7OTV: DNA-PKcs

DNA-PKcs in complex with wortmannin. Determined by electron microscopy at 3.24 Å resolution. Released 12 Jan 2022.

Method
Electron microscopy
Resolution
3.24 Å
Organism
Homo sapiens
Chains
1
Atoms
29,041
Mol. weight
471.8 kDa
Ligands
KWT
Released
12 Jan 2022

Explore 7OTV in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7OTV contains 227 α-helices and 25 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 227 helices, 25 β-strands

ElementResiduesLengthSheet
α-helix12-2211
α-helix34-4411
α-helix54-574
α-helix59-7214
α-helix78-9619
α-helix104-11613
α-helix130-14112
α-helix148-1503
α-helix154-1618
α-helix162-1643
α-helix174-18411
α-helix192-20615
α-helix218-2225
α-helix224-2318
α-helix242-25413
α-helix267-27711
α-helix285-2884
α-helix291-30111
α-helix309-32820
α-helix335-35016
α-helix357-36812
α-helix371-3766
α-helix381-39212
α-helix393-3975
α-helix410-42112
α-helix429-4313
α-helix432-44413
α-helix451-46818
α-helix473-4742
α-helix475-4806
α-helix481-49111
α-helix494-4952
α-helix528-5347
α-helix540-5445
α-helix545-5473
α-helix560-57617
β-strand583-58531
β-strand612-61431
α-helix617-63317
α-helix639-6413
α-helix643-6453
α-helix646-65914
α-helix665-67915
α-helix698-71720
α-helix725-7339
α-helix738-7436
α-helix745-75915
α-helix763-77917
α-helix782-7854
α-helix786-7883
α-helix789-7924
α-helix793-7997
α-helix802-8043
α-helix848-86114
α-helix867-8715
α-helix873-8764
β-strand893-89532
β-strand904-90632
α-helix907-9104
α-helix911-92010
α-helix926-94419
α-helix959-97315
α-helix978-99518
α-helix1003-10053
α-helix1008-10114
α-helix1024-104320
α-helix1046-10505
α-helix1056-106712
α-helix1076-108510
α-helix1093-111321
α-helix1114-11163
α-helix1123-114018
α-helix1142-11454
β-strand114913
β-strand116313
α-helix1165-117410
α-helix1181-119414
α-helix1195-11973
α-helix1204-121411
α-helix1218-12258
α-helix1253-127119
α-helix1278-12814
α-helix1290-12978
α-helix1327-135024
α-helix1355-13606
α-helix1365-137713
α-helix1379-13824
α-helix1391-140818
α-helix1412-14209
α-helix1425-14328
α-helix1442-146120
α-helix1464-14674
α-helix1477-14804
α-helix1482-14887
α-helix1507-151913
α-helix1525-15328
β-strand153714
β-strand154015
β-strand155115
β-strand155414
α-helix1555-15628
α-helix1564-157310
α-helix1575-158410
α-helix1592-160615
α-helix1612-162413
α-helix1626-16294
α-helix1639-165517
α-helix1668-167912
α-helix1686-16927
α-helix1693-16953
α-helix1696-16994
α-helix1707-172115
α-helix1734-175320
α-helix1756-176611
α-helix1775-178511
α-helix1791-180515
α-helix1814-18185
α-helix1819-18235
α-helix1824-18285
α-helix1835-185218
α-helix1864-188118
α-helix1886-18894
β-strand189816
β-strand190117
β-strand190216
β-strand190317
α-helix1911-192313
α-helix1935-195521
α-helix1971-19744
α-helix2094-210512
α-helix2124-213411
α-helix2140-215213
α-helix2154-21574
α-helix2158-21603
α-helix2161-217111
α-helix2184-219512
α-helix2206-222116
α-helix2228-224417
α-helix2255-22606
α-helix2268-22703
α-helix2271-228212
α-helix2296-23049
α-helix2305-23084
α-helix2313-233220
α-helix2338-235114
α-helix2358-236912
α-helix2372-23743
α-helix2379-23857
α-helix2386-23883
α-helix2392-240312
α-helix2414-24174
α-helix2420-24234
α-helix2430-244213
α-helix2443-24453
α-helix2448-245811
α-helix2459-24613
α-helix2470-248314
α-helix2495-250814
α-helix2509-25113
α-helix2515-252511
α-helix2535-25417
α-helix2542-25454
α-helix2558-25636
α-helix2788-279811
α-helix2802-281918
α-helix2826-284520
α-helix2852-286312
α-helix2868-28703
α-helix2873-288210
α-helix2886-289914
α-helix2918-293215
α-helix2936-29427
α-helix2943-29475
α-helix2955-29617
α-helix2965-297612
α-helix2988-300417
α-helix3008-30136
α-helix3041-305313
α-helix3062-30709
α-helix3075-30806
α-helix3083-309311
α-helix3096-311621
α-helix3122-31309
α-helix3133-314513
α-helix3154-316613
α-helix3168-31703
α-helix3176-319520
α-helix3231-324818
α-helix3254-32618
α-helix3272-328615
α-helix3291-330616
α-helix3319-33235
α-helix3324-334320
α-helix3346-33516
α-helix3355-33639
α-helix3370-339122
α-helix3407-342923
α-helix3442-345514
α-helix3459-34635
α-helix3466-34716
α-helix3476-34794
α-helix3483-34875
α-helix3496-34983
α-helix3499-35024
α-helix3503-35053
α-helix3515-352410
α-helix3530-35378
α-helix3549-356214
α-helix3567-357610
α-helix3581-359313
α-helix3606-36083
α-helix3609-36168
α-helix3627-36359
α-helix3640-36434
α-helix3650-36523
α-helix3658-367013
α-helix3671-36733
α-helix3687-36893
β-strand370018
α-helix3712-37132
β-strand371818
β-strand3719-372249
β-strand3727-372829
β-strand3736-374279
β-strand3746-375279
α-helix3759-377618
α-helix3780-37834
β-strand3793-379759
β-strand3800-380459
β-strand3809-3811310
α-helix3812-38187
α-helix3822-38298
α-helix3835-384511
α-helix3854-38618
α-helix3866-387510
α-helix3882-38898
α-helix3894-391724
α-helix3925-39273
β-strand3928-3931410
β-strand3937-3939310
α-helix3948-39514
α-helix3965-39684
α-helix3979-399315
α-helix3995-400612
α-helix4013-40219
α-helix4044-40496
α-helix4056-406712
α-helix4074-40818
α-helix4102-411110
α-helix4114-41174
α-helix4122-41243
α-helix6003-60097

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic…Aprotein4148Homo sapiensP78527
Sequence of entity 1 (A), FASTA
>7OTV_1 DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-PKcs (chains A)
MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFS
RDFGLLVFVRKSLNSIEFRECREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKDRA
AKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGL
LGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEE
DPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKW
CAHTNVELKKAALSALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNVDSNNKELS
IAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASV
LLYLDTVPEVYTPVLEHLVVMQIDSFPQYSPKMQLVCCRAIVKVFLALAAKGPVLRNCIS
TVVHQGLIRICSKPVVLPKGPESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQM
MDSILADEAFFSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGV
WMIPTSDPAANLHPAKPKDFSAFINLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRL
PLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQ
YKDELLASCLTFLLSLPHNIIELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYI
DRHVMQPYYKDILPCLDGYLKTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNL
SSNEAISLEEIRIRVVQMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFRE
MKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQ
LYKRTFPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDP
VDSTLRDFCGRCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASL
AFNNIYREFREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEK
KHVSLNKAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPG
NRSPNLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLL
LAALECYNTFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAGN
RTSPQEGERYNYSKCTVVVRIMEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCEPA
SIGFNIGDVQVMAHLPDVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPD
AQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPGDERQCL
PSLDLSCKQLASGLLELAFAFGGLCERLVSLLLNPAVLSTASLGSSQGSVIHFSHGEYFY
SLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGMLDQSFRERANQKHQGLKLAT
TILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSSVSFNTSHGSFPEVFTTYISLLA
DTKLDLHLKGQAVTLLPFFTSLTGGSLEELRRVLEQLIVAHFPMQSREFPPGTPRFNNYV
DCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRRIARRGSCVTQVGLLES
VYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDVLKSRFTKLNE
STFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVFHGSCITEGNELTKTLIKLCY
DAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFEN
LIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAANGDSDGPSYMSSLSYLADSTLSEEM
SQFDFSTGVQSYSYSSQDPRPATGRFRRREQRDPTVHDDVLELEMDELNRHECMAPLTAL
VKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKLGNPIVPLNIRLFLAKLVINTEEVFRPY
AKHWLSPLLQLAASENNGGEGIHYMVVEIVATILSWTGLATPTGVPKDEVLANRLLNFLM
KHVFHPKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSGKDPNSKDNSVGIQLLGIV
MANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVYAAAAEVLGLILRYVMERKNILEES
LCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEV
VLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKLKPVELRELLNPVVE
FVSHPSTTCREQMYNILMWIHDNYRDPESETDNDSQEIFKLAKDVLIQGLIDENPGLQLI
IRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATNFLLEMTSMSPDYPNPMFEHP
LSECEFQEYTIDSDWRFRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQ
QHDFTLTQTADGRSSFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDF
GKKRLGLPGDEVDNKVKGAAGRTDLLRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKSE
LKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSLFSGILKEM
DKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGC
LASLQQPVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLR
GIFTSEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLD
CYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQS
LLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVL
LHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWD
DIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKM
KMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTV
LKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRIL
ELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAGVIDAYMTLADFC
DQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETL
SLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESY
SFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTP
VNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFN
DITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIA
GFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSA
CSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYK
DWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLAL
RSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMP
FRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKM
LKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAV
ARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPWMXXXXXXXXXXXX
XXXXXXXX

Ligands and cofactors

IDNameFormulaCopies
KWT(1S,6BR,9AS,11R,11BR)-9A,11B-dimethyl-1-[(methyloxy)methyl]-3,6,9-trioxo-1,6,6B…C23 H24 O81

Primary citation

Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs. Liang, S., Thomas, S.E., Chaplin, A.K. et al. Nature (2022) 601:643-648. DOI 10.1038/s41586-021-04274-9 · PubMed

Other PDB entries of the same protein (UniProt P78527), best resolution first:

Browse structure collections

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