7P4R: Ribonuclease pancreatic

Ultra High Resolution X-ray Structure of Orthorhombic Bovine Pancreatic Ribonuclease at 100K. Determined by X-ray diffraction at 0.85 Å resolution. Released 27 Jul 2022.

Method: X-ray diffraction
Resolution: 0.85 Å
Organism: Bos taurus
Chains: 1
Atoms: 1,490
Mol. weight: 14.89 kDa
Ligands: EOH
Released: 27 Jul 2022

Explore 7P4R in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7P4R contains 4 α-helices and 10 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain AAA: 4 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	4-12	9
β-strand	13	1	1
α-helix	25-32	8
β-strand	43-47	5	1
α-helix	51-55	5
α-helix	56-59	4
β-strand	61-63	3	2
β-strand	72-74	3	2
β-strand	79-86	8	1
β-strand	91	1	3
β-strand	94	1	3
β-strand	97-104	8	1
β-strand	106-111	6	2
β-strand	116-123	8	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Ribonuclease pancreatic	AAA	protein	124	Bos taurus	P61823 (AlphaFold model)

Sequence of entity 1 (AAA), FASTA

>7P4R_1 Ribonuclease pancreatic (chains AAA)
KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQ
KNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHF
DASV

Ligands and cofactors

ID	Name	Formula	Copies
EOH	Ethanol	C2 H6 O	11

Water and common crystallization additives (SO4) are not listed.

Primary citation

Ultra-high resolution X-ray structure of orthorhombic bovine pancreatic Ribonuclease A at 100K. Lisgarten, D.R., Palmer, R.A., Cooper, J.B. et al. BMC Chem (2023) 17:91-91. DOI 10.1186/s13065-023-00959-6 · PubMed

Other PDB entries of the same protein (UniProt P61823 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6ETK 0.85 Å, Atomic resolution structure of RNase A (data collection 1)
6ETL 0.85 Å, Atomic resolution structure of RNase A (data collection 2)
1DY5 0.87 Å, Deamidated derivative of bovine pancreatic ribonuclease
6ETM 0.92 Å, Atomic resolution structure of RNase A (data collection 3)
6ETN 0.92 Å, Atomic resolution structure of RNase A (data collection 4)
6ETO 1.02 Å, Atomic resolution structure of RNase A (data collection 5)
6ETP 1.02 Å, Atomic resolution structure of RNase A (data collection 6)
1KF3 1.05 Å, Atomic Resolution Structure of RNase A at pH 5.9
2E3W 1.05 Å, X-ray structure of native RNase A
6ETQ 1.08 Å, Atomic resolution structure of RNase A (data collection 7)
1KF2 1.1 Å, Atomic Resolution Structure of RNase A at pH 5.2
1KF4 1.1 Å, Atomic Resolution Structure of RNase A at pH 6.3

Browse structure collections

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