7NFC: NHEJ super-complex
Cryo-EM structure of NHEJ super-complex (dimer). Determined by electron microscopy at 4.14 Å resolution. Released 18 Aug 2021.
- Method
- Electron microscopy
- Resolution
- 4.14 Å
- Organism
- Homo sapiens
- Chains
- 18
- Atoms
- 89,069
- Mol. weight
- 1710.54 kDa
- Released
- 18 Aug 2021
Explore 7NFC in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7NFC contains 600 α-helices and 193 β-strands across 14 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 227 helices, 21 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 11-21 | 11 | |
| α-helix | 28-45 | 18 | |
| α-helix | 52-69 | 18 | |
| α-helix | 76-93 | 18 | |
| α-helix | 98-100 | 3 | |
| α-helix | 101-113 | 13 | |
| α-helix | 114-118 | 5 | |
| α-helix | 125-140 | 16 | |
| α-helix | 150-160 | 11 | |
| α-helix | 170-172 | 3 | |
| α-helix | 173-178 | 6 | |
| α-helix | 187-208 | 22 | |
| α-helix | 217-221 | 5 | |
| α-helix | 222-231 | 10 | |
| α-helix | 241-254 | 14 | |
| α-helix | 267-277 | 11 | |
| α-helix | 280-282 | 3 | |
| α-helix | 290-300 | 11 | |
| α-helix | 306-329 | 24 | |
| α-helix | 333-336 | 4 | |
| α-helix | 337-341 | 5 | |
| α-helix | 342-348 | 7 | |
| α-helix | 358-375 | 18 | |
| α-helix | 378-397 | 20 | |
| α-helix | 410-423 | 14 | |
| α-helix | 429-431 | 3 | |
| α-helix | 432-444 | 13 | |
| α-helix | 451-468 | 18 | |
| α-helix | 472-491 | 20 | |
| α-helix | 494-495 | 2 | |
| α-helix | 527-535 | 9 | |
| α-helix | 538-546 | 9 | |
| α-helix | 560-578 | 19 | |
| β-strand | 584 | 1 | 1 |
| β-strand | 613 | 1 | 1 |
| α-helix | 617-633 | 17 | |
| α-helix | 634-636 | 3 | |
| α-helix | 645-659 | 15 | |
| α-helix | 664-679 | 16 | |
| α-helix | 698-717 | 20 | |
| α-helix | 718-720 | 3 | |
| α-helix | 726-735 | 10 | |
| α-helix | 738-741 | 4 | |
| α-helix | 745-758 | 14 | |
| α-helix | 763-779 | 17 | |
| α-helix | 782-785 | 4 | |
| α-helix | 786-788 | 3 | |
| α-helix | 789-792 | 4 | |
| α-helix | 793-797 | 5 | |
| α-helix | 835-839 | 5 | |
| α-helix | 849-862 | 14 | |
| α-helix | 864-867 | 4 | |
| α-helix | 868-870 | 3 | |
| β-strand | 895 | 1 | 2 |
| β-strand | 904 | 1 | 2 |
| α-helix | 907-910 | 4 | |
| α-helix | 911-919 | 9 | |
| α-helix | 924-943 | 20 | |
| α-helix | 960-973 | 14 | |
| α-helix | 979-994 | 16 | |
| α-helix | 1005-1014 | 10 | |
| α-helix | 1023-1043 | 21 | |
| α-helix | 1046-1051 | 6 | |
| α-helix | 1056-1068 | 13 | |
| α-helix | 1072-1089 | 18 | |
| α-helix | 1093-1098 | 6 | |
| α-helix | 1101-1115 | 15 | |
| α-helix | 1123-1140 | 18 | |
| α-helix | 1143-1146 | 4 | |
| β-strand | 1149 | 1 | 3 |
| α-helix | 1151-1154 | 4 | |
| β-strand | 1163 | 1 | 3 |
| α-helix | 1165-1174 | 10 | |
| α-helix | 1181-1197 | 17 | |
| α-helix | 1206-1214 | 9 | |
| α-helix | 1218 | 1 | |
| α-helix | 1219-1223 | 5 | |
| α-helix | 1232-1237 | 6 | |
| α-helix | 1250-1273 | 24 | |
| α-helix | 1278-1279 | 2 | |
| α-helix | 1280-1284 | 5 | |
| α-helix | 1288-1299 | 12 | |
| α-helix | 1327-1351 | 25 | |
| α-helix | 1354-1356 | 3 | |
| α-helix | 1357-1360 | 4 | |
| α-helix | 1361-1363 | 3 | |
| α-helix | 1368-1377 | 10 | |
| α-helix | 1379-1382 | 4 | |
| α-helix | 1390-1408 | 19 | |
| α-helix | 1412-1422 | 11 | |
| α-helix | 1427-1431 | 5 | |
| α-helix | 1443-1460 | 18 | |
| α-helix | 1477-1488 | 12 | |
| α-helix | 1489-1491 | 3 | |
| α-helix | 1505-1519 | 15 | |
| α-helix | 1524-1532 | 9 | |
| β-strand | 1537-1539 | 3 | 4 |
| β-strand | 1552-1554 | 3 | 4 |
| α-helix | 1555-1562 | 8 | |
| α-helix | 1564-1573 | 10 | |
| α-helix | 1577-1585 | 9 | |
| α-helix | 1591-1606 | 16 | |
| α-helix | 1613-1624 | 12 | |
| α-helix | 1626-1628 | 3 | |
| α-helix | 1639-1655 | 17 | |
| α-helix | 1668-1680 | 13 | |
| α-helix | 1686-1694 | 9 | |
| α-helix | 1696-1698 | 3 | |
| α-helix | 1708-1721 | 14 | |
| α-helix | 1730 | 1 | |
| α-helix | 1734-1753 | 20 | |
| α-helix | 1756-1766 | 11 | |
| β-strand | 1767 | 1 | 5 |
| β-strand | 1769 | 1 | 5 |
| α-helix | 1775-1786 | 12 | |
| α-helix | 1791-1805 | 15 | |
| α-helix | 1816-1819 | 4 | |
| α-helix | 1820-1825 | 6 | |
| α-helix | 1826-1830 | 5 | |
| α-helix | 1835-1842 | 8 | |
| α-helix | 1844-1851 | 8 | |
| α-helix | 1864-1883 | 20 | |
| α-helix | 1912-1923 | 12 | |
| α-helix | 1935-1952 | 18 | |
| α-helix | 2094-2107 | 14 | |
| α-helix | 2126-2134 | 9 | |
| α-helix | 2140-2152 | 13 | |
| α-helix | 2154-2160 | 7 | |
| α-helix | 2161-2172 | 12 | |
| α-helix | 2182-2193 | 12 | |
| α-helix | 2206-2222 | 17 | |
| α-helix | 2230-2244 | 15 | |
| α-helix | 2255-2261 | 7 | |
| α-helix | 2271-2281 | 11 | |
| α-helix | 2301-2308 | 8 | |
| α-helix | 2313-2328 | 16 | |
| α-helix | 2330-2332 | 3 | |
| α-helix | 2339-2350 | 12 | |
| α-helix | 2360-2370 | 11 | |
| α-helix | 2372-2377 | 6 | |
| α-helix | 2379-2385 | 7 | |
| α-helix | 2386-2388 | 3 | |
| α-helix | 2392-2402 | 11 | |
| α-helix | 2406-2409 | 4 | |
| α-helix | 2412-2417 | 6 | |
| α-helix | 2420-2425 | 6 | |
| α-helix | 2429-2442 | 14 | |
| α-helix | 2443-2445 | 3 | |
| α-helix | 2448-2458 | 11 | |
| α-helix | 2459-2461 | 3 | |
| α-helix | 2467-2484 | 18 | |
| α-helix | 2493-2509 | 17 | |
| α-helix | 2515-2525 | 11 | |
| α-helix | 2535-2542 | 8 | |
| α-helix | 2554-2563 | 10 | |
| α-helix | 2566-2568 | 3 | |
| β-strand | 2575 | 1 | 6 |
| β-strand | 2586-2587 | 2 | 7 |
| α-helix | 2724-2730 | 7 | |
| α-helix | 2731-2734 | 4 | |
| α-helix | 2738-2764 | 27 | |
| α-helix | 2766-2767 | 2 | |
| β-strand | 2777-2778 | 2 | 7 |
| β-strand | 2786 | 1 | 6 |
| α-helix | 2787-2798 | 12 | |
| α-helix | 2802-2819 | 18 | |
| α-helix | 2820-2823 | 4 | |
| α-helix | 2826-2846 | 21 | |
| α-helix | 2852-2864 | 13 | |
| α-helix | 2866-2869 | 4 | |
| α-helix | 2873-2883 | 11 | |
| α-helix | 2886-2900 | 15 | |
| α-helix | 2920-2932 | 13 | |
| α-helix | 2937-2944 | 8 | |
| α-helix | 2951-2961 | 11 | |
| α-helix | 2966-2976 | 11 | |
| α-helix | 2988-3004 | 17 | |
| α-helix | 3008-3015 | 8 | |
| α-helix | 3035-3053 | 19 | |
| α-helix | 3060-3069 | 10 | |
| α-helix | 3073-3081 | 9 | |
| α-helix | 3083-3092 | 10 | |
| α-helix | 3096-3116 | 21 | |
| α-helix | 3122-3143 | 22 | |
| α-helix | 3150-3152 | 3 | |
| α-helix | 3156-3161 | 6 | |
| α-helix | 3163-3167 | 5 | |
| α-helix | 3176-3196 | 21 | |
| α-helix | 3227-3248 | 22 | |
| α-helix | 3256-3266 | 11 | |
| α-helix | 3270-3286 | 17 | |
| α-helix | 3292-3298 | 7 | |
| α-helix | 3301-3307 | 7 | |
| α-helix | 3308-3310 | 3 | |
| α-helix | 3320-3343 | 24 | |
| α-helix | 3348-3351 | 4 | |
| α-helix | 3356-3363 | 8 | |
| α-helix | 3370-3393 | 24 | |
| α-helix | 3408-3426 | 19 | |
| α-helix | 3442-3455 | 14 | |
| α-helix | 3459-3462 | 4 | |
| α-helix | 3465-3474 | 10 | |
| α-helix | 3476-3482 | 7 | |
| α-helix | 3496-3498 | 3 | |
| α-helix | 3499-3505 | 7 | |
| α-helix | 3512-3524 | 13 | |
| α-helix | 3530-3536 | 7 | |
| α-helix | 3548-3561 | 14 | |
| α-helix | 3566-3578 | 13 | |
| α-helix | 3581-3596 | 16 | |
| α-helix | 3606-3613 | 8 | |
| α-helix | 3614-3618 | 5 | |
| α-helix | 3628-3643 | 16 | |
| α-helix | 3658-3669 | 12 | |
| α-helix | 3685-3688 | 4 | |
| α-helix | 3697-3699 | 3 | |
| α-helix | 3710-3713 | 4 | |
| β-strand | 3736-3741 | 6 | 8 |
| β-strand | 3747-3753 | 7 | 8 |
| α-helix | 3759-3776 | 18 | |
| α-helix | 3779-3783 | 5 | |
| β-strand | 3793-3794 | 2 | 8 |
| β-strand | 3801-3804 | 4 | 8 |
| β-strand | 3809-3811 | 3 | 9 |
| α-helix | 3812-3817 | 6 | |
| α-helix | 3822-3830 | 9 | |
| α-helix | 3834 | 1 | |
| α-helix | 3835-3839 | 5 | |
| α-helix | 3854-3860 | 7 | |
| α-helix | 3864-3877 | 14 | |
| α-helix | 3882-3890 | 9 | |
| α-helix | 3894-3918 | 25 | |
| α-helix | 3925-3927 | 3 | |
| β-strand | 3928-3931 | 4 | 9 |
| β-strand | 3937-3939 | 3 | 9 |
| α-helix | 3965-3968 | 4 | |
| α-helix | 3979-3990 | 12 | |
| α-helix | 3994-3996 | 3 | |
| α-helix | 3998-4002 | 5 | |
| α-helix | 4040-4052 | 13 | |
| α-helix | 4056-4065 | 10 | |
| α-helix | 4074-4081 | 8 | |
| α-helix | 4086-4089 | 4 | |
| α-helix | 4090-4092 | 3 | |
| α-helix | 4100-4107 | 8 | |
| α-helix | 4108-4112 | 5 | |
| α-helix | 4113-4118 | 6 | |
| α-helix | 6006-6018 | 13 | |
Chain B: 22 helices, 26 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 35-43 | 9 | 10 |
| α-helix | 59-67 | 9 | |
| α-helix | 70-77 | 8 | |
| β-strand | 83-88 | 6 | 10 |
| β-strand | 94 | 1 | 10 |
| β-strand | 102-109 | 8 | 10 |
| α-helix | 113-119 | 7 | |
| α-helix | 120-122 | 3 | |
| α-helix | 124-134 | 11 | |
| α-helix | 143-155 | 13 | |
| β-strand | 161-169 | 9 | 10 |
| α-helix | 180-196 | 17 | |
| β-strand | 199-203 | 5 | 10 |
| α-helix | 217-219 | 3 | |
| α-helix | 238-244 | 7 | |
| β-strand | 260-262 | 3 | 11 |
| β-strand | 268-270 | 3 | 11 |
| β-strand | 271-274 | 4 | 12 |
| β-strand | 277 | 1 | 13 |
| α-helix | 282-284 | 3 | |
| β-strand | 285-289 | 5 | 14 |
| β-strand | 297-303 | 7 | 15 |
| α-helix | 309 | 1 | |
| β-strand | 310 | 1 | 15 |
| α-helix | 311-312 | 2 | |
| β-strand | 316-322 | 7 | 16 |
| β-strand | 325-329 | 5 | 16 |
| α-helix | 331-337 | 7 | |
| β-strand | 344 | 1 | 17 |
| β-strand | 345-346 | 2 | 11 |
| β-strand | 347-352 | 6 | 12 |
| α-helix | 364-365 | 2 | |
| β-strand | 367-370 | 4 | 12 |
| α-helix | 378-387 | 10 | |
| β-strand | 394-400 | 7 | 12 |
| β-strand | 401 | 1 | 17 |
| β-strand | 409-416 | 8 | 12 |
| β-strand | 420 | 1 | 18 |
| β-strand | 426 | 1 | 18 |
| β-strand | 431-436 | 6 | 12 |
| α-helix | 437-438 | 2 | |
| α-helix | 440-442 | 3 | |
| β-strand | 443 | 1 | 19 |
| α-helix | 456-468 | 13 | |
| α-helix | 481-494 | 14 | |
| α-helix | 509-510 | 2 | |
| α-helix | 513-518 | 6 | |
| α-helix | 521-524 | 4 | |
Chain C: 20 helices, 22 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 8-9 | 2 | 20 |
| β-strand | 11-12 | 2 | 21 |
| α-helix | 18-20 | 3 | |
| α-helix | 30-47 | 18 | |
| β-strand | 54-59 | 6 | 21 |
| β-strand | 77-84 | 8 | 21 |
| α-helix | 88-97 | 10 | |
| α-helix | 107-124 | 18 | |
| β-strand | 129-130 | 2 | 20 |
| β-strand | 132-134 | 3 | 21 |
| α-helix | 147-154 | 8 | |
| β-strand | 161-163 | 3 | 21 |
| α-helix | 199-216 | 18 | |
| α-helix | 218-221 | 4 | |
| α-helix | 227-231 | 5 | |
| β-strand | 247-253 | 7 | 19 |
| β-strand | 257-267 | 11 | 19 |
| α-helix | 268-270 | 3 | |
| β-strand | 277-280 | 4 | 16 |
| α-helix | 286-288 | 3 | |
| β-strand | 290-296 | 7 | 15 |
| β-strand | 304 | 1 | 15 |
| α-helix | 307-309 | 3 | |
| β-strand | 310-316 | 7 | 14 |
| β-strand | 319-321 | 3 | 14 |
| α-helix | 325-331 | 7 | |
| β-strand | 341-347 | 7 | 19 |
| α-helix | 353-355 | 3 | |
| β-strand | 361-366 | 6 | 19 |
| α-helix | 371-386 | 16 | |
| β-strand | 389-395 | 7 | 19 |
| β-strand | 404-412 | 9 | 19 |
| β-strand | 417-424 | 8 | 19 |
| β-strand | 430 | 1 | 13 |
| α-helix | 442-444 | 3 | |
| α-helix | 445-447 | 3 | |
| α-helix | 448-458 | 11 | |
| β-strand | 464 | 1 | 22 |
| β-strand | 475 | 1 | 22 |
| α-helix | 485-499 | 15 | |
| α-helix | 512-516 | 5 | |
| α-helix | 520-536 | 17 | |
Chain F: 224 helices, 24 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 11-21 | 11 | |
| α-helix | 28-45 | 18 | |
| α-helix | 52-69 | 18 | |
| α-helix | 76-93 | 18 | |
| α-helix | 98-103 | 6 | |
| α-helix | 104-116 | 13 | |
| α-helix | 118-121 | 4 | |
| α-helix | 125-140 | 16 | |
| α-helix | 150-160 | 11 | |
| α-helix | 169-173 | 5 | |
| α-helix | 174-178 | 5 | |
| α-helix | 187-208 | 22 | |
| α-helix | 217-231 | 15 | |
| α-helix | 241-251 | 11 | |
| α-helix | 263-265 | 3 | |
| α-helix | 266-277 | 12 | |
| α-helix | 280-282 | 3 | |
| α-helix | 290-300 | 11 | |
| α-helix | 306-328 | 23 | |
| α-helix | 333-336 | 4 | |
| α-helix | 337-342 | 6 | |
| α-helix | 343-348 | 6 | |
| α-helix | 358-375 | 18 | |
| α-helix | 379-394 | 16 | |
| α-helix | 410-423 | 14 | |
| α-helix | 429-431 | 3 | |
| α-helix | 432-444 | 13 | |
| α-helix | 451-468 | 18 | |
| α-helix | 472-492 | 21 | |
| α-helix | 494-495 | 2 | |
| α-helix | 527-535 | 9 | |
| α-helix | 538-546 | 9 | |
| α-helix | 560-578 | 19 | |
| β-strand | 583-584 | 2 | 23 |
| β-strand | 613-614 | 2 | 23 |
| α-helix | 617-633 | 17 | |
| α-helix | 645-659 | 15 | |
| α-helix | 664-679 | 16 | |
| α-helix | 698-717 | 20 | |
| α-helix | 718-720 | 3 | |
| α-helix | 726-734 | 9 | |
| α-helix | 738-741 | 4 | |
| α-helix | 745-747 | 3 | |
| α-helix | 749-758 | 10 | |
| α-helix | 759-761 | 3 | |
| α-helix | 763-779 | 17 | |
| α-helix | 782-785 | 4 | |
| α-helix | 786-788 | 3 | |
| α-helix | 789-792 | 4 | |
| α-helix | 794-797 | 4 | |
| α-helix | 849-862 | 14 | |
| α-helix | 864-867 | 4 | |
| α-helix | 868-870 | 3 | |
| β-strand | 893-895 | 3 | 24 |
| β-strand | 904-906 | 3 | 24 |
| α-helix | 907-909 | 3 | |
| α-helix | 910-919 | 10 | |
| α-helix | 924-943 | 20 | |
| α-helix | 944-946 | 3 | |
| β-strand | 952 | 1 | 25 |
| β-strand | 954 | 1 | 25 |
| α-helix | 959-973 | 15 | |
| α-helix | 978-994 | 17 | |
| α-helix | 1005-1016 | 12 | |
| α-helix | 1023-1043 | 21 | |
| α-helix | 1046-1051 | 6 | |
| α-helix | 1056-1068 | 13 | |
| α-helix | 1072-1089 | 18 | |
| α-helix | 1093-1098 | 6 | |
| α-helix | 1101-1115 | 15 | |
| α-helix | 1123-1140 | 18 | |
| α-helix | 1143-1146 | 4 | |
| β-strand | 1149 | 1 | 26 |
| α-helix | 1151-1154 | 4 | |
| β-strand | 1163 | 1 | 26 |
| α-helix | 1165-1174 | 10 | |
| α-helix | 1181-1194 | 14 | |
| α-helix | 1206-1214 | 9 | |
| α-helix | 1218-1221 | 4 | |
| α-helix | 1232-1236 | 5 | |
| α-helix | 1250-1272 | 23 | |
| α-helix | 1278-1281 | 4 | |
| α-helix | 1288-1300 | 13 | |
| α-helix | 1327-1351 | 25 | |
| α-helix | 1354-1356 | 3 | |
| α-helix | 1358-1361 | 4 | |
| α-helix | 1368-1377 | 10 | |
| α-helix | 1379-1382 | 4 | |
| α-helix | 1390-1408 | 19 | |
| α-helix | 1412-1422 | 11 | |
| α-helix | 1443-1460 | 18 | |
| α-helix | 1477-1488 | 12 | |
| α-helix | 1489-1491 | 3 | |
| α-helix | 1505-1520 | 16 | |
| α-helix | 1524-1532 | 9 | |
| β-strand | 1537 | 1 | 27 |
| β-strand | 1554 | 1 | 27 |
| α-helix | 1555-1562 | 8 | |
| α-helix | 1564-1573 | 10 | |
| α-helix | 1577-1584 | 8 | |
| α-helix | 1585-1587 | 3 | |
| α-helix | 1591-1606 | 16 | |
| α-helix | 1613-1624 | 12 | |
| α-helix | 1626-1628 | 3 | |
| α-helix | 1639-1655 | 17 | |
| α-helix | 1668-1680 | 13 | |
| α-helix | 1686-1693 | 8 | |
| α-helix | 1696-1698 | 3 | |
| α-helix | 1708-1721 | 14 | |
| α-helix | 1730 | 1 | |
| α-helix | 1734-1753 | 20 | |
| α-helix | 1756-1766 | 11 | |
| α-helix | 1775-1786 | 12 | |
| α-helix | 1791-1803 | 13 | |
| α-helix | 1816-1819 | 4 | |
| α-helix | 1820-1824 | 5 | |
| α-helix | 1825-1830 | 6 | |
| α-helix | 1835-1848 | 14 | |
| α-helix | 1849-1851 | 3 | |
| α-helix | 1864-1883 | 20 | |
| α-helix | 1911-1924 | 14 | |
| α-helix | 1935-1952 | 18 | |
| α-helix | 2095-2107 | 13 | |
| α-helix | 2126-2134 | 9 | |
| α-helix | 2140-2152 | 13 | |
| α-helix | 2158-2160 | 3 | |
| α-helix | 2161-2172 | 12 | |
| α-helix | 2182-2195 | 14 | |
| α-helix | 2206-2222 | 17 | |
| α-helix | 2230-2245 | 16 | |
| α-helix | 2254-2260 | 7 | |
| α-helix | 2271-2282 | 12 | |
| α-helix | 2301-2308 | 8 | |
| α-helix | 2313-2329 | 17 | |
| α-helix | 2330-2333 | 4 | |
| α-helix | 2339-2350 | 12 | |
| α-helix | 2359-2368 | 10 | |
| α-helix | 2372-2378 | 7 | |
| α-helix | 2379-2385 | 7 | |
| α-helix | 2386-2388 | 3 | |
| α-helix | 2392-2402 | 11 | |
| α-helix | 2406-2409 | 4 | |
| α-helix | 2412-2417 | 6 | |
| α-helix | 2420-2425 | 6 | |
| α-helix | 2429-2442 | 14 | |
| α-helix | 2443-2445 | 3 | |
| α-helix | 2448-2458 | 11 | |
| α-helix | 2459-2461 | 3 | |
| α-helix | 2467-2484 | 18 | |
| α-helix | 2493-2509 | 17 | |
| α-helix | 2515-2526 | 12 | |
| α-helix | 2535-2544 | 10 | |
| α-helix | 2554-2564 | 11 | |
| β-strand | 2575 | 1 | 28 |
| β-strand | 2586-2587 | 2 | 29 |
| α-helix | 2724-2730 | 7 | |
| α-helix | 2738-2764 | 27 | |
| β-strand | 2777-2778 | 2 | 29 |
| β-strand | 2786 | 1 | 28 |
| α-helix | 2787-2798 | 12 | |
| α-helix | 2802-2820 | 19 | |
| α-helix | 2821-2823 | 3 | |
| α-helix | 2826-2846 | 21 | |
| α-helix | 2852-2864 | 13 | |
| α-helix | 2866-2869 | 4 | |
| α-helix | 2873-2882 | 10 | |
| α-helix | 2886-2900 | 15 | |
| α-helix | 2920-2932 | 13 | |
| α-helix | 2937-2944 | 8 | |
| α-helix | 2951-2961 | 11 | |
| α-helix | 2966-2976 | 11 | |
| α-helix | 2988-3004 | 17 | |
| α-helix | 3008-3015 | 8 | |
| α-helix | 3030-3032 | 3 | |
| α-helix | 3035-3053 | 19 | |
| α-helix | 3060-3069 | 10 | |
| α-helix | 3072-3092 | 21 | |
| α-helix | 3096-3116 | 21 | |
| α-helix | 3122-3143 | 22 | |
| α-helix | 3150-3152 | 3 | |
| α-helix | 3157-3161 | 5 | |
| α-helix | 3163-3167 | 5 | |
| α-helix | 3176-3196 | 21 | |
| α-helix | 3227-3249 | 23 | |
| α-helix | 3256-3265 | 10 | |
| α-helix | 3266-3268 | 3 | |
| α-helix | 3270-3286 | 17 | |
| α-helix | 3292-3298 | 7 | |
| α-helix | 3305-3310 | 6 | |
| α-helix | 3313-3316 | 4 | |
| α-helix | 3320-3343 | 24 | |
| α-helix | 3348-3351 | 4 | |
| α-helix | 3356-3363 | 8 | |
| α-helix | 3370-3392 | 23 | |
| α-helix | 3408-3426 | 19 | |
| α-helix | 3442-3455 | 14 | |
| α-helix | 3459-3462 | 4 | |
| α-helix | 3465-3474 | 10 | |
| α-helix | 3476-3482 | 7 | |
| α-helix | 3496-3498 | 3 | |
| α-helix | 3499-3505 | 7 | |
| α-helix | 3512-3524 | 13 | |
| α-helix | 3530-3535 | 6 | |
| α-helix | 3548-3561 | 14 | |
| α-helix | 3565-3578 | 14 | |
| α-helix | 3581-3596 | 16 | |
| α-helix | 3606-3613 | 8 | |
| α-helix | 3614-3618 | 5 | |
| α-helix | 3628-3643 | 16 | |
| α-helix | 3658-3669 | 12 | |
| α-helix | 3685-3688 | 4 | |
| α-helix | 3697-3699 | 3 | |
| α-helix | 3710-3713 | 4 | |
| β-strand | 3719 | 1 | 30 |
| β-strand | 3727 | 1 | 31 |
| β-strand | 3736-3741 | 6 | 31 |
| β-strand | 3742 | 1 | 30 |
| β-strand | 3747-3753 | 7 | 31 |
| α-helix | 3759-3776 | 18 | |
| α-helix | 3779-3783 | 5 | |
| β-strand | 3793-3797 | 5 | 31 |
| β-strand | 3800-3804 | 5 | 31 |
| β-strand | 3810-3811 | 2 | 32 |
| α-helix | 3812-3817 | 6 | |
| α-helix | 3822-3830 | 9 | |
| α-helix | 3835-3839 | 5 | |
| α-helix | 3840-3842 | 3 | |
| α-helix | 3854-3860 | 7 | |
| α-helix | 3864-3877 | 14 | |
| α-helix | 3882-3889 | 8 | |
| α-helix | 3894-3917 | 24 | |
| α-helix | 3925-3927 | 3 | |
| β-strand | 3928-3931 | 4 | 32 |
| β-strand | 3936-3939 | 4 | 32 |
| α-helix | 3965-3968 | 4 | |
| α-helix | 3979-3990 | 12 | |
| α-helix | 3994-3996 | 3 | |
| α-helix | 3998-4001 | 4 | |
| α-helix | 4040-4052 | 13 | |
| α-helix | 4056-4068 | 13 | |
| α-helix | 4074-4082 | 9 | |
| α-helix | 4086-4089 | 4 | |
| α-helix | 4090-4092 | 3 | |
| α-helix | 4100-4106 | 7 | |
| α-helix | 4107-4112 | 6 | |
| α-helix | 4113-4118 | 6 | |
| α-helix | 4122-4124 | 3 | |
| α-helix | 6006-6018 | 13 | |
Chain G: 18 helices, 21 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 35-43 | 9 | 33 |
| α-helix | 59-77 | 19 | |
| β-strand | 81-88 | 8 | 33 |
| β-strand | 94 | 1 | 33 |
| β-strand | 102-109 | 8 | 33 |
| α-helix | 113-120 | 8 | |
| α-helix | 124-134 | 11 | |
| α-helix | 143-156 | 14 | |
| β-strand | 161-169 | 9 | 33 |
| α-helix | 180-196 | 17 | |
| β-strand | 200-203 | 4 | 33 |
| α-helix | 238-244 | 7 | |
| β-strand | 258-262 | 5 | 34 |
| β-strand | 268-274 | 7 | 34 |
| α-helix | 282-285 | 4 | |
| β-strand | 286-289 | 4 | 35 |
| β-strand | 295 | 1 | 35 |
| β-strand | 296-303 | 8 | 36 |
| β-strand | 316-322 | 7 | 37 |
| β-strand | 325-329 | 5 | 37 |
| α-helix | 331-338 | 8 | |
| β-strand | 344-352 | 9 | 34 |
| α-helix | 364-365 | 2 | |
| β-strand | 367-370 | 4 | 34 |
| α-helix | 378-387 | 10 | |
| β-strand | 394-401 | 8 | 34 |
| β-strand | 409-415 | 7 | 34 |
| β-strand | 420 | 1 | 38 |
| β-strand | 426 | 1 | 38 |
| β-strand | 432-436 | 5 | 34 |
| α-helix | 437-438 | 2 | |
| α-helix | 440-442 | 3 | |
| β-strand | 443 | 1 | 39 |
| α-helix | 456-468 | 13 | |
| α-helix | 481-492 | 12 | |
| α-helix | 503-505 | 3 | |
| α-helix | 509-510 | 2 | |
| α-helix | 513-518 | 6 | |
| α-helix | 521-524 | 4 | |
Chain H: 23 helices, 19 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 8-12 | 5 | 40 |
| β-strand | 13-15 | 3 | 41 |
| α-helix | 18-21 | 4 | |
| α-helix | 30-48 | 19 | |
| β-strand | 57-59 | 3 | 41 |
| β-strand | 77-79 | 3 | 41 |
| α-helix | 88-95 | 8 | |
| α-helix | 108-124 | 17 | |
| β-strand | 129-134 | 6 | 40 |
| α-helix | 148-157 | 10 | |
| β-strand | 160-163 | 4 | 40 |
| α-helix | 199-212 | 14 | |
| α-helix | 218-222 | 5 | |
| α-helix | 227-232 | 6 | |
| α-helix | 243-246 | 4 | |
| β-strand | 247-253 | 7 | 39 |
| β-strand | 257-267 | 11 | 39 |
| β-strand | 277-280 | 4 | 37 |
| β-strand | 290-297 | 8 | 36 |
| β-strand | 304 | 1 | 36 |
| β-strand | 310-315 | 6 | 35 |
| β-strand | 320-323 | 4 | 35 |
| α-helix | 325-331 | 7 | |
| β-strand | 340-347 | 8 | 39 |
| α-helix | 353-355 | 3 | |
| β-strand | 357-365 | 9 | 39 |
| α-helix | 371-387 | 17 | |
| β-strand | 389-395 | 7 | 39 |
| α-helix | 402-403 | 2 | |
| β-strand | 404-411 | 8 | 39 |
| β-strand | 418-423 | 6 | 39 |
| α-helix | 448-458 | 11 | |
| β-strand | 462 | 1 | 34 |
| α-helix | 485-499 | 15 | |
| α-helix | 512-515 | 4 | |
| α-helix | 520-536 | 17 | |
| α-helix | 594-605 | 12 | |
| α-helix | 610-621 | 12 | |
| α-helix | 629-648 | 20 | |
| α-helix | 652-668 | 17 | |
| α-helix | 676-681 | 6 | |
| α-helix | 694-703 | 10 | |
Chain K: 4 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 21 | 1 | 42 |
| α-helix | 24-25 | 2 | |
| β-strand | 35 | 1 | 42 |
| β-strand | 36-37 | 2 | 43 |
| β-strand | 42-43 | 2 | 43 |
| β-strand | 44 | 1 | 44 |
| α-helix | 49-58 | 10 | |
| α-helix | 66-75 | 10 | |
| β-strand | 89 | 1 | 45 |
| β-strand | 94 | 1 | 45 |
| β-strand | 114 | 1 | 44 |
| α-helix | 120-199 | 80 | |
Chain L: 6 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 2-3 | 2 | 46 |
| β-strand | 23-24 | 2 | 46 |
| α-helix | 28-30 | 3 | |
| β-strand | 34-37 | 4 | 47 |
| β-strand | 42-45 | 4 | 47 |
| α-helix | 49-51 | 3 | |
| α-helix | 54-56 | 3 | |
| α-helix | 64-74 | 11 | |
| α-helix | 84-86 | 3 | |
| β-strand | 89 | 1 | 48 |
| β-strand | 94 | 1 | 48 |
| β-strand | 98-100 | 3 | 49 |
| β-strand | 105-107 | 3 | 49 |
| α-helix | 121-200 | 80 | |
6 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic… | A, F | protein | 4148 | Homo sapiens | P78527 |
| X-ray repair cross-complementing protein 6 | B, G | protein | 609 | Homo sapiens | P12956 (AlphaFold model) |
| X-ray repair cross-complementing protein 5 | C, H | protein | 732 | Homo sapiens | P13010 (AlphaFold model) |
| DNA repair protein XRCC4 | K, L, N, O | protein | 336 | Homo sapiens | Q13426 (AlphaFold model) |
| DNA ligase 4 | M, P | protein | 911 | Homo sapiens | P49917 |
| Non-homologous end-joining factor 1 | Q, R | protein | 299 | Homo sapiens | Q9H9Q4 |
| DNA (27-mer) | D | DNA | 27 | Homo sapiens | |
| DNA (28-mer) | E, I | DNA | 28 | Homo sapiens | |
| DNA (27-mer) | J | DNA | 27 | Homo sapiens | |
Sequence of entity 1 (A, F), FASTA
>7NFC_1 DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-PKcs (chains A, F)
MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFS
RDFGLLVFVRKSLNSIEFRECREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKDRA
AKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGL
LGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEE
DPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKW
CAHTNVELKKAALSALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNVDSNNKELS
IAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASV
LLYLDTVPEVYTPVLEHLVVMQIDSFPQYSPKMQLVCCRAIVKVFLALAAKGPVLRNCIS
TVVHQGLIRICSKPVVLPKGPESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQM
MDSILADEAFFSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGV
WMIPTSDPAANLHPAKPKDFSAFINLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRL
PLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQ
YKDELLASCLTFLLSLPHNIIELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYI
DRHVMQPYYKDILPCLDGYLKTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNL
SSNEAISLEEIRIRVVQMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFRE
MKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQ
LYKRTFPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDP
VDSTLRDFCGRCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASL
AFNNIYREFREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEK
KHVSLNKAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPG
NRSPNLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLL
LAALECYNTFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAGN
RTSPQEGERYNYSKCTVVVRIMEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCEPA
SIGFNIGDVQVMAHLPDVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPD
AQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPGDERQCL
PSLDLSCKQLASGLLELAFAFGGLCERLVSLLLNPAVLSTASLGSSQGSVIHFSHGEYFY
SLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGMLDQSFRERANQKHQGLKLAT
TILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSSVSFNTSHGSFPEVFTTYISLLA
DTKLDLHLKGQAVTLLPFFTSLTGGSLEELRRVLEQLIVAHFPMQSREFPPGTPRFNNYV
DCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRRIARRGSCVTQVGLLES
VYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDVLKSRFTKLNE
STFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVFHGSCITEGNELTKTLIKLCY
DAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFEN
LIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAANGDSDGPSYMSSLSYLADSTLSEEM
SQFDFSTGVQSYSYSSQDPRPATGRFRRREQRDPTVHDDVLELEMDELNRHECMAPLTAL
VKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKLGNPIVPLNIRLFLAKLVINTEEVFRPY
AKHWLSPLLQLAASENNGGEGIHYMVVEIVATILSWTGLATPTGVPKDEVLANRLLNFLM
KHVFHPKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSGKDPNSKDNSVGIQLLGIV
MANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVYAAAAEVLGLILRYVMERKNILEES
LCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEV
VLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKLKPVELRELLNPVVE
FVSHPSTTCREQMYNILMWIHDNYRDPESETDNDSQEIFKLAKDVLIQGLIDENPGLQLI
IRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATNFLLEMTSMSPDYPNPMFEHP
LSECEFQEYTIDSDWRFRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQ
QHDFTLTQTADGRSSFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDF
GKKRLGLPGDEVDNKVKGAAGRTDLLRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKSE
LKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSLFSGILKEM
DKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGC
LASLQQPVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLR
GIFTSEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLD
CYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQS
LLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVL
LHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWD
DIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKM
KMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTV
LKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRIL
ELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAGVIDAYMTLADFC
DQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETL
SLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESY
SFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTP
VNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFN
DITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIA
GFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSA
CSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYK
DWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLAL
RSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMP
FRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKM
LKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAV
ARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPWMXXXXXXXXXXXX
XXXXXXXX
Sequence of entity 2 (B, G), FASTA
>7NFC_2 X-ray repair cross-complementing protein 6 (chains B, G)
MSGWESYYKTEGDEEAEEEQEENLEASGDYKYSGRDSLIFLVDASKAMFESQSEDELTPF
DMSIQCIQSVYISKIISSDRDLLAVVFYGTEKDKNSVNFKNIYVLQELDNPGAKRILELD
QFKGQQGQKRFQDMMGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDNPHGNDS
AKASRARTKAGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISIAEDEDLRVHFEESSKLE
DLLRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIKLYRETNEPVKTKT
RTFNTSTGGLLLPSDTKRSQIYGSRQIILEKEETEELKRFDDPGLMLMGFKPLVLLKKHH
YLRPSLFVYPEESLVIGSSTLFSALLIKCLEKEVAALCRYTPRRNIPPYFVALVPQEEEL
DDQKIQVTPPGFQLVFLPFADDKRKMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFEN
PVLQQHFRNLEALALDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKV
TKRKHDNEGSGSKRPKVEYSEEELKTHISKGTLGKFTVPMLKEACRAYGLKSGLKKQELL
EALTKHFQD
Sequence of entity 3 (C, H), FASTA
>7NFC_3 X-ray repair cross-complementing protein 5 (chains C, H)
MVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFG
TDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQH
ETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGD
GPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKI
ERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDD
DETEVLKEDIIQGFRYGSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQ
VLKVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPHIKHNYECLV
YVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAKKDEKTDTLEDLFPTT
KIPNPRFQRLFQCLLHRALHPREPLPPIQQHIWNMLNPPAEVTTKSQIPLSKIKTLFPLI
EAKKKDQVTAQEIFQDNHEDGPTAKKLKTEQGGAHFSVSSLAEGSVTSVGSVNPAENFRV
LVKQKKASFEEASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQRFNNFLK
ALQEKVEIKQLNHFWEIVVQDGITLITKEEASGSSVTAEEAKKFLAPKDKPSGDTAAVFE
EGGDVDDLLDMI
Sequence of entity 4 (K, L, N, O), FASTA
>7NFC_4 DNA repair protein XRCC4 (chains K, L, N, O)
MERKISRIHLVSEPSITHFLQVSWEKTLESGFVITLTDGHSAWTGTVSESEISQEADDMA
MEKGKYVGELRKALLSGAGPADVYTFNFSKESCYFFFEKNLKDVSFRLGSFNLEKVENPA
EVIRELICYCLDTIAENQAKNEHLQKENERLLRDWNDVQGRFEKCVSAKEALETDLYKRF
ILVLNEKKTKIRSLHNKLLNAAQEREKDIKQEGETAICSEMTADRDPVYDESTDEESENQ
TDLSGLASAAVSKDDSIISSLDVTDIAPSRKRRQRMQRNLGTEPKMAPQENQLQEKENSR
PDSSLPETSKKEHISAENMSLETLRNSSPEDLFDEI
Sequence of entity 5 (M, P), FASTA
>7NFC_5 DNA ligase 4 (chains M, P)
MAASQTSQTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKNHKDV
TDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTHG
DAGDFAMIAYFVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSA
LEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGLSDISI
TLFSAFKPMLAAIADIEHIEKDMKHQSFYIETKLDGERMQMHKDGDVYKYFSRNGYNYTD
QFGASPTEGSLTPFIHNAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRMVEDSDL
QTCYCVFDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKNEVIDALNE
AIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKGSRGGMM
SHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSSILC
GTEKPEVYIEPCNSVIVQIKAAEIVPSDMYKTGCTLRFPRIEKIRDDKEWHECMTLDDLE
QLRGKASGKLASKHLYIGGDDEPQEKKRKAAPKMKKVIGIIEHLKAPNLTNVNKISNIFE
DVEFCVMSGTDSQPKPDLENRIAEFGGYIVQNPGPDTYCVIAGSENIRVKNIILSNKHDV
VKPAWLLECFKTKSFVPWQPRFMIHMCPSTKEHFAREYDCYGDSYFIDTDLNQLKEVFSG
IKNSNEQTPEEMASLIADLEYRYSWDCSPLSMFRRHTVYLDSYAVINDLSTKNEGTRLAI
KALELRFHGAKVVSCLAEGVSHVIIGEDHSRVADFKAFRRTFKRKFKILKESWVTDSIDK
CELQEENQYLI
Sequence of entity 6 (Q, R), FASTA
>7NFC_6 Non-homologous end-joining factor 1 (chains Q, R)
MEELEQGLLMQPWAWLQLAENSLLAKVFITKQGYALLVSDLQQVWHEQVDTSVVSQRAKE
LNKRLTAPPAAFLCHLDNLLRPLLKDAAHPSEATFSCDCVADALILRVRSELSGLPFYWN
FHCMLASPSLVSQHLIRPLMGMSLALQCQVRELATLLHMKDLEIQDYQESGATLIRDRLK
TEPFEENSFLEQFMIEKLPEACSIGDGKPFVMNLQDLYMAVTTQEVQVGQKHQGAGDPHT
SNSASLQGIDSQCVNQPEQLVSSAPTLSAPEKESTGTSGPLQRPQLSKVKRKKPRGLFS
Sequence of entity 7 (D), FASTA
>7NFC_7 DNA (27-MER) (chains D)
CCAAATAATAGTTTTTAGTTTATTGGG
Sequence of entity 8 (E, I), FASTA
>7NFC_8 DNA (28-MER) (chains E, I)
GCTAATAAACTAAAAACTATTATTATGG
Sequence of entity 9 (J), FASTA
>7NFC_9 DNA (27-MER) (chains J)
CATAATAATAGTTTTTAGTTTATTGGG
Primary citation
Cryo-EM of NHEJ supercomplexes provides insights into DNA repair. Chaplin, A.K., Hardwick, S.W., Stavridi, A.K. et al. Mol Cell (2021) 81:3400-3409. DOI 10.1016/j.molcel.2021.07.005 · PubMed
Other PDB entries of the same protein (UniProt P78527), best resolution first:
- 7Z87 2.91 Å, DNA-PK in the active state
- 7OTY 2.96 Å, DNA-PKcs in complex with M3814
- 7OTW 2.99 Å, DNA-PKcs in complex with AZD7648
- 7SGL 3.0 Å, DNA-PK complex of DNA end processing
- 7K11 3.21 Å, CryoEM structure of inactivated-form FATKIN domain of DNA-PK
- 6ZFP 3.24 Å, Cryo-EM structure of DNA-PKcs (State 2)
- 7OTV 3.24 Å, DNA-PKcs in complex with wortmannin
- 7K10 3.3 Å, CryoEM structure of activated-form FATKIN domain of DNA-PK
- 7SU3 3.3 Å, CryoEM structure of DNA-PK complex VII
- 7OTM 3.33 Å, Cryo-EM structure of DNA-PKcs in complex with NU7441
- 7TYR 3.33 Å, Cryo-EM structure of the basal state of the Artemis:DNA-PKcs complex (see COMPND 13/14)
- 7Z88 3.33 Å, DNA-PK in the intermediate state
Browse structure collections
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