7OWD: CYLD CAP-Gly3

Structure of CYLD CAP-Gly3 (467-552) bound to Ub; tetragonal space group. Determined by X-ray diffraction at 1.71 Å resolution. Released 20 Oct 2021.

Method: X-ray diffraction
Resolution: 1.71 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,349
Mol. weight: 17.96 kDa
Released: 20 Oct 2021

Explore 7OWD in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7OWD contains 4 α-helices and 16 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	2-7	6	1
β-strand	12-16	5	1
β-strand	22	1	4
α-helix	23-34	12
α-helix	38-40	3
β-strand	41-45	5	1
β-strand	48-49	2	1
β-strand	55	1	4
α-helix	57-59	3
β-strand	66-71	6	1

Chain B: 1 helix, 9 β-strands

Element	Residues	Length	Sheet
β-strand	474	1	1
β-strand	475-478	4	2
β-strand	484-492	9	2
β-strand	501-506	6	2
β-strand	514	1	2
β-strand	517-518	2	3
β-strand	521-522	2	3
β-strand	531-535	5	2
α-helix	536-538	3
β-strand	540-541	2	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Ubiquitin carboxyl-terminal hydrolase CYLD	B	protein	86	Homo sapiens	Q9NQC7 (AlphaFold model)
Ubiquitin	A	protein	76	Homo sapiens	P0CG48 (AlphaFold model)

Sequence of entity 1 (B), FASTA

>7OWD_1 Ubiquitin carboxyl-terminal hydrolase CYLD (chains B)
SHGLEVGSLAEVKENPPFYGVIRWIGQPPGLNEVLAGLELEDECAGCTDGTFRGTRYFTC
ALKKALFVKLKSCRPDSRFASLQPVS

Sequence of entity 2 (A), FASTA

>7OWD_2 Ubiquitin (chains A)
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYN
IQKESTLHLVLRLRGG

Primary citation

Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains. Elliott, P.R., Leske, D., Wagstaff, J. et al. Cell Rep (2021) 37:109777-109777. DOI 10.1016/j.celrep.2021.109777 · PubMed

Other PDB entries of the same protein (UniProt Q9NQC7 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9TMK 1.8 Å, Structure of CYLD CAP-Gly2 bound to Listeria effector protein InlC
7OWC 1.85 Å, Structure of CYLD CAP-Gly3 (467-565) bound to Ub; orthorhobic space group
2VHF 2.8 Å, Structure of the CYLD USP domain
1IXD Solution structure of the CAP-GLY domain from human cylindromatosis tomour-suppressor CYLD
1WHL Solution structure of the 1st CAP-Gly domain in human cylindromatosis tumor suppressor…
1WHM Solution structure of the 2nd CAP-Gly domain in human cylindromatosis tumor suppressor…

Browse structure collections

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