGAGGGACGGCCGGGGGCAUUCGUAUUGCGCCGCUAGAGGU
GAAAUUCUUGGACCGGCGCAAGACGGACCAGAGCGAAAGCAUUUGCCAAGAAUGUUUUCA
UUAAUCAAGAACGAAAGUCGGAGGUUCGAAGACGAUCAGAUACCGUCGUAGUUCCGACCA
UAAACGAUGCCGACCGGCGAUGCGGCGGCGUUAUUCCCAUGACCCGCCGGGCAGCUUCCG
GGAAACCAAAGUCUUUGGGUUCCGGGGGGAGUAUGGUUGCAAAGCUGAAACUUAAAGGAA
UUGACGGAAGGGCACCACCAGGAGUGGAGCCUGCGGCUUAAUUUGACUCAACACGGGAAA
CCUCACCCGGCCCGGACACGGACAGGAUUGACAGAUUGAUAGCUCUUUCUCGAUUCCGUG
GGUGGUGGUGCAUGGCCGUUCUUAGUUGGUGGAGCGAUUUGUCUGGUUAAUUCCGAUAAC
GAACGAGACUCUGGCAUGCUAACUAGUUACGCGACCCCCGAGCGGUCGGCGUCCCCCAAC
UUCUUAGAGGGACAAGUGGCGUUCAGCCACCCGAGAUUGAGCAAUAACAGGUCUGUGAUG
CCCUUAGAUGUCCGGGGCUGCACGCGCGCUACACUGACUGGCUCAGCGUGUGCCUACCCU
ACGCCGGCAGGCGCGGGUAACCCGUUGAACCCCAUUCGUGAUGGGGAUCGGGGAUUGCAA
UUAUUCCCCAUGAACGAGGAAUUCCCAGUAAGUGCGGGUCAUAAGCUUGCGUUGAUUAAG
UCCCUGCCCUUUGUACACACCGCCCGUCGCUACUACCGAUUGGAUGGUUUAGUGAGGCCC
UCGGAUCGGCCCCGCCGGGGUCGGCCCACGGCCCUGGCGGAGCGCUGAGAAGACGGUCGA
ACUUGACUAUCUAGAGGAAGUAAAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAA
GGAUCAUUAACG
Sequence of entity 3 (L2), FASTA
>7MQ9_3 U3 snoRNA (chains L2)
AAGACUAUACUUUCAGGGAUCAUUUCUAUAGUGUGUUACUAGAGAAGUUUCUCUGAACGU
GUAGAGCACCGAAAACCACGAGGAAGAGAGGUAGCGUUUUCUCCUGAGCGUGAAGCCGGC
UUUCUGGCGUUGCUUGGCUGCAACUGCCGUCAGCCAUUGAUGAUCGUUCUUCUCUCCGUA
UUGGGGAGUGAGAGGGAGAGAACGCGGUCUGAGUGGU
Sequence of entity 4 (L3), FASTA
>7MQ9_4 40S ribosomal protein S18 (chains L3)
MSLVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDLTKRAGELT
EDEVERVITIMQNPRQYKIPDWFLNRQXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
Sequence of entity 5 (L4), FASTA
>7MQ9_5 40S ribosomal protein S4 X isoform (chains L4)
MARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIIFLRNRLKYALTGDE
VKKICMQRFIKIDGKVRTDITYPAGFMDVISIDKTGENFRLIYDTKGRFAVHRITPEEAK
YKLCKVRKIFVGTKGIPHLVTHDARTIRYPDPLIKVNDTIQIDLETGKITDFIKFDTGNL
CMVTGGANLGRIGVITNRERHPGSFDVVHVKDANGNSFATRLSNIFVIGKGNKPWISLPR
GKGIRLTIAEERDKRLAAKQSSG
Sequence of entity 6 (L5), FASTA
>7MQ9_6 40S ribosomal protein S5 (chains L5)
MTEWETAAPAVAETPDIKLFGKWSTDDVQINDISLQDYIAVKEKYAKYLPHSAGRYAAKR
FRKAQCPIVERLTNSMMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVNAIINSG
PREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLADELINA
AKGSSNSYAIKKKDELERVAKSNR
Sequence of entity 7 (L6), FASTA
>7MQ9_7 40S ribosomal protein S6 (chains L6)
MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQG
FPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKD
IPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLV
TPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRAS
TSKSESSQK
Sequence of entity 8 (L7), FASTA
>7MQ9_8 40S ribosomal protein S7 (chains L7)
MFSSSAKIVKPNGEKPDEFESGISQALLELEMNSDLKAQLRELNITAAKEIEVGGGRKAI
IIFVPVPQLKSFQKIQVRLVRELEKKFSGKHVVFIAQRRILPKPTRKSRTKNKQKRPRSR
TLTAVHDAILEDLVFPSEIVGKRIRVKLDGSRLIKVHLDKAQQNNVEHKVETFSGVYKKL
TGKDVNFEFPEFQL
Sequence of entity 9 (L8), FASTA
>7MQ9_9 40S ribosomal protein S8 (chains L8)
MGISRDNWHKRRKTGGKRKPYHKKRKYELGRPAANTKIGPRRIHTVRVRGGNKKYRALRL
DVGNFSWGSECCTRKTRIIDVVYNASNNELVRTKTLVKNCIVLIDSTPYRQWYESHYALP
LGRKKGAKLTPEEEEILNKKRSKKIQKKYDERKKNAKISSLLEEQFQQGKLLACIASRPG
QCGRADGYVLEGKELEFYLRKIKARKGK
Sequence of entity 10 (L9), FASTA
>7MQ9_10 40S ribosomal protein S9 (chains L9)
MPVARSWVCRKTYVTPRRPFEKSRLDQELKLIGEYGLRNKREVWRVKFTLAKIRKAAREL
LTLDEKDPRRLFEGNALLRRLVRIGVLDEGKMKLDYILGLKIEDFLERRLQTQVFKLGLA
KSIHHARVLIRQRHIRVRKQVVNIPSFIVRLDSQKHIDFSLRSPYGGGRPGRVKRKNAKK
GQGGAGAGDDEEED
Sequence of entity 11 (LA), FASTA
>7MQ9_11 40S ribosomal protein S12 (chains LA)
MAEEGIAAGGVMDVNTALQEVLKTALIHDGLARGIREAAKALDKRQAHLCVLASNCDEPM
YVKLVEALCAEHQINLIKVDDNKKLGEWVGLCKIDREGKPRKVVGCSCVVVKDYGKESQA
KDVIEEYFKCKK
Sequence of entity 12 (LC), FASTA
>7MQ9_12 40S ribosomal protein S16 (chains LC)
MPSKGPLQSVQVFGRKKTATAVAHCKRGNGLIKVNGRPLEMIEPRTLQYKLLEPVLLLGK
ERFAGVDIRVRVKGGGHVAQIYAIRQSISKALVAYYQKYVDEASKKEIKDILIQYDRTLL
VADPRRCESKKFGGPGARARYQKSYR
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| GTP | Guanosine-5'-triphosphate | C10 H16 N5 O14 P3 | 1 |
| SAH | S-adenosyl-L-homocysteine | C14 H20 N6 O5 S | 2 |
| ATP | Adenosine-5'-triphosphate | C10 H16 N5 O13 P3 | 2 |
| ZN | Zinc ion | Zn | 3 |
| MG | Magnesium ion | Mg | 22 |
Primary citation
Nucleolar maturation of the human small subunit processome. Singh, S., Vanden Broeck, A., Miller, L. et al. Science (2021) 373:eabj5338-eabj5338. DOI 10.1126/science.abj5338 · PubMed
Other PDB entries of the same protein (UniProt P62269 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 8GLP 1.67 Å, mRNA decoding in human is kinetically and structurally distinct from bacteria (Consensus…
- 8QOI 1.9 Å, Structure of the human 80S ribosome at 1.9 A resolution - the molecular role of chemical…
- 9O3W 1.9 Å, Human 80S ribosome bound to IDB-001 stalled on MYC nascent chain
- 8YOO 2.0 Å, Cryo-EM structure of the human 80S ribosome with 100 um Tigecycline
- 9C3H 2.0 Å, Structure of the CNOT3-bound human 80S ribosome with tRNA-ARG in the P-site.
- 29IZ 2.08 Å, Dormant 80S:eEF2:SERBP1:tRNA complex from human cells treated with toxin NT-2
- 9TV2 2.1 Å, 80S ribosomes from primary B-cells infected with delta v-snoRNA1 EBV
- 7R4X 2.15 Å, Cryo-EM reconstruction of the human 40S ribosomal subunit - Full map
- 9I2D 2.19 Å, NMT1-NAC bound human RNC with 10 amino acid ARF1-linker
- 9PBE 2.19 Å, In situ human 80S ribosome (composite map)
- 8YOP 2.2 Å, Cryo-EM structure of the human 80S ribosome with 4 um Tigecycline
- 9O3V 2.2 Å, Human 80S ribosome stalled on MYC nascent chain
Browse structure collections
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