7OW3: HLA-A*11:01

Crystal structure of HLA-A*11:01 in complex with KRAS peptide (VVVGAGGVGK). Determined by X-ray diffraction at 2.46 Å resolution. Released 20 Jul 2022.

Method: X-ray diffraction
Resolution: 2.46 Å
Organism: Homo sapiens
Chains: 12
Atoms: 12,705
Mol. weight: 178.31 kDa
Released: 20 Jul 2022

Explore 7OW3 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7OW3 contains 51 α-helices and 120 β-strands across 10 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and D: 10 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	3-12	10	1
α-helix	20	1
β-strand	21-28	8	1
β-strand	31-37	7	1
β-strand	46-47	2	1
α-helix	50-52	3
α-helix	57-84	28
β-strand	94-103	10	1
β-strand	109-118	10	1
β-strand	121-126	6	1
β-strand	133-135	3	1
α-helix	138-149	12
α-helix	152-160	9
α-helix	163-174	12
α-helix	176-179	4
β-strand	183	1	2
α-helix	184-185	2
β-strand	186-193	8	3
β-strand	198-208	11	3
β-strand	209	1	2
β-strand	214-219	6	4
β-strand	222-223	2	4
β-strand	228-230	3	3
α-helix	231-233	3
β-strand	234-235	2	3
β-strand	241-250	10	3
α-helix	254-256	3
β-strand	257-262	6	4
β-strand	270-272	3	4

Chains B, E, H and K: 2 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	5
α-helix	4-5	2
β-strand	6-11	6	6
β-strand	21-30	10	6
β-strand	31	1	5
β-strand	36-41	6	7
β-strand	44-45	2	7
β-strand	50-51	2	6
α-helix	52-54	3
β-strand	55-56	2	6
β-strand	62-70	9	6
β-strand	78-83	6	7
β-strand	91-94	4	7

Chain C: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	2-4	3

Chain G: 10 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	3-12	10	15
β-strand	21-28	8	15
β-strand	31-37	7	15
β-strand	46-47	2	15
α-helix	50-52	3
α-helix	57-84	28
β-strand	94-103	10	15
β-strand	109-118	10	15
β-strand	121-126	6	15
β-strand	133-135	3	15
α-helix	138-149	12
α-helix	152-158	7
α-helix	159-163	5
α-helix	164-174	11
α-helix	176-179	4
β-strand	183	1	16
α-helix	184-185	2
β-strand	186-193	8	17
β-strand	198-208	11	17
β-strand	209	1	16
β-strand	214-219	6	18
β-strand	222-223	2	18
β-strand	228-230	3	17
α-helix	231-233	3
β-strand	234-235	2	17
β-strand	241-250	10	17
α-helix	254-256	3
β-strand	257-262	6	18
β-strand	270-272	3	18

Chain J: 11 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	3-12	10	22
α-helix	20	1
β-strand	21-28	8	22
β-strand	31-37	7	22
β-strand	46-47	2	22
α-helix	50-52	3
α-helix	57-84	28
β-strand	94-103	10	22
β-strand	109-118	10	22
β-strand	121-126	6	22
β-strand	133-135	3	22
α-helix	138-149	12
α-helix	152-158	7
α-helix	159-163	5
α-helix	164-174	11
α-helix	176-179	4
β-strand	183	1	23
α-helix	184-185	2
β-strand	186-193	8	24
β-strand	198-208	11	24
β-strand	209	1	23
β-strand	214-219	6	25
β-strand	222-224	3	25
β-strand	228-230	3	24
α-helix	231-233	3
β-strand	234-235	2	24
β-strand	241-250	10	24
α-helix	254-256	3
β-strand	257-262	6	25
β-strand	270-272	3	25

Chain L: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	7-9	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
MHC class I antigen	A, D, G, J	protein	275	Homo sapiens	A0A583ZB34 (AlphaFold model)
Beta-2-microglobulin	B, E, H, K	protein	100	Homo sapiens	P61769 (AlphaFold model)
KRAS peptide (VVVGAGGVGK)	C, F, I, L	protein	10	Homo sapiens	P01111 (AlphaFold model)

Sequence of entity 1 (A, D, G, J), FASTA

>7OW3_1 MHC class I antigen (chains A, D, G, J)
GSHSMRYFYTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYW
DQETRNVKAQSQTDRVDLGTLRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDG
KDYIALNEDLRSWTAADMAAQITKRKWEAAHAAEQQRAYLEGRCVEWLRRYLENGKETLQ
RTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGT
FQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWE

Sequence of entity 2 (B, E, H, K), FASTA

>7OW3_2 Beta-2-microglobulin (chains B, E, H, K)
MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKD
WSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Sequence of entity 3 (C, F, I, L), FASTA

>7OW3_3 KRAS peptide (VVVGAGGVGK) (chains C, F, I, L)
VVVGAGGVGK

Primary citation

Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen. Poole, A., Karuppiah, V., Hartt, A. et al. Nat Commun (2022) 13:5333. DOI 10.1038/s41467-022-32811-1

Other PDB entries of the same protein (UniProt A0A583ZB34 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7OW4 1.81 Å, Crystal structure of HLA-A*11:01 in complex with KRAS G12D peptide (VVVGADGVGK)
8RYN 1.97 Å, Structure of S2 TCR in complex with HLA-A*11:01 bound to ELFSYLIEK peptide
8WTE 2.17 Å, Crystal structure of TCR in complex with HLA-A*11:01 bound to KRAS-G12V peptide…
8WUL 2.36 Å, Crystal structure of affinity enhanced TCR in complex with HLA-A*11:01 bound to…
8RYQ 2.49 Å, Structure of S8-9F3 TCR in complex with HLA-A*11:01 bound to ELFSYLIEK peptide
7OW5 2.58 Å, Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS peptide (VVVGAGGVGK)
7OW6 2.64 Å, Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS G12D peptide…
7PB2 3.41 Å, Crystal structure of JDI TCR in complex with HLA-A*11:01 bound to KRAS G12D peptide…

Browse structure collections

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