7NFE: NHEJ super-complex

Cryo-EM structure of NHEJ super-complex (monomer). Determined by electron microscopy at 4.29 Å resolution. Released 18 Aug 2021.

Method
Electron microscopy
Resolution
4.29 Å
Organism
Homo sapiens
Chains
10
Atoms
44,554
Mol. weight
887.13 kDa
Released
18 Aug 2021

Explore 7NFE in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7NFE contains 286 α-helices and 122 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 211 helices, 26 β-strands

ElementResiduesLengthSheet
α-helix11-2212
α-helix27-4519
α-helix50-5910
α-helix61-688
α-helix79-9113
α-helix101-11616
α-helix125-14016
α-helix142-1465
α-helix150-16011
α-helix173-1786
α-helix187-1915
α-helix193-20816
α-helix218-23114
α-helix242-25514
α-helix267-27711
α-helix279-2824
α-helix283-2886
α-helix290-30112
α-helix306-32722
α-helix335-34915
α-helix356-36813
α-helix370-3767
α-helix378-39518
α-helix410-42314
α-helix431-44515
α-helix446-4483
α-helix451-46818
α-helix473-4753
α-helix477-49216
α-helix494-4952
α-helix520-5223
α-helix524-5263
α-helix528-5369
α-helix538-5458
α-helix560-57819
β-strand583-58531
β-strand612-61431
α-helix617-63317
α-helix645-65915
α-helix664-67916
α-helix698-71720
α-helix718-7203
α-helix726-7349
α-helix745-75915
α-helix763-77917
α-helix786-79510
α-helix7971
α-helix798-8025
α-helix848-86114
α-helix864-8674
α-helix868-8703
α-helix877-8815
β-strand88412
β-strand893-89533
α-helix896-8972
β-strand904-90633
α-helix910-91910
α-helix924-94522
α-helix959-97315
α-helix978-99619
α-helix998-10003
α-helix1005-101814
α-helix1023-104321
α-helix1053-106816
α-helix1072-108918
α-helix1093-111523
α-helix1123-114523
β-strand114914
α-helix1152-11543
β-strand116314
α-helix1165-117511
α-helix1181-119414
α-helix1204-122219
α-helix1252-127221
α-helix12781
α-helix1279-12835
α-helix1290-12967
α-helix1297-13015
α-helix1302-13032
α-helix1325-135127
α-helix1361-137717
α-helix1391-140818
α-helix1412-142211
α-helix1427-14348
α-helix1443-146119
α-helix1464-14674
α-helix1477-148913
α-helix1505-152016
α-helix1525-15339
β-strand1538-153925
β-strand1552-155325
α-helix1555-157319
α-helix1575-158511
α-helix1591-160717
α-helix1612-162413
α-helix1631-16333
α-helix1639-165517
α-helix1659-16624
α-helix1668-167912
α-helix1686-169510
α-helix1697-17004
α-helix1704-17063
α-helix1707-172115
α-helix1734-175320
α-helix1756-176611
α-helix1775-178814
α-helix1791-180616
α-helix1813-18186
α-helix1819-18257
α-helix1826-18305
α-helix1833-185220
α-helix1861-188121
α-helix1910-192415
α-helix1934-195421
α-helix1972-19754
α-helix2094-210714
α-helix2124-213411
α-helix2140-215213
α-helix2161-217010
α-helix2184-219512
α-helix2206-222217
α-helix2228-224417
α-helix2255-22584
α-helix2271-228212
α-helix2298-23058
α-helix2315-232713
α-helix2340-235314
α-helix2357-236812
α-helix2372-23776
α-helix2379-23857
α-helix2392-240312
α-helix2412-24176
α-helix2420-24256
α-helix2429-244214
α-helix2443-24453
α-helix2448-245811
α-helix2459-24613
α-helix2468-248417
α-helix2493-250816
α-helix2509-25113
α-helix2515-252612
α-helix2535-254410
α-helix2554-256714
β-strand257516
β-strand2587-258827
β-strand2776-277727
β-strand278616
α-helix2788-280013
α-helix2802-282322
α-helix2826-284621
α-helix2852-286312
α-helix2867-28704
α-helix2873-288311
α-helix2886-289813
α-helix2919-293315
α-helix2936-294510
α-helix2951-296111
α-helix2965-297713
α-helix2988-300417
α-helix3008-30125
α-helix3013-30186
α-helix3029-30313
α-helix3035-305319
α-helix3061-30699
α-helix3072-308110
α-helix3083-309311
α-helix3096-311621
α-helix3122-31298
α-helix3131-314616
α-helix3149-31524
α-helix3155-316511
α-helix3176-319419
α-helix3228-324922
α-helix3252-326110
α-helix3263-32686
α-helix3270-328718
α-helix3291-330414
α-helix3314-33185
α-helix3321-334323
α-helix3354-336310
α-helix3370-339324
α-helix3408-342720
α-helix3441-345515
α-helix3459-347416
α-helix3480-34878
α-helix3496-34983
α-helix3499-35079
α-helix3512-352413
α-helix3531-35377
α-helix3548-356114
α-helix3564-35663
α-helix3567-357812
α-helix3581-359717
α-helix3604-361310
α-helix3614-36185
α-helix3627-364216
α-helix3660-367314
α-helix3675-36784
α-helix3681-36833
α-helix3685-36895
β-strand370018
α-helix3711-37122
β-strand371818
β-strand3719-3728109
β-strand3736-374279
β-strand3747-375489
α-helix3759-377719
α-helix3780-37834
β-strand3793-379539
β-strand3800-380459
β-strand3810-3811210
α-helix3812-38198
α-helix3822-38276
α-helix3835-384410
α-helix3853-38608
α-helix3864-387714
α-helix3882-38909
β-strand389112
α-helix3896-391722
α-helix3925-39273
β-strand3928-3930310
β-strand3937-3939310
α-helix3965-39706
α-helix3979-399315
α-helix3996-400712
α-helix4009-40113
α-helix4013-402311
α-helix4040-405213
β-strand4054111
α-helix4056-406813
α-helix4074-40818
β-strand4096111
α-helix4100-411213
α-helix4114-41185
α-helix4122-41243
α-helix5010-50145
α-helix6006-601813
Chain B: 15 helices, 22 β-strands
ElementResiduesLengthSheet
β-strand36-43812
α-helix59-7719
β-strand82-88712
β-strand102-109812
α-helix113-1208
α-helix125-13511
α-helix143-15614
β-strand163-170812
α-helix182-19615
β-strand199-204612
α-helix215-2173
β-strand259-262413
β-strand269-275713
α-helix278-2803
α-helix282-2854
β-strand286-289414
β-strand295114
β-strand296115
β-strand304116
β-strand309116
α-helix313-3153
β-strand317-322617
β-strand325-330617
α-helix331-3388
β-strand344-352913
β-strand366-370513
α-helix377-39115
β-strand394-401813
β-strand409-416813
β-strand419118
β-strand427118
β-strand431-436613
β-strand449119
α-helix456-46712
α-helix475-4773
α-helix481-49515
α-helix511-5144
Chain C: 18 helices, 26 β-strands
ElementResiduesLengthSheet
β-strand8-14720
α-helix30-4819
β-strand53-59720
β-strand77-84820
α-helix88-969
α-helix107-12115
β-strand129-134620
β-strand135121
α-helix147-15711
β-strand160-161220
β-strand164-165221
α-helix199-21517
α-helix218-2236
β-strand225-226221
α-helix230-2345
β-strand249-252422
β-strand258-265822
β-strand277-279317
β-strand296123
β-strand297115
β-strand304123
α-helix307-3093
β-strand310-313414
β-strand314-316324
β-strand319-321324
α-helix325-3306
α-helix333-3353
β-strand340-347822
β-strand357-3661022
α-helix371-38717
β-strand389-395722
β-strand404-412922
β-strand416119
β-strand417-423722
α-helix424-4263
α-helix427-4293
α-helix448-46013
β-strand462113
β-strand464125
β-strand475125
α-helix485-49915
α-helix506-5094
α-helix510-5167
α-helix520-53617
Chain F: 10 helices, 2 β-strands
ElementResiduesLengthSheet
β-strand23126
β-strand38126
α-helix51-6111
α-helix69-768
α-helix128-1314
α-helix132-1365
α-helix144-16623
α-helix167-1715
α-helix182-1843
α-helix186-1927
α-helix198-2025
α-helix214-2163
Chain G: 9 helices, 10 β-strands
ElementResiduesLengthSheet
α-helix3-64
β-strand16-17227
β-strand22-23227
β-strand30128
β-strand33128
α-helix51-6010
β-strand62129
β-strand65129
α-helix69-779
β-strand105-106230
β-strand111-112231
β-strand115-116231
β-strand121-122230
α-helix128-1314
α-helix132-1365
α-helix144-15815
α-helix160-17011
α-helix187-1926
α-helix198-2014
Chain H: 4 helices, 9 β-strands
ElementResiduesLengthSheet
β-strand3132
β-strand7-8233
β-strand18-19233
β-strand23132
β-strand36-37233
β-strand42-44333
α-helix52-598
α-helix65-7410
β-strand85-89534
β-strand94-98534
α-helix101-1033
β-strand114-115233
α-helix120-19980
Chain I: 4 helices, 11 β-strands
ElementResiduesLengthSheet
β-strand4-9635
β-strand10136
β-strand17-22635
β-strand33-37535
β-strand42-46535
α-helix53-564
α-helix63-697
α-helix70-745
β-strand88136
β-strand89137
β-strand94137
β-strand101138
β-strand104138
β-strand112137
α-helix119-20082
Chain J: 15 helices, 16 β-strands
ElementResiduesLengthSheet
β-strand660139
β-strand663-666440
α-helix675-68410
β-strand687139
β-strand688-690340
β-strand697-701540
α-helix707-7148
β-strand720-721240
α-helix723-73210
β-strand743140
α-helix748-7514
α-helix753-7564
β-strand758141
β-strand764141
α-helix771-78010
α-helix782-7832
α-helix789-7913
α-helix792-7965
α-helix797-8026
β-strand818-819242
β-strand823143
β-strand832143
α-helix833-8342
α-helix840-8467
β-strand853142
β-strand862-864342
α-helix872-8787
β-strand887-889342
α-helix891-8933
α-helix907-9093
β-strand910142

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic…Aprotein4156Homo sapiensP78527
X-ray repair cross-complementing protein 6Bprotein609Homo sapiensP12956 (AlphaFold model)
X-ray repair cross-complementing protein 5Cprotein732Homo sapiensP13010 (AlphaFold model)
Non-homologous end-joining factor 1F, Gprotein299Homo sapiensQ9H9Q4 (AlphaFold model)
DNA repair protein XRCC4H, Iprotein336Homo sapiensQ13426
DNA ligase 4Jprotein911Homo sapiensP49917
DNA (5'-d(p*ap*ap*tp*ap*ap*ap*cp*tp*ap*ap*ap*ap*ap*cp*tp*ap*tp*tp*ap*tp*tp*ap*tp*g)-3')DDNA24Homo sapiens
DNA (5'-d(p*tp*ap*ap*tp*ap*ap*tp*ap*gp*tp*tp*tp*tp*tp*ap*gp*tp*tp*tp*ap*tp*tp*ap*g)-3')EDNA24Homo sapiens
Sequence of entity 1 (A), FASTA
>7NFE_1 DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit (chains A)
MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFS
RDFGLLVFVRKSLNSIEFRECREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKDRA
AKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGL
LGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEE
DPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKW
CAHTNVELKKAALSALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNVDSNNKELS
IAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASV
LLYLDTVPEVYTPVLEHLVVMQIDSFPQYSPKMQLVCCRAIVKVFLALAAKGPVLRNCIS
TVVHQGLIRICSKPVVLPKGPESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQM
MDSILADEAFFSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGV
WMIPTSDPAANLHPAKPKDFSAFINLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRL
PLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQ
YKDELLASCLTFLLSLPHNIIELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYI
DRHVMQPYYKDILPCLDGYLKTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNL
SSNEAISLEEIRIRVVQMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFRE
MKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQ
LYKRTFPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDP
VDSTLRDFCGRCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASL
AFNNIYREFREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEK
KHVSLNKAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPG
NRSPNLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLL
LAALECYNTFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAGN
RTSPQEGERYNYSKCTVVVRIMEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCEPA
SIGFNIGDVQVMAHLPDVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPD
AQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPGDERQCL
PSLDLSCKQLASGLLELAFAFGGLCERLVSLLLNPAVLSTASLGSSQGSVIHFSHGEYFY
SLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGMLDQSFRERANQKHQGLKLAT
TILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSSVSFNTSHGSFPEVFTTYISLLA
DTKLDLHLKGQAVTLLPFFTSLTGGSLEELRRVLEQLIVAHFPMQSREFPPGTPRFNNYV
DCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRRIARRGSCVTQVGLLES
VYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDVLKSRFTKLNE
STFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVFHGSCITEGNELTKTLIKLCY
DAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFEN
LIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAANGDSDGPSYMSSLSYLADSTLSEEM
SQFDFSTGVQSYSYSSQDPRPATGRFRRREQRDPTVHDDVLELEMDELNRHECMAPLTAL
VKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKLGNPIVPLNIRLFLAKLVINTEEVFRPY
AKHWLSPLLQLAASENNGGEGIHYMVVEIVATILSWTGLATPTGVPKDEVLANRLLNFLM
KHVFHPKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSGKDPNSKDNSVGIQLLGIV
MANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVYAAAAEVLGLILRYVMERKNILEES
LCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEV
VLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKLKPVELRELLNPVVE
FVSHPSTTCREQMYNILMWIHDNYRDPESETDNDSQEIFKLAKDVLIQGLIDENPGLQLI
IRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATNFLLEMTSMSPDYPNPMFEHP
LSECEFQEYTIDSDWRFRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQ
QHDFTLTQTADGRSSFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDF
GKKRLGLPGDEVDNKVKGAAGRTDLLRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKSE
LKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSLFSGILKEM
DKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGC
LASLQQPVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLR
GIFTSEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLD
CYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQS
LLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVL
LHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWD
DIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKM
KMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTV
LKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRIL
ELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAGVIDAYMTLADFC
DQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETL
SLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESY
SFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTP
VNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFN
DITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIA
GFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSA
CSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYK
DWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLAL
RSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMP
FRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKM
LKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAV
ARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPWMXXXXXXXXXXXX
XXXXXXXXXXXXXXXX
Sequence of entity 2 (B), FASTA
>7NFE_2 X-ray repair cross-complementing protein 6 (chains B)
MSGWESYYKTEGDEEAEEEQEENLEASGDYKYSGRDSLIFLVDASKAMFESQSEDELTPF
DMSIQCIQSVYISKIISSDRDLLAVVFYGTEKDKNSVNFKNIYVLQELDNPGAKRILELD
QFKGQQGQKRFQDMMGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDNPHGNDS
AKASRARTKAGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISIAEDEDLRVHFEESSKLE
DLLRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIKLYRETNEPVKTKT
RTFNTSTGGLLLPSDTKRSQIYGSRQIILEKEETEELKRFDDPGLMLMGFKPLVLLKKHH
YLRPSLFVYPEESLVIGSSTLFSALLIKCLEKEVAALCRYTPRRNIPPYFVALVPQEEEL
DDQKIQVTPPGFQLVFLPFADDKRKMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFEN
PVLQQHFRNLEALALDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKV
TKRKHDNEGSGSKRPKVEYSEEELKTHISKGTLGKFTVPMLKEACRAYGLKSGLKKQELL
EALTKHFQD
Sequence of entity 3 (C), FASTA
>7NFE_3 X-ray repair cross-complementing protein 5 (chains C)
MVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFG
TDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQH
ETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGD
GPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKI
ERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDD
DETEVLKEDIIQGFRYGSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQ
VLKVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPHIKHNYECLV
YVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAKKDEKTDTLEDLFPTT
KIPNPRFQRLFQCLLHRALHPREPLPPIQQHIWNMLNPPAEVTTKSQIPLSKIKTLFPLI
EAKKKDQVTAQEIFQDNHEDGPTAKKLKTEQGGAHFSVSSLAEGSVTSVGSVNPAENFRV
LVKQKKASFEEASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQRFNNFLK
ALQEKVEIKQLNHFWEIVVQDGITLITKEEASGSSVTAEEAKKFLAPKDKPSGDTAAVFE
EGGDVDDLLDMI
Sequence of entity 4 (F, G), FASTA
>7NFE_4 Non-homologous end-joining factor 1 (chains F, G)
MEELEQGLLMQPWAWLQLAENSLLAKVFITKQGYALLVSDLQQVWHEQVDTSVVSQRAKE
LNKRLTAPPAAFLCHLDNLLRPLLKDAAHPSEATFSCDCVADALILRVRSELSGLPFYWN
FHCMLASPSLVSQHLIRPLMGMSLALQCQVRELATLLHMKDLEIQDYQESGATLIRDRLK
TEPFEENSFLEQFMIEKLPEACSIGDGKPFVMNLQDLYMAVTTQEVQVGQKHQGAGDPHT
SNSASLQGIDSQCVNQPEQLVSSAPTLSAPEKESTGTSGPLQRPQLSKVKRKKPRGLFS
Sequence of entity 5 (H, I), FASTA
>7NFE_5 DNA repair protein XRCC4 (chains H, I)
MERKISRIHLVSEPSITHFLQVSWEKTLESGFVITLTDGHSAWTGTVSESEISQEADDMA
MEKGKYVGELRKALLSGAGPADVYTFNFSKESCYFFFEKNLKDVSFRLGSFNLEKVENPA
EVIRELICYCLDTIAENQAKNEHLQKENERLLRDWNDVQGRFEKCVSAKEALETDLYKRF
ILVLNEKKTKIRSLHNKLLNAAQEREKDIKQEGETAICSEMTADRDPVYDESTDEESENQ
TDLSGLASAAVSKDDSIISSLDVTDIAPSRKRRQRMQRNLGTEPKMAPQENQLQEKENSR
PDSSLPETSKKEHISAENMSLETLRNSSPEDLFDEI
Sequence of entity 6 (J), FASTA
>7NFE_6 DNA ligase 4 (chains J)
MAASQTSQTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKNHKDV
TDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTHG
DAGDFAMIAYFVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSA
LEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGLSDISI
TLFSAFKPMLAAIADIEHIEKDMKHQSFYIETKLDGERMQMHKDGDVYKYFSRNGYNYTD
QFGASPTEGSLTPFIHNAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRMVEDSDL
QTCYCVFDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKNEVIDALNE
AIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKGSRGGMM
SHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSSILC
GTEKPEVYIEPCNSVIVQIKAAEIVPSDMYKTGCTLRFPRIEKIRDDKEWHECMTLDDLE
QLRGKASGKLASKHLYIGGDDEPQEKKRKAAPKMKKVIGIIEHLKAPNLTNVNKISNIFE
DVEFCVMSGTDSQPKPDLENRIAEFGGYIVQNPGPDTYCVIAGSENIRVKNIILSNKHDV
VKPAWLLECFKTKSFVPWQPRFMIHMCPSTKEHFAREYDCYGDSYFIDTDLNQLKEVFSG
IKNSNEQTPEEMASLIADLEYRYSWDCSPLSMFRRHTVYLDSYAVINDLSTKNEGTRLAI
KALELRFHGAKVVSCLAEGVSHVIIGEDHSRVADFKAFRRTFKRKFKILKESWVTDSIDK
CELQEENQYLI
Sequence of entity 7 (D), FASTA
>7NFE_7 DNA (5'-D(P*AP*AP*TP*AP*AP*AP*CP*TP*AP*AP*AP*AP*AP*CP*TP*AP*TP*TP*AP*TP*TP*AP*TP*G)-3') (chains D)
AATAAACTAAAAACTATTATTATG
Sequence of entity 8 (E), FASTA
>7NFE_8 DNA (5'-D(P*TP*AP*AP*TP*AP*AP*TP*AP*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*AP*G)-3') (chains E)
TAATAATAGTTTTTAGTTTATTAG

Primary citation

Cryo-EM of NHEJ supercomplexes provides insights into DNA repair. Chaplin, A.K., Hardwick, S.W., Stavridi, A.K. et al. Mol Cell (2021) 81:3400-3409. DOI 10.1016/j.molcel.2021.07.005 · PubMed

Other PDB entries of the same protein (UniProt P78527), best resolution first:

Browse structure collections

About this viewer

MolViewer shows 7NFE directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.