7MU8: PDB entry 7MU8

Structure of the minimally glycosylated human CEACAM1 N-terminal domain. Determined by X-ray diffraction at 1.7 Å resolution. Released 9 Feb 2022.

Method: X-ray diffraction
Resolution: 1.7 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,883
Mol. weight: 25.48 kDa
Ligands: NAG
Released: 9 Feb 2022

Explore 7MU8 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7MU8 contains 4 α-helices and 22 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and B: 2 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	3-7	5	1
β-strand	10-11	2	2
β-strand	17-22	6	1
β-strand	28-35	8	3
α-helix	41-43	3
β-strand	44-49	6	3
β-strand	54-57	4	3
β-strand	65-67	3	1
β-strand	73-75	3	1
α-helix	80-82	3
β-strand	84-92	9	3
β-strand	98-104	7	3
β-strand	105-106	2	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Carcinoembryonic antigen-related cell adhesion molecule 1	A, B	protein	107	Homo sapiens	P13688 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>7MU8_1 Carcinoembryonic antigen-related cell adhesion molecule 1 (chains A, B)
QLTTESMPFNVAEGKEVLLLVHNLPQQLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPA
NSGRETIYPNASLLIQNVTQNDTGFYTLQVIKSDLVNEEATGQFHVY

Ligands and cofactors

ID	Name	Formula	Copies
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose	C8 H15 N O6	3

Water and common crystallization additives (SO4, GOL) are not listed.

Primary citation

Human CEACAM1 N-domain dimerization is independent from glycan modifications. Belcher Dufrisne, M., Swope, N., Kieber, M. et al. Structure (2022) 30:658-670.e5. DOI 10.1016/j.str.2022.02.003 · PubMed

Other PDB entries of the same protein (UniProt P13688 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6XO1 1.76 Å, Crystal structure of N97A mutant of human CEACAM1
23VF 1.79 Å, Crystal structure of CEACAM1 in complex with MG1124 antibody
6XNO 1.9 Å, Crystal structure of E99A mutant of human CEACAM1
6XNW 1.9 Å, Crystal structure of V39A mutant of human CEACAM1
4QXW 2.04 Å, Crystal structure of the human CEACAM1 membrane distal amino terminal (N)-domain
9U94 2.11 Å, Cryo-EM structure of Fusobacterium nucleatum CbpF in complex with human CEACAM1
2GK2 2.2 Å, Crystal structure of the N terminal domain of human CEACAM1
7RPP 2.2 Å, Crystal structure of human CEACAM1 with GFCC' and ABED face
4WHD 2.5 Å, Human CEACAM1 N-domain homodimer
6GBH 2.59 Å, Helicobacter pylori adhesin HopQ type II bound to the N-terminal domain of human CEACAM1
6AW2 2.68 Å, Crystal structure of the HopQ-CEACAM1 complex
9GH5 2.7 Å, Complex of Fusobacterium nucleatum CbpF with human CEACAM1

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